To further elucidate the influence mechanism of side vents on the dynamic characteristics of gas explosions in tubes is helpful to design more reasonable vent layouts. In this paper, 9.5% methane-air explosion experiments were conducted in a tube with two side-vented ducts, and the effects of vent layouts and vent areas on the dynamic characteristics of explosion overpressure and flame propagation speed were investigated. The results demonstrate that under the same condition with a single vent area of 100 mm × 100 mm, when only the end vent is open, the maximum explosion overpressure and the maximum flame propagation speed are the highest among the five vent layouts. When the side vents 1 and 2 and the end vent are open, the maximum explosion overpressure is the lowest, and an unusual discovery is that the flame front changes into a hemispherical shape, finger shape, quasi-plane shape, tulip shape and wrinkled structure. When only side vent 1 is open, a unique Helmholtz oscillation occurs, and a new discovery is that there is a consistent oscillation relationship among the overpressure, flame propagation speed and flame structure. Helmholtz oscillation occurs only when a single vent area is 100 mm × 100 mm–60 mm × 60 mm, and the oscillation degree decreases with decreasing vent area. During the vent failure stage, the maximum explosion overpressure is generated, the flame front begins to appear irregular shape, and the flame propagation speed shows a prominent characteristic peak. After the vent failure stage, the driving effect of the end vent on the flame is higher than that of the side vent on the flame. Furthermore, the correlation equations of the mathematical relationships among the maximum explosion overpressure Pred, the static activation pressure Pstat and the vent coefficient Kv under four vent layouts are established, respectively.