Premixed Charge Compression Ignition (PCCI) combustion is an alternative to conventional diffusion-controlled combustion for Mono-nitrogen oxides (NOx) and soot emissions reduction in DI diesel engines. However, bringing the center of combustion (CoC) near top dead center (TDC) to reduce brake specific fuel consumption is challenging. In this study, for two Early Intake Valve Closing (EIVC) profiles of split injection strategy, combustion characteristics and emissions of a heavy-duty direct injection (HDDI) diesel engine are evaluated by CFD simulations. Combustion efficiency, Indicated Specific Fuel Consumption (ISFC), NOx, soot, and carbon monoxide (CO) emissions are evaluated for 40 ˚CA and 80˚CA EIVC timings with respect to the base diesel combustion with 0, 30, 50, and 70% Exhaust Gas Recirculation (EGR) rates at 3 bar Brake Mean Effective Pressure (BMEP).CFD simulations reveal that EIVC strategy can displace the CoC towards TDC up to 5–10 ˚CA depending on the EGR rate. Moreover, up to 30% NOx reduction can be achieved in EIVC cases. In 70% EGR case, lower ISFC and near zero NOx emissions can be obtained compared to conventional diesel combustion due to CoC being closer to TDC. However, the EIVC strategy with EGR increases CO emissions due to incomplete combustion of a lower air/fuel ratio mixture.