Heat Stroke Research Articles

ANP Improves The Water And Salt Metabolism During Cooling Treatment For Exertional Heat Stroke

ANP Improves The Water And Salt Metabolism During Cooling Treatment For Exertional Heat Stroke

Quantifying Relative Importance Of Risk Factors For Exertional Heat Illness During Military Training

Quantifying Relative Importance Of Risk Factors For Exertional Heat Illness During Military Training

Limitations Exist In Reducing Exertional Heat Illness Risk Through Activity Modifications In Organized School Sports

Limitations Exist In Reducing Exertional Heat Illness Risk Through Activity Modifications In Organized School Sports

Exertional Heat Illness In Japanese Collegiate Basketball: Knowledge And Prevention Behaviors

Exertional Heat Illness In Japanese Collegiate Basketball: Knowledge And Prevention Behaviors

Examining the impact of climate change on local ecosystems and communities

We examine the particular impacts of rising temperatures, changed precipitation patterns, and an increase in the frequency of extreme weather events using climate models, field data, and socioeconomic analysis. The results of our investigation show that phenology, biodiversity, and species distributions are all significantly changing in the local ecosystems. Ecosystem services including pollination, water purification, and carbon sequestration are being hampered by these changes. One of the most important environmental issues facing humanity in the twenty-first century is climate change. The world's wealthiest and poorest nations are both impacted by climate change. In areas that are susceptible, for instance, shorter growing seasons and more frequent droughts are reducing agricultural productivity and leading to food insecurity. In addition to the environmental effects, local residents have substantial financial challenges. According to economic assessments, climate-related calamities such as floods and droughts have a substantial financial impact on both infrastructure and people. Particularly impacted are communities that depend on agriculture and natural resources, which has a big impact on their standard of living and economic stability. Our research also demonstrates how different adaptation tactics, including as water conservation and sustainable land management, can improve community resilience. Another important component of our research is the effects on health. We see a rise in climate-sensitive health outcomes, especially in areas with poor access to healthcare, such as vector-borne infections and heat-related illnesses. The mediating function of socioeconomic factors, such as income and education levels, on these health outcomes is significant. Our results highlight the necessity of focused interventions and policies to improve adaptive ability and reduce health risks. The study's finding highlights how intricately local ecosystems and communities are impacted by climate change. By providing a comprehensive analysis, our aim is to inform stakeholders and policymakers about workable mitigation and adaptation strategies. Future research should focus on longer observation periods and developing comprehensive approaches to address the complex issues caused by climate change. The paper concludes that although policy frameworks are necessary, their implementation and enforcement are hampered by Africa's poor governance structure and lack of political will.

Forecasting thermal stress for sports tourists at the 2026 FIFA World Cup.

This study explores thermal stress conditions (i.e. heat, humidity, sunlight exposure) sports tourists can expect when attending the 2026 FIFA World Cup. Sports tourism's growth is driven by international mega-events like FIFA World Cups and Olympic Games. With planning ongoing for the 2026 FIFA World Cup football (soccer) tournament, what remains unstudied are the heat conditions spectators can expect at the 16 host stadiums in the United States, Mexico, and Canada. The inquiry is important considering (1) the tournament is taking place in warm-weather months of June and July, (2) thermal stress contributes to heat-related illnesses like heat stroke, and (3) many destination-bound tourists will be at elevated risk to heat. Accordingly, we report historical and forecasted thermal stress levels documenting expected conditions at each host stadium. Notably, forecasts indicate worsening thermal stress compared to long-term means, providing support for the study's methodology. Practical implications and limitations are provided.

Risedronate prevents exercise-induced hypercalcemia but not nausea or vomit in humans: a double blind randomized controlled trial

Reportedly, nausea or vomiting after heavy exercise was associated with post-exercise increased blood calcium (Ca) levels, which was correlated with enhanced bone resorption. We conducted a randomized, double-blind, placebo-controlled trial, enrolling 104 healthy trained male members of the Japan Ground Self-Defense Forces. Risedronate (17.5 mg) or placebo was prescribed 3 and 10 days before heavy exercise lasting approximately 5 h. The primary outcome was the severity of nausea or vomiting assessed by a visual analog scale during or post-exercise. The secondary outcomes included clinical symptoms associated with heat illness, post-exercise serum total Ca (tCa), whole blood ionized Ca (iCa), and serum tartrate-resistant acid phosphatase 5b (TRACP-5b) levels. The mean age was 26 years. The exercise resulted in a 4.5% weight loss. The two groups were comparable in terms of the symptoms, including primary outcome. However, post-exercise tCa and TRACP-5b were significantly lower with risedronate. A similar result was observed for iCa. The post-exercise urinary Ca/Magnesium ratio and the incidence of hypercalcemia (defined as tCa or iCa levels ≥ each median value of all subjects) were significantly lower with risedronate (78.0% vs. 58.5%). A stronger treatment effect of risedronate on blood Ca levels was observed in participants who lost substantial body weight. Post-exercise hypercalcemia is attributed to enhanced bone resorption but not the cause of nausea.

Adverse health effects of climate change and air pollution in people with disabilities: a systematic review.

Global warming and air pollution adversely affect the health of the entire human population, particularly older adults, people with disabilities (PWDs), and children. In this systematic review, we investigated the adverse health effects of climate change and air pollution in PWDs. We conducted a comprehensive literature search of the PubMed database using the terms "disab*," "air pollution," and "climate change" on July 4, 2023, and August 8, 2023 and searched the Web of Science (WOS) database on December 28, 2023. We identified 425 and 1169 studies on climate change cited in PubMed and WOS, respectively, as well as 333 studies on air pollution in PubMed and 495 studies on air pollution in WOS. The studies were classified by type of exposure, and full-text screening was conducted to confirm that the population, intervention or exposure, comparator, outcome statement, and inclusion and exclusion criteria were met. The Newcastle-Ottawa Scale was used to assess the quality of the included cohort and case-control studies and for data analysis. In extreme temperatures, PWDs experienced higher rates of injury, heat-related illness, functional impairment, heart disease, mental disorders, and mortality than people who were nondisabled (ND). Exposure to air pollution resulted in higher rates of obesity, cardiovascular disease, poststroke neurological and functional disability, and mortality in PWDs than in people who were ND. Therefore, because PWDs were more affected by climate change and air pollution than people who were ND, sensitive policies and preparedness measures should be developed for PWDs.

Mitigating the Impact of Climate Change on Public Health: Strategies for Resilience

This article examines the impact of climate change on public health and explores strategies for building resilience to mitigate its adverse effects. Climate change, through rising temperatures, extreme weather events, and shifting ecosystems, poses significant challenges to global public health, exacerbating health issues such as heat-related illnesses, vector-borne diseases, respiratory conditions, and food and water insecurity. Vulnerable populations, including the elderly, low-income communities, and those in developing regions, are disproportionately affected. This study reviews the current scientific literature on the health impacts of climate change and identifies key strategies for enhancing public health resilience. These strategies include the development of early warning systems, strengthening healthcare infrastructure, improving access to clean water and sanitation, and fostering community-based adaptation initiatives. Additionally, it highlights the importance of cross-sectoral collaboration between governments, public health agencies, and civil society in addressing climate-related health risks. The role of policy frameworks, such as integrating climate adaptation into public health planning and promoting sustainable practices, is also discussed. Case studies from countries with proactive climate health strategies provide insights into successful resilience-building efforts. The findings suggest that a comprehensive, proactive approach to climate change mitigation and adaptation can significantly reduce public health vulnerabilities and enhance community resilience. The article concludes by recommending targeted investments in public health infrastructure, education, and policy reform to safeguard communities from the growing health threats posed by climate change.

Climate change's implications for practice: Pharmacologic considerations of heat-related illness.

Climate change's implications for practice: Pharmacologic considerations of heat-related illness.

Health risk assessment of residential overheating under the heat waves in Guangzhou

During extreme heatwave events, indoor overheating caused by power outages poses a significant threat to human health, especially for low-income groups exposed to hot and humid conditions for extended periods. However, currently, the definition and quantification standards for indoor overheating are not well-defined, and relying solely on thermal comfort indicators is insufficient to accurately assess the health risks associated with indoor overheating. This study proposes the use of maximum heat index (HImax) and heat index hazard hours when the heat index exceeds the caution level (HIHHCaution) to assess the health risk of indoor overheating. Taking various types of residential buildings in Guangzhou as examples, the study employs field surveys, simulation analysis, and statistical regression to analyze the impact of power outages during heatwaves on the indoor thermal environment and key human thermal physiological parameters, thereby establishing the basis for measuring indoor overheating and reference thresholds for assessing heat health risks. The results indicate that for young adults and the elderly, HIHHCaution exceeding 1174 °C·h and 850 °C·h respectively, or HImax nearing 55 °C, are likely to result in heat-related illnesses. In Guangzhou, most urban village housing with poor insulation cannot withstand the risk of power outages lasting more than a day during heatwaves, while old housing and commodity housing that meets the energy-efficiency standards of different periods still face varying degrees of indoor overheating risk. The findings enhance understanding of indoor overheating health risks and provide a scientific basis for strategies to improve living environments during heatwaves.

Altered static brain activity and functional connectivity after heat stroke.

This study aimed to investigate the alteration of brain function based on resting-state functional MRI in patients after heat stroke. This study included 10 cases of patients after heat stroke and 10 cases of healthy controls. Abnormal brain function was calculated using amplitude of low-frequency fluctuations (ALFF) and degree centrality analysis, as well as functional connectivity analysis based on regions of interest (ROI). Correlation analyses were performed to evaluate the association between brain function changes and clinical scales. Combining ALFF and degree centrality results, the decreased brain regions included the left cuneus and the right angular gyrus, while the increased brain regions included the right cerebellar_Crus1. Using the left cuneus with significant differences in ALFF and degree centrality as ROI, the functional connectivity results revealed decreased brain regions including bilateral lingual gyrus, bilateral postcentral cingulate gyrus, and left precentral gyrus. The degree centrality value of the right cerebellar_Crus1 was positively correlated with glasgow coma scale (GCS) scores ( r = 0.726, P = 0.027), and the functional connectivity value of the right posterior cingulate gyrus was positively correlated with GCS scores ( r = 0.717, P = 0.030). Heat stroke patients exhibit abnormal activity in multiple brain regions, which has important clinical significance for evaluating the severity of the disease.

Sex differences in biomarkers of end-organ damage following exertional heat stroke in humans.

Women are participating in military and athletic activities in the heat in increasing numbers, but potential sex differences in sequelae from exertional heat illness remain poorly understood. We tested the hypothesis that women suffering from exertional heat stroke (EHS) would have similar severity of organ damage biomarkers compared with men, as measured in a hospital setting. We studied women and men presenting with EHS to the emergency department at Fort Moore, GA. We measured creatinine (CR), creatine kinase (CK), alanine-transaminase (ALT), aspartate aminotransferase (AST), and estimated glomerular filtration rate (eGFR). Core temperature was also assessed by medical personnel. Biomarker data were obtained for 62 EHS cases (11 women). Men were significantly taller, and heavier, and had larger body mass index (BMI) and body surface area (P < 0.05 for all). The highest recorded body core temperature was not different between groups [women: 41.11°C (40.06, 41.67); men: 41.11°C (40.28, 41.72), P = 0.57]. Women had significantly lower peak CR [women: 1.39 (1.2, 1.48) m·dL-1; men: 1.75 (1.53, 2.16) mg·dL-1, P < 0.01] and peak CK [women: 584 (268, 2,412) U·L-1; men: 2,183 (724, 5,856) U·L-1, P = 0.02]. Peak ALT and AST were not different between groups; during recovery time points, ALT and AST were either similar or lower in women. Women spent approximately half as much time in the hospital following admittance compared with men. Our findings suggest that women may be less susceptible to organ injury resulting from EHS. Further research is necessary to understand the pathophysiology underlying these differences and how biomarkers of end-organ damage severity can differ between women and men following EHS.NEW & NOTEWORTHY We studied otherwise healthy women and men after exertional heat stroke in a military training environment. Peak values for biomarkers of kidney and muscle damage were lower in women compared with men despite similar (highest recorded) body core temperatures. During recovery, organ damage markers were similar or lower in women. These sex differences may indicate differences in the pathophysiology of responses, but more work is needed to clarify specific mechanisms.

Pre-, Per- and post-cooling strategies used by competitive tennis players in hot dry and hot humid conditions.

This research investigated the pre-, per- and post cooling strategies used by competitive tennis players from various levels of play who occasionally train and compete in hot (>28°C) and humid (>60% rH), and dry (<60% rH) environments. 129 male tennis players (Mage = 24.9) competing at regional (N = 54), national (N = 30) and international (N = 45) levels, completed an online questionnaire regarding their use (i.e., timing, type, justification and effectiveness) of pre- (i.e., before practice), per- (i.e., during exercise) and post-cooling strategies when playing tennis in hot dry (HD) and hot humid (HH) conditions. Individual follow-up interviews were also carried on 3 participants to gain an in-depth understanding of the player's experience. Competitive tennis players used both internal and external cooling strategies to combat the negative effects of HD and HH conditions, but considered the HH to be more stressful than HD and experienced more heat-related illness in HH environments. International players used cold packs and cold towel more frequently than the regional and national players in hot environments, and used cold water immersion and cold vest more frequently than the latter in HH. Differences in strategy use were mostly observed during per-cooling where regional and national players more frequently used cold drinks than international players who more frequently used cold packs in HD and cold towel in HH conditions. Moreover the latter more frequently used cold towel, cold packs and cold water immersion as post-cooling strategies than regional players. When playing tennis in the heat, it is strongly recommended to employ cooling strategies to maintain health, limit declines in performance, and promote recovery. We also recommend improving education regarding the appropriate use and effectiveness of cooling strategies, and increasing their availability in tournaments.

Voluntary head dunk: cooperative care for irrigating canine noses and eyes and rapid cooling.

To demonstrate the methods to teach dogs to voluntarily immerse (dunk) their head in a container of water, and to identify the 3 indications for voluntary head dunk: to clear a dog's nostrils of dust/debris, flush a dog's eyes, and cool a dog after exercise. Dogs. With the use of cooperative care and positive reinforcement training, the dog is taught to retrieve a toy or treat from a bucket or large container. Clean, room temperature water is added stepwise until the dog is comfortable immersing its nose and blowing bubbles or immersing its head to retrieve the toy or treat. The training may require minutes, weeks, or months, depending on the dog's motivation. Voluntary head dunk can remove dust and debris from the nasal passages and eyes and can facilitate cooling, especially after exercise. Positive reinforcement creates a cooperative environment in which first aid can be effectively administered. Contraindications include treatment of heat stroke, persistent or serious nasal or ocular discharge, or dogs that are uncomfortable or unable to dunk their heads. Pet owners and handlers of working dogs or canine athletes can teach their dogs to head dunk and implement this first aid technique for exercise-related cooling or ocular/nasal flush, even in environments with limited resources. Some dogs may be rapidly trained in the veterinary environment as an initial approach to a nasal or ocular flush. Cooperative care provides an effective intervention that preserves and enhances the human-animal bond.

Punishment and survival – incarcerated persons' experiences with extreme heat in Texas prisons

PurposeThe impact of extreme heat on prisons and carceral facilities is becoming increasingly visible, yet remains overlooked by scholars, practitioners and policymakers. Prisons are a unique type of infrastructure designed to severely limit and control the movement of hundreds and even thousands of individuals as a form of punishment. This leads to many significant challenges to mitigating the risk of heat-related illness in prisons and other carceral spaces that have remained overlooked across many disciplines including emergency management, disasters, corrections and public health.Design/methodology/approachFor this study, we analyzed 192 surveys from incarcerated persons in state prisons throughout Texas to understand how incarceration and the punitive prison environment create challenges to managing extreme heat in prisons.FindingsWe found that characteristics of modern incarceration, including communal distribution of resources, crowded conditions and a lack of agency for incarcerated people, create barriers to accessing resources during periods of extreme heat. Furthermore, the punitive nature of the prison environment as manifested in the relationship between staff and incarcerated persons and certain prison policies also create barriers to incarcerated persons accessing resources to reduce their risk of heat-related illness and death.Social implicationsThese issues are particularly relevant to the health and safety of incarcerated persons during periods of extreme temperatures but also speak broadly to the implications of incarceration, disaster risk, and the advancement of human rights for incarcerated people.Originality/valueThis article addresses a gap in the literature by including the perspectives of persons incarcerated in Texas prisons experiencing extreme heat and implicates the characteristics of incarceration and punishment in the production of disaster risk.

A cross-sectional study: the impact of extreme weather, sleep quality, and physical activity

This study aims to explore the impact of extreme weather condition on sleep quality and physical activity in Gorontalo using a cross-sectional research design. The data were collected from 220 respondents aged 18-25 using the Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and weather information from BMKG Gorontalo. The results showed that extreme weather, especially high temperatures, significantly reduced physical activity and affected sleep quality. Respondents with higher physical activity levels showed better sleep quality (lower PSQI scores). Extreme weather also reduces motivation to exercise, increasing the risk of health problems such as dehydration and heat stroke. In conclusion, public health interventions that promote physical activity and improved sleep quality during extreme weather conditions are urgently needed to reduce associated health risks. This study emphasises the importance of understanding the specific mechanisms of how extreme weather affects sleep and physical activity, and developing strategies to maintain healthy routines despite adverse weather conditions. Keywords: extreme weather, sleep quality, physical activity, public health, health interventions.

Vitamin E Supplementation to Quail (Coturnix-coturnix Japonica) Treated by Heat Stress: Effects on Blood Hematology Parameters

Heat stress is a major problem in poultry farming. Environmental temperature and humidity greatly in fluence the performance of poultry, especially quails raised in tropical environments. Vitamin E is a fat-soluble vitamin that has an antioxidant effect. This study aimed to evaluate the effect of vitamin E supplementation on the blood profile of quails kept under heat stress. This study used 4 treatments of T0 as Control (Commercial Feed + Heat Stress 35 oC); T1 (Control + 100 mg of vitamin E/kg); T2 (Control + 150 mg of vitamin E/kg) and T3 (Control + 200 mg of vitamin E/kg). Observed parameters of leukocytes, heterophylls, lymphocytes and monocytes. The data was analyzed by Analysis of Variant (ANOVA) if there were differences between treatments, followed by the Duncan test. The observation results showed that the addition of vitamin E could increase the number of leukocytes, lymphocytes, monocytes and reduce the number of heterophytes and the H/L ratio of quail blood that experienced heat stroke. Based on the blood profile, the addition of vitamin E as much as 200 mg/kg in feed is able to reduce heat stress due to heat stress in laying quails.

Curcumin nanoparticles in heat stroke management

ObjectiveThe exacerbation of extreme high-temperature events due to global climate change poses a significant challenge to public health, particularly impacting the central nervous system through heat stroke. This study aims to develop Poly(amidoamine) (PAMAM) nanoparticles loaded with curcumin (PAMAM@Cur) to enhance its therapeutic efficacy in hypothalamic neural damage in a heat stroke model and explore its potential mechanisms.MethodsCurcumin (Cur) was encapsulated into PAMAM nanoparticles through a hydrophobic interaction method, and various techniques were employed to characterize their physicochemical properties. A heat stroke mouse model was established to monitor body temperature and serum biochemical parameters, conduct behavioral assessments, histological examinations, and biochemical analyses. Transcriptomic and proteomic analyses were performed to investigate the therapeutic mechanisms of PAMAM@Cur, validated in an N2a cell model.ResultsPAMAM@Cur demonstrated good stability, photostability, cell compatibility, significant blood–brain barrier (BBB) penetration capability, and effective accumulation in the brain. PAMAM@Cur markedly improved behavioral performance and neural cell structural integrity in heat stroke mice, alleviated inflammatory responses, with superior therapeutic effects compared to Cur or PAMAM alone. Multi-omics analysis revealed that PAMAM@Cur regulated antioxidant defense genes and iron death-related genes, particularly upregulating the PCBP2 protein, stabilizing SLC7A11 and GPX4 mRNA, and reducing iron-dependent cell death.ConclusionBy enhancing the drug delivery properties of Cur and modulating molecular pathways relevant to disease treatment, PAMAM@Cur significantly enhances the therapeutic effects against hypothalamic neural damage induced by heat stroke, showcasing the potential of nanotechnology in improving traditional drug efficacy and providing new strategies for future clinical applications.SignificanceThis study highlights the outlook of nanotechnology in treating neurological disorders caused by heat stroke, offering a novel therapeutic approach with potential clinical applications.Graphical abstract

Surviving a classic heat stroke/hyperthermia > 42 °C – a case report

IntroductionClassic heat stroke is a severe trauma which can lead to multi-organ dysfunctions and is associated with a high mortality.Case presentationIn this case report we present a 73-year-old patient with a classic heat stroke. His initial core body temperature was over 42 °C and he had a GCS of 3. Due to severe burn injuries the patient was transferred to a specialized burn center. The patient developed different organ failures and showed a prolonged course on the intensive care unit. Although the patient demonstrated different impaired organ systems, he recovered completely after receiving painstaking supportive therapy.ConclusionsThis is a rare case of a patient who fully recovered after a heat stroke with a temperature over 42 °C and severe sequelae.