Heating Research Articles

Influence of chemical forms and homogenization process on the stability of vitamin A in infant follow-on formulas

Vitamin A is an essential micronutrient for infant development, and its stability is crucial to ensure adequate intake. This study aimed to investigate the vitamin A stability in infant follow-on formulas (IFF) depending on its chemical forms and on the homogenization process. For this propose, model IFF representative of commercialized formulas were formulated with varying vitamin A forms (retinol, retinyl esters or carotenoids) and homogenization process applied. Losses of vitamin A were assessed either before or after the homogenization process, or after a storage of 20 days at 40 °C. The homogenization process led to a vitamin A loss up to 14.3% at high pressure (350/40 bars, 8 passes) explained by important shearing forces leading to local heating of molecules. The presence of carotenoids and especially β-carotene led to a stabilization effect with a loss of only 40.7% of vitamin A during storage compared to 84.9% without carotenoids. Carotenoids provide a better resistance to lipid oxidation due to their synergetic effect with vitamin E. This study highlights that a good knowledge of vitamin A reactivity during processing and selection of chemical form with potential synergy with other compounds can improve its stability in IFF.

Investigating intermolecular interactions of surfactant solutions using femtosecond thermal lens spectroscopy

In this study, we examined the impact of various surfactants (oleic acid, butyric acid, Span-20, and CTAB) on the thermophysical properties of methanol (MeOH) using a femtosecond laser-induced thermal lens (TL) spectroscopic technique. Methanol was chosen for its unique convective properties under intense localized heating, making it a promising candidate for studying photothermal responses. We discovered that the TL characteristics of both pure methanol and methanol-surfactant mixtures are significantly influenced by the molecular interactions and physical properties of the components. Our experimental results indicate that the addition of surfactants notably alters the heat transfer dynamics of the solvent by restricting natural molecular movement and modifying thermal properties, which in turn affect the TL signatures. Beyond the surfactant concentration, we observed that the extent of variation in steady-state TL signals, inflection points, and heat transfer mechanisms depends on the molecular properties of the surfactants, such as chain length, the number of active (hydrophilic) groups per molecule, thermal conductivity, viscosity, and intermolecular interactions. Our TL findings provide a detailed investigation into the effect of surfactants on the photothermal response and heat transfer process of a solvent for the first time.

The impact of film cooling on the heat release within a rotating detonation combustor

Rotating detonation combustors establish a detonation wave that continuously circulates inside a small annulus. The presence of the detonation wave and the downstream oblique shock within the small annulus coupled with high mass flow induces a high heat load to the combustor wall. Preliminary analysis shows that for higher thermal power, internal air cooling alone is not sufficient to remove the heat out of the walls to maintain them below the maximum temperature of the metal. A possible solution is to use film cooling to reduce the heat flux to the combustor walls. One issue, though, is that the introduction of film cooling provides additional air into the system that can influence the combustion process as well as providing a location for secondary combustion.This paper represents the first investigation to study the secondary implications on combustion of using film cooling in a rotating detonation combustor. The TU Berlin RDC architecture was modified with the introduction of 480 film cooling holes placed in the oblique shock region. High fidelity LES investigations were performed for different coolant plenum pressures to show the benefits of using film cooling. However, due to the presence of unburnt fuel in this post-detonation region, the coolant can result in additional combustion leading to an increase in temperature near the wall. One the one hand, these secondary reactions result in an increase of the overall heat release increasing combustion efficiency, however this also results in higher temperatures and reduced film cooling effectiveness. A simulation performed with nitrogen as a coolant enabled the effects of increased mixing caused by the ejection of coolant gases to be separated from the additional heat release. The simulation with nitrogen shows a reduction of 88% in the local heat release in the post detonation region resulting in similar performance as the uncooled case and significantly cooler walls.

Facile fabrication of superhydrophobic carbon-doped nanofibrous mat for solar-driven desalination

Recently, solar-driven localized heating interfacial evaporation for desalination has attracted much attention to draw freshwater from sewage or seawater. However, salt scaling resulted from concentration polarization, as well as the subsequently deterioration of evaporation rate and energy efficiency, are the major obstacles for the application of solar desalination. In this work, carbon-doped nanofibrous mat with photothermal and superhydrophobic properties were facilely fabricated via incorporation of activated carbon (AC) nanoparticles and hydrophobic modification with polydimethylsiloxane (PDMS). The obtained nanofibrous mat exhibited outstanding light absorption (> 93.0%), superhydrophobic characteristics (> 155°) and high porosity (> 82%). Solar-driven evaporation experiments demonstrated that evaporation rate of the nanofibrous mat reached up to 1.2kg·m-2·h-1 with energy efficiency of 82.1%. Moreover, crystal nucleation and growth on the superhydrophobic carbon-doped mat were dramatically suppressed, whose lifespan was prolonged from 4h to as long as 19h with near-saturated NaCl solution as the feedwater. Therefore, the fabricated superhydrophobic carbon-doped nanofibrous mat might find its applications in stable solar-driven evaporation for seawater desalination or wastewater reclamation.

Influence of supply temperature and booster technology on the energetic performance and levelized cost of heat of a district heating network with central heat pump

The development of new low-temperature district heating networks in existing urban areas can accelerate the replacement of fossil-fuel-based heating systems by collective heating using electricity or renewable heat sources. Buildings can either be connected to the network in their current, non-refurbished state for rapid deployment or be refurbished before connection to achieve maximum energy efficiency. To assess the difference between these two strategies, this paper examines eight low-temperature district heating concepts with central heat pump, comparing their energy use and levelized cost of heat. The study includes four scenarios for each strategy, considering supply temperatures ranging from 10 °C to 75 °C. Heat pumps or electric heaters are used as booster technology when the network supply temperature is too low for space heating or domestic hot water purposes. The use of booster heat pumps shows the highest seasonal coefficient of performance for both refurbished (4.61) and non-refurbished buildings (3.43). However, booster technologies result in the highest levelized cost of heat, driven mainly by the high investment cost of the network and booster units. Lowest levelized cost of heat of 213 €/MWhth is obtained for non-refurbished buildings at 75 °C and 297 €/MWhth for refurbished buildings at 55 °C without boosters.

Mapping PM2.5 Sources and Emission Management Options for Bishkek, Kyrgyzstan

Harsh winters, aging infrastructure, and the demand for modern amenities are major factors contributing to the deteriorating air quality in Bishkek. The city meets its winter heating energy needs through coal combustion at the central heating plant, heat-only boilers, and in situ heating equipment, while diesel and petrol fuel its transportation. Additional pollution sources include 30 km2 of industrial area, 16 large open combustion brick kilns, a vehicle fleet with an average age of more than 10 years, 7.5 km2 of quarries, and a landfill. The annual PM2.5 emission load for the airshed is approximately 5500 tons, resulting in an annual average concentration of 48 μg/m3. Wintertime daily averages range from 200 to 300 μg/m3. The meteorological and pollution modeling was conducted using a WRF–CAMx system to evaluate PM2.5 source contributions and to support scenario analysis. Proposed emissions management policies include shifting to clean fuels like gas and electricity for heating, restricting secondhand vehicle imports while promoting newer standard vehicles, enhancing public transport with newer buses, doubling waste collection efficiency, improving landfill management, encouraging greening, and maintaining road infrastructure to control dust emissions. Implementing these measures is expected to reduce PM2.5 levels by 50–70% in the mid- to long-term. A comprehensive plan for Bishkek should expand the ambient monitoring network with reference-grade and low-cost sensors to track air quality management progress and enhance public awareness.

Soil Parameters Monitoring System

Soil parameters monitoring is vital for different areas such as climatological and ecological studies, agriculture, etc. Large scale measurement systems are based on satellite technologies however their spatial and temporal resolutions still must be improved for real-time measurement tasks and control of local areas. Such systems also require in-situ measurements for calibration. It rises the need of local sensor networks development. The paper proposes a soil monitoring system which allows measuring temperature and humidity. Wireless communication between sensors and data collection unit allows to form sensor array at required area without additional cables. Usage of thermal noise method allows to perform measurement of both parameters with a single sensor which allows to avoid soil moisture content changes due to absence of local soil heating which could be caused by probing currents in other methods. Proposed method also allows to increase measurement accuracy.

Nano-structured urchin-like photothermal covalent organic frameworks for efficient Solar-Driven interfacial water evaporation

Solar-driven interfacial water evaporation is a promising sustainable technology to alleviate the global energy crisis and clean water shortage. The design of advanced photothermal materials play the critical role to utilize photothermal heat for water evaporation. Covalent organic frameworks (COFs) as a new class of crystalline porous polymer semiconductor materials have been deemed as an ideal nanoscale platform for designing photothermal materials with notable features like highly ordered structures, porous open channels, and tunable structure and functionality. In this work, we focus on the regulation of the multi-scale structure of COFs and design hierarchically nano-structured photothermal COFs for efficient solar-driven interfacial water evaporation. At the molecular scale, we synthesize a photothermal functionalized COF-366-OH using photosensitive 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) and 2,5-dihydroxyterephthalaldehyde (DHTA) as building blocks. At the micro-nano scale, we introduce the π-conjugated catechol molecule 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) to regulate COF polycondensation and assembly, which enable the shaping of COF-366-OH into urchin-like nano-morphologies (namely UCOF-366-OH). The synthesized UCOF-366-OH exhibits high crystallinity, large surface area, excellent photothermal conversion capacity, and strong hydrophilicity. Furthermore, UCOF-366-OH is processed into a photothermal composite membrane. With localized solar heating and optimized water transport at the water evaporation interface, a high evaporation rate of 2.51 kg m−2h−1 with solar-to-vapor efficiency of 97.3 % is achieved. This work paves a new way for the multi-scale structural design of COF-based photothermal materials and highlights their innovative application in solar water evaporation.

Influence of a local diabatic heating source on the midlatitude circulation

AbstractDiabatic heating due to latent heat release in the storm tracks plays an important but poorly understood role in the midlatitude circulation. To examine how localised diabatic heating affects the circulation, a dry model is used to apply midtropospheric perturbations to the radiative‐equilibrium temperature profile to which the model is relaxed. This allows us to isolate the one‐way causal influence of diabatic heating on the circulation without feedbacks of the circulation onto the heating. By applying switch‐on perturbations at various latitudes, the mechanisms by which an equilibrated state is reached are examined. In all cases, the equilibrated circulation exhibits a dynamically insensitive jet structure with eddies maintaining a region of self‐concentrated baroclinicity, latitudinally shifted away from the heating perturbation. However, the initial response is generally very different. For heating poleward of the jet, there is an initial thermal‐wind adjustment and weakened eddy heat fluxes, followed later by weakened eddy momentum fluxes that maintain an equilibrated equatorward jet shift. For heating equatorward of the jet, the evolution is more complex with an initial strengthening of the eddy heat fluxes that dominantly balance the imposed heating, as well as a weakening of the Hadley cell. Further, the initial thermal‐wind adjustment immediately modifies the subtropical critical lines and eddy momentum fluxes that encourage an 15° poleward propagation from the Subtropics to Midlatitudes, yielding an equilibrated poleward jet shift. The overall determining factor in balancing the imposed heating at equilibration is the local climatological heat budget: if the climatological eddy heat fluxes locally warm, such as in mid‐to‐high latitudes, then this effect weakens, whereas if the climatological overturning circulation locally warms, such as in the Subtropics, then this effect weakens. The insensitivity of the equilibrated jet profile to the imposed heating is remarkable given the maintenance mechanisms vary drastically according to heating latitude.

Enhanced Magnetic Heating for Efficient Oxygen Evolution Reaction by Pinning Effect of Ferromagnetic/Antiferromagnetic Coupling.

The magnetic heating effect under alternating magnetic fields (AMFs) has recently gained attention in catalysis due to its potential to greatly boost catalytic activities by providing localized heating around magnetic nanoparticles. However, nanoparticles still suffer from low magnetic heating efficiency due to their low magnetic anisotropy and thermal fluctuation, which is a key barrier in the wide application of AMF-assisted catalysis. Herein, by introducing the pinning effect of ferromagnetic/antiferromagnetic (FM/AFM) coupling, NiO/NiOOH (AFM/FM) core-shell nanoparticles exhibit significantly enhanced oxygen evolution reaction activity and resistance to thermal fluctuations under AMF, compared to NiOOH nanoparticles. Notably, magnetized NiO/NiOOH nanoparticles provide an overpotential of 186 mV at 10 mA cm-2, outperforming unmagnetized ones (218 mV) under the same conditions, further emphasizing the prominent role of the pinning effect in enhanced magnetic heating efficiency. This work provides valuable inspiration to design advanced magnetic catalysts and meet the challenge of the development of AMF-assisted catalysis.

Synergistic Interactions among Vacuum, Solar Heating, and UV Irradiation Enhance the Lethality of Interplanetary Space

A Planetary Atmospheric Chamber (PAC) was used to create simulations of interplanetary conditions to test the spore survival of three Bacillus spp. exposed to interacting conditions of vacuum (VAC), simulated solar heating (HEAT), and simulated solar ultraviolet irradiation (UV). Synergism was observed among the experimental factors for all three Bacillus spp. tested that suggested the increased lethality of HEAT and UV when concomitantly exposed to VAC. The most aggressive biocidal effects were observed for assays with VAC + HEAT + UV conditions run simultaneously over short time-steps. The results were used to predict the accumulation of extremely rapid Sterility Assurance Levels (SALs; def., −12 logs of bioburden reduction) measured in a few minutes to a few hours for external surfaces of interplanetary spacecraft. Furthermore, the results were extrapolated to predict that approx. 1 × 104 SAL exposures might be accumulated for external surfaces on the Europa Clipper spacecraft during a 3.5-year transit time between Venus (0.7 AU) and Mars (1.5 AU) during a series of Venus–Earth–Earth gravity assists (VEEGA trajectory) to Jovian space. The results are applicable to external spacecraft surfaces exposed to direct solar heating and UV irradiation during transits though the inner solar system.

Decadal Relationship Between Arctic SAT and AMOC Changes Modulated by the North Pacific Oscillation

AbstractThe faster warming for Arctic Ocean surface air temperature (SAT) relative to that at lower latitude is connected with various processes, including local radiation feedback, poleward oceanic and atmospheric heat transport. It is unclear how combinations of different low‐frequency internal climate modes influence Arctic amplification on the decadal timescale. Here, the decadal Arctic SAT variation, its connection with the Atlantic meridional overturning circulation (AMOC) and possible underlying mechanisms, are investigated based on several independent observational proxies, pre‐industrial experiments, and historical large ensembles of two CMIP6 models. Our study suggests that AMOC and Arctic SAT vary in phase on the decadal timescale, whereas this relationship is insignificant at the interannual timescale. Further analysis shows that the AMOC accompanied with cross‐basin oceanic water/heat transport between Atlantic and Arctic would alter air–sea interface exchange over the melting ice regions, and then amplified poleward atmospheric heat and moisture transports. The resulting enhanced downward longwave radiation ultimately warms the Arctic SAT. Additionally, the decadal‐scale North Pacific Oscillation (NPO) can modulate the relationship between AMOC and Arctic SAT by influencing poleward moisture transport and cross‐basin circulation. Specifically, the phase shift of combined NPO and AMOC can contribute 14%–41% covariance relationship between AMOC and Arctic SAT. Our study provides potential sources for predicting the Arctic climate and constraining its uncertainty in future projections.

Use of open fires or closed solid fuel appliances for residential heating and cognitive decline in older adults

ObjectivesUse of solid fuel appliances is a major contributor to air pollution. Indoor solid fuel burning for cooking and heating in lower-middle income countries is associated with lower cognitive function and faster decline. Less is known, however, about the potential risk to brain health from burning solid fuels in open fires and closed appliances for heating purposes only, particularly in higher income countries. The current study aimed to investigate the association between burning solid fuels for home heating and cognitive decline in older Irish adults, also testing whether results differ by sex/gender. Design and ParticipantsThe sample consisted of 4,537 participants aged 50 and older from The Irish Longitudinal Study on Ageing, a population-based cohort study. Participants were surveyed every two years between 2012 and 2018. Solid fuel use in 2012 (Wave 2) and cognitive function (word recall and verbal fluency) at waves 2, 3, 4 and 5 were analysed. Hierarchical linear mixed effects regression models were used to examine the association between solid fuel use and cognitive decline, controlling for multiple confounders. ResultsThere was a significant main effect of solid fuel use on cognitive function, such that individuals who reported using a solid fuel appliance or open fire as a main source of heating had lower cognitive scores than those who did not report such use at all waves, but there was no difference in the slope of the trajectory over time and no clear sex differences. ConclusionsOlder Irish adults who reported burning solid fuels (in an open fire or closed appliance) as a main way source of home heating had lower observed cognitive function across 6 years in TILDA but no evident faster decline than non-users. These findings further expand the evidence base on indoor air pollution and brain health.

Relationships between morphological factors and heat extraction from the upper arm using liquid cooling garment

Astronauts wear liquid perfused garments inside their outer spacesuits for regulating body temperature. The present study explored relationships between local heat production from the upper arm and body morphology while wearing liquid perfused sleeve. Heat extraction from the upper arm of 19 subjects (8 males and 11 females) during three different exercise modes (running at 6–8 km∙h−1, cycling at 40–55 W, and arm ergometer at 10–20 W) and rest has been investigated. The total body fat (27.5 ± 7.2%), body mass index (24.4 ± 2.7 kg·m−2), arm surface area (589 ± 90 cm2), and arm volume (1300 ± 300 mL) were considered as covariates. Subjects wore a liquid perfused sleeve over the upper arm (left) with the water inlet temperature of 24.0 ± 0.3 °C and the heat extraction was calculated using the water flow rate and temperature differences. Heat extraction from the upper arm showed no significant differences among the three exercises. During cycling, there was a negative relationship between heat extraction and total body fat (r = − 0.527, P < 0.05). Heat extraction was more related to the arm volume (P < 0.05) than the surface area of the upper arm, which was significant only for the male group in the cycling mode. For the female group, heat extraction was related to upper arm temperature in the cycling and arm exercise modes (for both exercises P < 0.05). These results can be applied to improve liquid cooling garments for astronauts, considering their body morphology and sex.

Micro-Channel Cooling of Hot Spots Through Non-Uniform Aspect Ratio Designs

Abstract Electronic devices experience spatial variation in power dissipation, which results in high-temperature hot spots. These locations require aggressive thermal management, which can be complex and costly. Simple solutions such as single-phase micro-channels can provide adequate heat transfer, but they are not designed to control heat transfer locally. However, micro-channels can be tailored to control local flow rates and heat transfer, potentially mitigating hot spot temperatures. Using a conductive and convective resistance network for a micro-channel, an analytical model is generated for heat transfer within an individual passage. For a given channel width, this model relates the channel depth to its resistance through a power law. Over a wide range of heat fluxes, the optimal design balances local temperatures to within 3 K. The analytical model is validated using computational simulations of the optimized heat sink. For a randomly-generated, non-uniform power distribution, device temperatures are balanced with a sample standard deviation below 2.5%, which is significantly better than a baseline design. When heat spreading is incorporated, the temperature increase is smaller but remains uniform, indicating that the hot spots can be mitigated.

The 3D Crustal Structure of the Wilkes Subglacial Basin, East Antarctica, Using Variation of Information Joint Inversion of Gravity and Magnetic Data

AbstractDirect geological information in Antarctica is limited to ice free regions along the coast, high mountain ranges, or isolated nunataks. Therefore, indirect methods are required to reveal subglacial geology and heterogeneities in crustal properties, which are critical steps toward interpreting geological history. We present a 3D crustal model of density and susceptibility distribution in the Wilkes Subglacial Basin (WSB) and the Transantarctic Mountains (TAM) based on joint inversion of airborne gravity and magnetic data. The applied “variation of information” technique enforces a coupling between inferred susceptibility and density, relating these quantities to the same gravity and magnetic sources to give an enhanced inversion result. Our model reveals a large body located in the interior of the WSB interpreted as a batholithic intrusive structure, as well as a linear dense body at the margin of the Terre Adélie Craton. Density and susceptibility relationships are used to inform the interpretation of petrophysical properties and the reconstruction of the origin of those crustal bodies. The petrophysical relationship indicates that the postulated batholitic intrusion is granitic, but independent from the Granite Harbor Igneous Complex described previously in the TAM area. Emplacement of a large volume of intrusive granites can potentially elevate local geothermal heat flow significantly. Finally, we present a new conceptual tectonic model based on the inversion results, which includes development of a passive continental margin with seaward dipping basalt horizons and magmatic underplating followed by two distinct intrusive events associated with the protracted Ross Orogen.

Engineering Coatings Inspired by Cell Membrane Thermal Dynamics to Enhance Photothermal Therapy and Osteogenesis for Implant Infections.

Photothermal therapy (PTT) encounters challenges of rapid thermal loss and potential tissue damage. In response, we propose a Heat-Boost and Lock implant coating strategy inspired by the thermal adaptation of biological membranes, enabling precise local photothermal utilization. This coating incorporates a poly(tannic acid) (pTA) bridging layer on implants, facilitating stable layer-by-layer integration of a black phosphorus (BP) photothermal layer and a top cell membrane Heat-Boost and Lock layer. The cell membrane layer significantly curtails photothermal loss (extending the heat retention by 17.62%) and stores energy within its phospholipid bilayer, boosting photothermal effects near implants (achieving a temperature increasement of 275%). Theoretical analysis indicates that these local heat preservation properties of the cell membrane arise from its low thermal conductivity and phase-change properties. In a Staphylococcus aureus-infected bone implant model, our coating demonstrates precise antibacterial action around implants (reach an antibacterial ratio of 99.52%). The synergetic locking function of cell membrane and pTA delays BP biodegradation, ensuring favorable photothermal stability and long-term osteo-inductive performance (increasing the bone volume fraction by 53.45%). Beyond providing an endogenic biointerface, this strategy extends the application of cell membrane in local thermal management, offering possibilities for effective and safe PTT modalities.

Computational influences of convection micropolar fluid influx and permeability on characteristics of heating rate and skin friction over vertical plate

This manuscript merits at examining of an embedded orthogonal plate inside porous domain exposed to uniform heat influx to elaborate on how micro polar fluid factors and permeability characteristic affect the local skin friction, heating rate, and angular velocity inside boundary layer. The plate is subjected to forced convective micro polar fluid influx under steady, incompressible, and viscous circumstances. To facilitate dependable numerical solution, similarity approach is implemented to mutate set of coupled governing equations relevant to the adopted study into a constrained dimensionless differential equations. Computational analysis has been executed hiring Runge-Kutta scheme by Matlab function bvp4c to settle the governing equations. Study's results are highlighted graphically the impact of micro polar fluid factors on the local skin friction, heating rate, and angular velocity curves. High degree of acceptability of present findings compare with prior research results. It is found that the rising of Darcy parameter drives to decrease linearly both heating rate and local skin friction. Among the examined factors, the benchmark parameter of decreasing skin friction is the porosity. Additionally, it is found that an increasing of Prandtl number and micro rotation element lead to enhance Nusselt number. Once curves of micro rotation are interfered at certain distance from the plate due to increase in porosity, Darcy, Forchheimer's, and microelement rotation, the micro rotation curves are inverted.

Thermo-Convective Solution Growth of Vertically Aligned Zinc Oxide Nanowire Arrays for Piezoelectric Energy Harvesting

The search for a synthesis method to create longer ZnO NWAs with high-quality vertical alignment, and the investigation of their electrical properties, have become increasingly important. In this study, a hydrothermal method for growing vertically aligned arrays of ZnO nanowires (NWs) using localized heating was utilized. To produce longer NWs, the temperature environment of the growth system was optimized with a novel reaction container that provided improved thermal insulation. At a process temperature above ~90 °C, ZnO NWs reached a length of ~26.8 µm within 24 h, corresponding to a growth rate of 1.1 µm/h, nearly double the rate of 0.6 µm/h observed in traditional chemical bath growth using a glass reactor. The densely grown NWs (~1.9/µm2), with a diameter of ~0.65 µm, exhibited a preferred hexagonal c-axis orientation and were vertically aligned to the (100) silicon (Si) substrate. These NW structures have multiple applications, e.g., in piezotronic strain sensors, gas sensing, and piezoelectric energy harvesting. As proof of concept, a piezoelectric nanogenerator (PENG) was fabricated by embedding the NWs in an S1818 polymer matrix over a 15 mm × 15 mm area. Under repeated impulse-type compressive forces of 0.9 N, a maximum peak output voltage of ~95.9 mV was recorded, which is higher by a factor of four to five than the peak output voltage of 21.6 mV previously obtained with NWs measuring ~1.8 µm in length.

Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing.

Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compare the microcirculatory function (transcutaneous oxygen pressure (TcPO2) on the foot and laser Doppler flowmetry on the arm) and several blood biological parameters between nine SCA patients with active LU (LU+) and 56 SCA patients with no positive history of LU (LU-). We also tested the effects of plasma from LU+ and LU- patients on endothelial cell activation. We observed a reduction of the TcPO2 in LU+ compared to LU- patients. In addition, LU+ patients exhibited lower cutaneous microvascular vasodilatory capacity in response to acetylcholine, current and local heating compared to LU- patients. Inflammation and endothelial cell activation in response to plasma did not differ between the two groups. Among the nine patients from the LU+ group, eight were followed and six achieved healing in 4.4 ± 2.5 months. Among thus achieving healing, microvascular vasodilatory capacity in response to acetylcholine, current and local heating and TcPO2 improved after healing. In conclusion, microcirculatory function is impaired in patients with LU, and improves with healing.