Hemisphere In Order Research Articles

Interhemispheric Symmetry and Asymmetry of Absence Type Spike-Wave Discharges Caused by Systemic Administration of Pentylenetetrazole

Absence epilepsy is a specific generalized non-convulsive form occurring almost exclusively in children and adolescents. It is traditionally thought that the resulting seizure is completely generalized in the cortex of both hemispheres, as seen in humans on surface electroencephalograms and magnetoencephalograms. However, most studies were performed on animals, mainly rats – genetic (WAG/Rij and GAERS lines) and pharmacological models, since signals not only from the cortex, but also from subcortical structures such as the thalamus must be measured, what cannot be done on humans, who have no medical indications for intracranial surgery. In animals, measurements of local field potentials were almost always made from one hemisphere in order to cover the maximum number of brain structures involved. At the same time, the degree of synchrony of seizure onsets and terminations in different hemispheres in animals was practically not studied, and the markup itself in the vast majority of cases was done on the basis of one channel from motor or somato-sensory cortex. This work aims to reveal differences and similarities in the course of spike-wave discharges (the main encephalographic marker of absence seizures) in the cortex of the two hemispheres in a known pharmacological model of rats exposed to pentylentetrazole. For discharge detection, a method of automatic discharge marking is proposed and its sensitivity and specificity are evaluated using records of nine animals. We used it to mark seizures in symmetrical cortical sites from both hemispheres separately. According to the results of the analysis of seizure duration it turned out that for five out of nine animals the distribution of discharges significantly differed between the hemispheres, and for the other four was equal. Consequently, in the rat model, spike-wave activity may be generalized both symmetrically and asymmetrically, which may be due to individual peculiarities or different discharge triggering scenarios.

Selection of Elms Tolerant to Dutch Elm Disease in South-West Romania

Ophiostoma novo-ulmi continues to be one of the most dangerous invasive fungi, destroying many autochthonous elm forests and cultures throughout the world. Searching for natural genotypes tolerant to Dutch elm disease (DED) is one of the main objectives of silviculturists all over the northern hemisphere in order to save the susceptible elms and to restore their ecosystem biodiversity. In this regard, the first trial was established between 1991 and 1994, in south-west Romania (Pădurea Verde, Timișoara), using three elm species (Ulmus minor, U. glabra, and U. laevis) with 38 provenances. A local strain of Ophiostoma novo-ulmi was used to artificially inoculate all elm variants and the DED evolution was observed. Furthermore, in 2018–2021 the trial was inventoried to understand the local genotype reaction to DED in the local environmental conditions after almost 30 years. The outcomes of the present study proved the continuous presence of the infections in the comparative culture and its proximity, but the identified pathogen had a new hybrid form (found for the first time in Romania) between O. novo-ulmi ssp. americana x O. novo-ulmi ssp. novo-ulmi. Wych elm (U. glabra) was extremely sensitive to DED: only 12 trees (out of 69 found in 2018) survived in 2021, and only one tree could be selected according to the adopted health criteria (resistance and vigour). The field elm (U. minor) was sensitive to the pathogen, but there were still individuals that showed good health status and growth. In contrast, the European white elm (U. laevis) proved constant tolerance to DED: only 15% had been found dead or presented severe symptoms of dieback. Overall, the results of this study report the diverse reactions of the Romanian regional elm genotypes to DED over the last three decades, providing promising perspectives for improving the presence of elms in the forest ecosystems of the Carpathian basin.

A PSF-based Approach to TESS High quality data Of Stellar clusters (PATHOS) – IV. Candidate exoplanets around stars in open clusters: frequency and age–planetary radius distribution

ABSTRACT The knowledge of the ages of stars hosting exoplanets allows us to obtain an overview on the evolution of exoplanets and understand the mechanisms affecting their life. The measurement of the ages of stars in the Galaxy is usually affected by large uncertainties. An exception are the stellar clusters: For their coeval members, born from the same molecular cloud, ages can be measured with extreme accuracy. In this context, the project PATHOS is providing candidate exoplanets orbiting members of stellar clusters and associations through the analysis of high-precision light curves obtained with cutting-edge tools. In this work, we exploited the data collected during the second year of the Transiting Exoplanet Survey Satellite mission. We extracted, analysed, and modelled the light curves of $\sim 90\, 000$ stars in open clusters located in the Northern ecliptic hemisphere in order to find candidate exoplanets. We measured the frequencies of candidate exoplanets in open clusters for different orbital periods and planetary radii, taking into account the detection efficiency of our pipeline and the false positive probabilities of our candidates. We analysed the age–RP distribution of candidate and confirmed exoplanets with periods <100 d and well constrained ages. While no peculiar trends are observed for Jupiter-size and (super-)Earth-size planets, we found that objects with $4 \lesssim R_{\rm P} \lesssim 13R_{\rm Earth}$ are concentrated at ages ≲200 Myr; different scenarios (atmospheric losses, migration, etc.) are considered to explain the observed age–RP distribution.

Ewolucja albo substytucja, czyli jaka przyszłość NATO

The author analyses the North Atlantic Alliance through the prism of community of values as the foundation of the system of collective self-defence. The starting point of the discussion was the construction of a “security community” by the states of the western hemisphere in order to repel the direct existential threat from the USSR. This constructed ‘community’ proved to be an institution capable of transformation – after the end of the ‘Cold War’ – in the face of new security threats. The 21st century has confronted the Allies and NATO with new challenges. These challenges come both from counter-system states – strategic rivals – and from within the Alliance itself, from states rejecting common values. The subjects of an in-depth comparative analysis are: internal challenges, examined in the form of case studies; the “hub and spokes system”, treated as a possible alternative to the Alliance; and NATO’s internal study – a report on challenges and the possibilities of meeting them. The author presents a catalogue of existential internal challenges with which NATO is confronted and the organisation’s search for ways to cope with these challenges. He presents an alternative model of bilateral alliances as a way to ensure security of the western hemisphere in case of NATO’s inability to survive. The aim of the study is to answer the question within the framework of the disjunctive alternative: will it be possible to transform (by the parties to the Washington Treaty) NATO into a community of values? Or will it be necessary to replace NATO with a network of bilateral agreements, that is, to replace the plurilateral institution with structured bilateral cooperation? The study is based on the conclusions of a legal survey of primary sources and representative literature on the subject.

Upper Motor Neuron Diseases and Laryngeal Presentations

The purpose of this manuscript is to review laryngeal manifestations of upper motor neuron disease. A review of the relevant neuroanatomy is performed as well as a description of common laryngeal signs of upper motor neuron disease and the disease entities that cause them. Upper motor neuron lesions must occur in the brainstem or in the bilateral cerebral hemisphere in order to cause signs and symptoms in the larynx. The presence of bilateral vocal fold paralysis or paresis with concurrent signs of myoclonus, tremor, rigidity, hyperactive gag reflex, and/or laryngospasm episodes should prompt an investigation for possible medullary brainstem or bilateral cerebral cortex pathology.

The expression of the Oceanic Anoxic Event 2 (OAE2) in the northeast of Brazil (Sergipe-Alagoas Basin)

Global oceanic anoxic events occurred throughout the Cretaceous and changed the sedimentation patterns in many sedimentary basins around the world. There is still a lack of data and the need to identify new sections affected by these events in the Southern Hemisphere in order to provide insights on the extent of low-oxygen oceanic conditions. This study presents sedimentological, petrographic, and geochemical data from a continuous 439-m-thick well core drilled in the Sergipe-Alagoas Basin. The analytical data suggest that anoxic conditions prevailed at the end of Cenomanian and the beginning of Turonian, being globally correlatable to the Oceanic Anoxic Event 2 (OAE2). The results on the delimitation and extent of the OAE2 in the Sergipe-Alagoas Basin aid to better define the paleoceanographic changes that occurred in the South Atlantic Ocean during OAE2 and provide a new set of data that enables further studies and correlation to other sections distributed worldwide.

Терагерцовый микроскоп на основе эффекта твердотельной иммерсии для визуализации биологических тканей-=SUP=-*-=/SUP=-

A novel method of terahertz (THz) microscopy was proposed for imaging of biological tissues with sub-wavelength spatial resolution. It allows for overcoming the Abbe diffraction limit and provides a sub-wavelength resolution thanks to the solid immersion effect – i.e. to the reduction in the dimensions of electromagnetic beam caustic, when the beam is focused in free space, at a small distance (smaller than the wavelength) behind the medium featuring high refractive index. An experimental setup realizing the proposed method was developed. It uses a backward wave oscillator, as a THz-wave emitter, and a Golay cell, as a THz-wave detector. In this setup, the radiation is focused behind the silicon hemisphere in order to realize the solid immersion effect. The spatial resolution of 0.15λ was demonstrated for the developed microscope, while the measurements were carried out at the wavelength of λ=500 μm, with the metal-air interface as a test object. Such a high spatial resolution represents a significant advantage over that of the previously reported arrangements of solid immersion microscopes. The solid immersion microscopy does not imply using any diaphragms or other near-field probes for achieving the sub-wavelength spatial resolution; thus, it eliminates the energy losses associated with such elements. The proposed methods were applied for imaging of biological tissues, and the observed results highlight its potential in biology and medicine.

Asymmetric Changes in Limbic Cortex and Planum Temporale in Patients with Alzheimer Disease.

There are several cortical areas related to the limbic system that form the output from the hippocampal formation whose cellular and morphological features are important for the onset and progression of AD. We hypothesized that there would be a significant difference in the size of cortical pyramidal neurons and that there would also be a hemispheric asymmetry between Alzheimer disease patients and controls. These differences would potentially be accompanied by an increase in the numbers of Fluoro-Jade B-positive degenerating cortical neurons and a corresponding decrease in the numbers of DAPI-stained cortical neuronal nuclei in subjects with AD compared to controls. Such changes could potentially be used as another marker in postmortem neuropathological diagnosis of AD. We measured absolute numbers of DAPI and Fluoro-Jade B stained cells in five cortical areas of the limbic system and four subareas of planum temporale in the post-mortem brains of subjects with Alzheimer disease. We also measured the size of pyramidal neurons in layer III in the five cortical areas of the limbic system in these subjects. All measurements were performed separately for the left and right hemisphere in order to identify asymmetries between the two hemispheres. We observed a significant decrease in numbers of DAPI stained cells in layers IV-VI of the anterior cingulate gyrus on the right side, in layers I-III of the posterior cingulate gyrus on the left side, in layers IV-VI in the transition region from superior temporal gyrus into planum temporale on the right and in layers IV-VI in the transition from planum temporale to insular cortex on the left. We also observed a significant increase in the numbers of Fluoro-Jade stained cells in layers I-III of the anterior cingulate gyrus and in layers I-III on the left and layers IV-VI of the right gyrus of Heschl. Shortening of the size of layer III pyramidal neurons in subjects with Alzheimer´s disease was found in the anterior cingulate gyrus on the right, in the posterior cingulate gyrus and entorhinal cortex on the left and on the right in the parahippocampal gyrus. Our study demonstrates asymmetries in different cortical regions of the temporal lobe that can be used as another marker in the postmortem diagnosis of AD.

From South Korea to the Southern Hemisphere

Among the most salient global cultural phenomena of recent years has been the spread of Korean popular music, as exemplified not only by the viral success of Psy’s ‘Gangnam Style’ but in flash mob performances, social networking services, YouTube dance cover bands and international media coverage. What, taken in the aggregate, can instances of K-pop fandom (and equally importantly, its absences) in the southern hemisphere teach observers? In this article, I examine the flow of South Korean popular music to various nations in the southern hemisphere in order to interrogate the factors that have led to the uptake of K-pop fandom in specific contexts. In doing so, I test the hypothesis that broadening K-pop fandom indicates that the genre’s appeal relies not so much on cultural proximity as its ability to evoke an interaction between the local and the international that simultaneously bridges two national contexts. I argue that K-pop fandom has become entrenched in much of the southern hemisphere and is unlikely to be dislodged soon. Importantly, however, the evidence also suggests, often in striking contrast to the rhetorical framing of discussions of K-pop, that the genre will not pose an ever greater challenge to other international music industries but rather cater to a steady niche market that sees unusually active participation among a small segment of local inhabitants.

High-resolution Imaging of Transiting Extrasolar Planetary systems (HITEP)

(abridged) Context. Wide binaries are a potential pathway for the formation of hot Jupiters. The binary fraction among host stars is an important discriminator between competing formation theories, but has not been well characterised. Additionally, contaminating light from unresolved stars can significantly affect the accuracy of photometric and spectroscopic measurements in studies of transiting exoplanets. Aims. We observed 101 transiting exoplanet host systems in the Southern hemisphere in order to create a homogeneous catalogue of both bound companion stars and contaminating background stars. We investigate the binary fraction among the host stars in order to test theories for the formation of hot Jupiters, in an area of the sky where transiting exoplanetary systems have not been systematically searched for stellar companions. Methods. Lucky imaging observations from the Two Colour Instrument on the Danish 1.54m telescope at La Silla were used to search for previously unresolved stars at small angular separations. The separations and relative magnitudes of all detected stars were measured. For 12 candidate companions to 10 host stars, previous astrometric measurements were used to evaluate how likely the companions are to be physically associated. Results. We provide measurements of 499 candidate companions within 20 arcseconds of our sample of 101 planet host stars. 51 candidates are located within 5 arcseconds of a host star, and we provide the first published measurements for 27 of these. Calibrations for the plate scale and colour performance of the Two Colour Instrument are presented. Conclusions. We find that the overall multiplicity rate of the host stars is 38 +17 -13%, consistent with the rate among solar-type stars in our sensitivity range, suggesting that planet formation does not preferentially occur in long period binaries compared to a random sample of field stars.

A Study of Magnetic Fields on Bright-Rimmed Clouds

AbstractWe have made near-infrared (JHKs) imaging polarimetry toward 24 bright-rimmed clouds in the southern hemisphere in order to reveal their magnetic field structures. The obtained polarization vector maps show that the magnetic field directions inside the bright rim are different from its ambient magnetic field direction, implying that magnetic field structures just inside the ionized front of the clouds are due to the gas compression by UV radiation from nearby massive star. Our investigation into the relation between the magnetic field configuration and the shape of the cloud suggests that the magnetic field configuration affects the evolution of the cloud shape.

Decomposition of Atmospheric Disturbances into Standing and Traveling Components, with Application to Northern Hemisphere Planetary Waves and Stratosphere–Troposphere Coupling

Abstract This study updates a body of literature that aims to separate atmospheric disturbances into standing and traveling zonal wave components. Classical wavenumber–frequency analysis decomposes longitude- and time-dependent signals into contributions from distinct spatial and temporal scales. Here, an additional decomposition of the spectrum into standing and traveling components is described. Previous methods decompose the power spectrum into standing and traveling parts with no explicit allowance for covariance between the two. This study provides a simple method to calculate the variance of each of these components and the covariance between them. It is shown that this covariance is typically a significant portion of the variance of the total signal. The approach also preserves phase information and allows for the reconstruction of the real-space standing and traveling components. The technique is applied to reanalysis wintertime geopotential height anomalies in the Northern Hemisphere in order to investigate planetary wave interference effects in stratosphere–troposphere coupling. The results show that for planetary waves 1–3, standing waves explain the largest portion of the variance at low frequencies. An exception is for wave 1 in the high-latitude troposphere, where there is a strong westward-traveling wave. Furthermore, the antinodes of the standing waves have preferred longitudes that tend to align with the extremes of the climatological wave, suggesting that standing waves contribute to a linear interference effect that has been shown to be an important part of stratosphere–troposphere interactions.

Synchronicity of historical dry spells in the Southern Hemisphere

Abstract. A shift in climate occurred during the mid-1970s that affected the hydroclimate of the Southern Hemisphere resulting in drying trends across continental regions including Australia, New Zealand and southern and western Africa. There is also anecdotal evidence of other periods of climatic synchronicity in the Southern Hemisphere (e.g., the 1920s and 1940s), indicating that the mid-1970s event may not be anomalous. This paper identifies periods within the last ~120 years using statistical analysis where dry spells (in terms of annual to multi-decadal rainfall deficiencies) have coincided across the continental Southern Hemisphere in order to characterize temporal consistency. It is shown that synchronicity of dry spells is (a) most likely common over the last 120 years and (b) associated with changes in the large-scale climate modes of the Pacific, Indian and Southern Oceans. Importantly, the findings presented in this paper have marked implications for drought management and drought forecasting studies in the Southern Hemisphere.

A 950 yr temperature reconstruction from Duckhole Lake, southern Tasmania, Australia

A lack of quantitative high resolution paleoclimate data from the Southern Hemisphere limits the ability to examine current trends within the context of long-term natural climate variability. This study presents a temperature reconstruction for southern Tasmania based on analyses of a sediment core from Duckhole Lake (43.365°S, 146.875°E). The relationship between non-destructive whole core scanning reflectance spectroscopy measurements in the visible spectrum (380–730 nm) and the instrumental temperature record (ad 1911–2000) was used to develop a calibration-in-time reflectance spectroscopy-based temperature model. Results showed that a trough in reflectance from 650 to 700 nm, which represents chlorophyll and its derivatives, was significantly correlated to annual mean temperature. A calibration model was developed ( R = 0.56, pauto < 0.05, root mean squared error of prediction (RMSEP) = 0.21°C, five-year filtered data, calibration period 1911–2000) and applied down-core to reconstruct annual mean temperatures in southern Tasmania over the last c. 950 years. This indicated that temperatures were initially cool c. ad 1050, but steadily increased until the late ad 1100s. After a brief cool period in the ad 1200s, temperatures again increased. Temperatures steadily decreased during the ad 1600s and remained relatively stable until the start of the 20th century when they rapidly decreased, before increasing from ad 1960s onwards. Comparisons with high resolution temperature records from western Tasmania, New Zealand and South America revealed some similarities, but also highlighted differences in temperature variability across the mid-latitudes of the Southern Hemisphere. These are likely due to a combination of factors including the spatial variability in climate between and within regions, and differences between records that document seasonal (i.e. warm season/late summer) versus annual temperature variability. This highlights the need for further records from the mid-latitudes of the Southern Hemisphere in order to constrain past natural spatial and seasonal/annual temperature variability in the region, and to accurately identify and attribute changes to natural variability and/or anthropogenic activities.

Strategic design for pediatric neurosurgery missions across the Western Hemisphere

Background:With growing interest in global health, surgeons have created outreach missions to improve health care disparities in less developed countries. These efforts are mainly episodic with visiting surgeons performing the operations and minimal investment in local surgeon education. To create real and durable advancement in surgical services in disciplines that require urgent patient care, such as pediatric neurosurgery, improving the surgical armamentarium of the local surgeons must be the priority.Methods:We propose a strategic design for extending surgical education missions throughout the Western Hemisphere in order to transfer modern surgical skills to local neurosurgeons. A selection criteria and structure for targeted missions is a derivative of logistical and pedagogical lessons ascertained from previous missions by our teams in Peru and Ukraine.Results:Outreach programs should be applied to hospitals in capital cities to serve as a central referral center for maximal impact with fiscal efficiency. The host country should fulfill several criteria, including demonstration of geopolitical stability in combination with lack of modern neurosurgical care and equipment. The mission strategy is outlined as three to four 1-week visits with an initial site evaluation to establish a relationship with the hospital administration and host surgeons. Each visit should be characterized by collaboration between visiting and host surgeons on increasingly complex cases, with progressive transfer of skills over time.Conclusion:A strategic approach for surgical outreach missions should be built on collaboration and camaraderie between visiting and local neurosurgeons, with the mutual objective of cost-effective targeted renovation of their surgical equipment and skill repertoire.

How do our brain hemispheres cooperate to avoid false memories?

Memories are not always as reliable as they may appear. The occurrence of false memories can be reduced, however, by enhancing the cooperation between the two brain hemispheres. Yet is the communication from left to right hemisphere as helpful as the information transfer from right to left? To address this question, 72 participants were asked to learn 16 word lists. Applying the Deese–Roediger–McDermott paradigm, the words in each list were associated with an unpresented prototype word. In the test condition, learned words and corresponding prototypes were presented along with non-associated new words, and participants were asked to indicate which of the words they recognized. Crucially, both study and test words were projected to only one hemisphere in order to stimulate each hemisphere separately. It was found that false recognitions occurred significantly less often when the right hemisphere studied and the left hemisphere recognized the stimuli. Moreover, only the right-to-left direction of interhemispheric communication reduced false memories significantly, whereas left-to-right exchange did not. Further analyses revealed that the observed reduction of false memories was not due to an enhanced discrimination sensitivity, but to a stricter response bias. Hence, the data suggest that interhemispheric cooperation does not improve the ability to tell old and new apart, but rather evokes a conservative response tendency. Future studies may narrow down in which cognitive processing steps interhemispheric interaction can change the response criterion.

A last‐saturation diagnosis of subtropical water vapor response to global warming

We used boreal winter output from an IPCC AR4 GCM simulation to drive an atmospheric tracer transport model with water vapor last saturation tracers over the northern hemisphere in order to identify processes that contribute to the projected increase in specific humidity of the subtropical relative humidity minimum. Most of the increase in specific humidity at the relative humidity minimum can be attributed to last saturation within what will be a warmer free troposphere. The water vapor content of the relative humidity minimum is projected to increase in the 21st century primarily as a function of increased last saturation temperatures in the tropical lower troposphere, effectively yielding more water vapor via poleward transport. The increase in specific humidity is to a degree kept in check by a poleward and upward shift of baroclinic instability and saturation patterns that effectively yield drier air to the RH minimum via isentropic transport.

Distribution and orientation of northern-hemisphere gullies on Mars from the evaluation of HRSC and MOC-NA data

Martian gullies show morphologic characteristics that indicate the presence of a flowing liquid during their formation process. However, the current climate in the northern hemisphere of Mars does not allow the existence of substantial amounts of liquid water and, therefore, an assessment of the regional distribution and characteristics of gullies is required in order to understand the most recent climatic development of Mars. We examined High Resolution Stereo Camera (HRSC) and Mars Orbiter Camera—Narrow Angle (MOC-NA) data covering the northern hemisphere in order to determine the distribution, geological setting and orientation of gullied slopes. We used these results to test the consistency of formation models proposed in earlier works and to define the climate dependence. Gully orientations were analyzed only at impact crater walls, because craters have an azimuthally uniform distribution of slopes. This is ideal when investigating the influence of insolation on the distribution and development of landforms. We examined 230 HRSC and ~ 21,000 MOC-NA images and identified more than 2200 gullies on HRSC and more than 3100 gullies in MOC-NA data. Both surveys show the highest densities of gullies between 35°N and 55°N and a shift of gully orientation at 40°N from pole-facing slopes to slopes facing the equator. Orientation trends as well as the latitudinal distribution of identified gullies strongly support the view of gully formation caused by insolation/climatic conditions. This result suggests that formation mechanisms based on the assumption of atmospheric water-ice deposition proposed in earlier work are more likely than processes related to groundwater flow. Further support for a theory related to deposition is gained through observation of the high occurrence of gullies at isolated knobs and hills, which cannot be associated with formation models based upon groundwater flow.

Use of transcranial magnetic stimulation of the brain in stroke rehabilitation

Preliminary studies suggest that stimulation of the motor cortex enhances motor recovery after stroke. Most of these studies employed transcranial magnetic stimulation of the brain and two different approaches have been evaluated. The first approach is based on the use of protocols of stimulation that increase cortical excitability, targeting the hemisphere in which the stroke occurred in order to enhance the output of the motor cortex and the response to physiotherapy. The second approach is based on the use of protocols of stimulation that suppress cortical excitability, targeting the intact hemisphere in order to counteract the imbalance due to the increased interhemispheric inhibition onto the lesioned cortex, and reducing the potential negative interference of the intact hemisphere with the function of the affected one. Cumulatively, preliminary studies suggest that transcranial magnetic stimulation might be a suitable method to combine with physiotherapy and improve recovery of useful limb function in stroke patients. However, further studies are needed to determine the best stimulation parameters and how to select patients who are likely to respond to this treatment.

Stroke recovery can be enhanced by using repetitive transcranial magnetic stimulation (rTMS)

Post-stroke recovery is based on plastic changes in the central nervous system that can compensate the loss of activity in affected brain regions. In particular, monohemispheric stroke is thought to result in disinhibition of the contralesional unaffected hemisphere. Neurorehabilitation programs improve function partly by enhancing cortical reorganization. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive way of producing potent changes in cortical excitability. Therefore, the application of rTMS was recently proposed to promote functional recovery in stroke patients, owing to the induced neuroplasticity. This review discusses the first clinical results that were obtained by rTMS in patients with post-stroke motor deficit, visuospatial neglect, or aphasia. These results are promising and depend on the site and frequency of stimulation. In summary, functional recovery might be obtained either when rTMS is applied at low-frequency (around 1 Hz) over the disinhibited, unaffected hemisphere in order to restore defective inhibition or when rTMS is applied at high-frequency (5 Hz or more) over the affected hemisphere in order to reactivate hypoactive regions. The overall procedure remains to be optimized, in particular regarding the number of rTMS sessions and the time of rTMS application after stroke. Cortical stimulation is an exciting perspective for improving functional recovery from stroke. Transient application of non-invasive transcranial stimulation during the time of the rehabilitation process will be preferable to the temporary implantation of epidural cortical electrodes, as recently proposed. Therefore, in the future, acute or recent stroke might be a major indication of rTMS in neurological practice.