Hematological Biochemical Changes Research Articles

FACTORS DETERMINING THE SUCCESSFUL PERFORMANCE OF CYTOREDUCTIVE OPERATIONS IN OVARIAN CANCER PATIENTS

The article reviews literature data on attempts to create various prognostic models with the goal of optimizing indications for surgical treatment and achieving optimal cytoreductive operations in patients with a common form of ovarian cancer. The data of various authors on the sensitivity and specificity of X-ray methods of investigation, laparoscopy, tumor markers, etc. are given in the diagnosis of the spreading of ovarian cancer and their prognostic value for planning optimal cytoreductive operations. There have been demonstrated created by different authors prognostic models which use a complex approach to the surgical treatment of ovarian cancer, which in addition to diagnosing the spreading of the tumor process consider the functional state of the patient, concomitant diseases, age, hematological biochemical changes in the blood, etc.

Comparison the Effect of Metoclopromide, Atropine, Midazolam and Acepromazine on Capturing Stress in Pigeons (Columba liviadomestica)

In pigeons (Columba liviadomestica) like any other unhandled animals, release of catecholamine and corticosteroids occurs following capturing and restriction. This hormonal response can changes some hematological, biochemical and clinical parameters that known as stress features. This study determined some stress responses in means of hematologic-biochemical changes following intramuscular (IM) injection of metoclopromide (0.5 mg/kg), atropine (0.04 mg/kg), midazolam (0.2 mg/kg) and acepromazine (0.1 mg/kg) in time zero, 30 and 90 minutes after injection. For this purpose, this study was conducted on 40 healthy male pigeons. Following injection of metoclopromide or atropine, significantly higher serum cortisol level was observed. However there was a decrease in plasma cortisol concentration with midazolam. Packet cell volume was only changed increasingly in atropine group. The merely drug that kept Heterophil/Lymphocyte (H/L) index constant was midazolam whereas in other drugs group increase of this factor was observed. Higher H/L index belongs to atropine administered group after injection. Acepromazine has the ability of maintaining basic cortisol level during surgery procedure. In contrast, midazolam achieves peak of its effect about 30 minutes after intramuscular injection which can decreased cortisol to the basic level at the moment. Blood sugar increased in all groups after handling of the birds. Higher blood glucose concentration relies on internal glucocorticoids and indicates that these drugs cannot decrease glucose in the short time period. Total protein remains unchanged during short time of the study.

Humoral immune response in Oreochromis niloticus: modified direct agglutination test

Understanding the functional mechanisms of the humoral and cellular immune responses among teleost broadens the possibilities for intervention and improvement of vaccination methods. The aim of this study was to evaluate the dynamics of the humoral immune response, hematological biochemical changes, and electrophoretic profile of proteins in Oreochromis niloticus, when submitted to antigen stimulation using sheep erythrocytes in a single dose and with booster doses. Seventy O. niloticus were distributed in two groups (n = 35): one received a single dose and the other received two doses of antigen. Evaluations were made at the following predetermined times: zero (pre-immune, i.e., before inoculation with the first injection of sheep erythrocytes, negative control) and on 7th, 14th, 21st, and 28th days after the first immunization to evaluate the hemogram, biochemistry, and electrophoresis of proteins and direct hemagglutination. Twenty-eight days after antigen inoculation, it was observed that there had been an increase in the serum antibody titer and fractions gamma globulins after second antigen stimulation. The results suggest that teleost fish have the capacity to produce antibodies from a single stimulation, and a second antibody production wave after second stimulation.