Purpose: Determination of changes in metabolic status in new-fluxed cows and twisters when metric and the role of oxidant stress in the pathogenesis of inflammation of the uterus.Materials and methods. The two groups of animals 15 goals were investigated in each. The clinical diagnosis of an acute metric in cows and first elevators in the early postpartum period was carried out in cancer of obstetric and gynecological examinations. Blood fences for hematological studies took from cows before morning feeding. General ketone bodies (OCT), beta-hydroxyma acid (BH), acetone with acetoxus acid (ACAC), progesterone, estradiol, testosterone, cortisol; Ketodines and conjugate trimes (cdist), diene conjugates (DK), isolated double bonds and ketodines, malonic dialdehyde (HMDa), glutathione restored and oxidized, soda, catalase, vitamins C and E.Results. With acute metric, in cows and twisters, there is a fatty dystrophy of centrolobular localization in the liver, in which the indicators of EN / ASAS, Oct and VV amounted to 1.9 ± 0.43 mmol / l, 2.49 ± 0.12 and 1.82 ± 0.05 mmol / l, respectively. Large values of the indicators of EN / ASAS, Oct and VN are installed and in the absence of visible fatty dystrophy: 3.8 ± 0.6 mmol / l, 3.22 ± 0.11 and 2.53 ± 0.23 mmol / l, respectively. The asas in the blood of these cows was higher - 0.97 ± 0.07 mmol / l. In cows and primaries patients with metric, MDA content increased by 1.32 times in comparison with indicators in healthy animals of a similar physiological period (p <0.05). At the same time, the catalase is increased (p <0.01) from 24.4 ± 0.23 mm H202 / lchmin to 34.1 ± 0.26 mm H202 / Lchmin. At the same time, the content of vitamin C and E in comparison with the control decreased. So insulated double bonds in patients with cows and first metrics have reliable differences (p <0.05) in the indicators of clinically healthy animals 1,244 ± 0.41 against 1.686 ± 0.42 SL. Units, and conjugate trimes and ketodines with 0.116 ± 0.05 to 0.186 ± 0.07 SL. units. Reducing the superoxiddismutase index is less than a level of 1.55 SL. Ur, also indicates the presence of oxidant stress.Conclusion. According to the data presented, one of the main etiological factors in the pathogenesis of metric in cows and primaries in the early period of Pueerperia is oxidant stress arising from animals against the background of a negative energy balance. Therefore, traditionally used in the algorithm for the diagnosis of animals, patients with metric in the initial postpartum period, biochemical blood biochemical indicators have a lower degree specificity and sensitivity than the parameters of the system "peroxidation of lipids - antioxidant protection".