Heath Park Research Articles

Correspondence*

AnaesthesiaVolume 31, Issue 5 p. 702-703 Free Access Correspondence* Michael Rosen MB, FFARCS, Michael Rosen MB, FFARCS Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this authorG. Rees MB, FFARCS, G. Rees MB, FFARCS Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this authorJ. F. Pearson MD, J. F. Pearson MD Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this author Michael Rosen MB, FFARCS, Michael Rosen MB, FFARCS Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this authorG. Rees MB, FFARCS, G. Rees MB, FFARCS Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this authorJ. F. Pearson MD, J. F. Pearson MD Department of Anaesthetics, University Hospital of Wales, Heath Park, CardiffSearch for more papers by this author First published: June 1976 https://doi.org/10.1111/j.1365-2044.1976.tb11854.x * Correspondence should be addressed to the Editor of Anaesthesia, Association of Anaesthetists of Great Britain & Ireland, Tavistock House South, Tavistock Square, London WCIH 9JP, England. The Sub-Editor of this section is Dr Richard H. Ellis, Consultant Anaesthetist, St Bartholomew's Hospital, London. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume31, Issue5June 1976Pages 702-703 RelatedInformation

The Influence of Androgen—Receptor Complexes on Transcription by Rat and Human Prostatic Ribonucleic Acid Polymerases

s of Communications Meeting of the Biochemical Society Steroid Group held at Imperial College, London, 1 July 1975 HORMONAL. REGULATION OF MACROMOLECULAR SYNTHESES : a Colloquium organized by W. I. P. Mainwaring (London) The Influence of Androgen-Receptor Complexes on Transcription by Rat and Human Prostatic Ribonucleic Acid Polymerases PETER DAVIES Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardifs CF4 4XX, U.K. The many changes in cellular components that occur in a sensitive tissue in response to hormonal stimulation are largely secondary to the key molecular step at the genomic or transcriptional level, resulting in an enhancement of RNA synthesis (Williams-Ashman & Reddi, 1971 ; Jensen & DeSombre, 1972). The eukaryotic transcriptional machinery involves acomplexity of functional, structural and regulatory macromolecules, and RNA synthesis may be controlled at the level of chromatin template activity and activity, RNA polymerase activity, biosynthesis and pool size of RNA precursors or RNA processing and maturation. Androgenic influences in the rat ventral prostate gland are mediated by the metabolism of testosterone to 5a-dihydrotestosterone, the binding of this latter compound to proteins of selective high affinity and the transfer of the complex thus formed to nuclear acceptor sites with steroid and tissue specificity [see review by Minguell & Sierralta (1975)l. Previous investigations using reconstituted cell-free systems based on nuclei or on chromatin transcribed by purified prostatic RNA polymerases have shown that 5a-dihydrotestosterone-receptor complexes prepared from subcellular fractions of rat ventral prostate have significant stimulatory effects on the activities of discrete RNA polymerases from the same source (Davies & Griffiths, 1973a,b; 1974a,b). Studies on transcription of chromatin by solubilized RNA polymerases have shown that for stimulation to occur the steroid-receptor complex, rather than the steroid or receptor protein alone, must be present together with prostatic chromatin rather than chromatin from non-target tissues or naked DNA, the chromatin specificity depending on the presence of a small proportion of non-histone proteins tightly bound to the DNA (Davies & Griffiths, 1973a,b). The abilities of the specific cytoplasmic and nuclear steroid-receptor complexes to stimulate RNA polymerase activity to equivalent extents have been attributed to the ‘activation’ of the cytoplasmic form in the assay medium, causing it to undergo a temperature-dependent conversion into a form similar to that of the complex extractable from nuclear preparations (Davies & Griffiths, 1974b). Recent studies have indicated that the macromolecules specifically binding 5adihydrotestosterone in rat ventral prostate and human benign hypertrophic prostate have similar properties and that the cytoplasmic receptor complexes in each case may transfer the steroid to homologous or heterologous nuclear fractions of androgenVOl. 3

Evidence that the deferential vein acts as a local transport system for androgen in the rat and the dog: Pierrepoint, C. G., P. Davies, D. Millington and B. John: J. Reprod. Fert., [formula omitted]:293, 1975. Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XX, U.K.

Evidence that the deferential vein acts as a local transport system for androgen in the rat and the dog: Pierrepoint, C. G., P. Davies, D. Millington and B. John: J. Reprod. Fert., [formula omitted]:293, 1975. Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XX, U.K.

Horner's syndrome as a complication of lumbar epidural block

Two cases of Horner's syndrome complicating lumbar epidural block in pregnant women in labour are described. The aetiology of the complication is discussed and it is suggested that epidural injections should not be made while the patient is in the lithotomy position.

The clinical use of serum ferritin estimation.

British Journal of HaematologyVolume 31, Issue 1 p. 1-3 THE CLINICAL USE OF SERUM FERRITIN ESTIMATION A. Jacobs, Corresponding Author A. Jacobs Department of Haematology, Welsh National School of Medicine, Cardiff Professor A. Jacobs, Department of Haematology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XW.Search for more papers by this authorM. Worwood, M. Worwood Department of Haematology, Welsh National School of Medicine, CardiffSearch for more papers by this author A. Jacobs, Corresponding Author A. Jacobs Department of Haematology, Welsh National School of Medicine, Cardiff Professor A. Jacobs, Department of Haematology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XW.Search for more papers by this authorM. Worwood, M. Worwood Department of Haematology, Welsh National School of Medicine, CardiffSearch for more papers by this author First published: September 1975 https://doi.org/10.1111/j.1365-2141.1975.tb00825.xCitations: 29AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume31, Issue1September 1975Pages 1-3 RelatedInformation

Demonstration of a specific cytosol receptor in the normal and hyperplastic canine prostate for 5α-androstane-3α, 17α-diol: Evans, C. R. & C. G. Pierrepoint., J. Endocr.: [formula omitted](3):539–548, 1975. Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XX, England

Demonstration of a specific cytosol receptor in the normal and hyperplastic canine prostate for 5α-androstane-3α, 17α-diol: Evans, C. R. & C. G. Pierrepoint., J. Endocr.: [formula omitted](3):539–548, 1975. Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XX, England

LOST PORTRAIT OF DR. DAVID DANIEL DAVIS

Journal Article LOST PORTRAIT OF DR. DAVID DANIEL DAVIS Get access GLYNNE R. JONES, M.B., M.R.C.P., F.S.A.(Scot.) GLYNNE R. JONES, M.B., M.R.C.P., F.S.A.(Scot.) University Hospital of WalesWard B.7, Heath Park, Cardiff, CF4 4XW Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 20, Issue 4, April 1973, Pages 143-b–143, https://doi.org/10.1093/nq/20-4-143b Published: 01 April 1973

Potassium and the anaesthetist. A review.

AnaesthesiaVolume 28, Issue 2 p. 118-131 Free Access Potassium and the anaesthetist A review R. S. VAUGHAN, Corresponding Author R. S. VAUGHAN MBBS, FFARCS, Lecturer, Department of Anaesthetics, Welsh National School of Medicine.Dr R.S. Vaughan, Department of Anaesthetics, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN.Search for more papers by this authorJ.N. LUNN, J.N. LUNN MD, FFARCS, Senior Lecturer, Department of Anaesthetics, Welsh National School of Medicine.Search for more papers by this author R. S. VAUGHAN, Corresponding Author R. S. VAUGHAN MBBS, FFARCS, Lecturer, Department of Anaesthetics, Welsh National School of Medicine.Dr R.S. Vaughan, Department of Anaesthetics, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN.Search for more papers by this authorJ.N. LUNN, J.N. LUNN MD, FFARCS, Senior Lecturer, Department of Anaesthetics, Welsh National School of Medicine.Search for more papers by this author First published: March 1973 https://doi.org/10.1111/j.1365-2044.1973.tb00303.xCitations: 21AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume28, Issue2March 1973Pages 118-131 ReferencesRelatedInformation

The effect of local anaesthetics on lipolysis in fat-cells

Research Article| November 01 1972 The effect of local anaesthetics on lipolysis in fat-cells K Siddle; K Siddle 1Department of Chemical Pathology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: This Site PubMed Google Scholar C N Hales C N Hales 1Department of Chemical Pathology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 130 (1): 34P. https://doi.org/10.1042/bj1300034P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation K Siddle, C N Hales; The effect of local anaesthetics on lipolysis in fat-cells. Biochem J 1 November 1972; 130 (1): 34P. doi: https://doi.org/10.1042/bj1300034P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.