Hemisphere Areas Research Articles

Impaired Gait, Postural Instability, and Rigidity in Relation to CB1 Receptor Availability in Parkinson's Disease.

In Parkinson's disease (PD), postural instability and gait disorder (PIGD) symptoms are associated with a worse prognosis for an unknown reason. The objective was to explore the relationship between cannabinoid receptor type 1 (CB1R) availability and motor symptoms in PD with [18F]FMPEP-d2 positron emission tomography (PET). Fifteen individuals with PD underwent [18F]FMPEP-d2 PET to measure cerebral CB1R availability. The Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) was used to evaluate the motor symptoms. A negative correlation was observed between [18F]FMPEP-d2 VT and PIGD score (P = 0.002) as well as rigidity subscore (P < 0.001). Both clusters covered widespread areas of both hemispheres. In contrast, tremor or bradykinesia did not correlate to [18F]FMPEP-d2 VT. Gait, postural instability, and rigidity in PD are associated with decreased CB1R availability, unlike tremor or bradykinesia, suggesting that the endocannabinoid system has a role in the pathophysiology of different motor symptoms in PD. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

EEG synchronization patterns during a Go/No-Go task in individuals with aphasia in subacute and chronic phases of stroke

Stroke and subsequent neuroregenerative processes cause changes in neural organization of attentional functions. In this study, we attempted to identify differences in neural synchronization patterns during a visual Go/No-Go task in people with post-stroke aphasia in both subacute and chronic stroke phases. To identify neuronal underpinnings of the behavioral differences we investigated pairwise connectivity patterns using corrected imaginary phase locking value and graph-theoretic measures (efficiency, modularity and clustering coefficient) at global and local level in subacute (n = 13) and chronic stroke phases (n = 14) during a Go/No-Go task. We observed significantly lower phase synchronization in the Subacute Group in the alpha band in the connections spanning frontal and central areas of both hemispheres alongside lower local efficiency and clustering coefficient in the left frontal region. Additionally, we observed higher modularity in the beta band in the unaffected right parietal region in the Subacute Group which may denote inhibition of motor and attention functions. Those mechanisms could serve to align cognitive abilities between the damaged and healthy hemispheres, harmonizing the activity of the neuronal networks of both hemispheres disrupted by the effects of the stroke. Our findings have potential implications for rehabilitation therapies, which should take into account the pattern of connectivity changes during different phases of reovery.

Music literacy shapes the specialization of a right hemispheric word reading area

This study aimed to examine differences in the brain activity of professional musicians and non-musicians, particularly in relation to neuroplastic changes that may be associated with musical training. Specifically, we investigated whether the ability to read complex musical notation might be linked to neurofunctional adaptations that could influence word reading mechanisms. The study involved 80 participants (half of which were musicians). High-density EEG recordings and swLORETA inverse solutions were employed to analyze brain activity related to word processing and orthographic analysis. The electromagnetic signals were analyzed in the temporal window corresponding to the latency of N170 component (150–190 ms). Musicians and musically naïve people (controls) were matched based on native language, sociocultural and educational status, age, and laterality preference. Behavioural data and reading proficiency tests demonstrated higher reading skills (for words, non-words and text), and faster RTs to target letters embedded in words, in musicians. Source reconstruction showed fundamental differences in word reading mechanisms between musicians and non-musicians, including a larger involvement of the right occipitotemporal cortex, in the former than the latter. In particular, musicians showed a bilateral activation of the middle occipital gyrus (BA19, Visual Word Form Area), which was strongly lateralized to the left hemisphere in controls, during word orthographic analysis. A relationship is proposed between music literacy, enhanced reading skills and the development of a right-sided reading area for notation recognition in musicians, which could serve as a potential protective factor for ‘surface’ dyslexia.

Unveiling Functional Biomarkers in Schizophrenia: Insights from Region of Interest Analysis Using Machine Learning.

Schizophrenia is a complex and disabling mental disorder that represents one of the most important challenges for neuroimaging research. There were many attempts to understand these basic mechanisms behind the disorder, yet we know very little. By employing machine learning techniques with age-matched samples from the auditory oddball task using multi-site functional magnetic resonance imaging (fMRI) data, this study aims to address these challenges. The study employed a three-stage model to gain a better understanding of the neurobiology underlying schizophrenia and techniques that could be applied for diagnosis. At first, we constructed four-level hierarchical sets from each fMRI volume of 34 schizophrenia patients (SZ) and healthy controls (HC) individually in terms of hemisphere, gyrus, lobes, and Brodmann areas. Second, we employed statistical methods, namely, t-tests and Pearson's correlation, to assess the group differences in cortical activation. Finally, we assessed the predictive power of the brain regions for machine learning algorithms using K-nearest Neighbor (KNN), Naive Bayes, Decision Tree (DT), Random Forest (RF), Support Vector Machines (SVMs), and Extreme Learning Machine (ELM). Our investigation depicts promising results, obtaining an accuracy of up to 84% when applying Pearson's correlation-selected features at lobes and Brodmann region level (81% for Gyrus), as well as Hemispheres involving different stages. Thus, the results of our study were consistent with previous studies that have revealed some functional abnormalities in several brain regions. We also discovered the involvement of other brain regions which were never sufficiently studied in previous literature, such as the posterior lobe (posterior cerebellum), Pyramis, and Brodmann Area 34. We present a unique and comprehensive approach to investigating the neurological basis of schizophrenia in this study. By bridging the gap between neuroimaging and computable analysis, we aim to improve diagnostic accuracy in patients with schizophrenia and identify potential prognostic markers for disease progression.

Surgical pearl: Use of micropore tape for easy harvestation and transfer of suction blister epidermal graft

Epidermal graft produced by suction is useful in treating vitiligo. However, it is very difficult to handle thin, flimsy, and translucent epidermis due to its in-curling and wrinkling properties. This is due to the hemispherical blister roof surface area which is twice its circular base. The correction of the epidermal surface and its resizing is a cumbersome and time-consuming task during epidermal grafting. To combat these problems, the blister roof is patched with micropore adhesive tape as a novel technique for harvestation and transfer of the suction blister graft.

The White-light Superflares from Cool Stars in GWAC Triggers

M-type stars are the ones that flare most frequently, but how big their maximum flare energy can reach is still unknown. We present 163 flares from 162 individual M2 through L1-type stars that triggered the GWAC, with flare energies ranging from 1032.2 to 1036.4 erg. The flare amplitudes range from △G = 0.84 to ∼10 mag. Flare energy increases with stellar surface temperature (T eff) but both △G and equivalent duration log10(ED) seem to be independent of T eff. Combining periods detected from light curves of TESS and K2, spectra from LAMOST, the Sloan Digital Sky Survey, the 2.16 m telescope, and the Gaia DR3 data, we found that these GWAC flare stars are young. For the stars that have spectra, we found that these stars are in or very near the saturation region, and log10(LHα/Lbol) is lower for M7–L1 stars than for M2–M6 stars. We also studied the relation between GWAC flare bolometric energy E bol and stellar hemispherical area S, and found that log10Ebol (in erg) increases with increasing S (in square centimeters), and the maximum flare energy log10Ebol,max≥log10S+14.25 . For M7–L1 stars, there seem to be other factors limiting their maximum flare energies in addition to the stellar hemispherical area.

Behavioral, Functional Imaging, and Neurophysiological Outcomes of Transcranial Direct Current Stimulation and Speech-Language Therapy in an Individual with Aphasia.

Speech-language therapy (SLT) is the most effective technique to improve language performance in persons with aphasia. However, residual language impairments remain even after intensive SLT. Recent studies suggest that combining transcranial direct current stimulation (tDCS) with SLT may improve language performance in persons with aphasia. However, our understanding of how tDCS and SLT impact brain and behavioral relation in aphasia is poorly understood. We investigated the impact of tDCS and SLT on a behavioral measure of scripted conversation and on functional connectivity assessed with multiple methods, both resting-state functional magnetic resonance imaging (rs-fMRI) and resting-state electroencephalography (rs-EEG). An individual with aphasia received 15 sessions of 20-min cathodal tDCS to the right angular gyrus concurrent with 40 min of SLT. Performance during scripted conversation was measured three times at baseline, twice immediately post-treatment, and at 4- and 8-weeks post-treatment. rs-fMRI was measured pre-and post-3-weeks of treatment. rs-EEG was measured on treatment days 1, 5, 10, and 15. Results show that both communication performance and left hemisphere functional connectivity may improve after concurrent tDCS and SLT. Results are in line with aphasia models of language recovery that posit a beneficial role of left hemisphere perilesional areas in language recovery.

Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats.

The neuroprotective activity of tryptanthrin and its oxime was compared in male Wistar rats with a model of intraluminal occlusion of the middle cerebral artery. Neurobehavioral tests were performed 4, 24, and 48 h after focal cerebral infarction (FCI) using a modified neurological severity score (mNSS); additionally, the horizontal stability test, the plantar sensitivity test of the fore and hind limbs, holding on the tilted cage top test, and negative geotaxis test were performed. The size of FCI and the severity of brain tissue swelling were examined on day 2 after occlusion. Tryptanthrin and its oxime were administered at a dose of 10 mg/kg intraperitoneally during FCI, then daily for 2 days. In the control group, the mean score of neurological deficit remained at a high level for 2 days. FCI size was 43.8±3.4% of hemisphere area, and the hemisphere volume increased by 18.5±2.0% due to brain tissue swelling and edema. Administration of tryptanthrin and its oxime significantly decreased neurological deficits at all control points and reduced FCI size (by 24.2 and 30.4%, respectively) and brain tissue swelling of the affected hemisphere (by 64.9 and 62.7%, respectively). Therefore, the neuroprotective effect of tryptanthrine and its oxime in the acute period of FCI is largely determined by their anti-inflammatory activity.

Enhancement of neuroprotective and anti-edema action in mice ischemic stroke model using T3 loaded nanoparticles

Background: cerebral ischemia still represents one of the most common causes of death and disability worldwide. A prompt treatment using strong neuroprotective medications is one potential method of pharmacological therapy for brain ischemic stroke patients. Thyroid hormone (T3) has been demonstrated to protect against ischemic damage. Despite the fact that thyroid hormone may pass across the blood-brain barrier (BBB). Objective: we hypothesized that the effectiveness of thyroid hormone in ischemic brain stroke can be improved by encapsulation in nanoparticulate delivery vehicles. Methods: We tested our hypothesis by generating thyroid hormone encapsulated in nanoparticles or brain-targeted nanoparticles using biodegradable polymers by utilizing an environment-friendly Supercritical Assisted Atomization (SAA) process as an alternative to a thyroid hormone solution in the setting of the MCAO stroke model. The biggest benefit of our proposed exploit of thyroid hormones in ischemic stroke is the fact that this strategy uses the body’s endogenous hormones at sub-toxic levels to afford significant improvement in a life-endangering situation. According to our preliminary studied considerations, some tests were performed setting the saturator operating conditions in a pressure range between 5 and 15MPa and a temperature range between 70 and 90oC. Results: The best results in terms of stability of the process and morphology of thyroid hormone nanoparticles were observed operating at 10MPa and 80oC. Our preliminary investigations also show that treatment with T3 significantly decreased infarct area (~36%) and analysis of hemispheric areas for edema formation showed that the edema formation induced by transient-MCAO was reduced by ~60% upon T3 treatment. Conclusion: Thus, innovation in our proposal lies in our hypothesis, and our novel approaches directed at tackling edema in stroke.

Male and Female Brain Activity During the Screening of a Violent Movie: An EEG Study

Movies have the ability to trigger our emotions and affect us in powerful ways. But the impact is not the same among all the audience and, according to our results, also not between women and men. In this study, we used an electroencephalogram (EEG) to register the brain activity of a group of 30 students while they watched a violent scene. The results showed that both male and female groups activated the left temporal lobe. However, the female group also activated the left insula and orbitofrontal areas of both hemispheres. The results of Hotelling’s T-squared distribution also showed significant differences in occipital areas of the brain in favour of women. Thus, our findings evidence that the violent scene activated emotional areas in both male and female groups, but in women there was also an activation of brain areas related to shape and colour recognition and to cognitive processes.

Study of the Failure Mechanism of a High-Density Polyethylene Liner in a Type IV High-Pressure Storage Tank.

The use of Type IV cylinders for gas storage is becoming more widespread in various sectors, especially in transportation, owing to the lightweight nature of this type of cylinder, which is composed of a polymeric liner that exerts a barrier effect and an outer composite material shell that primarily imparts mechanical strength. In this work, the failure analysis of an HDPE liner in a Type IV cylinder for high-pressure storage was carried out. The breakdown occurred during a cyclic pressure test at room temperature and manifested in the hemispherical head area, as cracks perpendicular to the liner pinch-off line. The failed sample was thoroughly investigated and its characteristics were compared with those of other liners at different stages of production of a Type IV cylinder (blow molding, curing of the composite material). An examination of the liner showed that no significant chemical and morphological changes occurred during the production cycle of a Type IV cylinder that could justify the liner rupture, and that the most likely cause of failure was a design-related fatigue phenomenon.

Cognitive Reserve in Parkinson's Disease without Dementia: β-Amyloid and Metabolic Assessment.

Cognitive reserve (CR) is the mismatch between preserved cognition and neuropathological damage. Amyloidopathy in Parkinson's disease (PD) could be associated with faster progression to dementia, but the putative protective effect of CR is unknown. To evaluate the effect of CR on β-amyloid burden and brain metabolism in non-demented PD subjects. Participants with PD (n = 53) underwent a clinical evaluation, [18 F]-fluorodeoxyglucose and [18 F]-flutemetamol positron emission tomography magnetic resonances, and were classified according to CR. The metabolic pattern of 16 controls was compared to PD subjects. The PD subjects showed hypometabolism mainly in the bilateral posterior cortex. Superior-CR subjects (n = 22) exhibited better cognitive performance, increased amyloid burden, and higher metabolism in several right hemisphere areas compared to low-medium-CR subjects (n = 31). Higher CR in non-demented PD is associated with better cognitive performance, which might reduce vulnerability to the effect of β-amyloid. Whether superior CR leads to protection against metabolic deterioration, and predominantly right hemisphere involvement, deserves further exploration.

Complexity of STG signals and linguistic rhythm: a methodological study for EEG data.

The superior temporal and the Heschl's gyri of the human brain play a fundamental role in speech processing. Neurons synchronize their activity to the amplitude envelope of the speech signal to extract acoustic and linguistic features, a process known as neural tracking/entrainment. Electroencephalography has been extensively used in language-related research due to its high temporal resolution and reduced cost, but it does not allow for a precise source localization. Motivated by the lack of a unified methodology for the interpretation of source reconstructed signals, we propose a method based on modularity and signal complexity. The procedure was tested on data from an experiment in which we investigated the impact of native language on tracking to linguistic rhythms in two groups: English natives and Spanish natives. In the experiment, we found no effect of native language but an effect of language rhythm. Here, we compare source projected signals in the auditory areas of both hemispheres for the different conditions using nonparametric permutation tests, modularity, and a dynamical complexity measure. We found increasing values of complexity for decreased regularity in the stimuli, giving us the possibility to conclude that languages with less complex rhythms are easier to track by the auditory cortex.

Developmental Regulation of Matrix Metalloproteinases in Response to Multifactorial, Severe Traumatic Brain Injuries during Immaturity

Introduction: A striking pattern in young children after severe TBI is when the entire cortical ribbon displays tissue damage: hemispheric hypodensity (HH). HH is often a result of abusive head trauma (AHT). We previously reported a model of HH in a gyrencephalic species where a combination of injuries consisting of (1) cortical impact, (2) midline shift, (3) subdural hematoma/subarachnoid hemorrhage, (4) traumatic seizures, and (5) brief apnea and hypoventilation resulted in extensive, hypoxic-ischemic-type injury. Importantly, this mechanism closely resembles that seen in children, with relative sparing of the contralateral cortex, thus ruling out a pure asphyxia mechanism. In this model, piglets of similar developmental stage to human toddlers (postnatal day 30, PND30) have extensive hypoxic-ischemic damage to the cortical ribbon with sparing of the contralateral hemisphere and deep gray matter areas. However, piglets of similar developmental stage to human infants (postnatal day 7, PND7) have less hypoxic-ischemic damage that is notably bilateral and patchy. We therefore sought to discover whether the extensive tissue damage observed in PND30 was due to a greater upregulation of matrix metalloproteinases (MMPs). Materials and Methods: In PND7 or PND30 piglets receiving AHT injuries (cortical impact, midline shift, subdural hematoma/subarachnoid hemorrhage, traumatic seizures, and brief apnea and hypoventilation) or a sham injury, the pattern of albumin extravasation and MMP-9 upregulation throughout the brain was determined via immunohistochemistry, brain tissue adjacent to the cortical impact where the tissue damage spreads was collected for Western blots, and the gelatinase activity was determined over time in peripheral plasma. EEG was recorded, and piglets survived up to 24 h after injury administration. Results: The pattern of albumin extravasation, indicating vasogenic edema, as well as increase in MMP-9, were both present at the same areas of hypoxic-ischemic tissue damage. Evidence from immunohistochemistry, Western blot, and zymogens demonstrate that MMP-2, -3, or -9 are constitutively expressed during immaturity and are not different between developmental stages; however, active forms are upregulated in PND30 but not PND7 after in response to AHT model injuries. Furthermore, peripheral active MMP-9 was downregulated after model injuries in PND7. Conclusions: This differential response to AHT model injuries might confer protection to the PND7 brain. Additionally, we find that immature gyrencephalic species have a greater baseline and array of MMPs than previously demonstrated in rodent species. Treatment with an oral or intravenous broad-spectrum matrix metalloproteinase inhibitor might reduce the extensive spread of injury in PND30, but the exposure to metalloproteinase inhibitors must be acute as to not interfere with the homeostatic role of matrix metalloproteinases in normal postnatal brain development and plasticity as well as post-injury synaptogenesis and tissue repair.

Effects of anodal tDCS on resting state eeg power and motor function in acute stroke: a randomized controlled trial

BackgroundAnodal transcranial direct current stimulation (tDCS) is a beneficial adjunctive tool in stroke rehabilitation. However, only a few studies have investigated its effects on acute stroke and recruited only individuals with mild motor deficits. This study investigated the effect of five consecutive sessions of anodal tDCS and conventional physical therapy on brain activity and motor outcomes in individuals with acute stroke, with low and high motor impairments.MethodsThirty participants were recruited and randomly allocated to either the anodal or sham tDCS group. Five consecutive sessions of tDCS (1.5 mA anodal or sham tDCS for 20 min) were administered, followed by conventional physical therapy. Electroencephalography (EEG), Fugl-Meyer Motor Assessment (FMA), and Wolf Motor Function Test (WMFT) were performed at pre-, post-intervention (day 5), and 1-month follow-up. Sub-analyses were performed on participants with low and high motor impairments. The relationship between EEG power and changes in motor functions was assessed.ResultsLinear regression showed a significant positive correlation between beta bands and the FMA score in the anodal group. Elevated high frequency bands (alpha and beta) were observed at post-intervention and follow-up in all areas of both hemispheres in the anodal group, while only in the posterior area of the non-lesioned hemisphere in the sham group; however, such elevation induced by tDCS was not greater than sham. Lower limb function assessed by FMA was improved in the anodal group compared with the sham group at post-intervention and follow-up only in those with low motor impairment. For the upper limb outcomes, no difference between groups was found.ConclusionsFive consecutive days of anodal tDCS and physical therapy in acute stroke did not result in a superior improvement of beta bands that commonly related to stroke recovery over sham, but improved lower extremity functions with a post-effect at 1-month follow-up in low motor impairment participants. The increase of beta bands in the lesioned brain in the anodal group was associated with improvement in lower limb function.Trial registration: NCT04578080, date of first registration 10/01/2020.

Neural Coupling between Interhemispheric and Frontoparietal Functional Connectivity during Semantic Processing.

Interhemispheric and frontoparietal functional connectivity have been reported to increase during explicit information processing. However, it is unclear how and when interhemispheric and frontoparietal functional connectivity interact during explicit semantic processing. Here, we tested the neural coupling hypothesis that explicit semantic processing promotes neural activity in the nondominant right hemispheric areas, owing to synchronization with enhanced frontoparietal functional connectivity at later processing stages. We analyzed electroencephalogram data obtained using a semantic priming paradigm, which comprised visual priming and target words successively presented under direct or indirect attention to semantic association. Scalp potential analysis demonstrated that the explicit processing of congruent targets reduced negative event-related potentials, as previously reported. Current source density analysis showed that explicit semantic processing activated the right temporal area during later temporal intervals. Subsequent dynamic functional connectivity and neural coupling analyses revealed that explicit semantic processing increased the correlation between right temporal source activities and frontoparietal functional connectivity in later temporal intervals. These findings indicate that explicit semantic processing increases neural coupling between the interhemispheric and frontoparietal functional connectivity during later processing stages.

Concentration contextualisation, temporal patterns and sources of hydrogen sulphide at a site on the South African Highveld

South Africa is one of the largest atmospheric sulphur emitting countries, but the contribution of H2S to this regional burden is not known. Also, no H2S source apportionment for South Africa have been undertaken, although H2S has adverse effects on the environment and human health both directly and after being oxidised. Measurements were conducted for 2 years at a site on the Mpumalanga Highveld (South Africa), which is influenced by multiple sources. A mean of 3.1 ppb H2S was obtained, which is similar than concentrations reported for some large Northern Hemisphere cities and areas close to gas processing plants. Well defined seasonal and diurnal patterns indicated that low-level emission sources likely made a significant contribution to the ambient H2S concentrations. In this study, a receptor method was developed to enable identification of sources and quantification of their contribution to atmospheric H2S levels above the baseline concentrations. The results indicate that emissions from urban areas on the Mpumalanga Highveld, associated with sources in towns, as well as semi- and informal settlements (e.g. ineffective household combustion of low grade coal, sewage waste water treatment facilities, landfills, small industries and traffic) contributed most to atmospheric H2S levels in excess of baseline concentrations (34.6%), followed by pyrometallurgical smelters (19.8%) and a petrochemical operation near Secunda (17.9%). The Johannesburg-Pretoria megacity, coal-fired power stations, burning coal dumps and cattle feedlots contributed 10.9, 4.7, 3.8 and 0.4%, respectively, to H2S concentrations in excess of the baseline levels, respectively. The results from this study will be informative for legislation that is currently being considered, wherein regional ambient H2S standards for South Africa are suggested.

Incidence of resting-state functional connectivity to secondary language areas and contralateral language areas in patients with brain tumors.

Secondary language areas, including the pre-supplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), and the visual word form area (VWFA) play important roles in speech, but have been under-evaluated in the realm of resting-state (rs)-fMRI. The purpose of this study is to determine the incidence that secondary language areas and contralateral language areas can be localized using seed-based correlation (SBC) rs-fMRI. We retrospectively reviewed 40 rs-fMRIs for functional connectivity (FC) to secondary language areas in cases where FC to Broca's or Wernicke's area near tumor in the left hemisphere were successfully generated using SBC analysis. Logistical regression was used for statistical analysis. SBC rs-fMRI with a seed in the left Broca's or Wernicke's area ipsilateral to the tumor was performed in the 40 patients. 72.5% of cases showed FC to the left DLPFC, 67.5% to left pre-SMA, and 52.5% of cases had FC to right Broca's area. In addition to other correlations, we found older patients have a lower incidence of FC to the right Wernicke's area when seeded from both left Broca's and left Wernicke's area (p-value = .016, odds ratio = 0.94). SBC rs-fMRI can detect left hemispheric secondary language areas as well as right hemispheric primary and secondary language areas. The left DLPFC showed the highest incidence of FC, followed by the left pre-SMA when seeded from both left Broca's and Wernicke's area. Logistics regression also showed in some instances, differences in the incidence of FC to language areas was dependent on age, seed location, and gender.

Effect of rTMS at SMA on task-based connectivity in PD

BackgroundTranscranial magnetic stimulation (TMS) can aid in alleviating clinical symptoms in Parkinson’s disease (PD). To better understand the neural mechanism of the intervention, neuroimaging modalities have been used to assess the effects of rTMS. ObjectiveTo study the changes in cortical connectivity and motor performance with rTMS at supplementary motor area (SMA) in PD using clinical assessment tools and task-based functional MRI. Methodology3000 pulses at 5 Hz TMS were delivered at the left SMA once a week for a total of 8 consecutive weeks in 4 sham sessions (week 1–4) and 4 real sessions (week 5 to week 8) in 16 subjects with PD. The outcomes were assessed with UPDRS, PDQ 39 and task-based fMRI at baseline, after sham sessions at week 4, and after real sessions at week 8. Visuo-spatial functional MRI task along with T1 weighted scans (at 3 Tesla) were used to evaluate the effects of rTMS intervention. Multivariate pattern analysis (MVPA) was used to analyse task-based fMRI using Conn toolbox. ResultsImprovements (p < 0.05) were observed in UPDRS II, III, Mobility and ADL of PDQ39 after real sessions of rTMS. MVPA of task-based connectivity revealed clusters of activation in right hemispheric precentral area, superior frontal gyrus, middle frontal gyrus, thalamus and cerebellum (cluster threshold pFDR=0.001). ConclusionsWeekly rTMS sessions at SMA incurred clinical motor benefits as revealed by an improvement in clinical scales and dexterity performance. These benefits could be attributed to changes in connectivity remote brain regions in the motor network.

Subcortical Role in Figurative Processing by Persian- speaking Alzheimer and Parkinson’s Patients

Introduction: The production of figurative expressions, particularly idioms, and proverbs, is negatively affected by damage to the left hemisphere and subcortical area of the brain. Alzheimer patients, thanks to the preservation of basal ganglia, can produce these expressions. In contrast, compared to Alzheimer’s patients, Parkinson’s patients cannot produce these expressions due to the malfunction of the basal ganglia. This study attempts to compare the linguistic and cognitive performance of Persian-speaking patients with Alzheimer’s disease, Parkinson’s disease, and healthy counterparts regarding the production and comprehension of these figurative expressions.&#x0D; Materials and Methods: In doing so, by selecting a sample of participants composed of 10 Alzheimer’s patients, 10 Parkinson’s patients, and 10 healthy individuals matched with each other regarding age and education. Then, different tests, including Arizona battery for communication disorders of dementia, famous names, and face test, structured conversation, figurative expression completion, elicitation of response based on situational context, Northridge evaluation of idioms and proverbs in situational context, conventional and figurative expression evaluation were condcuted to analyze their performance.&#x0D; Results: The results of Arizona battery for communication disorders of dementia indicated that Alzheimer’s patients were in the middle stage of the disease while Parkinson’s participants were classified as non-dementia patients. Although the result of the Renown face and name recognition test demonstrated a significant difference between Alzheimer’s patients and the healthy group regarding cognition and confidence levels, the same result was not observed between healthy control and Alzheimer’s patients. Furthermore, in the test of structured conversation, the proportion of produced words by Alzheimer’s patients was more than that of Parkinson’s patients. However, the results of sentence and figurative expression completion tests corroborated the weaker performance of Alzheimer’s patients compared to their Parkinson and healthy counterparts. Furthermore, notwithstanding in the test of Elicitation of response based on Situational Context, Parkinson’s patients performed more poorly than their Alzheimer and healthy counterparts, in the tests of conventional and figurative expression evaluation, Alzheimer’s patients’ pattern of performance was different from that of other groups as they performed more weakly than Parkinson patients.&#x0D; Conclusion: The observed dissociation in the performance of Alzheimer as well as Parkinson’s patients in the linguistic production and comprehension tests shed light on the significant role of the subcortical area of the brain in the production of idioms and proverbs.