The catalytic total oxidation of propane over platinum was investigated experimentally and numerically at pressures of 1–7 bar and catalyst temperatures up to 700 K. A wire microcalorimeter was employed to determine the global rate parameters of the catalytic reaction within the kinetically controlled regime. For 1 bar pressure, the dissociative adsorption of C3H8 on Pt and its subsequent decomposition were modeled as two lumped steps based on global reaction parameters. A detailed and thermodynamically consistent catalytic mechanism was constructed by incorporating these lumped steps with an existing atmospheric-pressure H-C2 elementary reaction model. Two-dimensional CFD simulations using the developed global and detailed reaction mechanisms closely reproduced the measured heat release rates. The intricate dependence of catalytic ignition and reactivity on pressure was further elucidated. Ignition temperatures were found to be linearly correlated to pressures, due to the weaker net adsorption of oxygen compared to that of propane, which progressively aggravated at higher pressures and in turn hindered ignition. More importantly, a non-monotonic pressure dependence of the C3H8 catalytic reactivity on Pt, which gradually diminishes with increasing temperatures, is reported for the first time. The temperature range of this non-monotonic behavior (< 650 K) is of special importance for part-load and idling operations of gas turbines using hybrid hetero-/homogeneous combustion approaches and for normal operations of recuperative microreactors. Thus, this work provides key information for the design and optimization of such devices utilizing Pt as catalyst.