Bleeding In Group Research Articles

Intracranial haemorrhage and falls: cause or effect?

A difficult question in autopsy practice is whether intracranial haemorrhage has resulted from or brought about a fall. To address this we undertook a retrospective study of all autopsy reports (N= 2126) complied over a 10 year period (2009-2018). Of 720 patients who underwent a comprehensive post mortem neuropathologic examination we found 226 patients who had a history of a fall. Of the 226 with a history of fall, 175 (79%) had an intracranial haemorrhage which was classified as truamatic (n= 134, 77%) or spontaneous (n= 41, 23%. Within the traumatic group, falls from a standing height (51%) were more common than falls involving stairs (31%) or falls from a height (12%). Cerebral contusional injury (51%) and subdural haemorrhage (45%) were the most common type of haemorrhage in the traumatic group. In the spontaneous haemorrhage group cerebral amyloid angiopathy (49%) was the commonest detected cause and was typically lobar in distribution). We are of the view that a comprehensive analysis of fatal falls with intracranial haemorrhage warrants a detailed neuropathologic examination as part of the overall death analysis.

Efficacy of endoscopic treatment oncolorectal laterally spreading tumor and risk factors of delayed bleeding after operation

Objective: To evaluate the endoscopic treatment efficacy of colorectal laterally spreading tumor (LST) and analyze the risk factors for delayed post-polypectomy bleeding (DPPB). Methods: Between January 2015 and December 2020, patients underwent colorectal endoscopic submucosal dissection (ESD) or hybrid ESD were recruited from the Second Affiliated Hospital of Zhejiang University. Complete resection rate, perforation rate, bleeding rate, operation time and lesion adhesion were compared between the ESD and hybrid ESD groups. Patients were divided into bleeding and non-bleeding groups based on the presence of DPPB. Multivariate logistic regression analysis was used to analyze the risk factors of DPPB. Results: A total of 665 patients with colorectal LST were enrolled, including 376 males and 289 females, with an average age of (57.4±0.4) years. There were 471 cases underwent ESD and 194 cases underwent hybridized ESD. There were no significant differences in gender, age, history of smoking and drinking, and prevalence of hypertension between the two groups (all P>0.05). Likewise, the rate of lesion adhesion (4.2% vs 7.7%, P=0.067), lesion complete resection (96.8% vs 93.8%, P=0.418), perforation (0.6% vs 1.0%, P=0.594), delayed bleeding (2.8% vs 2.1%, P=0.605) were not statistically significant between the two groups. Seventeen patients (2.6%) developed DPPB after endoscopic treatment. Multivariate logistic regression analysis showed that the lesion was in the rectum (OR=3.594, 95%CI: 1.237-10.443, P=0.019) and the diameter of the lesion>2 cm (OR=3.776, 95%CI: 1.411-10.106, P=0.008) were risk factors for DPPB. Conclusions: Both ESD and hybrid ESD are successful treatments for colorectal LST. Colorectal LST lesion site and lesion size>2 cm are risk factors of DPPB.

Acute hemicranial pain accompanied with a pearl and string type dissection of intracranial vertebral artery: Consideration for the time when to finish the medical observation.

The International Classification of Headache Disorder (ICHD) clearly guides the suspicion of intracranial vertebral artery dissection (ICVAD) in headache patients, but guidelines on how observational or imaging studies should be performed to detect dangerous progression early are unclear. Fifty-six cases with pearl and string type intracranial vertebral artery dissection were divided into 3 groups: 39 in the headache group, 6 in the infarction group, and 11 in the hemorrhagic group. Clinical and angiographic data were analyzed and compared. Most headaches resolved within 2 weeks and did not exceed 8 weeks. Of the 33 patients (84.6%) who underwent continuous follow-up imaging, 18 (54.5%) returned to normal, but 3 (9%) had deteriorated. All the patients survived without subsequent bleeding or infarction. Image changes started before 3rd month and ended after 6 to 7 months. In acute ICVADs, image changes occur at the same time as the headache resolves and continue for several months after the headache has subsided. Since the dissection is likely to worsen even after the headache disappears, the image changes continue over several months, and prediction of rupture of unruptured ICVAD is unpredictable, it is desirable to conduct continuous imaging studies regularly after the initiation of dissection until stabilization is confirmed.

Safety and efficacy of using portable coagulation monitor for INR examination after left-sided mechanical prosthetic valve replacement

BackgroundTime in therapeutic range (TTR) is an index to assess the effectiveness of anticoagulation and is important to predict the risk of bleeding and thrombosis in patients taking warfarin. In recent years, the portable coagulation monitor, a point-of-care testing device for patients to perform self-management international normalized ratio (INR) examination, has provided an opportunity to improve the quality of oral warfarin treatment. In this study, we applied TTR to evaluate the safety and efficacy of the portable coagulation monitor for patients with oral anticoagulant warfarin after left-sided mechanical prosthetic valve (MPV) replacement.MethodsIt is a single-centre cohort study. From September 2019 to June 2021, a total of 243 patients who returned to our institution for outpatient clinic revisit at 3 months after left-sided MPV replacement, met the inclusion criteria and agreed to be followed up were included. Self-management group used portable coagulation monitor for INR examination, and patients in the conventional group had their INR monitored in routine outpatient visits. Clinical data of the patients would be recorded for the next 12 months, and results were compared between the two groups to assess the effect of the coagulation monitor on TTR and complications related to bleeding and thrombosis in patients with left-sided MPV replacement.ResultsA total of 212 individuals provided complete and validated INR data spanning of 1 year. Those who applied the portable coagulation monitor had higher TTR values and larger number of tests for INR. No significant differences were seen between the two groups in postoperative bleeding and thromboembolic complications, but portable coagulation monitor showed a trend toward fewer bleeding events.ConclusionPortable devices for coagulation monitoring are safe and can achieve a higher TTR. Patients who use the portable coagulation monitor for home INR self-management can achieve a safe and effective warfarin therapy.

CAUSES OF EXCESSIVE BLEEDING IN PATIENTS UNDERGONE OPEN HEART SURGERY DURING EARLY POSTOPERATIVE PERIOD; OUR EXPERİENCES FOR TWO YEARS

<h3>Objective</h3> The rate of excessive bleeding during open-heart surgery is 10 %. The rate of re-exploration is about 4-6 %. Therefore, it makes the mortality and morbidity increase after surgery The aim of our study is to identify the incidence of excessive bleeding and its causes during the early postoperative phases in patients undergone open-heart surgery in our institution for two years respectively. <h3>Design and Method</h3> It reviewed the hospital database to identify patients who underwent elective open-heart surgery between Jan.2019 and Jan.2021. It was defined as excessive bleeding involved measuring the amount of hemorrhage during the 1st, 2nd, 3rd, and 24th hours. We divided the cases into two groups, Group Bleeding; Group B; if excessive bleeding was present, and Group Control; Group C; if it was not. Data on demographics, clamping and pumping times in the operating room, intraoperative interventions, and clinical data such as the need for blood and blood products replacement in the ICU were recorded in the case files. Data were analyzed Student's t, Mann Witney U, Pearson Chi-Square Tests and Correlations tests. p<0.05 is statically significant. <h3>Results</h3> The incidence of bleeding was 9.7%. The rate of re-exploration was 33%. The presence of chronic lung disease was significantly higher in the bleeding group (Group B) (p=0.006). Preoperative use of anti-aggregates and diuretics was significantly higher in Group B than in Group C (p=0.00 and p=0.02, respectively). There was no significant difference between the groups in terms of bleeding and coagulation laboratory values and the use of intraoperative blood and blood products (Table 1). Postoperative use of blood and blood products was significantly higher in Group B (p<0.001, Table 2). Negative correlation between the female gender and higher EF and bleeding (p=0.032, p=0.047, respectively). A positive correlation was found between chronic lung disease, presence of CRF, diuretic, anticoagulant, EuroScore level, duration of ECD, and duration of CC and bleeding. The incidence of anemia among all patients was found at 41 % <h3>Conclusion</h3> Patients undergoing open-heart surgery under elective conditions had a 9.7% occurrence of excess bleeding and the rate of re-exploration was 33% in the early postoperative period. The presence of chronic lung disease, use of anti-aggregates and diuretics prior to surgery, a low EF score and high EuroScore, and the duration of the patient's CC and ECD were all highly predictive of excessive bleeding. In a conclusion, we thought that to improve the anemia, stopping the anti-aggregates drugs convenient time and having optimum control of the chronic diseases during preoperative evaluation might be effective for preventing excessive bleeding during the perioperative period.

Splenic CT radiomics nomogram predicting the risk of upper gastrointestinal hemorrhage in cirrhosis

ObjectiveTo explore the application value of splenic CT radiomics nomogram in predicting the risk of upper gastrointestinal hemorrhage. MethodsFrom October 2019 to September 2021, a total of 110 patients with cirrhotic portal hypertension were retrospectively analyzed. All patients underwent abdominal CT plain scan and gastroscopy. According to the results of the gastroscopy, the patients were divided into a low and medium-risk bleeding group (n = 45) and a high-risk bleeding group (n = 65). The samples were randomly divided into a training set and a validation set according to the ratio of 7:3. A total of 1647 unscanned splenic radiomics features were extracted, and 12 radiomics features closely related to gastrointestinal hemorrhage were analyzed and screened by the national variance threshold method and LASSO algorithm. The clinical bleeding risk factors PLT obtained from multiple regression analysis were modeled, and the radiomics model was combined to construct a nomogram predicting the risk of upper gastrointestinal hemorrhage. ResultsThe area under the curve values of the combined radiomics model and clinical high-risk bleeding factor model in the training and test sets were 0.947 and 0.924, which were higher than those of the radiomics model alone and the clinical high-risk bleeding factor PLT model. ConclusionThe splenic CT radiomics nomogram combined with clinical high-risk factors has high consistency in predicting upper gastrointestinal hemorrhage with digestive endoscopy.

Comprehensive analysis of coagulation factor delivery strategies in a cohort of trauma patients

PurposeThe 5th edition of The European recommendations for the management of major bleeding and coagulopathy following trauma leaves room for various coagulation factor administration strategies. The present study examines these strategies reporting prevalence and timing of administration, quantity dispensed, and transfusion ratios in French trauma centers and their compliance with recommendations alongside associated mortality data. MethodsAll adult patients, admitted directly to participating centers between 2011 and 2019, were extracted from a trauma registry. Two subpopulations were studied: severe hemorrhage (SH) and massive transfusion (MT) groups. ResultsA total of 19,396 patients were included, among whom 8.4% (1630) experienced SH and 3% (579) received MT. Within the first 24 hours, 10% received fresh frozen plasma (FFP), rising to 93% and 99% in the subgroups of patients experiencing SH and MT respectively. Only, 8% received fibrinogen concentrate (FC), increasing to 75% and 92% in subgroups SH and MT respectively. Co-administration of FFP and FC became the dominant strategy with 68% of patients at 6 h and 72% at 24 h in SH subgroup. In unadjusted data, mortality was systematically lower in groups that complied with recommendations, a lower mortality than expected was mostly observed in contrast to non-compliant subgroups. The per-patient compliance to studied recommendations was 21% and 22% in SH and MT subgroups. ConclusionThe main hemostatic strategy for major bleeding combined the administration of both FFP and FC, favoring an early additional supply of fibrinogen. Compliance with the recommendations was low in SH and MT subgroups.

Prediction of intracerebral hemorrhage in patients with out-of-hospital cardiac arrest using post-resuscitation electrocardiogram: An observational cohort study

AimWe evaluated the characteristics of patients with intracerebral hemorrhage in nontraumatic out-of-hospital cardiac arrests (OHCA) after return of spontaneous circulation (ROSC) to identify patients who required brain computed tomography as the next diagnostic workup. MethodsWe conducted a retrospective cohort study on 1303 consecutive patients with nontraumatic OHCA who were admitted to Miyazaki Prefectural Nobeoka Hospital between 2008 and 2020. Among these, 454 patients achieved sustained ROSC. We excluded 126 patients with obvious extracardiac causes. Clinical and demographic characteristics of patients and post-resuscitation 12-lead electrocardiogram were compared. Patients were categorized into the intracerebral hemorrhage (n = 32, 10%) and no intracerebral hemorrhage group (n = 296). All causes of intracerebral hemorrhage were diagnosed based on brain computed tomography images by board-certified radiologists. ResultsWe included 328 patients (mean age, 74 years; women, 36%) who achieved ROSC. Logistic regression analyses showed that female sex, younger age (<75 years), no shockable rhythm changes, tachycardia (≥100 bpm), lateral ST-segment elevation, and inferior ST-segment depression on post-resuscitation electrocardiogram were independently associated with intracerebral hemorrhage. We developed a new predictive model for intracerebral hemorrhage by considering 1 point for each of the six factors. The odds ratio for intracerebral hemorrhage increased 2.36 for each 1-point increase (P < 0.001). A score ≥ 4 had 43.7% sensitivity, 90.8% specificity, 34.1% positive predictive value, and 93.7% negative predictive value. ConclusionOur new predictive model might be useful for risk stratification of intracerebral hemorrhage in patients with OHCA who achieved ROSC.

Analysis of risk factors and prognostic factors for gastrointestinal stromal tumors with gastrointestinal hemorrhage: Based on propensity score matching method

BackgroundThis study aimed to analyze the relationship between risk factors and prognosis of patients with gastrointestinal stromal tumor associated with gastrointestinal bleeding. MethodsAccording to whether there was gastrointestinal bleeding, 246 patients with gastrointestinal stromal tumors were divided into 2 groups. The clinicopathological baseline characteristics of the 2 groups of patients were balanced by propensity score matching, and the Kaplan-Meier method was used to draw the survival curve and analyze the overall survival of the 2 groups of patients. The receiver operating characteristic curve was drawn to evaluate the accuracy of Modified National Institutes of Health criteria and Armed Forces Institute of Pathology criteria in predicting the prognosis and postoperative recurrence of patients. Logistic regression analysis of risk factors affecting gastrointestinal stromal tumor with gastrointestinal bleeding before matching. Univariate and multivariate analyses of risk factors affecting the prognosis of patients with gastrointestinal stromal tumors after matching were performed using Cox regression models. ResultsBefore matching, the accuracy of Modified National Institutes of Health criteria in predicting postoperative survival status and recurrence was higher than that of Armed Forces Institute of Pathology criteria. Modified National Institutes of Health criteria and relapse were the risk factors for gastrointestinal stromal tumor with gastrointestinal bleeding independent risk factors (P < .05). After 1:1 matching, the general clinical data of patients with gastrointestinal bleeding group and nongastrointestinal bleeding group were balanced (P > .05). The results of matched survival analysis indicated that tumor location and gastrointestinal bleeding were independent risk factors for the prognosis of patients with gastrointestinal stromal tumors (P < .05). The results of subgroup analysis according to anatomical site showed that there was no significant difference between the gastrointestinal bleeding group and the nongastrointestinal bleeding group (P > .05). Survival analysis showed that patients with gastrointestinal stromal tumors with gastrointestinal bleeding had a worse prognosis, and the results were also applicable in different tumor anatomical locations and different Modified National Institutes of Health criteria. ConclusionModified National Institutes of Health criteria and relapse are independent risk factors for gastrointestinal stromal tumors with gastrointestinal bleeding; gastrointestinal bleeding is associated with poor prognosis in patients with gastrointestinal stromal tumors, and patients with gastrointestinal stromal tumors with gastrointestinal bleeding have a worse prognosis.

Pharmacokinetics of Phenprocoumon in Emergency Situations-Results of the Prospective Observational RADOA-Registry (Reversal Agent Use in Patients Treated with Direct Oral Anticoagulants or Vitamin K Antagonists Registry).

Phenprocoumon has been used as an oral anticoagulant in patients with thromboembolic disease for more than 40 years. So far its pharmacokinetics have not been analyzed in emergency situations. Phenprocoumon-treated patients with major bleeding or urgent surgery were included in a prospective, observational registry. Phenprocoumon drug concentrations were analyzed in samples, collected as part of routine care using ultraperformance liquid chromatography tandem mass spectrometry. Moreover, anticoagulant intensity and drug half-life (t1/2) were calculated. 115 patients were included. Phenprocoumon levels declined over time with a half-life of 5.27 and 5.29 days in patients with major bleedings (n = 82) and with urgent surgery (n = 33). Baseline phenprocoumon levels were 2.2 times higher in the bleeding group compared to the surgery group (1.92 vs. 0.87 ng/mL, p &lt; 0.0001). International normalized ratio (INR) values decreased rapidly during the first 24 h. In 27.6% of patients a rebound of INR (recurrent increase &gt; 1.5) was observed which was associated with significantly increased bleeding rates (22% vs. 4.2% in patients with or without INR rebound, p = 0.012). In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.

The value of the optic nerve sheath diameter measured using computerized brain tomography in the evaluation of mortality status in patients admitted to the emergency department with intracranial hemorrhage

Background/Aim: The optic nerve sheath diameter (ONSD) measurement is a non-invasive method that can be obtained from computerized tomography (CT) images. It can therefore be a useful diagnostic tool in determining prognosis in the emergency department. The aim of this study was to investigate the relationship between ONSD and mortality status in patients with intracranial hemorrhage who presented to the emergency department by measuring ONSD on computerized brain tomography images taken during admission. Methods: This retrospective cohort study was carried out in the emergency department of a tertiary hospital between December 1, 2018 and December 1, 2020 and included intracranial hemorrhage patients and patients with normal brain CT scans that had been obtained for any reason. Bilateral ONSDs were measured in both the intracranial hemorrhage and control groups. We first evaluated whether ONSD would differ between the two groups after which the relationship between ONSD and mortality was analyzed in the patient group who presented with bleeding. Results: Intracranial hemorrhage was present in half the cases and midline shift in 21.5%. A statistically significant increase in ONSD was observed in cases with intracranial hemorrhage (P &lt; 0.001). Similarly, a statistically significant increase in ONSD was found in cases with midline shifts and mortality (P &lt; 0.001). A cut-off value of 4.19 mm for mean optic nerve diameter exhibited 100% sensitivity and 70% specificity in terms of hemorrhage detection (area under the curve [AUC]: 0.952; P &lt; 0.001). A cut-off value of 6.03 mm for ONSD exhibited 76% sensitivity and 74% specificity in terms of hemorrhage detection (AUC: 0.730; P = 0.001). The odds ratio for prediction of mortality based on a regression analysis was 8.838 in cases with intracranial hemorrhage (P &lt; 0.001). Conclusion: ONSSD measured on CT images is a promising tool for prediction of intracranial hemorrhage, midline shift, and mortality status.

Elevated sdLDL level and LDLR rs688 C>T mutation are independent risk factors for ischemic stroke

PurposeTo investigate the level of sdLDL and the frequency of LDLR rs688 polymorphisms, as well as the correspondence between them, and to analyze the risk factors for stroke. MethodsBetween March 2019 and November 2019, 232 patients diagnosed with stroke and 96 health volunteers were enrolled in Quanzhou First Hospital. Subjects were divided into control group, ischemic stroke group (n=120) and hemorrhagic stroke group (n=112). The level of sdLDL and the genotypes and allele frequencies of LDLR rs688 were compared between groups, the correspondence was analyzed with Spearman method. Risk factors were analyzed with Binary logistic regression. ResultsThe level of sdLDL was highest in ischemic group, followed by hemorrhagic stroke group and lowest control group. The differences of genotypes and allele frequencies of LDLR rs688 were significant in ischemic stroke group (p=0.0000 and 0.0000 respectively), while were not significant in hemorrhagic group (p=0.184 and .0137). There was no obvious correlation between the level of sdLDL and LDLR rs688 genotype by Spearman analysis (p=0.116). ConclusionElevated sdLDL level and the C>T mutation of LDLR rs688 are independent risk factors for ischemic stroke, while they are not correlative to hemorrhagic stroke. The surveillance and regulatory of sdLDL level, the detection of LDLR rs688 gene polymorphisms may contribute to the prevention of ischemic stroke.

Immediate versus delayed postpartum insertion of contraceptive implant and IUD for contraception.

Immediate versus delayed postpartum insertion of contraceptive implant and IUD for contraception.

Similar clinical outcomes with transcatheter aortic valve implantation and surgical aortic valve replacement in octogenarians with aortic stenosis.

Transcatheter aortic valve implantation (TAVI) is the preferred treatment option for severe aortic stenosis in the elderly and in patients with comorbidities. We sought to compare outcomes after TAVI and surgical aortic valve replacement (SAVR) in octogenarians. In this retrospective cohort study conducted at our tertiary center, clinical data were gathered before and after TAVI and SAVR procedures performed from January 2013 to May 2019; follow-up completed in March 2021. The primary outcome was 1-year mortality. Patients were stratified according to Society of Thoracic Surgeons (STS) score and procedure type. Propensity score-based matching was also performed. Of 542 patients who matched the inclusion criteria, 273 underwent TAVI and 269 SAVR. TAVI patients were older (85.8 ± 3.0 vs. 82.2 ± 2.2 years; P < 0.001) and had a higher mean STS score (5.0 ± 4.0 vs. 2.8 ± 1.3; P < 0.001) and EuroSCORE II (5.3 ± 4.1 vs. 2.8 ± 6.0; P < 0.001). Rates of postoperative permanent pacemaker insertion (15.0% vs. 9.3%; P = 0.040) and paravalvular leak (9.9% vs. 0.8%; P < 0.001) were higher and acute kidney injury lower (8.8% vs. 32.7%; P < 0.001) after TAVI, with no difference between treatment groups for major bleeding (11.0% vs. 6.7%; P = 0.130) or 30-day mortality (5.5% vs. 3.7%; P = 0.315). A statistically significant difference was found between TAVI and SAVR in low- and intermediate-risk groups when it came to occurrence of paravalvular leak, acute kidney injury, and new onset AF (all P < 0.001). This analysis of an octogenarian "real-life" population undergoing TAVI or SAVR (with a biological valve) showed similar outcomes regarding clinical endpoints in low- and medium-risk (STS score) groups.

Postoperative bleeding adversely affects total knee arthroplasty outcomes in hemophilia

BackgroundHemophilic arthropathy can result in severe degenerative arthritis and functional limitations in the knees of relatively young patients. Total knee arthroplasty (TKA) provides pain relief and gain of function in advanced-stage hemophilic arthropathy cases. However, little is known about the long-term effects of early major postoperative bleeding (MPOB) in people with hemophilia (PWH). The aim of this study was to evaluate the effects of early MPOB on the final functional outcome, complications, and implant survival of TKA in a single-center hemophilia cohort. MethodPWH who underwent TKA between 1998 and 2019 in a single center were reviewed. Demographic data, clinical data, and radiographic images were evaluated. Hospital for Special Surgery (HSS), Knee Society Score (KSS), and Knee Society Function Score (KSS-F) scores were used to determine function. Patients with early bleeding complications (wound dehiscence, ecchymosis, hemarthrosis, hematoma formation, prolonged or recurrent bleeding attacks) were defined as the bleeding group. Patients who did not experience these complications were assigned to the control group. The bleeding group was compared with controls. Survival of the primary arthroplasty was analyzed by Kaplan–Meier curves. ResultsForty-five TKAs in 29 patients were included in the study. TKA led to an increase in the mean range of motion from 46.08° to 84.59° (P < 0.01). HSS scores increased from 48.33 preoperatively to 82.67 postoperatively (P < 0.01). There were improvements in both KSS and KSS-F scores from 34.22 and 53.3 preoperatively to 82.00 and 84.63 (P < 0.01), respectively. Ten patients (10 TKAs) (34%) experienced major bleeding during the postoperative period. Six of these patients had moderate hemophilia, and four had severe hemophilia. Three of these patients had hemarthroses (10.2%), one patient had a hematoma (3.4%), one patient had hemorrhagic bullae formation (3.4%), and five had excessive/prolonged bleeding from the wound (17%). The bleeding group (34%) had significantly worse HSS (63.78 vs 92.75, P < 0.001), KSS (61.78 vs 93.25, P < 0.001), and KSS-F (60.71 vs 96.25, P = 0.005) scores compared with controls. Preoperative and postoperative flexion contractures were positively correlated (+0.33, P = 0.003). One of the patients with postoperative hemarthrosis also had an accompanying transient common peroneal nerve palsy, and one patient (3.4%) had a periprosthetic fracture. Three knees (6.6%), two of whom were in the bleeding group, developed periprosthetic infections. Four knees (8.8%) in three patients underwent revision surgery, and two knees (4.4%) ended up in arthrodeses. Kaplan–Meier analysis revealed a mean survival duration of 17.04 years for the bleeding group and 22.15 years for the control group (P = 0.83). Survival rates were 80.0% for the bleeding group and 96.4% for the control group (P = 0.83). ConclusionsIn this study, MPOB after TKA in PWH was common and led to significantly worse function. MPOB after TKA in PWH was associated with a higher rate of complications and lower survival rates, although the differences were not statistically significant. Efforts must be made to avoid MPOB after TKA in PWH.

Pulmonary hemorrhage in very low birth weight infants: risk factors and clinical outcome

To investigate the risk factors for pulmonary hemorrhage and its clinical outcome in very low birth weight infants (VLBWIs). The medical data were collected from all live VLBWIs (gestational age <35 weeks) who were admitted to Jiangsu Women and Children Health Hospital and Children's Hospital of Nanjing Medical University between January 1, 2020 and December 31, 2021. Based on inclusion and exclusion criteria, 574 VLBWIs were included in the study, with 44 VLBWIs in the pulmonary hemorrhage group and 530 VLBWIs in the non-pulmonary hemorrhage group. The clinical data were compared between the two groups. A multivariate logistic regression analysis was used to identify the risk factors for pulmonary hemorrhage. There were significant differences between the two groups in maternal age, rate of positive-pressure ventilation for resuscitation, rate of tracheal intubation for resuscitation, and minimum body temperature within 1 hour after birth (P<0.05). The pulmonary hemorrhage group had a higher proportion of VLBWIs with grade Ⅲ-Ⅳ respiratory distress syndrome or early-onset sepsis than the non-pulmonary hemorrhage group (P<0.05). The pulmonary hemorrhage group also had a higher proportion of VLBWIs with a capillary refilling time of >3 seconds within 1 hour after birth and with the maximum positive end-expiratory pressure (PEEP) of <5 cmH2O within 24 hours after birth (P<0.05). The multivariate regression analysis showed that maternal age of 30-<35 years (OR=0.115, P<0.05) was a protective factor against pulmonary hemorrhage, while a lower temperature (<34°C) within 1 hour after birth, the maximum PEEP of <5 cm H2O within 24 hours after birth, and early-onset sepsis were risk factors for pulmonary hemorrhage (OR=11.609, 11.118, and 20.661, respectively; P<0.05). For all VLBWIs, the pulmonary hemorrhage group had a longer duration of invasive ventilation and a higher mortality rate than the non-pulmonary hemorrhage group (P<0.05); for the survival VLBWIs, the pulmonary hemorrhage group had a higher incidence rate of bronchopulmonary dysplasia than the non-pulmonary hemorrhage group (P<0.05). Maintaining the stability of temperature, giving appropriate PEEP, and identifying sepsis as early as possible can reduce the incidence rate of pulmonary hemorrhage, thereby helping to reduce the incidence of bronchopulmonary dysplasia and mortality in VLBWIs.

The Risk of Major Bleeding With Apixaban Administration in Patients With Acute Kidney Injury.

Apixaban is eliminated by the kidneys and in acute kidney injury (AKI) there is potential for an increase in apixaban exposure and bleeding events. In one instance, data have shown higher than normal bleed risk in patients with AKI, unless calibrated anti-factor Xa monitoring is used, which is not widely available. To evaluate bleeding with apixaban administration to hospitalized patients with an AKI in an unmonitored real-world scenario. We conducted a retrospective study of patients admitted to a large urban academic teaching hospital from April 2015 to March 2022, who received apixaban for venous thromboembolism or nonvalvular atrial fibrillation (NVAF). The primary outcome evaluated major bleeding when apixaban was administered to patients with or without an AKI. A total of 232 patients were evaluated (116 per group). Most patients (79.7%) were on apixaban for NVAF, 32.7% had chronic kidney disease, 58.2% were on a medication increasing bleed risk, and HAS-BLED score was a median of 2 in both groups. No differences were noted between groups for bleeding (AKI group 7.8% vs non-AKI 3.4%; P = 0.15), and on regression analysis, coadministration of a P2Y12 inhibitor was predictive of major bleeding (odds ratio = 5.9; 95% confidence interval = 1.4-23.6). Although no differences between groups were noted, apixaban use in the AKI group resulted in a higher than normally reported incidence of apixaban-associated major bleeding, and concomitant antiplatelet use increased bleed risk as well. Cautious use of apixaban and further investigation with larger studies are warranted in this area.

The Effectiveness of Compression Therapy in the Prevention of Venous Thromboembolic Complications in Patients With COVID-19

Background The main method for preventing thrombotic complications in patients with coronavirus infection is anticoagulant therapy (ACT). However, its use is not always possible, in particular in patients with bleeding. The only method of prevention in this case is elastic compression (EC) of the lower extremities. Aim of study To evaluate the effectiveness of lower extremity EC for the prevention of venous thromboembolic complications (VTEC) in patients with a new coronavirus infection. Material and methods The study was approved by the local Ethics Committee of the Ryazan State Medical University of the Ministry of Health of Russian Federation and registered on the ClinicalTrials.gov platform (identifier NCT05143567). The study included 69 patients without prophylactic compression (Group 1) and 65 patients who used prophylactic compression stockings (Group 2). The patients were treated in the covid hospital from July to November 2021. All patients had verified coronavirus infection, they took ACT and underwent ultrasound duplex scanning of the veins of the lower extremities upon admission, in the intensive care unit and upon discharge. We assessed the frequency of venous thromboembolic complications (VTEC), hemorrhagic complications, and mortality. To assess the severity of bleeding, the classification of the Committee of the International Society on Thrombosis and Haemostasis (ISTH) was used. Results In patients without prophylactic compression (Group 1) there were 7 VTEC cases (10.14%); deep vein thrombosis (DVT) — 4 (5.8%), pulmonary embolism (PE) — 3 (4.3%). All 6 cases (8.7%) with PE were fatal. It was noted that 2 cases of PE (2.8%) were verified upon autopsy, and not clinically. In patients of the 2nd group with the use of elastic compression, the overall incidence of VTEC was only one case (1.6%). When analyzing the frequency of bleeding in the 1st group, there was one pulmonary bleeding (1.4%), in the 2nd group there was also one case of intense intermuscular hematoma (1.6%). Significant bleeding was observed in one patient (1.4%) of the 1st group, and in 3 (4.8%) cases of the 2nd group. The minor bleeding was observed in 11 patients (15.9%) of the 1st group, and in 8 (12.7%) patients of the 2nd group. The mortality during hospitalization was 11 (15.9%) cases in patients of the 1st group (without EC) and 7 (11.1%) in patients of the 2nd group (with EC) (p=0.419). Conclusions The mortality in patients with coronavirus infection without compression therapy is higher than in patients with compression stockings (p=0.419). Patients wearing compression stockings in the hospital had a low incidence of VTEC (1.6% of cases in group 2 versus 10.14% of cases in group 1, p=0.039). The study groups had the same frequency of bleeding (group 1 — one case (1.4%), group 2 — one case (1.6%). The use of preventive compression at the inpatient stage of treatment of a new coronavirus infection makes it possible to prevent VTEC in patients with bleeding when anticoagulant therapy is not possible.

S658 Risk Factors Associated With Upper Gastrointestinal Bleeding in Cancer Patients Exposed to Immune Checkpoint Inhibitors

Introduction: Immune checkpoint inhibitors (ICIs) have emerged as effective treatment options for many advanced malignancies. These agents have been associated with several immune related adverse events (irAEs) that may lead to discontinuation of therapy. Gastrointestinal (GI) side effects are amongst the most commonly reported irAEs. Currently, limited data exists on upper GI bleed (UGIB) in patients exposed to ICIs. The aim of this study was to evaluate the characteristics and risk factors associated with UGIB among cancer patients treated with ICIs. Methods: We performed a retrospective study on all cancer patients from Cleveland Clinic health system who received treatment with ICI’s till June 2021. Only the patients with clinical and endoscopic evidence of upper GI bleed were included in the study. The study group (GI Bleed) was matched with control group (non-Bleeders) in 1:3. We compared characteristics of both groups (Bleeders and Non-Bleeders) using univariate and multivariate analysis. Results: Of the 6820 patients that received ICIs over the study period, 401 patients developed GI bleed. 30 patients had clinical and endoscopic evidence of upper GI Bleed. The most common endoscopic findings were gastric and duodenal ulcers (63%). Compared with the non-bleeding cohort, patients who developed UGIB bleeding had lower BMI (p= 0.0203). Non-small cell lung cancer was the most frequently treated malignancy in the bleeding group. Patients in the bleeding group had higher exposure to pembrolizumab compared to the non-bleeding group (80% vs. 45.6%, p= 0.001). The incidence of ICI induced colitis and hepatotoxicity were more frequent in the bleeding group compared to the non-bleeding cohort (53.5% vs. 27.8%, p= 0.0106). The presence of cirrhosis, diabetes and chronic kidney disease were similar in both groups. On the multivariant analysis, exposure to pembrolizumab (OR=3.62, p=0.0211), aspirin (OR= 10.55, p=0.0002) and with history of ICI induced colitis and hepatotoxicity (OR=3.66 p=0.0108) were predictive factors in development of bleeding. (Table) Conclusion: This is a novel study that evaluates the risk of UGIB in cancer patients treated with ICIs. In this univariate and multivariate analysis, exposure to aspirin, pembrolizumab and overall incidence of IrAEs were associated with increased risk of bleeding. Although UGIB is a relatively rare irAE, more studies are needed for risk stratification of patients exposed to ICIs. Table 1. - Baseline Clinical Characteristics Of Cancer Patients Exposed To ICIs Variable Non-Bleeding (n=90) Bleeding (n=30) p-value Age, mean ± SD 70.6 ± 11.0 69.6 ± 11.3 0.6854 Gender (Male), n (%) 56 (62.2) 19 (63.3) 0.9133 Race (White), n (%) 76 (84.4) 23 (76.7) 0.3316 Hispanic, n (%) 1 (1.1) 2 (6.7) 0.1539 Medication Type, n (%) PembrolizumabOther 41 (45.6)49 (54.4) 24 (80.0)6 (20.0) 0.0010 BMI, n (%)< 26≥ 26 38 (42.2)52 (57.8) 20 (66.7)10 (33.3) 0.0203 History of Upper GI Bleed, n (%) 7 (7.8) 0 (0.0) 0.1902 On Aspirin prior to procedure, n (%) 5 (5.6) 12 (40.0) < 0.0001 On Plavix prior to procedure, n (%) 1 (1.1) 1 (3.3) 0.4391 On Warfarin prior to procedure, n (%) 0 (0.0) 1 (3.3) 0.2500 Chronic kidney disease, n (%) 34 (37.8) 13 (43.3) 0.5893 Diabetes, n (%) 33 (36.7) 9 (30.0) 0.5073 Cirrhosis, n (%) 4 (4.4) 1 (3.3) 1.0000 Type of cancer treated, n (%)Non-small cell lung cancerOther 25 (27.8)65 (72.2) 15 (50.0)15 (50.0) 0.0253 Evidence of metastasis to the GI Tract, n (%) 4 (4.4) 0 (0.0) 0.5710 ICPI induced side effect, n (%) 25 (27.8) 16 (53.3) 0.0106 Treatment with steroids, n (%) 21 (23.3) 11 (36.7) 0.1527 Treatment with Infliximab or Entyvio, n (%) 1 (1.1) 1 (3.3) 0.4391 Current alive, n (%) 29 (32.2) 8 (26.7) 0.5682 PPI, n (%)NoYes 53 (58.9)37 (41.1) 17 (56.7)13 (43.3) 0.8307 Footnote: PPI (protein pump inhibitor).

Relationship between the Amount of Menstrual Flow and Cardiac Status in Women with Fontan Circulation.

A high prevalence of heavy menstrual bleeding (HMB) has been reported in women with Fontan circulation. Cyanosis has been reported to contribute to HMB, and menstruation has been suggested to affect cardiac status in women with congenital heart disease. This study aimed to evaluate the relationship between the amount of menstrual flow and cardiac status in women with Fontan circulation.Twenty women who had undergone the Fontan procedure were prospectively investigated and the amount of their menstrual flow was evaluated using a questionnaire. Participants were divided into two groups-small and large menstrual bleeding groups-and their clinical data, including the results of hematological tests and echocardiographic findings, were evaluated.One (5%) woman showed primary amenorrhea. Eight of the remaining 19 (42%) women were included in the large menstrual bleeding group. Women with large menstrual bleeding showed a significantly higher hematocrit level (47.1% [36.2%-50.3%] versus 42.1% [35.3%-44.9%], P = 0.006) and longer QRS duration (106 [92-172] ms versus 88 [78-140] ms, P = 0.008), as well as a lower fractional area change (37.4% [35.6%-47.2%] versus 47.0% [38.2%-55.7%], P = 0.010) and global longitudinal strain (-10.5% [-14.9% to -6.6%] versus -13.9% [-20.5% to -7.8%], P = 0.041) of the dominant ventricle on echocardiography, than women with small bleeding.Erythrocytosis, longer QRS duration, and reduced ventricular function were related to increased menstrual bleeding in women with Fontan circulation. These functions may be interrelated with the amount of menstrual flow in such women.