ABSTRACT This research presents an alternative approach using numerical modelling for the prediction of simplified ultrasound distribution in a 3D water flow domain. The simulation was conducted using the Ansys-Fluent CFD commercial program. The results from this approach were compared with those from other researchers, covering an ultrasonic power range of 9.6–400 W and a frequency range of 24 kHz–1.7 MHz based on the parameters of mean axial and average velocity, Nusselt number, and the heat transfer coefficient. The maximum and minimum errors for the range of studies were 25.91% and 1.65%, respectively. Hence, this numerical setup can be utilized to achieve accurate prediction of the fluid flow and heat transfer over a controlled space which provides more realistic results for a whole domain with rapid calculation, especially in the far field region. Furthermore, this approach was applied to predict the augmentation of heat transfer in a vertically helical-coiled tube exchanger using 24 kHz ultrasonic waves. With very low numerical error, the results showed that the maximum thermal performance factor was 19% and 33% when the waves were emitted from one and two ultrasonic transducers at positions UT12 and UT12,9, respectively.