Hemisphere Stimulation Research Articles

Parietal stimulation destabilizes spatial updating across saccadic eye movements

Saccadic eye movements cause sudden and global shifts in the retinal image. Rather than causing confusion, however, eye movements expand our sense of space and detail. In macaques, a stable representation of space is embodied by neural populations in intraparietal cortex that redistribute activity with each saccade to compensate for eye displacement, but little is known about equivalent updating mechanisms in humans. We combined noninvasive cortical stimulation with a double-step saccade task to examine the contribution of two human intraparietal areas to transsaccadic spatial updating. Right hemisphere stimulation over the posterior termination of the intraparietal sulcus (IPSp) broadened and shifted the distribution of second-saccade endpoints, but only when the first-saccade was directed into the contralateral hemifield. By interleaving trials with and without cortical stimulation, we show that the shift in endpoints was caused by an enduring effect of stimulation on neural functioning (e.g., modulation of neuronal gain). By varying the onset time of stimulation, we show that the representation of space in IPSp is updated immediately after the first-saccade. In contrast, stimulation of an adjacent IPS site had no such effects on second-saccades. These experiments suggest that stimulation of IPSp distorts an eye position or displacement signal that updates the representation of space at the completion of a saccade. Such sensory-motor integration in IPSp is crucial for the ongoing control of action, and may contribute to visual stability across saccades.

Transcranial electric stimulation for intraoperative motor evoked potential monitoring: Stimulation parameters and electrode montages

Objective To evaluate the efficacy of constant current transcranial electric stimulation (TES) parameters for eliciting muscle motor evoked potentials (MEPs) in the abductor pollicis brevis muscles (APB) and the tibialis anterior muscles (TA). The following parameters were tested intraoperatively: interstimulus interval (ISI), individual stimulation pulse duration within a train of five stimuli. Different montages of stimulating electrodes were assessed for effectiveness and focality. Further, reference values for APB and TA motor thresholds in neurosurgical patients with normal motor status under total intravenous anesthesia were determined. Methods Motor thresholds of contralateral muscle MEPs were determined at 0.1, 0.2, 0.4, and 0.5 ms pulse duration and ISIs of 2, 3, 4, and 5 ms using a train of five monophasic constant current pulses with C3/C4 (27 patients). The stimulating electrodes were positioned at C1, C2, C3, C4, Cz, and Cz+6 cm. Different montages were used to determine the most effective and the most focal stimulation montages for the APB and TA muscles (30 patients). Eighty-six patients with clinically normal motor function were studied for motor threshold reference values. Results The prolongation of the pulse duration has the strongest effect to decrease the motor threshold, which proportionally increases the delivered charge. The lowest stimulation threshold to elicit muscle MEPs in the APB and TA muscles is achieved with a train of stimuli consisting of an individual stimulus pulse duration of 0.5 ms. An ISI of 4 ms gave the lowest motor thresholds, but did not reach statistical significance compared to 3 ms. The stimulating electrode montage C3/C4 (C4/C3) allows for the lowest stimulation thresholds, but the vigorous muscle contractions it has is a disadvantage. The most focal stimulating electrode montages for the contralateral APB muscles are C3/Cz and C4/Cz, respectively, and for the TA muscles Cz/Cz+6 cm. Conclusions In adult neurosurgical patients with a normal motor status under total intravenous anesthesia, an individual pulse duration of 0.5 ms and an ISI of 4 ms provide the lowest motor thresholds. Pragmatically, C1/C2, resp., C2/C1 montage provides monitorable responses in both APB and TA muscles at reasonable stimulation thresholds without inducing movements disturbing surgery and especially microdissection. If the most focal hemispheric stimulation for the distal upper extremity muscles is required, the use of C3 or C4 referenced to Cz is recommended. Significance The stimulation parameters within a train of five pulses with an individual pulse duration of 0.5 ms and an ISI of 4 ms provide the lowest motor threshold. These data confirm not only studies for D wave recovery but also provide optimal stimulation parameters for intraoperative near threshold stimulation.

Exploring Theta Burst Stimulation as an intervention to improve motor recovery in chronic stroke

ObjectiveTo explore the effects of a single session of repetitive Transcranial Magnetic Stimulation, given as Theta Burst Stimulation, on behavioural and physiological measures of hand function in chronic stroke patients. MethodsSix chronic stroke patients with incomplete recovery of the hand were tested under three conditions: excitatory TBS over the stroke hemisphere (iTBSSH), inhibitory TBS (cTBSIH) over the intact hemisphere and sham stimulation. Behavioural outcomes included simple and choice reaction time paradigms. Physiological effects were assessed using single pulse TMS on both sides. Changes were sought for up to 40min after TBS. ResultsImmediately after iTBSSH simple reaction times in the paretic hands were decreased and, compared to sham stimulation, remained significantly shorter throughout the testing period. The amplitude of the MEPs at rest and during background contraction and the area under the Input–Output curves were also increased on the stroke side after iTBSSH. cTBSIH suppressed the MEPs evoked in the healthy hands but did not change motor behaviour or the electrophysiology of the paretic hands. No side effects were encountered. ConclusionsTBS seems safe in chronic stroke patients. iTBS over the stroke hemisphere transiently improved motor behaviour and corticospinal output in the paretic hands. SignificanceExcitatory TBS may represent a useful rTMS protocol to apply to the stroke hemisphere in future longer term therapy trials.

The origin of activity in the biceps brachii muscle during voluntary contractions of the contralateral elbow flexor muscles

During strong voluntary contractions, activity is not restricted to the target muscles. Other muscles, including contralateral muscles, often contract. We used transcranial magnetic stimulation (TMS) to analyse the origin of these unintended contralateral contractions (termed "associated" contractions). Subjects (n = 9) performed maximal voluntary contractions (MVCs) with their right elbow-flexor muscles followed by submaximal contractions with their left elbow flexors. Electromyographic activity (EMG) during the submaximal contractions was matched to the associated EMG in the left biceps brachii during the right MVC. During contractions, TMS was delivered to the motor cortex of the right or left hemisphere and excitatory motor evoked potentials (MEPs) and inhibitory (silent period) responses recorded from left biceps. Changes at a spinal level were investigated using cervicomedullary stimulation to activate corticospinal paths (n = 5). Stimulation of the right hemisphere produced silent periods of comparable duration in associated and voluntary contractions (218 vs 217 ms, respectively), whereas left hemisphere stimulation caused a depression of EMG but no EMG silence in either contraction. Despite matched EMG, MEPs elicited by right hemisphere stimulation were approximately 1.5-2.5 times larger during associated compared to voluntary contractions (P < 0.005). Similar inhibition of the associated and matched voluntary activity during the silent period suggests that associated activity comes from the contralateral hemisphere and that motor areas in this (right) hemisphere are activated concomitantly with the motor areas in the left hemisphere. Comparison of the MEPs and subcortically evoked potentials implies that cortical excitability was greater in associated contractions than in the matched voluntary efforts.

Inferior Parietal RTMS Affects Performance in an Addition Task

Neuropsychological and neuroimaging studies strongly suggest that the inferior parietal cortex is important for calculation. However, the evidence from neuroimaging experiments for a left hemispheric dominance in calculation is not as clear as one would expect from the studies of patients. Often a concomitant activation of the homologous inferior parietal region of the right hemisphere is reported in the same tasks. The objective of this study was to replicate basic findings of acalculic patients and to investigate discrepancies between data from patients and results from neuroimaging studies in an addition task. Repetitive transcranial magnetic stimulation (rTMS) was applied over inferior parietal areas and the adjacent intraparietal sulcus (IPS) while subjects solved double-digit addition tasks. From studies of acalculic patients it was hypothesised that left hemispheric rTMS stimulation should result in longer reaction times (RTs) in the addition task. On addition trials without TMS subjects showed the classical problem size effect with longer RTs the larger the sum of the two operands. Magnetic stimulation over left inferior parietal areas disrupted performance significantly. The effect was specific to the left hemisphere stimulation. There was no increase in RTs for rTMS stimulation over the right hemisphere.

Neuropsychological intervention in kindergarten children with subtyped risks of reading retardation

Kindergarten children at risk of developing language problems were administered the Florida Kindergarten Screening Battery. A principal components analysis revealed a verbal and a visual-spatial component and subsequent discriminant function analyses a high verbal/low visual-spatial group (LAL: Latent L) and a high visual-spatial/low verbal group (LAP: Latent P). LAL- and LAP-children were considered at risk for developing an L- or P-type of dyslexia, respectively. As is common practice with children suffering from manifest L- or P- dyslexia, the LAL- and LAP-kindergartners received right and left hemisphere stimulation, respectively. The outcomes were compared with those of bilateral hemispheric stimulation and no intervention. Reading tests were administered in primary school Grades 1 and 5/6; teachers' evaluation of reading took place in Grade 5/6. Overall, the LAL- and LAP- groups showed significant backwardness in word and text reading, both at early and late primary school. Types of intervention made a difference though: not significantly backward in early word, late word, and late text reading were the LAL-children who had received right hemisphere stimulation. Nonintervened LAP-children did not show significant backwardness in early word reading and late text reading, nor did LAP-children who had received left hemisphere or bilateral stimulation. Early text reading was not affected by any treatment. Teacher's evaluations were in support of these findings.

Transcranial direct current stimulation of the unaffected hemisphere in stroke patients

Recovery of function after a stroke is determined by a balance of activity in the neural network involving both the affected and the unaffected brain hemispheres. Increased activity in the affected hemisphere can promote recovery, while excessive activity in the unaffected hemisphere may represent a maladaptive strategy. We therefore investigated whether reduction of the excitability in the unaffected hemisphere by cathodal transcranial direct current stimulation could result in motor performance improvement in stroke patients. We compared these results with excitability-enhancing anodal transcranial direct current stimulation of the affected hemisphere and sham transcranial direct current stimulation. Both cathodal stimulation of the unaffected hemisphere and anodal stimulation of the affected hemisphere (but not sham transcranial direct current stimulation) improved motor performance significantly. These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery.

Hemispheric metacontrol and cerebral dominance in healthy individuals investigated by means of chimeric faces

Cerebral dominance and hemispheric metacontrol were investigated by testing the ability of healthy participants to match chimeric, entire, or half faces presented tachistoscopically. The two hemi-faces compounding chimeric or entire stimuli were presented simultaneously or asynchronously at different exposure times. Participants did not consciously detect chimeric faces for simultaneous presentations lasting up to 40 ms. Interestingly, a 20 ms separation between each half-chimera was sufficient to induce detection of conflicts at a conscious level. Although the presence of chimeric faces was not consciously perceived, performance on chimeric faces was poorer than on entire- and half-faces stimuli, thus indicating an implicit processing of perceptual conflicts. Moreover, the precedence of hemispheric stimulation over-ruled the right hemisphere dominance for face processing, insofar as the hemisphere stimulated last appeared to influence the response. This dynamic reversal of cerebral dominance, however, was not caused by a shift in hemispheric specialization, since the level of performance always reflected the right hemisphere specialization for face recognition. Thus, the dissociation between hemispheric dominance and specialization found in the present study hints at the existence of hemispheric metacontrol in healthy individuals.

Does cortical motor neuron excitability change in peripheral nerve injury?

To investigate changes in cortical motor neuron excitability after peripheral nerve injury, evoked spinal cord potentials (ESCPs) following hemispheric transcranial magnetic stimulation (TMS) were recorded in awake patients with unilateral brachial plexus injury. ESCPs following hemispheric TMS were recorded in 6 patients with unilateral complete type brachial plexus injury. Studies were performed within 6 months from the time of injury. ESCPs were recorded from posterior epidural space using catheter electrodes. Hemispheric TMS was applied on the motor cortex using a figure-of-8 coil. The threshold of ESCPs following hemispheric TMS was measured. The number, latency, and amplitude of ESCPs following high stimulus hemispheric TMS were measured and compared. No significant change was observed in the threshold of ESCPs following TMS contra-lateral to the injured upper limb compared to that following TMS contra-lateral to the intact upper limb. Several ESCP components were recorded following high stimulus hemispheric TMS. No significant changes were observed in comparison with number, latency and amplitude of ESCPs following high stimulus TMS contra-lateral to the injured upper limb and those following TMS contra-lateral to the intact upper limb. From a study of ESCPs following single TMS, no evidence was obtained that cortical motor neuron excitability changes in patients with traumatic unilateral brachial plexus injury at relatively early stages. We investigated the changes of cortical motor neuron excitability in patients with brachial plexus injury from the ESCPs following TMS. In single TMS, our data gave no evidence for cortical excitability changes at relatively early stages.

Remote changes in cortical excitability after stroke.

Changes in the cerebral metabolism and the excitability of brain areas remote from an ischaemic brain lesion have been reported in animals and humans and implicated as a mechanism relevant to functional recovery. The aim of the present study was to determine whether changes in the inhibitory and excitatory activity in motor cortex of the non-affected hemisphere are present in stroke patients, and whether these changes are related to the extent of the patients' recovery of function. Transcranial magnetic stimulation (TMS) was used to study the first dorsal interosseus muscle (FDI) of the non-affected hand in 13 patients with good recovery of hand function after stroke, and was compared with left hemispheric stimulation in 13 healthy age-matched volunteers. In the first experiment, paired-pulse TMS with the conditioning stimulus (CS) set at 80% of the subject's motor threshold (MT) and interstimulus intervals (ISIs) of 2, 3, 10 and 15 ms was used. In the second experiment, different intensities of CS were used to study its inhibitory effect on a succeeding suprathreshold test stimulus at an ISI that was kept constant at 2 ms. In a third experiment, the rise in motor evoked potential (MEP) amplitudes with increasing stimulus intensities was measured. In two additional control experiments, the effect of left versus right hemispheric stimulation in normal volunteers and good versus poor recovery of hand function in patients after stroke on the excitability of inhibitory and excitatory activity was studied. MT, mean test MEP and recruitment curves were similar in patients and healthy volunteers. In those patients with good recovery, paired-pulse excitability was increased at ISIs of 2 and 3 ms, similar to healthy volunteers at ISIs of 10 and 15 ms. When tested with different CS intensities at an ISI of 2 ms, inhibitory activity was similar in patients and healthy subjects at small CS intensities, but faded rapidly at higher CS intensities in patients. In contrast, in patients with poor recovery, this increase in cortical excitability at higher CS intensities was not seen. The similarity of MT, mean test MEP and recruitment curves in patients and healthy volunteers indicates that the overall corticomotoneuronal excitability has not changed in patients. The similarity of the inhibitory effect at low CS intensities in the patients with good recovery and healthy subjects, and the steeper increase of conditioned MEP amplitude at higher CS intensities in the recovering patients suggest that in the patients' contralesional motor cortex the balance of excitatory and inhibitory activity was shifted towards an increase of excitatory activity in the neuronal circuits tested at ISIs of 2 and 3 ms. This shares similarities to mechanisms implicated as relevant for reorganizational processes after experimental brain injury and may be relevant for functional recovery after stroke. The absence of changes in cortical excitability in patients with poor recovery supports the relevance of our findings for recovery.

An investigation into asymmetrical cortical regulation of salivary S-IgA in conscious man using transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) can activate discrete areas of the cerebral cortex through the intact skull of healthy conscious volunteers. A magnetic coil generates a brief and focused magnetic field that penetrates the skull to activate the specific area of cerebral cortex beneath. This non-invasive procedure is painless, well tolerated by participants and now widely used to explore brain function. We used TMS to investigate asymmetrical cortical regulatory influences on one aspect of immune function: secretion of the antibody immunoglobulin A (S-IgA) into saliva. The right and left temporo-parietal-occipital cortex of 16 healthy, conscious subjects was stimulated on two different occasions, at least 1 week apart. There was an immediate increase in S-IgA concentration following both right and left stimulation. Saliva volume was reduced immediately post-right but not left stimulation. When secretion (μg/min) of S-IgA was calculated (controlling for changing saliva volume) an increase was apparent following left but not right hemisphere stimulation. Furthermore, a significant difference between the relationship between S-IgA concentration and volume of saliva post-left and right stimulation was observed. We conclude that TMS can be used as a tool to investigate cortical regulation of autonomic and immune function in healthy, conscious human subjects and that secretion of saliva and S-IgA is differentially affected by stimulation of the left and right cerebral cortex.

Transcranial magnetic stimulation of the human frontal eye field: effects on visual perception and attention.

When looking at one object, human subjects can shift their attention to another object in their visual field without moving the eyes. Such shifts of attention activate the same brain regions as those involved in the execution of eye movements. Here we investigate the role of one of the main cortical oculomotor area, namely, the frontal eye field (FEF), in shifts of attention. We used transcranial magnetic stimulation (TMS), a technique known to disrupt transiently eye-movements preparation. We hypothesized that if the FEF is a necessary element in the network involved in shifting attention without moving the eyes, then#10; TMS should also disrupt visuospatial attention. For each volunteer, we positioned the TMS coil over the probabilistic anatomical location of the FEF, and we verified that single pulses delayed eye movements. We then applied TMS during a visuospatial attention task. In this task, a central arrow directed shifts of attention and the subject responded by a keypress to a subsequent visual peripheral target without moving the eyes from the central fixation point. In a few trials, the cue was invalid or uninformative, yielding slower responses than when the cue was valid. We delivered single pulses either 53 msec before or 70 msec after target onset. Contrary to our prediction, the main effect of the stimulation was a decrease in reaction time when it was applied 53 msec before target onset. TMS over the left hemisphere facilitated responses to targets in the right hemifield only and for all cueing conditions, whereas TMS over the right hemisphere had a bilateral effect for valid and neutral but not invalid cueing. Thus, TMS interfered with shift of attention only in the case of right hemisphere stimulation: it increased the cost of invalid cueing. Our results suggest that TMS over the FEF facilitates visual detection, and thereby reduces reaction time. This finding provides new insights into the role of the human FEF in processing visual information. The functional asymmetry observed for both facilitation of visual detection and interference with shifts of attention provides further evidence for the dominance of the right hemisphere for those processes. Our results also underline that the disruptive or facilitative effect of TMS over a given region depends upon the behavioral context.

Geophysical variables and behavior: XCVII. Increased proportions of the left-sided sense of presence induced experimentally by right hemispheric application of specific (frequency-modulated) complex magnetic fields.

12 young men and women who were not aware of the stimulus order were exposed to 8 configurations of weak 1 microTesla) magnetic fields for 5 min. each, applied primarily over the right parietotemporal region. The numbers of sensed presences along the left side, right side, or front/back, as inferred by button presses at the time of the experience, were recorded. There were significantly (eta2= .37) more experiences along the left side than the right side during the presentations of a frequency-modulated (Thomas) pattern with 3-msec. point durations compared to the presentation of its temporally reversed structure or to patterns that were more or less complex. 40% of all left-sided presences occurred during the 5-min. presentation of this specific frequency-modulated pattern. These results suggest that the subjective lateralization of a sensed presence to the left during right hemispheric stimulation by weak magnetic fields is enhanced by the specific temporal structure of the applied field.

GEOPHYSICAL VARIABLES AND BEHAVIOR: XCVII. INCREASED PROPORTIONS OF THE LEFT-SIDED SENSE OF PRESENCE INDUCED EXPERIMENTALLY BY RIGHT HEMISPHERIC APPLICATION OF SPECIFIC (FREQUENCY-MODULATED) COMPLEX MAGNETIC FIELDS

12 young men and women who were not aware of the stimulus order were exposed to 8 configurations of weak (1 microTesla) magnetic fields for 5 min. each, applied primarily over the right parietotemporal region. The numbers of sensed presences along the left side, right side, or front/back, as inferred by button presses at the time of the experience, were recorded. There were significantly (η2 =.37) more experiences along the left side than the right side during the presentations of a frequency-modulated (Thomas) pattern with 3-msec. point durations compared to the presentation of its temporally reversed structure or to patterns that were more or less complex. 40% of all left-sided presences occurred during the 5-min. presentation of this specific frequency-modulated pattern. These results suggest that the subjective lateralization of a sensed presence to the left during right hemispheric stimulation by weak magnetic fields is enhanced by the specific temporal structure of the applied field.

Transcranial magnetic stimulation for depression and other psychiatric disorders.

Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible alternative to electroconvulsive therapy for the treatment of selected patients with depression, bipolar affective disorder and schizophrenia. The aim of this study was to evaluate the evidence for the effectiveness of rTMS in mood disorders and schizophrenia. Studies were identified using MEDLINE (1966 to January 2000), EMBASE/Excerpta Medica (1980 to January 2000), Biological Abstracts and Index to Scientific and Technical Proceedings. A number of biomedical and TMS related websites were also searched. We estimated the number needed to treat to show beneficial effect of rTMS when compared with the placebo controlled group. Seven controlled trials of rTMS depression were identified. Five of these were suitable for meta-analysis and show a beneficial effect of rTMS compared to placebo, with a number needed to treat of 2-3 with a 95 % confidence interval 1.6 to 4.0, total; 81 patients. A single trial of rTMS has also been performed in mania, which shows a beneficial effect of right hemisphere stimulation when compared with left hemisphere stimulation. A controlled trial in schizophrenia failed to show any benefit of rTMS. rTMS has demonstrable beneficial effects in depression. The extent and the duration of the anti-depressant effect of rTMS has yet to be defined. There now needs to be randomized controlled trials to compare rTMS directly with standardized electroconvulsive therapy in order to take this subject forward. With regard to the treatment of other mood disorders and schizophrenia, we are at an early stage in the assessment of further studies that are needed to examine any potential role for rTMS.

Geophysical variables and behavior: XCII. Experimental elicitation of the experience of a sentient being by right hemispheric, weak magnetic fields: interaction with temporal lobe sensitivity.

We tested the hypothesis that proportionally more people with above average numbers of complex partial epileptic-like experiences before the experiment would report a proximal presence during applications of a weak (1 microTesla), frequency-modulated magnetic field over the right hemisphere. Each of 16 subjects sat in a darkened, quiet room and was exposed for 20 min. to complex fields, applied through a helmet, either along the right hemisphere or across both hemispheres. None of the 8 subjects with below average scores reported a presence during the applications of the magnetic fields while 75% and 60% of the 8 subjects with above average scores reported a presence during right hemispheric and bilateral stimulation, respectively.

Experimental Production of Illusory (False) Memories in Reconstructions of Narratives: Effect Size and Potential Mediation by Right Hemispheric Stimulation from Complex, Weak Magnetic Fields

This experiment was designed to discern the proportion of false, inferential and verbatim memories that would be included in the reconstruction, on e week later, of a 5min narrative containing ambiguous but emotional content about a little boy. After 48 subjects were administered Spiegel's Hypnosis Induction Profile, they listened to the narrative, were exposed to on e of four applications of transcerebral weak, complex magnetic fields for 30min and then given either an accurate or inaccurate short summary of the story. One week later the group who received the erroneous summary reported more false memories about the original story than did the reference group; this treatment accommodated about 40% of the variance in numbers of false memories. Only an indicator of electrical lability within the temporal lobes (but not hypnotizability) was strongly associated with the numbers of inferential memories but not the numbers of false memories. The group that received transcerebral stimulation over the right hemisphere by a complex magnetic field and the erroneous summary reported three times the numbers of false memories compared to the other groups. Whereas verbatim memories showed a strong primacy effect inferential memories exhibited a strong recency effect (η2 =. 66).

Dyslexia Treated by Hemisphere Stimulation Technic

Results of treatment of severe dyslexia in 80 children, ages 6 to 15 years, using hemisphere stimulation technics, are reported from the outpatient Department for Dyslexia, Child Psychiatric Center, Paedological Institute, Amsterdam, The Netherlands.

Hemispheric object naming and interhemispheric transfer functions in reading disordered subjects

This study measured unilateral, tachistoscopic naming reaction times of normal and reading disordered children to objects representing two levels of picture vocabulary age. Results of an ANCOVA procedure on the latency data showed main effects for group and stimuli, but not visual field. The latency results suggested parallel, central picture naming operations for each group, with the reading disordered children evidencing significantly longer naming reaction times to each level of stimuli. Arc Sine transformed error data were submitted to an analysis of co-variance procedure and showed a significant stimuli x group interaction. Post hoc tests showed accelerated error rates following right hemispheric stimulation, suggesting anomalous interhemispheric transfer of visual images in the present group of reading disordered children. In addition, left hemispheric stimulations produced significantly more naming errors for the reading disordered subjects as compared to the normal children. Such findings may suggest that a group of higher-ordered processing operations may accompany reading disorders.

Modification of Semantic Memory in Normal Subjects by Application Across the Temporal Lobes of a Weak (1 Microt) Magnetic Field Structure that Promotes Long-Term Potentiation in Hippocampal Slices

Normal, right-handed human volunteers listened to a 5-min story and were then exposed to 15 min (3 successive segments of 5 min on/5 min off) of magnetic pulses (1 microT; 10 mG) whose temporal structure has been shown to enhance long-term potentiation (LTP) in hippocampal slices. There were four conditions: no stimulation, bilateral stimulation (across both temporoparietal regions), primary stimulation of the left temporoparietal lobes or primary stimulation of the right temporoparietal lobes. Reconstructions of the story were completed by the same subjects within 30 min (intermediate memory) and about 10 days (long-term memory) later. The strongest effect size (25% of the variance was accommodated) was due to the approximately two fold increase in the numbers of accurate details for the long-term memories for subjects who had received the left hemispheric stimulation. These results suggest that contemporary technology may have the capability to access fundamental algorithms of the neuronal activity asso...