We have investigated the particle production and fragmentation of nuclei participating in the interactions of 10.6 GeV/n gold nuclei in nuclear emulsions. A new criterion has been found to distinguish between the interactions of these gold nuclei with the light (H,C,N,O) and heavy (Ag, Br) target nuclei in the emulsion. This has allowed separate analyses of the multiplicity and pseudo-rapidity distributions of the singly charged particles emitted in Au-(H,C,N,O) and Au-(Ag,Br) interactions, as well as of the modes of breakup of the projectile and target nuclei. The pseudo-rapidity distributions show strong forward asymmetries, particularly for the interactions with the light nuclei. Heavy target nuclei produce a more severe breakup of the projectile gold nucleus than do the lighter targets. A negative correlation between the number of fragments emitted from the target nuclei and the degree of centrality of the collisions has been observed, which can be attributed to the total destruction of the relatively light target nuclei by these very heavy projectile nuclei.