The present study examines the comparison of heat transfer properties of magnetohydrodynamic (MHD) rotating traditional nanofluid with that of developing hybrid nanofluid. A new kind of standard fluid, “hybrid nanofluid” is used to improve heat transfer in boundary layer flow. Silver (Ag) and copper oxide (CuO) nano-size particles are considered to constitute our desired hybrid nanofluid. The rotation of nanofluid is accomplished about the vertical axis so that “angular velocity”, ω∗, is constant. The system of nonlinear and coupled ordinary differential equations is handled using numerical approach BVP-4C with shooting procedure. From the present research, it is noticed that, even in the presence of magnetic field, the rate of heat transfer of hybrid nanofluid (Ag–CuO/water) is higher than that of ordinary nanofluid (CuO/water). In hybrid nanofluid, the required rate of heat transfer can be accomplished by picking distinctive and suitable nanoparticle extents.