An improved wall boiling model with consideration of thin film heat transfer was employed with the Eulerian two-fluid model to investigate the three-dimensional flow boiling characteristics in a fuel assembly with 5 by 5 rod bundle and a vaned grid. Models were validated by using the experimental data for subcooled boiling, post-dryout heat transfer and critical heat flux. The calculated results agreed well with experimental data. Thermohydraulics in the rod bundle were obtained, including temperature, velocity, phasic volume fraction and pressure, based on which, the effects of mixing vane on the localized thermohydraulics were studied. Mixing vane can significantly reduce the cross section averaged vapor fraction and increase the heat transfer capacity due to the swirl effects on two-phase flow; however, it will increase the localized vapor fraction on the heated surface, which may result in the anticipation of boiling crisis, i.e., reach the critical heat flux. Besides, influences of heat flux profile on the flow and heat transfer characteristics were also obtained by comparing two cases with uniform and cosine heat flux distribution along the axial direction. Finally, the impacts of thin film heat transfer on the wall heat partition were investigated, proving that thin film heat transfer played an essential role in the modeling of wall boiling when the vapor fraction at heated surface exceeding 0.25.