Haematological Parameters In Children Research Articles

Study of Hematological Parameters in Children Suffering from Iron Deficiency Anaemia in Chattagram Maa-o-Shishu General Hospital, Chittagong, Bangladesh.

A total of 150 (30.61%) anemic patients out of 490 patients diagnosed to have iron deficiency anemia (IDA) have been selected for the first time in Bangladesh. For detailed study, blood samples from 150 anemic patients along with 25 controls were analyzed. Analysis of variance showed significant P value between mean platelet volume (MPV) in females (8.08 μm3) and males (7.59 μm3) (P < 0.05) in iron deficiency anemia patients. Besides, the value of white blood cells (WBC) in males (10946.08/cmm) was significantly higher than in females (9470.833/cmm) (P < 0.05). The significant correlation was observed among hemoglobin levels with hematocrits, hemoglobin with RBC, RBC with hematocrits, and MCV with MCH as well as MCH with MCHC. However, the negative correlation was observed between the hematological variables neutrophils and lymphocytes (r = −0.989). The common complaints we have found in the survey were weight loss 73.33%, attention problem 68%, dyspepsia 65%, decrease of appetite 72%, weakness 68%, diarrhea 65%, and headache 55% among IDA patients. ANOVA showed significant statistical difference in all the hematological and biochemical parameters. Analysis of variance test between anemias with only one of three biochemical parameters decreased and control showed that this group does not have iron deficiency.

Prognostic Value of Biochemical and Hematological Parameters in Children with Nephrotic Syndrome

Background: Nephrotic syndrome causes a great morbidity and mortality among the children.Objective: The purpose of the present study was to compare the biochemical and hematological parameters and their prognostic value in steroid resistant (SRNS), frequent relapse and steroid dependent (FRNS+SDNS) and infrequent relapse (IFRNS) groups.Methodology: A prospective study of 43 children with idiopathic nephrotic syndrome (INS) selected randomly out of 480 children admitted with the disease at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2003 to January 2005. There were 24 steroid sensitive nephrotic syndrome (SSNS) and 19 steroid resistant nephrotic syndrome (SRNS), of SSNS group 13 were infrequent relapse (IFRNS) and 11 were frequent relapse steroid dependent (FRNS+SDNS).Result: SRNS has low serum total protein (STP), albumin and hemoglobin compared to SSNS (P&lt;0.01, P&lt;0.001). SRNS also has high cholesterol, creatinine and urinary total protein (UTP) than SSNS (P&lt;0.01, P&lt;0.001). Higher difference was observed between SRNS and IFRNS (P&lt;0.001). High serum cholesterol, UTP and low hemoglobin were found in FRNS+SDNS compared to IFRNS (P&lt;0.01, P&lt;0.05).Conclusion: STP, albumin, creatinine were equally low in SRNS and FRNS+SDNS.DOI: http://dx.doi.org/10.3329/jssmc.v5i2.20764J Shaheed Suhrawardy Med Coll 2013;5(2):95-98

Effects of blood lead level on biochemical and hematological parameters in children with neurological diseases of Western Maharashtra, India

Lead is found in small but appreciable quantities in air, soil, drinking water, and food. Exposure to such amounts of lead does not lead to acute lead toxicity but produces subtle effects particularly in children. The aim of this study was to investigate the effects of blood lead level on biochemical and hematological parameters in children with neurological diseases in Western Maharashtra, India, and to estimate the blood lead level by liver and kidney function tests and hematological parameters in children with neurological disorders admitted to the pediatric ward and compare them with healthy controls. In this study, 30 children with various neurological disorders admitted to the pediatric ward of Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India, were compared with 30 age- and sex-matched healthy controls. Four milliliters of venous blood was collected for estimation of blood lead level, and biochemical and hematological parameters were determined using standard methods. Blood lead level was significantly increased in the study group (p<0.01, 65.38%) compared to that in the control group. When different neurological conditions were grouped into three groups according to blood lead levels, there was a significant difference between the groups. All other biochemical and hematological parameters were not significantly altered in the study group as compared to the control group. Neurologically challenged children are more vulnerable to lead intoxication. It is imperative for the parents to take extra care of their children's food habits and limit hand-to-mouth activities to prevent lead intoxication.

PP7.9 – 2061 Haematological parameters in children with epilepsy treated with levetiracetam monotherapy

PP7.9 – 2061 Haematological parameters in children with epilepsy treated with levetiracetam monotherapy

Vitamin a status and hematological values in sickle cell disorder cases

Sickle cell anemia (SCA), which is an inherited blood disorder characterized primarily by chronic anemia and oxidative stress plays a major role in pathophysiology. This study aims to evaluate vitamin A (serum retinol) status and hematological parameters in children with homozygous and heterozygous sickle cell disorders and compared with age- and sex-matched healthy controls. A sample of 80 referred cases (37 sickle cell disorders and 43 normal cases) aged 2-40 years were included in the study. Hematological parameters were measured in cell counter and serum retinol by high-performance liquid chromatography. The mean hemoglobin (Hb) and serum retinol were significantly lower among cases with sickle cell disease than in sickle cell trait and normal. Vitamin A deficiency (retinol < 20 μg/dl) reported to be higher in homozygous cases (46.2%) as compared to either heterozygous (29.2%) or control (23.2%) groups. Serum retinol was correlated directly with Hb, RBC count, and hematocrit levels, and inversely with percentage of sickling among sickle cell disorder cases. The results indicate that deprived vitamin A status with inductive oxidative stress is mainly due to sickling and hemolysis in SCA cases.

A Comparative Study of Haematological Parameters in Children Suffering from Sickle Cell Anaemia (SCA) from Different Regions of Saudi Arabia

Sickle cell anaemia (SCA) occurs frequently in several regions of Saudi Arabia but the haematological and clinical presentations are significantly variable. We investigated 264 Saudi children suffering from SCA originating from different regions of Saudi Arabia. Normal children from the same region were used as controls. Freshly obtained blood samples from patients and controls were used to estimate haematological parameters, red cell indices, Hb A2 and Hb F levels. The results of children from the different regions were separately analysed using the Statistical Analysis System (SAS). Significant variations were seen in the haematological parameters in SCA patients compared to controls in each region. In addition, comparison of patients from different areas also showed wide variations. The highest levels of haemoglobin, red blood cells and haematocrit were in the SCA children from the eastern province, and the lowest levels were from those in the western province. Red cell indices and Hb A2 levels did not differ significantly but HbF levels were significantly higher compared to the control group. Inter-regional differences were seen in the Hb F level. A slight but statistically significant increase was seen in the total haemoglobin with Hb F. This paper compares the haematological parameters of SCA in different regions of Saudi Arabia and shows a significant haematological heterogeneity in SCA in Saudis.