The main bridge of the Second Penang Bridge in Malaysia [1-2] is a two-pylon three-span prestressed concrete cable-stayed bridge, with span arrangement of (117.5+240+117.5) m.The pylons and the main girder are monolithic. The main girder, which is 34.6m wide, adopts the ladder type concrete deck section comprising top slab, transverse diaphragms and edge beams. The pylons are H-form pylons, and the stay cables are formed of parallel strands and are arranged in fan cable planes. Each pylon column carries 18 pairs of stay cables that are anchored by the deviation saddles in the pylons and anchor blisters in the main girder. The foundations consist of large diameter bored piles, varying from 2.3m to 2.0m in diameter. An optimized design scheme is tailored for the bridge, in which the main girder has the cross-section built up by a combination of slab, diaphragm and edge beam structuresand was constructed by using the rear supported form traveler and incorporating an optimization of construction timing. The scheme resolved the problems of load-bearing capacity verification for bridge deck and the verification of main girder prestress under the heavy vehicle loads prescribed in the BS5400. Meanwhile, a meticulous calculation method was put forward for the design and analysis of the main girder, to obtain the real load bearing conditions of the main girder and the bridge deck. The diaphragms were calculated by the spatial grillage analysis method, aimed at guaranteeing the load-bearing safety of the structure.