Heilongjiang University Research Articles

Therapeutic effect of cervical Jiaji electroacupuncture on postoperative intractable hiccup of liver neoplasms

Objective: To evaluate the therapeutic effect of cervical Jiaji electroacupuncture on postoperative intractable hiccup of liver neoplasms. Methods: A total of 39 patients with postoperative intractable hiccup of liver neoplasms in The First Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2013 to May 2017 were collected and divided into 2 groups randomly. The electroacupuncture group included 20 cases, the control group included 19 cases. Patients in the electroacupuncture group were treated by cervical Jiaji electroacupuncture (located in C3-5, sympathetic ganglion), while the control group were treated by metoclopramide combined with chlorpromazine for three days. The therapeutic effects of two groups were compared and the onset time were recorded. Results: Total effective rates of electroacupuncture group and control group were 95.0% and 47.4%, respectively. The onset time in electroacupuncture group and control group were (14.8±3.3) h and (30.5±3.1) h, respectively (P<0.01). Ten cases who resisted the control treatment were then treated by electroacupuncture for 3 days, 6 cases were recovered, 3 cases became better, while 1 case demonstrated no response. No serious adverse reactions were appeared in each group. Conclusion: Cervical Jiaji electroacupuncture is an effective and safe treatment for postoperative intractable hiccup of liver neoplasms, and it can be used as a remedy for intractable hiccup patients who don't respond to drug treatment.

Clinical observation on the effect of elemene injection maintenance treatment on the recurrence time of malignant pleural effusion

Objective To observe the effect of elemene injection for the maintenance treatment of malignant pleural effusion. Methods A total of 90 patients with malignant pleural effusion from May 2014 to Apirl 2016 in First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were collec-ted. They were divided into observation group (n=45) and control group (n=45) according to the random number table method. The patients of the two groups were treated with pleural effusion drainage through thoracocentesis, and Mannatide (Lifein) and carboplatin were poured. The observation group sequentially received maintenance treatment of elemene injection. The therapeutic effects of the two groups were compared. Results At the 12th month after treatment, the difference of relapse rate between the two groups was statistically significant(82.2% vs. 100.0%, χ2=8.780, P=0.003). The median progression-free survival (95%CI) of the observation group and the control group were 10.00 (9.15-10.85) months and 6.00(4.74-7.26) months respectively, with a significant difference (χ2=40.475, P<0.001). The improvement rates of life quality of the observation group were 82.22%, 57.78%, 54.55% respectively at one, six, twelve months after perfusion treatment, and the improvement rates of the control group were 84.44%, 23.26%, 0 respectively. The data differences between the two groups were statistically significant at six, twelve months (χ2=10.840, P=0.001; χ2=32.390, P<0.001). The one year survival rates of the observation group and the control group were 97.78% and 95.56%, and the difference was statistically significant (P=1.000). Conclusion The effect of elemene injection for the maintenance treatment of malignant pleural effusion is obvious, which can prolong the progression-free survival time and can significantly improve the quality of life. Key words: Pleural effusion, malignant; Drug therapy; Elemene

Borromean Windows for Three-Particle Systems under Screened Coulomb Interactions**Supported by the National Natural Science Foundation of China under Grant No. 11304086, the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province of China under Grant No. UNPYSCT-2015019, and the Natural Science Foundation for Distinguished Young Scholars in Heilongjiang University under Grant No. JCL201503

We have carried out calculations to search Borromean windows (BWs) for 11 different three-body systems interacting with screened Coulomb (Yukawa-type) potentials using Hylleraas-type wave functions within the framework of a variational approach. The critical values of the screening parameters for the ground states of the systems under consideration are reported for which the three-body systems are stable, while all the possible fragments are unbound; that is, it shows windows for Borromean binding.

Modernization of Acupuncture Education in Europe and China: A Report from Austria

The present report deals with some current important aspects of traditional Chinese medicine (TCM) education and practice in Europe and China. The data and facts are based on a lecture of one of the authors (G.L.) prepared for a conference in Wuhan about acupuncture education in Europe, and lectures of two high-ranking representatives of renowned Chinese institutions (State Administration of TCM and Heilongjiang University of Chinese Medicine, Harbin). In addition to current figures regarding TCM in general, the advantages of TCM are reported, and special cooperations of the important university in the North of China are introduced.

Immobilization of Polyoxometalate in the Metal-Organic Framework rht-MOF-1: Towards a Highly Effective Heterogeneous Catalyst and Dye Scavenger.

A series of three remarkable complexes [PMo12O40]@[Cu6O(TZI)3(H2O)9]4·OH·31H2O (H3TZI = 5-tetrazolylisophthalic acid; denoted as HLJU-1, HLJU = Heilongjiang University), [SiMo12O40]@[Cu6O(TZI)3(H2O)9]4·32H2O (denoted as HLJU-2), and [PW12O40]@[Cu6O(TZI)3(H2O)6]4·OH·31H2O (denoted as HLJU-3) have been isolated by using simple one-step solvothermal reaction of copper chloride, 5-tetrazolylisophthalic acid (H3TZI), and various Keggin-type polyoxometalates (POMs), respectively. Crystal analysis of HLJU 1−3 reveals that Keggin-type polyoxoanions have been fitted snuggly in the cages of rht-MOF-1 (MOF: metal−organic framework) with large cell volume in a range of 87968−88800 Å3 and large pore volume of about 68%. HLJU 1–3 exhibit unique catalytic selectivity and reactivity in the oxidation of alkylbenzene with environmental benign oxidant under mild condition in aqueous phase as well as the uptake capacity towards organic pollutants in aqueous solution.

五大连池药泉山大型土壤动物对旅游踩踏的响应

PDF HTML阅读 XML下载 导出引用 引用提醒 五大连池药泉山大型土壤动物对旅游踩踏的响应 DOI: 10.5846/stxb201603230518 作者: 作者单位: 哈尔滨师范大学;黑龙江大学,哈尔滨师范大学,黑龙江大学,北京林业大学 作者简介: 通讯作者: 中图分类号: 基金项目: 国家自然科学基金项目（41101048） Responses of soil macrofaunal communities to tourism trample in the Wudalianchi Yaoquan Mountains Author: Affiliation: Harbin Normal University;Heilongjiang University,Harbin Normal University,Heilongjiang University,Beijing Forestry University Fund Project: 摘要 | 图/表 | 访问统计 | 参考文献 | 相似文献 | 引证文献 | 资源附件 | 文章评论 摘要:以黑龙江省五大连池世界地质公园的药泉山为研究对象，按照距离游道的远近分为重度踩踏区，轻度踩踏区和非踩踏区3种踩踏干扰强度，分析大型土壤动物数量，群落组成，多样性对旅游踩踏干扰的响应。研究结果表明不同干扰区之间大型土壤动物类群数量差异显著（P<0.001），重度踩踏区显著低于轻度踩踏区和非踩踏区。不同干扰区大型土壤动物个体数差异明显（P<0.001），其中轻度踩踏区个体密度最大（68头/m2），重度踩踏区个体密度最小（10头/m2）。不同踩踏强度干扰区H’指数差异明显（P<0.05），轻度踩踏区及非踩踏区的多样性显著高于严重踩踏区。典型对应分析表明旅游踩踏主要通过改变土壤理化特性而影响大型土壤动物的组成及其多样性，重度踩踏区、轻度踩踏区和非踩踏区对大型土壤动物影响最显著的因子分别为土壤全氮含量，土壤含水率和土壤全磷含量。 Abstract:Trampling is widespread among various recreational activities, and this can become a significant problem as it represents a major disturbance affecting the vegetation and soil surface horizon. Soil macrofauna, mainly in the soil surface horizon, are good indicators for studying the impact of human activities. In the present study, Yaoquan Mountain of Wudalianchi World Geo-park was considered as a study example in 2012. The areas surrounding tourism trails were divided into no-trampling, mid-trampling, and high-trampling plots, which were divided based on three different interference types. The effect of human trampling on soil macrofaunal communities at a depth of 0-10 cm were studied along an increasing distance from the tourism trail of Yaoquan Mountain. A completely randomized design, including three replicates from three trampling interference sites, was used. Soil macrofauna were separated by hand, and were identified and counted. Soil bulk density, soil moisture content, soil organic matter content, total nitrogen content, and total phosphorus content were measured from each site. Our study evaluated the structure, composition, diversity, and distribution of soil macrofauna in three different tourism trample types, and assessed the impacts of human activity. The results were summarized as the following aspects:The total number of soil animal genera was significantly different in the three disturbance degree sites (P<0.001) and the least number of genera occurred in high trampling sites. The individual density of soil macrofauna was significantly different from the other kinds of soil animal fauna in the three disturbance degree sites (P<0.001), the maximum value was in the mid-trampling plots (68 ind./m2), and the minimum value was in the high-trampling sites (10 ind./m2). The Shannon index (H') of soil micro-fauna were seriously affected by trampling (P<0.05), and the high trampling sites had the lowest H' index. A canonical correspondence analysis indicated the soil macrofaunal distribution in the mid-trampling and high-trampling plots differed from the no-trampling plots. The main factor affecting soil macrofauna distribution was soil total nitrogen content, soil moisture content, and total phosphorus content in no-trampling, mid-trampling, and high-trampling plots, respectively. 参考文献 相似文献 引证文献

Chinese Obstetrics & Gynecology journal club: a randomised controlled trial

ObjectivesTo assess whether a journal club model could improve comprehension and written and spoken medical English in a population of Chinese medical professionals.Setting and participantsThe study population consisted of 52...

Letrozole, berberine, or a combination for infertility in Chinese women with polycystic ovary syndrome: a multicentre, randomised, double-blind, placebo-controlled trial

BackgroundLetrozole is superior to clomiphene in infertile women with polycystic ovary syndrome and leads to higher ovulation and live birth rates. Berberine, a major active component of Chinese herbal medicine Rhizoma coptidis and found in Cortex Phellodendri and Cortex Berberidis in the rest of the world, has similar but even more profound metabolic effects than metformin. Our hypothesis was that a combination of letrozole and berberine would result in a higher live birth rate than letrozole or berberine alone in infertile women with polycystic ovary syndrome. MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial in 19 participating centres in mainland China, we compared the effect of three interventions for up to six menstrual cycles: letrozole plus berberine placebo (letrozole group), berberine plus letrozole placebo (berberine group), or the combination of letrozole and berberine (combination group). The randomisation (1:1:1) was done through a web-based computer program operated by an independent data center in the China Academy of Chinese Medical Sciences. Participants, investigators, doctors, laboratory technicians, and data analysers were masked to the assignments. Eligible women (age 20–40 years) had polycystic ovary syndrome, as defined by the Rotterdam criteria, had at least one open Fallopian tube and normal uterine cavity, and had at least 1 year of infertility. Berberine or berberine placebo were administrated orally at a daily dose of 1·5 g for 6 months. Patients received an initial dose of 2·5 mg of letrozole or placebo on days 3–7 of the first three treatment cycles. This dose was increased to 5 mg letrozole or placebo on days 3–7 of the last three treatment cycles if not pregnant. Couples were instructed to have regular intercourse two to three times a week until becoming pregnant. The primary outcome was live birth rate after intervention for up to six menstrual cycles. We used either a χ2 test or Fisher's exact test a two-sided significance level of 0·05 to test differences between groups. Data were analysed according to the intention-to-treat principle. This study was approved by an Ethics Committee (2009LL-001) at First Affiliated Hospital in Heilongjiang University of Chinese Medicine. This trial is registered at Chinese Clinical Trials Registration, identifier ChiCTR-TRC-09000376, and at ClinicalTrials.gov, number NCT01116167. All participants provided written informed consent. FindingsWe enrolled 644 participants. The live birth rates were comparable between the letrozole group (78 [36%] of 215 births) and the combination group (74 [34%] of 215 birth) after treatment (odds ratio [OR] 0·92, 95% CI 0·62–1·37; p=0·687), whereas live birth rates in the berberine group (44 [22%] of 214 births) were lower than in the letrozole group (OR 2·02, 95% CI 1·32–3·10; p=0·001) and the combination group (OR 1·86, 95% CI 1·21–2·86; p=0·004). Conception, pregnancy, and ovulation rates were similar in the letrozole (46%, 39%, and 59%, respectively) and combination groups (49%, 38%, and 61%, respectively), and these were higher than in the berberine group. There was one twin birth in the letrozole group and three twin births in the combination group, but none in the berberine group (29%, 22%, and 6%, respecitively). Berberine was associated with constipation and nausea whereas letrozole was associated with fatigue and hot flashes. InterpretationFor ovulation and live births, the combination of letrozole and berberine did not improve outcomes compared with letrozole alone, but letrozole and the combination of letrozole and berberine improved fertility in women with polycystic ovary syndrome compared with berberine alone. Some limitations include the early study termination because of the expiration of the study drug berberine or placebo, not all participants had pelvic sonograms to assess for polycystic ovaries, and some participants had regular cycles. The major strength of this study is that it was a large multicentre, double-blind trial with close monitoring of adverse events and serious adverse events and tracking of live birth in line with our recent Harbin consensus. FundingNational Public Welfare Projects for Chinese Medicine (200807021) of China, the National Key Discipline of Chinese Medicine in Gynecology during the year of 2009–14, the Heilongjiang Province Foundation for Outstanding Youths (JC200804), the Intervention for Polycystic Ovary Syndrome Based on Traditional Chinese Medicine Theory—‘TianGui Shi Xu’ (2011TD006), and the National Clinical Trial Base in Chinese Medicine during the year of 2009–14 in First Affiliated Hospital, Heilongjiang University of Chinese Medicine.

Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome.

Can we build and validate predictive models for ovulation and pregnancy outcomes in infertile women with polycystic ovary syndrome (PCOS)? We were able to develop and validate a predictive model for pregnancy outcomes in women with PCOS using simple clinical and biochemical criteria particularly duration of attempting conception, which was the most consistent predictor among all considered factors for pregnancy outcomes. Predictive models for ovulation and pregnancy outcomes in infertile women with polycystic ovary syndrome have been reported, but such models require validation. This is a secondary analysis of the data from the Pregnancy in Polycystic Ovary Syndrome I and II (PPCOS-I and -II) trials. Both trials were double-blind, randomized clinical trials that included 626 and 750 infertile women with PCOS, respectively. PPCOS-I participants were randomized to either clomiphene citrate (CC), metformin, or their combination, and PPCOS-II participants to either letrozole or CC for up to five treatment cycles. Linear logistic regression models were fitted using treatment, BMI, and other published variables as predictors of ovulation, conception, clinical pregnancy, and live birth as the outcome one at a time. We first evaluated previously reported significant predictors, and then constructed new prediction models. Receiver operating characteristic (ROC) curves were constructed and the area under the curves (AUCs) was calculated to compare performance using different models and data. Chi-square tests were used to examine the goodness-of-fit and prediction power of logistic regression model. Predictive factors were similar between PPCOS-I and II, but the two participant samples differed statistically significantly but the differences were clinically minor on key baseline characteristics and hormone levels. Women in PPCOS-II had an overall more severe PCOS phenotype than women in PPCOS-I. The clinically minor but statistically significant differences may be due to the large sample sizes. Younger age, lower baseline free androgen index and insulin, shorter duration of attempting conception, and higher baseline sex hormone-binding globulin significantly predicted at least one pregnancy outcome. The ROC curves (with AUCs of 0.66-0.76) and calibration plots and chi-square tests indicated stable predictive power of the identified variables (P-values ≥0.07 for all goodness-of-fit and validation tests). This is a secondary analysis. Although our primary objective was to confirm previously reported results and identify new predictors of ovulation and pregnancy outcomes among PPCOS-II participants, our approach is exploratory and warrants further replication. We have largely confirmed the predictors that were identified in the PPCOS-I trial. However, we have also revealed new predictors, particularly the role of smoking. While a history of ever smoking was not a significant predictor for live birth, a closer look at current, quit, and never smoking revealed that current smoking was a significant risk factor. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grants U10 HD27049, U10 HD38992, U10HD055925, U10 HD39005, U10 HD33172, U10 HD38998, U10 HD055936, U10 HD055942, and U10 HD055944; and U54-HD29834. Heilongjiang University of Chinese Medicine Grants 051277 and B201005. R.S.L. reports receiving consulting fees from Euroscreen, AstraZeneca, Clarus Therapeutics, and Takeda, and grant support from Ferring, Astra Zeneca, and Toba. K.R.H. reports receiving grant support from Roche Diagnostics and Ferring Pharmascience. G.C. reports receiving Honorarium and grant support from Abbvie Pharmaceuticals and Bayer Pharmaceuticals. M.P.D. holds equity from Advanced Reproductive Care Inc. and DS Biotech, receives fees from Advanced Reproductive Care Inc., Actamax, Auxogyn, ZSX Medical, Halt Medical, and Neomed, and receives grant support from Boehringer-Ingelheim, Abbott, and BioSante, Ferring Pharmaceuticals, and EMD Serono. H.Z. receives research support from the Chinese 1000-scholar plan. Others report no disclosures other than NIH grant support. PPCOS-I and -II were respectively registered at Clinicaltrials.gov: NCT00719186 and NCT00719186.

Acupuncture at Houxi (SI 3) acupoint for acute neck pain caused by stiff neck: study protocol for a pilot randomised controlled trial

IntroductionThe use of acupuncture has been suggested for the treatment of acute neck pain caused by stiff neck in China. However, current evidence is insufficient to draw any conclusions about...

Moxibustion for the treatment of pressure ulcers: study protocol for a pilot, multicentre, randomised controlled trial

IntroductionPressure ulcers are common in the elderly and immobile. Currently, there are few proven effective treatments for pressure ulcers. This trial aims to evaluate the feasibility, efficacy and safety of...

Electrophysiological remodeling of linopirdine on neuroexcitability of myelinated A-type baroreceptor neurons in rats

A-type baroreceptor neurons in rats Tao Ban , Jin-Ling Yu , Yu-Yao Zhang , Pan-Xiang Cao , Sheng-Zhi Liu , Xiao-Long Wang , Li-Na Ba , Tian-Ci Zhang , Xin-Jing Guo , Xue Yu , Guo-Fen Qiao ⁎, Bai-Yan Li a,⁎ a Department of Pharmacology, Harbin Medical University, Harbin, China b Key Laboratory of Cardiovascular Research of Ministry of Education, Harbin Medical University, Harbin, China c Department of Anatomy, Histology, and Embryology, Heilongjiang University of Chinese Medicine, Harbin, China

Methods on application of Chinese medicine to protect ancient books

Objective Pest control is one of the measures in protecting ancient books.To conclude pest control methods of Heilongjiang University of Chinese Medicine Library,a suitable method for promotion can be found.Methods By integrating the practical experience of protecting ancient books in Heilongjiang University,this article discussed concrete applications of Lysimachia foenum-gracum Hance to protect ancient books from infestation.Results The pest control mechanism of Lysimachia foenum-gracum was analyzed.The best pest control effects can be achieved when we identify the origin,choose the right picking season,identify authenticity of the medicine,and correctly use it.Conclusion Using Chinese traditional medicine to keep away insect is an environmental friendly way,which is worthy of generalizing. Key words: Lysimachia foenum-gracum; Chinese Medicine; Protection of ancient books on traditional Chinese medicine

Chromatographic fingerprinting analysis of Zhizhu Wan preparation by high-performance liquid chromatography coupled with photodiode array detector.

Background:Traditional Chinese medicine (TCM) formula has been used for over 1000 years and most of them contain complicate chemical constituents. Chromatographic fingerprinting has been widely accepted as a crucial method for qualitative and quantitative analyses for TCM. Zhi Zhu Wan (ZZW), a classical Chinese medical formula, has been commonly used for the treatment of gastrointestinal disease, which pose a serious challenge to its quality control.Materials and Methods:In this work, a sensitive and reliable method of high-performance liquid chromatography coupled with photodiode array detector (HPLC-PDA) was developed to control the quality of ZZW for chemical fingerprint analysis and quantitative analysis of four major bioactive constituents, including hesperidin, naringin, neohesperidin, and atractylenolide I. The chromatographic separation was performed on a Waters Symmetry C18 column (4.6 mm × 250 mm, 5 μm particle size), with an aqueous 0.095% phosphate acid and acetonitrile mobile phase gradient.Results:Optimization of other experimental conditions was validated with satisfactory accuracy, precision, repeatability, and recovery. In quantitative analysis, the four components showed good regression (R > 0.9994) within test ranges, and the recovery method ranged from 99.32% to 100.630%. HPLC fingerprints of the ZZW samples were compared by performing similarity analysis.Conclusion:The results indicated that the newly developed HPLC-PDA fingerprint method would be suitable for quality control of ZZW.

Preliminary identification of the absorbed bioactive components and metabolites in rat plasma after oral administration of Shaoyao-Gancao decoction by ultra-performance liquid chromatography with electrospray ionization tandem mass spectrometry.

Background:Shaoyao-Gancao decoction (SGD), a traditional Chinese medicine formula, has been used for the treatment of abdominal pain and dysmenorrhea disease in Asia over long period of time. Its effectiveness has been confirmed in clinic, but its active constituents remain unclear.Materials and methods:In this paper, a rapid, sensitive and reliable ultra-performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight high-definition mass spectrometry (UPLC-ESI-Q-TOF-MS) in positive and negative ion mode were established to characterize the active constituents of SGD in vitro. The analysis was performed on a Waters UPLCTM HSS T3 (2.1 × 100 mm, 1.8 µm) using gradient elution system. Automated MetaboLynxTM technique was employed to screen for the potentially bioactive components in rat plasma after oral administration of SGD. MS/MS fragmentation behavior was proposed for aiding the structural identification of the components.Results:Based on the developed method of fingerprint analysis, an injection run of the plasma sample was finished in 15.0 min. A total of 12 compounds including 9 prototype components such as gallicacid, albiflorin, liquiritin, pallidiflorin, liquiritigenin, isoLiquiritigenin, formononetin, isolicoflavonol, licoricone, C9H10O3 and 2 metabolites such as liquiritigenin-4’-O-glucuronide, formononetin glucuronide were identified or tentatively characterized. Of note, 3 ingredients were identified from Radix Paeoniae Alba, and 9 were from Radix Glycyrrhizae.Conclusion:The compounds found in dosed plasma could be the effective substances of SGT for treating dysmenorrheal, and may provide important experimental data for further pharmacological and clinical research of SGD. Furthermore, this work has demonstrated that the feasibility of the UPLC-ESI-Q-TOF-MS for rapid and reliable characterization of identification and structural elucidation of the chemical constituents and their metabolites from herbal medicines.

Introduction of Biofilm with an Analysis of its Typical Process

The classification and mechanism of the biofilm for treatment wastewater were introduced in this paper. Bio-contact oxidation, a typical biofilm process was described in detail. The example of treatment sewage of Heilongjiang University of science and technology proved that bio-contact oxidation process was more efficient for treatment sewage. It was considered as a wide range of application prospects.

Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial

IntroductionLetrozole is being used as an alternative to clomiphene citrate in women with polycystic ovary syndrome (PCOS) requiring ovulation induction. Berberine, a major active component of Chinese herbal medicine rhizoma...

Effects of tanshinone on hyperandrogenism and the quality of life in women with polycystic ovary syndrome: protocol of a double-blind, placebo-controlled, randomised trial

IntroductionPolycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Chinese herbal medicine has been used for the treatment of PCOS, but the evidence for...

Study on the Seismic Performance of Cavity Walls Constraint Masonry Construction

Cavity walls structure is unsuitable in cold area for its faultiness of poor heat-insulating property. But the cavity walls constraint masonry construction is suitable in cold area for its high heat-insulating property. Studies are carried as setting up the restoring force model of the cavity walls confined masonry structure and analyzing the dynamic time-history of cavity walls constraint masonry structure under 7 degrees small earthquake, middle earthquake or large earthquake through EL centro wave, TALF wave, Ninghe wave and Qian'an wave, which indicates that cavity walls constraint masonry construction can satisfy seismic demand of 7 degree quake. Finally, the formula for calculating the interlayer displacement of cavity walls confined masonry structure near collapse is put forward and the counting result is compared with that of dynamic time-history analyzing, which shows that the accuracy of this formula is high enough to be used for analyzing the seismic performance of cavity walls constraint masonry structure. Foundation projects: Special Basic Scientific Research for Central Public Institute (2008B002, 2010A04), Open Fund of Key Laboratory of State Education Ministroy on Urben and Engineering Safe and Disaster Diminish &amp; Key Laboratory of Beijing on Engineering Seismic and Treatment (EESR2010-07), and High Level Talent Support Project of Heilongjiang University (HDTD2010-13).

哈尔滨市中药研发生产机构知识产权保护状况的调研报告

中医中药是中华民族的国粹，其效用具有不可替代性，然而中药的研发和生产同时面临着知识产权不被保护的问题。中药研发是中药产业化的基础阶段，而对中药知识产权保护的探究应当从基础阶段开始，所以中药研发机构的知识产权保护状况尤其值得关注。本项目以哈尔滨市区范围内中药研发机构如黑龙江省中医药大学、祖国医学研究所、中药研发公司等为调研对象，就知识产权保护状况进行调研，希望能够对未来的中药研发和生产的知识产权保护制度的健全起到借鉴作用。 Chinese medicine is the quintessence of Chinese Nation, and its effectiveness is irreplaceable. However, the development and production of traditional Chinese medicine faces the problem of lack of intellectual property. Chinese medicine research and development is the foundation stage of industrialization of Chinese medicine, and the exploration of the protection of intellectual property rights about it should be started from the foundation stage. So Intellectual Property Protection in traditional Chinese medicine research and development institutions is of particular concern. The object of the research is Harbin city limits, such as Heilongjiang University of Traditional Chinese Medicine, Institute of Chinese Medicine, Traditional Chinese Medicine Research and Development Company and it is about state of the protection of intellectual property rights. We hope it can work to the sound of intellectual property protection system in the future traditional Chinese medicine research and development.