Time-dependent transient heat conduction problems are widely encountered in aerospace, civil engineering, metallurgical engineering, etc., and for such problems, accurate and fast numerical approaches have always attracted attention in the past decades. To achieve this goal, this paper proposes an unconditionally stable single-step time integration method for general transient heat conduction systems. In the proposed method, the temperature vector and its time derivative are formulated independently by the Langrage interpolation function, and then the relation between the temperature vector and its time derivative is defined with the weighted residual method. Theoretical analysis, including convergence rate and amplification factor, illustrates that the proposed method is strictly second-order accurate for the temperature vector and its time derivative, and it has the strong algorithmic dissipation (L-dissipation), meaning that it can quickly filter out the unwanted numerical oscillations in the high-frequency range. At present, most existing time integration methods, such as the Crank-Nicolson method and the Galerkin method, are unconditionally stable for linear transient heat conduction systems, but they are conditionally stable for nonlinear ones. To this end, this work improved the stability analysis theory for nonlinear transient heat conduction systems proposed by Hughes and used the improved stability analysis theory to design the free parameters of the proposed method. Because of this reason, the proposed method is unconditionally stable for both linear and nonlinear transient heat conduction problems. Due to the desirable algorithmic stability, the proposed method can still provide accurate and stable predictions for nonlinear transient heat conduction problems where the excellent Crank-Nicolson method fails. Some linear and nonlinear transient heat conduction problems are solved in this paper, and the results of these problems show that compared to the currently popular time integration methods, such as the Crank-Nicolson method and the backward difference formula, the proposed method enjoys noticeable advantages in accuracy, dissipation and stability.