HEMA Concentration Research Articles

Association between urinary 2-hydroxyethyl mercapturic acid and dyslexia among school-aged children.

Ethylene oxide is commonly used in industrial synthesis and medical disinfection. It is a known human carcinogen and has neurotoxicity. However, the association between ethylene oxide exposure and neurodevelopmental disorders remains unclear. This study aimed to evaluate the association between urinary concentrations of 2-hydroxyethyl mercapturic acid (HEMA; metabolite of ethylene oxide) and dyslexia among school-aged children. A total of 355 dyslexic children and 390 controls from three cities in China were enrolled in this case-control study from November 2017 to December 2020. Urinary HEMA was detected in 100% of the urine samples, suggesting widespread exposure to ethylene oxide in the children. Notably, the children with dyslexia had higher concentrations of urinary HEMA compared to the controls (geometric mean: 2.92 vs. 2.47 ng/mL) (P = 0.004). In the multivariable-adjusted model, urinary concentrations of HEMA were significantly associated with dyslexia risk. The individuals within the highest HEMA concentration demonstrated a 1.97-fold increased odds of dyslexia compared to those within the lowest quartile (95% confidence interval: 1.20-3.23). Thus, these findings suggested the possible link between HEMA levels and the risk of dyslexia. Further studies are warranted to validate this finding and illustrate the underlying mechanism.

Radiation‐Induced Admicellar Graft Polymerization of 2‐Hydroxyethyl Methacrylate onto Polyvinylidene Fluoride Membranes Using an Electron Beam Accelerator

AbstractThe efficiency of admicellar graft polymerization in functionalizing polyvinylidene fluoride (PVDF) membranes was explored. The effect of 2‐hydroxyethyl methacrylate (HEMA) concentration and the absorbed dose was investigated using a simultaneous method of radiation‐induced graft polymerization. The degree of grafting increased with raising the absorbed dose and HEMA concentration. The Fourier transform infrared (FTIR) peak for C–O stretch and the asymmetric and symmetric stretching of the C–O–C bridge, respectively, proved the presence of poly(2‐hydroxyethyl methacrylate) (PHEMA) on the modified PVDF. As the grafting yield increased, rougher surfaces were observed. According to contact angle analysis, the grafted membrane with a higher grafting yield outperformed the low grafting yield membrane in terms of water flux and hydrophilicity.

Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents.

Poly(2-hydroxyethyl methacrylate) (polyHEMA) hydrogels are commonly used in biomaterials such as contact lenses. However, water evaporation from these hydrogels can cause discomfort to wearers, and the bulk polymerization method used to synthesize them often results in heterogeneous microstructures, reducing their optical properties and elasticity. In this study, we synthesized polyHEMA gels using a deep eutectic solvent (DES) instead of water and compared their properties to traditional hydrogels. Fourier-transform infrared spectroscopy (FTIR) showed that HEMA conversion in DES was faster than in water. DES gels also demonstrated higher transparency, toughness, and conductivity, along with lower dehydration, than hydrogels. The compressive and tensile modulus values of DES gels increased with HEMA concentration. A DES gel with 45% HEMA showed excellent compression-relaxation cycles and had the highest strain at break value in the tensile test. Our findings suggest that DES is a promising alternative to water for synthesizing contact lenses with improved optical and mechanical properties. Furthermore, DES gels' conduction properties may enable their application in biosensors. This study presents an innovative approach to synthesizing polyHEMA gels and provides insights into their potential applications in the biomaterials field.

Cytotoxicity and Apoptotic Mechanism of 2-Hydroxyethyl Methacrylate via Genotoxicity and the Mitochondrial-Dependent Intrinsic Caspase Pathway and Intracellular Reactive Oxygen Species Accumulation in Macrophages.

Macrophages are mainly active cells of the immune system and play a role in the defense of pathogens. However, the overactivation of macrophages by fatal pathogens can result in toxic responses. 2-hydroxyethyl methacrylate (HEMA), which is a hydrophilic monomer, is used in dental adhesive reagents and composite resins as well as biocompatible hydrogels. The mechanisms underlying the genotoxicity engendered by HEMA-induced apoptosis that leads to cytotoxicity remain unclear. Accordingly, this study was conducted to clarify such mechanisms. The results showed that HEMA induced cell toxicity in RAW264.7 macrophages depending on the concentration. A higher HEMA concentration was associated with a higher level of apoptosis and genotoxicity. Moreover, HEMA induced a concentration-dependent increase in mitochondrial dysfunction and the intrinsic caspase pathway, including the activation of caspase-3 and caspase-9. HEMA was also found to upregulate intracellular reactive oxygen species generation and to decrease the activity of antioxidant enzymes, including superoxide dismutase and catalase. Taken together, the mitochondrial-dependent intrinsic caspase pathway and intracellular reactive oxygen species accumulation were found to mediate HEMA-induced genotoxicity and apoptosis, leading to cytotoxicity in RAW264.7 macrophages.

Effect of fiber surface modifications on the properties of snake grass fiber reinforced polypropylene bio-composites

Snake grass fibers (SGFs)-reinforced polypropylene (PP)-based longitudinal bio-composites (40 wt% by fiber) were successfully manufactured by compression molding and tested for their physicomechanical, hardness, and thermal properties. SGFs were modified with non-ionizing radiation at different intensities and then bio-composites were fabricated. The mechanical properties of irradiated-SGF/PP bio-composites were significantly improved compared to untreated parts. Irradiated SGFs were grafted with 2-hydroxyethyl methacrylate (HEMA) monomers by photocuring under UV light. The number of UV passes and therefore the HEMA concentration were optimized with the extent of grafting of HEMA, tensile, and impact properties. Bio-composites reinforced with 10% HEMA and the 50th UV pass of SGF show maximum mechanical properties. Again, the irradiated SGFs were modified with alkali (NaOH) solutions of different concentrations at different temperatures. Optimized alkali-treated SGFs were then grafted with optimized HEMA by photocured with the same UV-pass and their composite samples rendered the best mechanical properties like tensile strength, tensile modulus, impact strength, and hardness. Optimized alkali-treated SGF with optimized HEMA grafted composite samples had higher thermal stability than other samples. Scanning electron microscopy, water absorption, and weather tests of composites were also investigated.

The effects of low-dose 2-hydroxyethyl methacrylate on apoptosis and survival in human dental pulp cells

2-hydroxyethyl methacrylate (HEMA) is one of the most major components in dentin bonding systems. Uncured HEMA is eluted through the dentin and harmful to pulp cells. The study aimed to investigate the death pattern, morphological change and factors of human dental pulp cells (HDPCs) cultured with low-dose HEMA. HDPCs were cultured with low-dose concentration of HEMA at 0mM (control), 0.125mM, 0.25mM, 1mM, 2mM and 4mM on Day 3 and 5. The cell morphology was observed with F-actin immunocytochemical staining. The flow cytometry was used to analyze the death pattern. NF-κB and Trx-1 were measured using ELISA kits. The major death pattern was early apoptosis and late apoptosis. The morphological characteristics of apoptosis were observed clearly at 4mM on Day 3 and Day 5. The phosphorylated NF-κB normalized to total NF-κB protein was significantly higher at 2mM and 4mM on Day 5. There was no difference of Trx-1 on Day 3, but significantly higher at 0.25mM and 1mM on Day 5. The trend line of phosphorylated NF-κB and Trx-1 showed highly positive correlations with HEMA concentration. The significant cellular morphology characteristics of apoptosis can be observed at higher dose and longer period after exposed to uncured HEMA. The expression of NF-κB was following the ratio of late apoptosis at longer exposure period. Clinically, the remaining dentin thickness should be enough to decrease HEMA concentration and thus to protect pulp cells free from harm.

The effects of 2-hydroxyethyl methacrylate on matrix metalloproteinases 2 and 9 in human pulp cells and odontoblast-like cells invitro.

To assess the effects of 2-hydroxyethyl methacrylate (HEMA) on proliferation and migration of human pulp cells, as well as on matrix metalloproteinase (MMP-2 and MMP-9) expression in human odontoblast-like cells, contributing to the goal of determining the relationship between resin materials and MMP activity in pulp-dentine complexes. Dental pulp cell cultures were established from pulp tissue of human teeth extracted for orthodontic purposes. Pulp cell differentiation was characterized in the presence of dentine sialophosphoprotein, bone sialoprotein and alkaline phosphatase by reverse transcription polymerase chain reaction. MMP activity was assessed by gelatine zymography with media containing HEMA. Cell viability was evaluated using methyl thiazolyl tetrazolium assay for 24-72h. Cell migration was tested using Transwell migration assay. Western blotting was used to visualize MMP expression with the nontoxic HEMA concentrations (0-400μgmL-1 ) for 48h. Pulp cell proliferation decreased with HEMA exposure in a time- and concentration-dependent manner. HEMA concentrations ≤400μgmL-1 did not induce changes in cell viability at 48h (P<0.05). Pulp cells were induced to differentiate into odontoblast-like cells in media containing 5mgmL-1 ascorbic acid and 10mmolL-1 β-sodium glycerophosphate for 3-4weeks. After incubation with HEMA, dose-dependent inhibition was observed; HEMA had a strong inhibitory effect on MMP activity. Compared with the control group, cell migration and MMP expression were inhibited significantly with increasing HEMA concentration at noncytotoxic doses (P<0.05). Cell viability was not affected at HEMA concentrations ≤400μgmL-1 . Within this range, HEMA inhibited MMP-2 and MMP-9 expression and activity, which may protect against type I collagen degradation effectively during dentine adhesive procedures.

Influence of hydrophobic monomers on secondary nucleation of hydroxyl-functionalized latexes

The influence of butyl acrylate (BA) and methyl methacrylate (MMA) on hydroxyl functionalized latexes was investigated. The hydrophobicity of the monomer feed was varied via the BA/MMA ratio. In addition to monitoring the effect of hydrophobic monomer feed on secondary nucleation, the polymerization kinetics and final latex properties were also obtained for comparison. Five different BA to MMA molar ratios were combined with five 2-hydroxyethyl methacrylate (HEMA) concentrations (0, 10, 20, 30 and 40 mol% in monomer composition). All latexes were synthesized through seeded semibatch emulsion polymerization process. Particle size distributions and average particle sizes of the latexes were determined by dynamic light scattering (DLS) and qualitatively compared with transmission electron microscope (TEM) images. The BA to MMA ratio significantly influences the boundary HEMA concentration at which homogeneous secondary nucleation occurs. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017

Phosphorylation of chitosan/HEMA interpenetrating polymer network prepared by γ-radiation for metal ions removal from aqueous solutions

Interpenetrating polymer network (IPN) hydrogels, based on chitosan (CS) and 2-hydroxyethyl methacrylate (HEMA), have been prepared by γ-radiation followed by chemical modification via phosphorylation reaction and used for adsorption of Ca(II), Cu(II) and Zn(II) ions from their aqueous solutions. The gel content (%) increases with increasing the HEMA concentration. The maximum swelling (%) observed at the ratio (70/30) (CS/HEMA). CS/pHEMA IPN showed a higher thermal stability than CS. The phosphorylated hydrogel, Phos-(CS/pHEMA), characterized by XRD, EDS, SEM, DSC and TGA techniques. FT-IR spectra before and after adsorption of metal ions have been studied. Factors affecting the maximum adsorption capacity were also investigated. The maximum adsorption capacity using 0.01g Phos-(CS/pHEMA) was 66.3, 57.6 and 48.7 (mg/g) for Cu(II), Zn(II) and Ca(II) ions, respectively. The adsorption isotherms were simulated by Langmuir and Freundlich models and the adsorption kinetics were simulated by the pseudo-first-order and pseudo-second-order kinetics. The adsorption follows Langmuir models and pseudo-second order. The IPN hydrogels showed effective adsorption of the three metal ions from aqueous solution.

Effect of layer thickness on the elution of bulk-fill composite components

ObjectiveAn increment layering technique in a thickness of 2mm or less has been the standard to sufficiently convert (co)monomers. Bulk fill resin composites were developed to accelerate the restoration process by enabling up to 4mm thick increments to be cured in a single step. The aim of the present study is to investigate the effect of layer thickness on the elution of components from bulk fill composites. MethodsThe composites ELS Bulk fill, SDR Bulk fill and Venus Bulkfill were polymerized according to the instruction of the manufacturers. For each composite three groups with four samples each (n=4) were prepared: (1) samples with a layer thickness of 2mm; (2) samples with a layer thickness of 4mm and (3) samples with a layer thickness of 6mm. The samples were eluted in methanol and water for 24h and 7 d. The eluates were analyzed by gas chromatography/mass spectrometry (GC/MS). ResultsA total of 11 different elutable substances have been identified from the investigated composites. Following methacrylates showed an increase of elution at a higher layer thickness: TEGDMA (SDR Bulk fill, Venus Bulk fill), EGDMA (Venus Bulk fill). There was no significant difference in the elution of HEMA regarding the layer thickness. The highest concentration of TEGDMA was 146μg/mL for SDR Bulk fill at a layer thickness of 6mm after 7 d in water. The highest HEMA concentration measured at 108μg/mL was detected in the methanol eluate of Venus Bulk fill after 7 d with a layer thickness of 6mm. SignificanceA layer thickness of 4mm or more can lead to an increased elution of some bulk fill components, compared to the elution at a layer thickness of 2mm.

Transcriptome modifications in human gingival fibroblasts exposed to 2-hydroxyethyl methacrylate

2-Hydroxyethyl methacrylate (HEMA),a tooth filling material, was proven to have toxic effects on different cell types, including human gingival fibroblasts (HGFs), and to be able to influence odontoblast vitality. The aim of the present study was to assess the differential transcriptome modulation induced by low HEMA concentration in cultured HGFs. RNA extracted from cultured HGFs exposed to 3mmol/l HEMA for 24 or 96h underwent a whole genome microarray analysis. Data analysis showed the presence of two gene clusters, composed by 310 transcripts differentially expressed after 24- and 96-h HEMA treatment compared to controls. Functional analysis demonstrated that these transcripts are mainly involved in cellular survival and death, and inflammatory response. The study highlighted an overall damage induced by HEMA exposure at both 24 and 96h, mainly leading to a proliferation impairment. Interestingly, 24-h HEMA treatment seems to induce the cells to trigger repair mechanisms, evidencing an early compensatory response, whereas 96-h incubation appears to cause the occurrence of apoptosis as a consequence of the chronic damage.

Reaction kinetics of dual setting α-tricalcium phosphate cements.

Addition of ductile polymers to calcium-deficient hydroxyapatite (CDHA)-forming bone cements based on α-tricalcium phosphate (α-TCP) is a promising approach to improve the mechanical performance of α-TCP cements and extend their application to load-bearing defects, which is else impeded by the brittleness of the hardened cement. One suitable polymer is poly-(2-hydroxyethylmethacrylate) (p-HEMA), which forms during cement setting by radical polymerisation of the monomer. In this study the hydration kinetics and the mechanical performance of α-TCP cements modified with addition of different HEMA concentrations (0-50 wt% in the cement liquid) was investigated by quantitative in situ XRD and four-point bending tests. Morphology of CDHA crystals was monitored by scanning electron microscopy. The hydration of α-TCP to CDHA was increasingly impeded and the visible crystal size of CDHA increasingly reduced with increasing HEMA concentration. Modification of the cements by adding 50 wt% HEMA to the cement liquid changed the brittle performance of the hardened cement to a pseudoplastic behaviour, reduced the flexural modulus and increased the work of fracture, while lower HEMA concentrations had no significant effect on these parameters. In such a composite, the extent of CDHA formation was considerably reduced (34.0 ± 1.8 wt% CDHA with 50 % HEMA compared to 54.1 ± 2.4 wt% CDHA in the reference formed after 48 h), while the general reaction kinetics were not changed. In conclusion, while the extent of CDHA formation was decreased, the mechanical properties were noticeably improved by addition of HEMA. Hence, α-TCP/HEMA composites might be suitable for application in some load-bearing defects and have adequate properties for mechanical treatment after implantation, like insertion of screws.

Molecular level evaluation on HEMA interaction with a collagen model

Objective2-Hydroxyethylmethacrylate (HEMA) diffuses in wet dentin and promotes adhesion during dentin priming and bonding. We have investigated the molecular level interaction between HEMA and a collagen model by using saturation transfer difference (STD) NMR. MethodsThe binding of HEMA to collagen was preliminarily investigated by suspending demineralized human dentin powders in a 4mM HEMA solution for 1h and measuring the decrease in the HEMA concentration on a spectrophotometer. The molecular level interaction of HEMA with atelocollagen, which was used as a collagen model, was investigated by STD-NMR spectroscopy. ResultsThe HEMA concentration in the suspension did not change, indicating that HEMA did not bind to dentin collagen. This was confirmed by STD-NMR; when the atelocollagen resonance was saturated, no saturation was propagated to HEMA and no STD signals were detected. SignificanceThe HEMA protons were not near the atelocollagen surface, indicating HEMA did not interact with atelocollagen. The collagen fibrils may be surrounded by water molecules in dentin/bond interfaces, which prevent the direct HEMA binding interaction.

Long-term bond strength, degree of conversion and resistance to degradation of a HEMA-free model adhesive

Aim: To evaluate the long-term bond strength, degree of conversion and resistance to degradation in ethanol of HEMA-containing and HEMA-free model adhesive resins of a three-step etch-andrinse adhesive system. Methods: The superficial dentin of 16 bovine incisor teeth was exposed, and the teeth were divided in two groups according to the HEMA concentration in the experimental adhesive (0% and 15%). In each tooth were made 6 cylindrical composite restorations. Half of the tooth restorations were submitted to microshear bond strength test after 24 h and the other half after 6 months. Degree of conversion of experimental resins was determined by Fourier transform infrared spectroscopy. Crosslink density was indirectly determined by the Knoop hardness of five specimens per group before and after immersion in ethanol for 6 h. Results: The group with 0% HEMA showed no difference in bond strength as compared to the group with 15% HEMA after 24 h or 6 months. There was no difference in degree of conversion and crosslink density between groups. Conclusions: HEMA content of the adhesive resin did not influence the bond strength to dentin, degree of conversion or resistance to degradation in ethanol.

Sensitized gelatin as a versatile biomaterial with tailored mechanical and optical properties

We have found that gelatin doped with tot'hema (medication used for curing anemia) and eosin becomes elastic, while retaining good optical properties. The mechanical properties of tot'hema–eosin-sensitized gelatin films (TESG) have been investigated for various concentrations of tot'hema (ranging from 5 to 30% v/v). TESG specimens were prepared according to the ASTM standards for elastic materials. Tensile strength, strain at break and Young's modulus were measured. The results show that the extensibility of TESG film increases with increasing tot'hema concentration, while the Young's modulus and stress at break exponentially decrease. Mechanical properties can be tailored to suit various biomedical applications such as blood vessels, human lens capsules and biosensors based on microlenses. Tunable (strain responsive) TESG microlenses were produced and a mechanical model of blood vessels was prepared.

Novel highly active polymer supported chiral Co(III)–salen catalysts for hydrolytic kinetic resolution of epichlorohydrin

A series of novel polymer supported chiral Co(III)–salen catalysts based on the hydroxyl functionalized gel-type resins, the HEMA resins, has been developed. The terpolymers used as supports for the immobilization of the salen catalysts were derived from the mixtures of 2-hydroxyethyl methacrylate (HEMA), styrene and different divinyl monomers (divinylbenzene, diethylene and triethylene glycol dimethacrylates, 1,4-butanediol and 1,6-hexanediol dimethacrylates). It was found that the novel catalysts show the high catalytic activity in the hydrolytic kinetic resolution (HKR) of rac-epichlorohydrin in the medium of THF, TBME, CH2Cl2 and CH3CN. tert-Butyl methyl ether appeared to be the best medium for performing the resolution. An effect of the nature of the polymer matrices on activity of the supported catalysts was also observed. The activity could be improved by optimization of HEMA concentration in the mixture of the monomers and by selection of the cross-linker. The most active catalyst was prepared based on the HEMA resin derived form 30mol.% of HEMA and diethylene glycol dimethacrylate as a cross-linker. In the presence of this catalyst the HKR could be performed even at 0.01mol.% concentration of Co(III) ions. The catalysts could be recycled 10th time at 0.5mol.% concentration without any additional reactivation. It allowed conducting the HKR of epichlorohydrin within less than 60min even in the 10th cycle. The catalyst with the highest loading of catalytic centers could be also used successfully for conducting the HKR of epichlorohydrin in solvent-free conditions. Its activity can be compared to the most active heterogeneous catalyst of the HKR described to date.

Diffusion of HEMA through Human Carious and Non‐Carious Dentin In Vitro

The aim of this study was to evaluate the diffusion of 2-Hydroxyethyl methacrylate (HEMA) from resin cement through dentin both affected and unaffected by caries through high-performance liquid chromatography (HPLC) at two time intervals. Ten freshly extracted restoration-free, caries-free and ten extracted carious human third molar teeth were used in this study. Standardized box-shaped Class I inlay cavities (6 mm long, 3 mm wide, 2 mm deep) were prepared in all teeth with a high-speed handpiece mounted on a standard cavity machine. In teeth affected by caries, after preparation, the remaining carious lesions were removed, with their removal guided by a proprietary caries detector dye. The remaining dentin thickness (RDT) between the pulpal wall of the cavity and the roof of the pulp chamber was measured at multiple points for each tooth so that groups of 10 teeth each were prepared with RDT 1.2 ± 0.5 mm. Lithium disilicate-based ceramic inlays were manufactured to restore the prepared cavities. A polypropylene chamber was attached to the cementoenamel junction of each tooth to contain 1 ml distilled water. Then, ceramic inlays were cemented with chemically polymerized resin cement (Multilink Automix) according to the manufacturer's instructions. Water elutes were analyzed by HPLC at 4.32 minutes and 24 hours. HEMA diffusion amounts were analyzed using two-way ANOVA and Tukey HSD tests (p < 0.05). HEMA was detected in the pulp chamber elutes of all the teeth. The diffused HEMA amounts were not significantly different between the affected caries and the unaffected groups (p= 0.80) or between time periods (p= 0.44). The carious dentin did not influence the amount of HEMA diffused through the dentin to the pulp space. The highest amount of eluted HEMA concentration detected was not viewed as critical for pulp tissue since the diffused HEMA amounts were below the level of cytotoxicity, according to the literature.

Anisotropic hydrogels fabricated with directional freezing and radiation-induced polymerization and crosslinking method

Biological gels are generally anisotropic in both structures and mechanical properties, but conventional synthetic hydrogels are generally isotropic. We developed a directional freezing and radiation-induced polymerization and crosslinking (DFRPC) method to fabricate anisotropic hydrogels starting from monomers. The obtained poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels show significant anisotropy in both microstructures and mechanical properties. The hydrogels exhibit an aligned porous structure along the freezing direction and an irregular porous structure in the vertical direction. Their elastic modulus and tensile stress in the parallel direction are significantly higher than those in the vertical direction, and the difference between the two directions decreases as the increase of HEMA concentration. This novel methodology offers a promising way to fabricate a wide variety of anisotropic hydrogels, and the anisotropic hydrogels may find practical applications in biomedical fields.

Effect of gamma radiation on the mechanical and barrier properties of HEMA grafted chitosan-based films

Chitosan films were prepared by dissolving 1% (w/v) chitosan powder in 2% (w/v) aqueous acetic acid solution. Chitosan films were prepared by solution casting. The values of puncture strength (PS), viscoelasticity coefficient and water vapor permeability (WVP) of the films were found to be 565N/mm, 35%, and 3.30gmm/m2 daykPa, respectively. Chitosan solution was exposed to gamma irradiation (0.1–5kGy) and it was revealed that PS values were reduced significantly (p≤0.05) after 1kGy dose and it was not possible to form films after 5kGy. Monomer, 2-hydroxyethyl methacrylate (HEMA) solution (0.1–1%, w/v) was incorporated into the chitosan solution and the formulation was exposed to gamma irradiation (0.3kGy). A 0.1% (w/v) HEMA concentration at 0.3kGy dose was found optimal-based on PS values for chitosan grafting. Then radiation dose (0.1–5kGy) was optimized for HEMA grafting. The highest PS values (672N/mm) were found at 0.7kGy. The WVP of the grafted films improved significantly (p≤0.05) with the rise of radiation dose.

Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology

To improve application of hydrophobic polymethyl methacrylate intraocular lens (PMMA IOL) in a convenient and continuous way, 2-hydroxyethyl methacrylate (HEMA) was immobilized by dielectric barrier discharge plasma at relatively high pressure. The hydrophilicity and topography of the modified IOL surface were comprehensively evaluated by contact angle and atomic force microscopy, while the surface biocompatibility of the modified IOL was investigated by platelets adhesion and cells proliferation experiments. The results revealed that the hydrophilicity of the HEMA-g-PMMA IOL samples were significantly and permanently improved. Less platelets attachment was observed on the modified IOL, especially in the HEMA2-g-PMMA IOL group (with 1.65 × 10−1 mol/L HEMA concentration), which also suppressed the proliferation of cells.