This paper develops a novel oscillator with wide output frequency range, continuous frequency adoption, anti-electromagnetic interference (EMI), and high precision in order to achieve the high energy conversion efficiency of DC-DC for micro direct methanol fuel cell (μDMFC). The oscillator employs the state of art including frequency jitter, slope compensation, and digital trimming to perform the load mode control and detection module, thus linearly adjusting the operating frequency and modulation according to the load. Based on the 0.18 μm microelectronics process, the transient output of the presented oscillator during continuously turning on exports a stable voltage square wave. The jitter frequency ranges only about −1.66% to +4.3% of the base frequency. Moreover, the oscillator can adjust the typical output frequency linearly from 100 kHz to 1 MHz continuously based on the light or heavy load state. The oscillator yields stable performance under EMI with the jittering rate ranges from −31.82% to 36.2%. The quantitative results validates the wide frequency range, continuous frequency adoption, anti-EMI, and high precision of the oscillator. The oscillator solves the low energy conversion efficiency of the μDMFC DC-DC. The oscillator will achieve high energy conversion efficiency and stable output voltage of μDMFC for practical application.