This study numerically examines active CPU cooling using hybrid nanofluids in a novel heatsink design. The proposed heatsink is a parallelepiped block filled with Al2O3-CuO/water nanofluid, traversed by four strategically placed cooling tubes. It meticulously investigates the effects of CPU temperature (10³ ≤ Ra ≤ 10⁶) and magnetic field strength (0 ≤ Ha ≤ 100) on overall cooling capacity. With hybrid nanofluids, heat transfer and cooling efficiency are substantially improved, according to comprehensive finite element analysis conducted in COMSOL Multiphysics. The study provides valuable insights for designing high-performance CPU cooling systems, carefully considering nanofluid properties, diverse thermal conditions, and complex magnetic effects. The promising results show that using advanced hybrid nanofluids and an optimized magnetic field can significantly enhance the cooling performance of modern high-powered CPUs. The groundbreaking research highlights the immense potential of combining cutting-edge nanotechnology and magnetohydrodynamics in innovative thermal management solutions. This novel approach could lead to more efficient, compact, and adaptable cooling systems for next-generation electronic devices, effectively addressing the persistent challenge of heat dissipation in high-performance computing environments.