Helical Angle Research Articles

Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs

ABSTRACTRetinoic acid-inducible gene I (RIG-I) is responsible for innate immunity via the recognition of short double-stranded RNAs in the cytosol. With the clue that G-U wobble base pairs in the influenza A virus’s RNA promoter region are responsible for RIG-I activation, we determined the complex structure of RIG-I ΔCARD and a short hairpin RNA with G-U wobble base pairs by X-ray crystallography. Interestingly, the overall helical backbone trace was not affected by the presence of the wobble base pairs; however, the base pair inclination and helical axis angle changed upon RIG-I binding. NMR spectroscopy revealed that RIG-I binding renders the flexible base pair of the influenza A virus’s RNA promoter region between the two G-U wobble base pairs even more flexible. Binding to RNA with wobble base pairs resulted in a more flexible RIG-I complex. This flexible complex formation correlates with the entropy-favoured binding of RIG-I and RNA, which results in tighter binding affinity and RIG-I activation. This study suggests that the structure and dynamics of RIG-I are tailored to the binding of specific RNA sequences with different flexibility.

Anatomically correct assessment of the orientation of the cardiomyocytes using diffusion tensor imaging.

Diffusion tensor imaging has been used for assessing the orientation of cardiac myocytes for decades. Striking methodological differences exist between studies when quantifying these orientations. This limits the comparability between studies, and impedes collaboration and the drawing of appropriate physiological conclusions. We have sought to elucidate these differences, permitting us to propose a standardised "tool set" that might better establish consensus in future studies. We fixed hearts from seven 25kg pigs in formalin, and scanned them using diffusion tensor imaging. Using various angle definitions as found in literature, we assessed the orientations of cardiomyocytes, comparing them in terms of helical and intrusion angles, along with the orientation of their aggregations. The difference between assessment of the helical angle with and without relation to the epicardial curvature was 25.2° (SD: 7.9) at the base, 5.8° (1.9) at the equatorial level, and 28.0° (7.0) at the apex, ANOVA P=0.001. In comparable fashion, the intrusion angle differed by 25.9° (12.9), 7.6° (0.98) and 17.5° (4.7), P=0.01, and the angle of the aggregates (E3-angle) differed by 25.0° (13.5) at the base, 9.4° (1.7) at the equator, and 23.1° (6.2) apically, P=0.003. When assessing 14 definitions used in literature to calculate the orientation of aggregates, only 4 rendered identical results. The findings show that any attempt to use projection of eigenvectors introduces considerable bias. The epicardial curvature of the ventricular cone needs to be taken into account when seeking to provide accurate quantification of the orientation of the aggregated cardiomyocytes, especially in the apical and basal regions. This means that projection of eigenvectors should be avoided prior to quantifying myocyte orientation, especially when assessing radial orientation. Based on our results, we suggest appropriate methods for valid assessment of myocyte orientation using diffusion tensor imaging.

Analyze The Effects of Helical Baffles Angles Variation On Shell Side Heat Transfer Coefficient And Pressure Drop of Shell And Tube Heat Exchange

E-201-11 is one of the components of heat exchanger which serves to increase the temperature of distillated crude oil before it going into the furnace. The use of segmental baffles on the heat exchanger causes dead zone. The fouling phenomenon that arises from the deposition of the compound content in the service fluid in dead zone can result in leakage of the shell and tube. It affects the performance of heat exchanger and production efficiency. The use of discontinuous helical baffle on the shell side minimizes fouling. Research on the variation of helical baffle angle by using Bell-Delaware method resulted in performance value of heat transfer coefficient and pressure drop on the shell side. Fluid flow behavior on the shell side with helical baffle was analyzed by Computational Fluid Dynamics (CFD). The fluid flow velocity is a factor that affects the value of heat transfer coefficient and pressure drop. Heat exchanger with an angle of 10º have fluid flow velocity of 0,893m/s resulting in the highest heat transfer coefficient and pressure drop value compared to angles of 15º and 20º with values of 585.725W/m²K and 13642.395Pa. The heat exchanger with helical baffle at 10° helix angle presents the best performance among the others variant helical baffles

Abstract AP19: COLLAGEN ALTERATIONS IN HUMAN OVARIAN CANCER PROBED BY SECOND HARMONIC GENERATION (SHG) IMAGING MICROSCOPY

Abstract PURPOSE: Significant remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer and has been observed in both high grade and low grade tumors as well as ovaries from high risk patients with BRCA mutations. Uniquely quantifying alterations in the tumor microenvironment (TME) could be used as a new diagnostic tool, e.g. to complement histology; provide insight into disease etiology; and assess treatment efficacy through minimally invasive in vivo imaging. Current clinical modalities (CT, MRI, PET) lack the resolution for this purpose. Our efforts have focused on examining collagen alterations across a spectrum of human ovarian tumors, where the changes can serve as quantitative biomarkers. Alterations can be reflected in increased collagen concentration, changes in alignment of collagen molecules within fibrils and/or fibers and/or up-regulation of different collagen isoforms, e.g. Col III. METHODS AND RESULTS: We used the collagen specific/sensitive Second Harmonic Generation (SHG) imaging microscopy to probe collagen architecture over size scales that range from the macromolecular structural properties to fibril/fiber morphology. First, we used SHG polarization analyses to probe collagen macromolecular/supramolecular properties to discriminate ex vivo human tissues (normal stroma, benign tumors, and high grade serous tumors) by determination of: i) collagen alpha helical pitch angle, ii) alignment of collagen molecules within fibrils, and iii) collagen helical chirality via SHG circular dichroism (SHG-CD). The largest differences were between normal stroma and benign tumors, consistent with gene expression data showing Col III is up-regulated in the latter. The different tissues also displayed differing collagen alignment within fibrils and SHG-CD responses, consistent with either Col III incorporation or randomization of Col I alignment within benign and high-grade tumors fibrils. These results collectively indicate the fibril assemblies are distinct in all tissues and likely result from synthesis of new collagen rather than remodeling of existing collagen. Importantly, these techniques do not require exogenous labels, and additionally, provide sub-resolution structural information previously obtained through ultrastructural analysis that cannot be performed on intact tissues. We next implemented a novel form of 3D texture analysis and machine learning to delineate the fibrillar morphology observed in SHG images of normal stroma, high risk stroma, benign tumors, and a spectrum of malignant tumors (high grade serous, low grade serous, and endometrioid). We extracted textural features in the 3D image sets to build statistical models of each class and we achieved clinically significant 83-91% classification accuracies for the six classes. Importantly, the 3D analysis significantly outperformed our prior 2D methods. This classification based on collagen morphology will complement conventional classification based on genetic profiles and can serve as an additional biomarker. CONCLUSIONS: Taken together, the combination of the macro/supramolecular probes and the fiber morphology classification will greatly increase our understanding of the TME evolution in human ovarian cancer. These methods and their findings have clinical translational significance in terms of understanding disease etiology, and also by enhancing prognostic and diagnostic capabilities. Citation Format: Kirby R. Campbell, Rajeev Chaudhary, Julia Handel, Bruce Wen, Vikas Singh, Manish Patankar and Paul J. Campagnola. COLLAGEN ALTERATIONS IN HUMAN OVARIAN CANCER PROBED BY SECOND HARMONIC GENERATION (SHG) IMAGING MICROSCOPY [abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium; Sep 13-15, 2018; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2019;25(22 Suppl):Abstract nr AP19.

Tooth Surface Modelling and Mesh Behaviors for Paralleled Beveloid Gears

Abstract This paper proposed a new tooth surface modeling method for beveloid gear based on the real cutter surface using two orthogonal variables. Then, the analytical mesh model with and without misalignments were derived and solved to study the influences of geometry design parameters on contact behaviors for paralleled beveloid gear pair. Loaded tooth contact analysis is used to validate the proposed mesh model by abaqus software, and the error is below 5%. Results suggest that the increase in pressure, cone, and helical angles enlarge the contact area for meshing without misalignments. The addendum coefficient has unsubstantial impacts on the contact behaviors. For meshing with axis error in the horizontal direction, the growth of pressure angle, cone angle, helical angle, and addendum coefficient improves the carrying capacity of single tooth. But the transmission error deteriorates with the increase in pressure, cone, and helical angles. All three types of misalignments have little influence on the size of the contact ellipse. The growth of axis errors in horizontal and vertical directions significantly increases the transmission error, but the center distance error has a little influence on the transmission precision.

A numerical study on subcooled flow boiling heat transfer in tubes with various helical angles at underwater vehicles conditions

As a direct source of power, the water vapor with high temperature and high pressure affects the thermal efficiency of an underwater vehicle power system. In this study, the subcooled flow boiling heat transfer performances in straight and helical tubes are studied at underwater vehicles conditions. A numerical model for the subcooled flow boiling in the tubes is established and verified by the existing experiment data. The local heat transfer capability, and content and distribution of the vapor are analyzed under various thermal conditions and helical angles. The results show that inlet mass flux, heat flux and inlet subcooling have obvious effects on the local heat transfer capacity, vapor content as well as wall temperature. It is found that the maximum local heat transfer coefficient in a helical tube increases by 20.75% compared with that in the straight one. The analyses of vapor volume fraction and secondary flow show that the vapor mainly distributes in the inside and top of tubes, and the secondary flow intensity increases along the axial direction, but it is little influenced by helical angles.

Orthogonal experimental research on the structural parameters of a novel drill bit used for ice core drilling with air reverse circulation

AbstractA new type of ice core drill bit, designed with a vane swirler, was developed for ice core drilling with air reverse circulation. An orthogonal experimental design method was employed to investigate the effects of the swirler structure parameters on the reverse circulation performance of the drill bit including helical angle, number of blades, blade length and blade central angle, etc. The entrainment ratio was used to evaluate the reverse circulation effectiveness of the drill bit. The results show that the helical angle is the dominant factor regardless of whether or not the flushing nozzles are part of the design of the drill bit. The number of blades is the least important factor for the drill bit designed with the flushing nozzles (referred to as drill bit I), while the outlet area of the swirling slot is the least influential factor for the drill bit without flushing nozzles (referred to as drill bit П). In addition, the appearance of the ice core has a certain effect on the air reverse circulation for both drill bits. Within the ranges of this study, the optimal structure of the drill bit was determined based on the range analysis of the orthogonal design.

Micro milling characteristics of LS-WEDM fabricated helical and corrugated micro end mill

Micro milling offers a high potential for fabricating three-dimensional micro structure, such as micro grooves, micro channels and micro dimples. However, the fabrication of solid micro end mills with hard materials and complex structures poses many challenges. In this study, a new method based on low speed wire electrical discharge machining (LS-WEDM) is presented to prepare solid helical micro end mills. The machining process of helical micro end mill is kinematically modeled and simulated, which can realize visual predictability and provide theoretical basis for parameters selection. Experimental results indicated that corrugated micro end mill with about 269.8 μm in diameter and 1850.2 μm in length, and three helical blades micro end mill with 123.8 μm in diameter and 800 μm in length, six spirals and varied helical angle micro end mills can be flexibly prepared. Furthermore, the use of these micro end mills in hard material of DD5 single crystal nickel-based superalloy substrates is described to demonstrate their potential. Thus, the technique proposed in this study is significantly contribute to the fabrication of complex solid micro end mills with helical blades.

Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24.

MHC class II receptors carry important function in adaptive immunity and their malfunctioning is associated with diabetes type I, chronic inflammatory diseases and other autoimmune diseases. The protein assembles from the DQ alpha-1 and DQ beta-1 subunits where the transmembrane domains of these type I membrane proteins have been shown to be involved in homo- and heterodimer formation. Furthermore, the DQ alpha 1 chain carries a sequence motif that has been first identified in the context of p24, a protein involved in the formation of COPI vesicles of the intracellular transport machinery, to specifically interact with sphingomyelin-C18 (SM-C18). Here we investigated the membrane interactions and dynamics of DQ beta-1 in liquid crystalline POPC phospholipid bilayers by oriented 15N solid-state NMR spectroscopy. The 15N resonances are indicative of a helical tilt angle of the membrane anchor sequence around 20°. Two populations can be distinguished by their differential dynamics probably corresponding the DQ beta-1 mono- and homodimer. Whereas, this equilibrium is hardly affected by the addition of 5 mole% SM-C18 a single population is visible in DMPC lipid bilayers suggesting that the lipid saturation is an important parameter. Furthermore, the DQ alpha-1, DQ beta-1 and p24 transmembrane helical domains were reconstituted into POPC or POPC/SM-C18 lipid bilayers where the fatty acyl chain of either the phosphatidylcholine or of the sphingolipid have been deuterated. Interestingly in the presence of both sphingolipid and polypeptide a strong decrease in the innermost membrane order of the POPC palmitoyl chain is observed, an effect that is strongest for DQ beta-1. In contrast, for the first time the polypeptide interactions were monitored by deuteration of the stearoyl chain of SM-C18. The resulting 2H solid-state NMR spectra show an increase in order for p24 and DQ alpha-1 which both carry the SM recognition motif. Thereby the data are suggestive that SM-C18 together with the transmembrane domains form structures imposing positive curvature strain on the surrounding POPC lipids. This effect is attenuated when SM-C18 is recognized by the protein.

Effects of Helical Tube Electrode Structure on Mixed Machining Product Transfer in Micro-Machining Channel during Tube Electrode High-Speed Electrochemical Discharge Machining.

In tube electrode high-speed electrochemical discharge machining (TSECDM), mixed products are constantly produced in the narrow machining gap by simultaneous discharge erosion and electrochemical dissolution. For the high-efficiency removal of these products from the machining gap, a tool electrode with an optimized helical structure was utilized in TSECDM in this study. Firstly, the concentration distributions of the processed products in the machining gap using tube electrode tools with three typical helical structures were studied through the simulation of solid–liquid coupling; this showed that a trapezoidal helical structure benefited the reduced accumulation of products in grooves and the effective removal of products from the machining gap. Secondly, the main geometric parameters of the trapezoidal helical structure, including the helical groove depth, pitch, and tooth angle, were optimized by gap flow-field simulation to enhance the removal effect on processed products. Finally, it was verified that the trapezoidal helical electrode showed a definitive and significant advantage over the ordinary cylindrical electrode in effectively removing processed products from the machining gap by the comparison of flow-field simulations and actual machining experiments.

Effects of the helix angle, the friction coefficient and mechanical errors on unsteady-state temperature field of helical gear and thermal sensitivity analysis

With the rapid development of modern industrial technology, helical gears have been extensively applied in various fields. To study the influence of the helical angle, the friction coefficient and mechanical errors on the unsteady-state temperature field of helical gears, we employ the finite element method to simulate helical gears with different helical angles. The influence of helical angles on the unsteady-state temperature field of helical gears is analyzed. Through setting different friction coefficients for helical gears with various helical angles, we can see the influence of different friction coefficients on the unsteady-state temperature field of the tooth root surface, the tooth profile surface and the tooth top surface. Besides, the relationship between the friction coefficient and the helical angle on temperature growth is analyzed in detail. The helix angle exerting the greatest influence on the unsteady-state temperature field under different friction coefficients is found, and the friction coefficient having the greatest influence on the unsteady-state temperature field under a certain helix angle is also analyzed. The finite element results with mechanical errors are compared with the finite element results with no fault. Additionally, the influence of mechanical errors on the unsteady-state temperature field of helical gears is revealed.

A Theoretical Study on the Effect of Structural Parameter on Tensile Properties of Helical Auxetic Yarns

When auxetic yarns with helical wrapping structure are axially stretched, pressure and friction between the yarn components exist during the deformation. The tensile property of auxetic yarns not only depends on the materials of the two components, but also the structure of the yarns. Thus, the structuring effects on the tensile properties were studied by theoretical modelling with the series arrangement of a linear spring and a Newton dashpot. Besides, analysing the experimental results by the OriginPro 9 software, the effectiveness of theoretical model was validated and all the values of correlation coefficients were higher than 0.97. The relations between stress and strain were presented and it was expected to be used for predicting the tensile property of auxetic yarns with different helical angles.

Vibration analysis of milling process with helix-angle cutter based on Euler method

The chatter vibration is the major limiting factor in increasing the metal removal rates of the machine tools. In this paper, a program for dynamic analysis of thin-walled milling process with helical milling cutter is developed, based on Euler iteration. The program can take into account the characteristics of thin-walled workpiece, the contact separation between workpiece and cutter, the helical angle of cutter teeth and other actual cutting process characteristics. Based on the stability lobe diagram obtained by semi-discrete method, the stability simulation in different cutting parameters around the stable island was carried out. The unstable form of the cutting process was determined by spectrum analysis and Poincare mapping method. The results show that the method is in good agreement with the results of stability Lobe diagram and can capture the stability island in small radial cutting process. This method can well grasp the cutting force and vibration evolution process in cutting process, and provide an effective means for stability analysis of cutting process.

Myoarchitectural disarray of hypertrophic cardiomyopathy begins pre-birth.

Myoarchitectural disarray – the multiscalar disorganisation of myocytes, is a recognised histopathological hallmark of adult human hypertrophic cardiomyopathy (HCM). It occurs before the establishment of left ventricular hypertrophy (LVH) but its early origins and evolution around the time of birth are unknown. Our aim is to investigate whether myoarchitectural abnormalities in HCM are present in the fetal heart. We used wild‐type, heterozygous and homozygous hearts (n = 56) from a Mybpc3‐targeted knock‐out HCM mouse model and imaged the 3D micro‐structure by high‐resolution episcopic microscopy. We developed a novel structure tensor approach to extract, display and quantify myocyte orientation and its local angular uniformity by helical angle, angle of intrusion and myoarchitectural disarray index, respectively, immediately before and after birth. In wild‐type, we demonstrate uniformity of orientation of cardiomyocytes with smooth transitions of helical angle transmurally both before and after birth but with traces of disarray at the septal insertion points of the right ventricle. In comparison, heterozygous mice free of LVH, and homozygous mice showed not only loss of the normal linear helical angulation transmural profiles observed in wild‐type but also fewer circumferentially arranged myocytes at birth. Heterozygous and homozygous showed more disarray with a wider distribution than in wild‐type before birth. In heterozygous mice, disarray was seen in the anterior, septal and inferior walls irrespective of stage, whereas in homozygous mice it extended to the whole LV circumference including the lateral wall. In conclusion, myoarchitectural disarray is detectable in the fetal heart of an HCM mouse model before the development of LVH.

Effect of Helical Winding Angle on External Pressure based Buckling of Partially Filled Thin Composite Cylindrical Shells

Effect of helical winding angle on buckling load of thin composite tubes is investigated in this work. Experiments are conducted on both empty and partially filled S2 glass tubes to estimate contribution of strength to the tubes by the filler material. Chosen filler material mechanically simulates behavior of typical solid propellant used in aerospace application. FE analysis with non-linear effect correlates well with the experimental data. Three series of experiments are conducted to quantify effect of helical winding angle and increase in volumetric loading fraction(VLF). Results confirm appreciable improvement in strength of filled tubes for higher VLF. For the chosen pattern of winding, lower winding angle provides more strength to the tubes against external pressure buckling. 

Feasibility of a new helical blade structure for a PV integrated wind turbine in a heat-driven swirling wind field

A controllable heat-driven swirling wind turbine system was integrated with a photovoltaics (PV) system for energy generation in a heat-collecting shed. This is a brand-new type of a wind energy generation system; and a helical three-blade structure in a vertical axis was introduced. The stationary pre-rotation vanes have a variable diameter and a helical twist angle of 225°. A numerical simulation was conducted to investigate the feasibility of a wind turbine blade structure for efficient energy output for industrial application. The computational fluid dynamics (CFD) tool OpenFOAM was used to simulate the operating conditions of the wind turbine. The findings illustrated the efficacy of the new system. The new helical blade structure is efficient for wind energy output of the turbine in a swirling wind field. The simulation under different heat source temperatures illustrated that an increase in heat source temperature could increase the output efficiency of the wind turbine energy system. The increment in output efficiency could be up to 19.07% when the temperature rises from 40 K to 80 K. The PV-swirling wind integrated system was shown to be more economical than a single solar photovoltaic system because its investment payoff period could be shortened by 2 years.

Thrust and Hydrodynamic Efficiency of the Bundled Flagella.

The motility mechanism of prokaryotic organisms has inspired many untethered microswimmers that could potentially perform minimally invasive medical procedures in stagnant fluid regions inside the human body. Some of these microswimmers are inspired by bacteria with single or multiple helical flagella to propel efficiently and fast. For multiple flagella configurations, the direct measurement of thrust and hydrodynamic propulsion efficiency has been challenging due to the ambiguous mechanical coupling between the flow field and mechanical power input. To address this challenge and to compare alternative micropropulsion designs, a methodology based on volumetric velocity field acquisition is developed to acquire the key propulsive performance parameters from scaled-up swimmer prototypes. A digital particle image velocimetry (PIV) analysis protocol was implemented and experiments were conducted with the aid of computational fluid dynamics (CFD). First, this methodology was validated using a rotating single-flagellum similitude model. In addition to the standard PIV error assessment, validation studies included 2D vs. 3D PIV, axial vs. lateral PIV and simultaneously acquired direct thrust force measurement comparisons. Compatible with typical micropropulsion flow regimes, experiments were conducted both for very low and higher Reynolds (Re) number regimes (up to a Re number = 0.01) than that are reported in the literature. Finally, multiple flagella bundling configurations at 0°, 90° and 180° helical phase-shift angles were studied using scaled-up multiple concentric flagella thrust elements. Thrust generation was found to be maximal for the in-phase (0°) bundling configuration but with ~50% lower hydrodynamic efficiency than the single flagellum. The proposed measurement protocol and static thrust test-bench can be used for bio-inspired microscale propulsion methods, where direct thrust and efficiency measurement are required.

Molecular dynamics study on axial elastic modulus of carbon nanoropes

Carbon nanoropes (CNRs) are of interest for a wide variety of nanotechnological applications. Since little attention has been paid to mechanical properties of CNRs, their axial elastic modulus is explored herein. Molecular dynamics (MDs) simulations are adopted for analysis of Young's modulus of CNRs. It is also shown that increase in the initial helical angle decreases Young's modulus; however, by increase in the number of CNTs and strands, different influence on Young's modulus emerges. Therefore, the highest value of Young's modulus obtained at the lower value of initial helical angle and consequently, Young's modulus of bundle of straight CNTs is higher than CNRs with hierarchical helical structure. It is further observed that Young's modulus experiences a non-monotonic variation with respect to the number of CNTs (n) and strands (N) such that the increasing procedure of Young's modulus with respect to the number of CNTs and strands switches to decrease ones at n=4 and N=3. Therefore, the results obtained in the present study assist to control the elastic property of CNR by suitable design of number of CNTs, strands and initial helical angle of CNT and strand and can lead to inspire optimal design of advanced nanostructures.

A High-Precision Automatic Wire Wrapping Approach Based on Microscopic Vision and Force Information

This paper proposes a wire wrapping approach, which enables high-precision, fully automatic, quality controllable, and visually monitored wire wrapping by actively rotating the rod and coordinately translating the wire based on microscopic vision and force information. Viewing the wire as a one-dimensional object, the proposed paper contributes to both the precision manipulation field and the engineering utilities to fabricate precision helical structures used in many fields. The basic technical contents involved are the active rotation of the rod and the coordinated translation of the manipulator, both of which are designed to keep the relative spatial relationship and the interactive force between the rod and the wire. Extensive experiments were conducted to validate the effectiveness of the proposed method to achieve high-precision wire wrapping. Experimental results show that with discretized active rotation increment about the rod axis of 6°, the local tensile deformation of the wire can be controlled within ±2 μ m error range, while the average local helical angle can be controlled within ±0.3° error range with standard deviation less than 1.5°.

Investigation on horizontal and deviated wellbore cleanout by hole cleaning device using CFD approach

AbstractThe application of the hole cleaning device in downhole is a new technology for removing cuttings bed, and it can increase the efficiency of cuttings transport. This paper mainly studies the effects of the helical angle and the rotational speed of the blade of the hole cleaning device on the swirl strength of decaying swirl flow and drilled cuttings deposition behavior. A three‐dimensional computational fluid dynamics (CFD) model is established using the Eulerian‐Eulerian two‐fluid model, Realizable k‐ε turbulence model, and Sliding Mesh technique for simulating the two‐phase fluid flow. The results have been compared with available data in the literature, and a good agreement is found. In order to understand the decay behavior of the swirl flow along the flow direction, the initial swirl strength, the swirl number, and the decay rate of swirl are analyzed in detail in single phase. The effects of the swirl flow induced by the blade on the deposition behavior of drilled cuttings under different rotational speed and helical angle are studied. A new deposition index is used to evaluate the effective distance and hole cleaning efficiency of the swirl flow under various parameters. It has been observed that using the hole cleaning device can improve the hole cleaning performance. The research results of this paper is instructive to the design of the hole cleaning device using in the drilling engineering.