Heart Valve Research Articles

Mid-term outcomes of valve replacement surgery with or without coronary artery bypass grafting in patients with overweight and obesity: A cohort study.

Current data evaluating outcomes of valve replacement surgery in patients with overweight/obesity is contradictory. There is a scarce study comparing outcomes of valve surgery considering the type of valve involved in the procedure. We followed outcomes in patients with overweight and obesity after valve replacement surgery with or without coronary artery bypass graft (CABG) and also patients with aortic valve replacement (AVR) and mitral valve replacement (MVR), separately to compare their mid-term prognosis in each group. Consecutive patients who had undergone cardiac valve surgery with or without CABG in Tehran Heart Center were enrolled. We enrolled 3158 patients. Median survival was 125.71 ± 82.20 weeks in patients with overweight/obesity. We found a significantly higher LVDd, LVDs and RVDd in patients with CABG (51.85 ± 7.31, 36.80 ± 8.81 and 30.04 ± 3.58, respectively) compared to the valve group (50.10 ± 6.35 mm, 35.08 ± 7.29 mm and 29.76 ± 4.07 mm, respectively). All-cause mortality is significantly higher in patients with AVR (5.7%) than those with MVR (3.3%). Patients with CABG are at higher risk of myocardial infarction (MI) compared to the ones without CABG (0.8% vs. 0.1%). No significant interaction was observed between the type of valve surgery (AVR/MVR) or valve surgery combinations (valve/valve + CABG) (p-values = .81 vs. .97, respectively). Post-operative outcomes in patients with overweight/obesity depend on several factors such as type of valve involved and presence of CABG. Risk management can lower the rate of mortality and morbidity in these patients.

Prosthetic valve dysfunction in patients with mechanical heart valves: Results from the Emergency Salam Centre cohort

IntroductionMechanical heart valve (MHV) replacement requires long-life anticoagulation due to the risk of Prosthetic Valve Dysfunction (PVD) and cardioembolism. MethodsWe report data from a prospective observational study conducted on MHV patients in the Khartoum Salam Centre for Cardiac Surgery built by ‘Emergency,’ an Italian Non-Governmental Organization, to evaluate the occurrence of PVD and associated risk factors. ResultsWe prospectively followed 3647 patients, and 38 patients (rate 1.04 × 100 pt-years) had PVD during follow-up. The time in therapeutic range (TTR) among patients without PVD was 53 % (IQR 37–67), and it was 43 % (IQR 19–58) among patients with PVD (p = 0.04). Twenty-three over 38 patients (60.5 %) were symptomatic, 18 (47.4 %) had obstructive valvular stenosis, 24 patients (63.2 %) had INR <2.0 at diagnosis, and 21 patients (55.3 %) had been off warfarin for a long time: 3 patients for 1 week, 1 patient for 2 weeks, and 17 patients for >4 weeks (6 patients were off warfarin from 3 to 12 months). Ten were uncompliant to treatment, and 8 were pregnant women. Ten patients (26.3 %) with PVD had had a previous episode of PVD, and 14 patients (36.8 %) had 2 or more associated risk factors. Only in 6 cases were no associate risk factors found. ConclusionsAmong MHV patients on warfarin treatment with a sub-optimal quality of anticoagulation, the rate of PVD is 1.04 % pt-years, and the most frequent associated risk factor for PVD occurrence is warfarin withdrawal lasting more than one week.

Clinical Effects of Hospital–Family Collaborative Cardiac Rehabilitation Training on Patients with Heart Failure after Cardiac Valve Prostheses

Background: Affected by factors, such as patients' age, course of disease, and underlying diseases, patients have high complications after cardiac valve replacement. This study applied hospital–family collaborative cardiac rehabilitation training to patients with heart failure undergoing cardiac valve prostheses and explored the clinical effect to provide guidance for postoperative rehabilitation. Methods: The clinical data of 213 patients with heart failure admitted to our hospital from January 2023 to January 2024 were retrospectively analyzed. After 12 cases who did not meet the inclusion criteria were excluded, 201 cases were finally included. In accordance with different nursing methods, patients were divided into reference group (n = 102) and observation group (n = 99). The reference group received routine nursing program, whereas the study group adopted hospital–family collaborative cardiac rehabilitation training on the basis of routine nursing. The levels of cardiac function indices [left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and stroke volume (SV)], quality of life, cardiovascular risk factors [total cholesterol (TC), triglyceride (TG), and fasting blood glucose (FBG)] and the rehospitalization rate were compared between the two groups. Results: Before management, the levels of LVEF, LVEDV, LVESV, SV, quality-of-life scores, TC, TG, and FBG in the two groups were similar (p &gt; 0.05). After management, the observation group had higher levels of LVEF, LVEDV, LVESV, and SV (p &lt; 0.001); a better quality of life (p &lt; 0.001); lower levels of TC, TG, and FBG (p &lt; 0.001); and a lower rehospitalization rate (p &lt; 0.05) than the reference group. Conclusion: Hospital–family collaborative cardiac rehabilitation training seems to improve the cardiac function indices of patients undergoing cardiac valve prostheses, and it has a certain clinical application value. However, the results should be promoted with caution, and more studies are needed to verify them.

Precisely Engineering a ROS‐Regulatable Decellularized Matrix to Rejuvenate Endogenous Repair for Heart Valve Remodeling in Diabetic Cohort

AbstractThe reconstruction of a heart valve through in situ tissue engineering remains a formidable challenge, particularly for patients with diabetes mellitus, because the pathophysiological alterations associated with diabetes substantially impair the cardiovascular system's intrinsic repair capacity. In this study, reactive oxygen species (ROS) regulation are integrated into the fabrication of pro‐endothelialization interfaces to counteract the adverse repair environment. Specifically, a heparin‐mimicking alginate‐derived glycopeptide and the natural ROS scavenger melanin are modified onto the surface of a decellularized extracellular matrix (dECM). This tailored interface significantly enhances endothelial cell (EC) adhesion while reducing platelet adhesion. The incorporation of melanin effectively suppresses ROS elevation in ECs and macrophages under hyperglycemic conditions. Consequently, this intervention promotes EC rejuvenation by enhancing proliferation, migration, and anti‐apoptotic capabilities, while concurrently attenuating the release of inflammatory and pro‐fibrotic factors by macrophages. The dECM is intravascularly implanted in a diabetic rabbit model after being fabricated into a covered stent, demonstrating favorable remodeling characteristics such as enhanced endothelialization and reduced fibrotic deposition. This scaffold design, specifically tailored to the pathological conditions of diabetes, offers a precise biomaterial strategy for in situ heart valve tissue engineering.

Mitral valve infective endocarditis as a manifestation of disseminatedCryptococcus neoformans infection: a case report

Infective endocarditis is a disease that affects mainly the endocardial surface of the heart and cardiac valves (native or prosthetic). The main risk factors for developing infective endocarditis are male sex, older age, intracardiac shunts, prosthetic valves, rheumatic, and congenital heart disease, intracardiac devices, intravenous drugs use, immunosuppression, and hemodialysis. Streptococci and Staphylococci spp. have been the most frequent isolated organisms. On the other hand, the most common fungal organism in infective endocarditis is Candida albicans (24-46%), followed by Aspergillus spp. (25%), and a few cases by Cryptococcus neoformans, which are associated with higher rate of mortality. This case provides an interesting case of Cryptococcus neoformans native valve infective endocarditis in a young woman with stage IV chronic kidney disease and severe malnutrition.

Implementation of Support Vector Machine (SVM) for Classification of Heart Failure Patients (Case Study: Prabumulih City Hospital)

The heart is a vital organ that functions as a blood pump to meet the body's oxygen and nutrient needs. Disorders of the heart can result in disruptions to blood circulation, underscoring the importance of maintaining heart health to prevent heart disease. The optimal function of the heart depends on the condition of the cardiac muscles, valves, and proper pumping rhythm. Heart failure, as one of the heart diseases, refers to the heart's inability to meet the body's blood demands. The management of heart disease involves comprehensive medical services provided in hospitals. One effort to improve the quality of healthcare services is to enhance the performance of hospitals. The Regional General Hospital of Kota Prabumulih is one healthcare institution that addresses various diseases, including heart disease. However, the classification process for heart disease at the Regional General Hospital is still conducted manually, consuming time and inefficient. To address this issue, the development of an intelligent system capable of classifying heart failure based on patient symptoms is necessary. This research proposes the implementation of the Support Vector Machine (SVM) method as a classification model, which is a high-dimensional hypothesis learning system. It is hoped that this system can assist medical professionals in determining the initial steps in managing heart failure quickly and effectively.

Successful transcatheter aortic valve implantation in a high-risk nonagenarian in Sri Lanka

Severe calcific aortic stenosis with repeated heart failure hospital admissions carries a high mortality and morbidity in the elderly. Despite a calculated high risk of periprocedural complications, Sri Lanka's first transcatheter heart valve replacement in an over 90-year-old patient in such a clinical condition could be performed with no major in-hospital adverse cardiac or cerebral events. Improved quality of life with freedom from repeated hospitalizations is an important clinical achievement in this age group following transcatheter heart valve therapy.

Phonocardiogram (PCG) Murmur Detection Based on the Mean Teacher Method.

Cardiovascular diseases (CVDs) are among the primary causes of mortality globally, highlighting the critical need for early detection to mitigate their impact. Phonocardiograms (PCGs), which record heart sounds, are essential for the non-invasive assessment of cardiac function, enabling the early identification of abnormalities such as murmurs. Particularly in underprivileged regions with high birth rates, the absence of early diagnosis poses a significant public health challenge. In pediatric populations, the analysis of PCG signals is invaluable for detecting abnormal sound waves indicative of congenital and acquired heart diseases, such as septal defects and defective cardiac valves. In the PhysioNet 2022 challenge, the murmur score is a weighted accuracy metric that reflects detection accuracy based on clinical significance. In our research, we proposed a mean teacher method tailored for murmur detection, making full use of the Phyionet2022 and Phyionet2016 PCG datasets, achieving the SOTA (State of Art) performance with a murmur score of 0.82 and an AUC score of 0.90, providing an accessible and high accuracy non-invasive early stage CVD assessment tool, especially for low and middle-income countries (LMICs).

Impact of prior hospitalization for heart failure on clinical outcomes of patients after transcatheter aortic valve implantation with new-generation devices: Insights from the LAPLACE-TAVI registry.

A history of hospitalization for heart failure (HHF) before transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement is associated with the prognosis of patients with severe aortic stenosis (AS). However, the impact of prior HHF on clinical outcomes after contemporary TAVI using new-generation transcatheter heart valves (THVs) has not been thoroughly investigated. Using data from the aLliAnce for exPloring cLinical prospects of AortiC valvE disease (LAPLACE)-TAVI registry, we investigated 2,752 patients who underwent TAVI with new-generation THVs with a median follow-up of 627 days. The primary outcomes were all-cause mortality and heart failure readmission after TAVI. Patients with a history of HHF (n = 809) showed a higher 30-day mortality than patients without prior HHF (n = 1,943). A Kaplan-Meier analysis revealed that the prior HHF group showed a higher incidence of the primary outcome than the non-prior HHF group (27.4% vs. 16.4%, log-rank p = 0.001). In a Cox regression analysis, prior HHF was significantly associated with the risk of the primary outcome, even after adjusting for covariates (hazard ratio, 1.344; 95% confidence interval, 1.103-1.638; p = 0.003). A subanalysis showed that the prior HHFgroup with ejection fraction (EF) ≥ 50% had a higher risk of the primary outcome than the non-prior HHFgroup, whereas the prior HHF group with EF < 50% had the worst outcome. A history of prior HHF is associated with worse outcomes in patients with severe AS, both in those with preserved EF and those with reduced EF, even after TAVI using new-generation devices.

The novel balloon-expandable Myval transcatheter heart valve: systematic review of aortic, mitral, tricuspid and pulmonary indications

Introduction and objectivesMyval technology represents the first balloon-expandable alternative since the Edwards system became commercially available. Despite certain controversies, its use has rapidly expanded. We aimed to gather all the available literature regarding its indications and outcomes. MethodsA comprehensive search of articles published between December 2016 and May 2024 was conducted using BioMedCentral, Google Scholar, and PubMed to evaluate the main outcomes of Myval for native aortic stenosis (AS) (meta-analysis) and off-label uses (systematic review). ResultsA total of 151 studies were identified, and 74 were included in the analysis, covering aortic (n=51), mitral (n=9), tricuspid (n=6), and pulmonary (n=8) valve positions. A meta-analysis of studies on native AS demonstrated that Myval is safe and effective, with a 30-day mortality rate of 1.3%, good hemodynamic performance, low rates of pacemaker implantation (8.8%), and ≥ moderate paravalvular regurgitation (1.3%). Compared with other contemporary devices, Myval was competitive and associated with lower rates of pacemaker implantation. In a systematic review of off-label indications, Myval was also found to be safe and effective. In bicuspid AS, pure regurgitation, and aortic valve-in-valve procedures, success rates were 100%, 92%, and 100%, respectively, with pacemaker rates of 9.9%, 22.2%, and 3%, respectively. For mitral valve-in-valve/in-ring procedures, the success rate was 96.9%, while in tricuspid and pulmonary positions, small case series reported 100% success rates for both, with minimal procedural complications. ConclusionsMyval technology is safe and effective for the treatment of native valvular disease and dysfunctional prostheses or rings in all heart valve positions, although larger scale studies are warranted.

Inequalities in access to and outcomes of cardiac surgery in England: retrospective analysis of Hospital Episode Statistics (2010–2019)

BackgroundWe aimed to characterise the variation in access to and outcomes of cardiac surgery for people in England.MethodsWe included people >18 years of age with hospital admission for ischaemic heart...

THE POSSIBILITY OF DONATION OF ORGANS AND TISSUES

Organ and tissue donation is a very important subject in our society in general. I intend to discuss what organ donation is. The importance of organ and tissue donation. About the importance of awareness. Organ or tissue donation is an act by which the living individual decides to help in the treatment of other people. Donation may be from organs (kidney, liver, heart, pancreas and lung) or tissue (cornea, skin, bones, heart valves, cartilage, bone marrow and umbilical cord blood). The donation of organs such as the kidney, part of the liver and bone marrow can be done in life. For the donation of organs of deceased persons, only after the confirmation of the diagnosis of brain death can the procedure be performed. The most common is that it happens to people who suffer some kind of accident that causes head trauma, or who are victims of a stroke (stroke) and evolved to brain death. To understand the transplantation of the organs it is necessary to emphasize that the right to separate parts of the living or dead body integrate the personality, according to the understanding of Maria Helena Diniz (2006, p.249). Most of the time, organ transplantation may be the only life expectancy or the opportunity for a fresh start to about 40,000 patients waiting in the queue for Brazil. The gesture of family members who lose a loved one and decide to donate is an act of life, altruism and generosity, as a single donor can benefit at least ten people and make the difference between life and death. Brazil has the largest public transplant system in the world, responsible for financing about 95% of transplants. It is the second country in absolute number of transplants, behind only the United States.

ENDOCARDITE E MIOCARDITE SECUNDÁRIA A COXSACKIEVIRUS: UM RELATO DE CASO

Myocarditis is marked by the infiltration of leukocytes in myocytes (heart muscles), while endocarditis is an infection of the inner lining and/or heart valves, usually of bacterial cause, which may or may not induce the formation of thrombi. Among the causes, infectious is prevalent, with Coxsackievirus B being one of the most common in the pediatric age group. The objective of this work is to report a case of myocarditis and endocarditis secondary to Coxsackievirus in order to train health professionals in the diagnosis and treatment of children with this pathology. A descriptive observational study was carried out by analyzing the medical records of a patient treated in the emergency room of a secondary hospital in the Federal District. To describe the case and discussion, a literature analysis was carried out in the UptoDate and American Heart Association databases, selecting the most relevant articles. The case reported is a male patient, 6 years old, previously healthy, who developed fever and asthenia seeking emergency care. In complementary exams, condensation of the middle lobe and cardiomegaly were visualized. With pneumonia and myocarditis suspected, the child was hospitalized and antibiotics were started. In subsequent investigations, thrombus/vegetation was identified on echocardiogram, increased D-dimer and serology with positive IgM antibodies to Coxsackie virus. He underwent treatment with Cefepime and Enoxaparin, showed clinical improvement and 4 months after diagnosis, the echocardiogram and serology for the virus in question were normal.

Emerging magnetic-responsive hydrogel actuators with anisotropic shape for intracardiovascular directional motion

A magnetically responsive valve actuator inspired by the starfish shape and fabricated with hydrophilic and hydrophobic surfaces was developed. The surface morphology and wettability of the magnetically responsive colloidal crystal hydrogel actuator were characterized using scanning electron microscopy and contact angle measurements. The actuator, resembling a flower, consists of Poly(HEMA-co-AAm)/Fe3O4/PDMS, exhibiting distinct Janus wettability with hydrophobic Fe3O4/PDMS and hydrophilic Poly(HEMA-co-AAm) surfaces. The directional movement of water droplets on the V-shaped structured film confirmed the anisotropic wetting behavior, influenced by the film’s wettability and structural dimensions. Moreover, the actuator demonstrated responsive angular and positional adjustments under varying magnetic fields, facilitated by embedded Fe3O4 particles aligning with magnetic lines of force. In experimental setups simulating intravascular applications, the actuator exhibited controlled movement within tubes and demonstrated effective adhesion to heart valve injuries under magnetic guidance. Additionally, a layered inverse opal film within the actuator showed promising capabilities for unidirectional fluid permeation, enhancing its functional versatility. These findings underscore the potential of the magnetically responsive colloidal crystal hydrogel actuator for biomedical applications, particularly in minimally invasive cardiac interventions requiring precise actuation and adhesive functionalities.

Cure and Prevention of Cardiovascular Diseases: Herbs for Heart

Context: Cardiovascular diseases (CVDs) account for 30% of deaths worldwide, making them the leading cause of mortality. Prosthetic valve endocarditis (PVE) is a microbial infection that occurs on the surface of a prosthetic valve or on a surgically reconstructed native heart valve. As age increases, the mortality rate from CVDs also rises. Additionally, gender differences were observed, with the mortality rate from cardiovascular disease being higher in women (51%) compared to men (42%). Methods: In this review study, English keywords such as "medicinal plants," "heart," "cardiomyopathy," and "cinnamaldehyde," as well as Persian keywords related to "medicinal plants" and "cardiovascular," were used in the title and abstract of articles. Databases including PubMed, Science Direct, Web of Science, Google Scholar, Scopus, and the academic database of Jihad Daneshgahi were searched without a time limit until March 2021. Results: The results show that several medicinal plants are known to effectively treat CVDs. Conclusions: The findings of this review indicate that medicinal plants have a positive impact on the treatment of cardiovascular diseases and can be considered as potential therapeutic options for managing these conditions.

Pentadecanoic Acid-Releasing PDMS: Towards a New Material to Prevent S. epidermidis Biofilm Formation

Microbial biofilm formation on medical devices paves the way for device-associated infections. Staphylococcus epidermidis is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against S. epidermidis of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS). This material exerted an antibiofilm activity by releasing PDA; however, a toxic effect on bacterial cells was observed, which could potentially favor the emergence of resistant strains. To develop a PDA-functionalized material for medical use and overcome the problem of toxicity, we produced PDA-doped PDMS by either spray-coating or PDA incorporation during PDMS polymerization. Furthermore, we created a strategy to assess the kinetics of PDA release using ADIFAB, a very sensitive free fatty acids fluorescent probe. Spray-coating resulted in the most promising strategy as the concentration of released PDA was in the range 0.8–1.5 μM over 21 days, ensuring long-term effectiveness of the antibiofilm molecule. Moreover, the new coated material resulted biocompatible when tested on immortalized human keratinocytes. Our results indicate that PDA spray-coated PDMS is a promising material for the production of medical devices endowed with antibiofilm activity.

4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves - a Pilot Study.

The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging techniques in the in-vitro analysis of hemodynamics in anatomical models. Specifically, by looking at the hemodynamic performance of state-of-the-art surgical heart valves in a 3D-printed aortic arch. The mock circulatory loop simulated physiological, pulsatile flow. Two mechanical and three biological aortic valves prostheses were compared in a 3D-printed aortic arch. 4D magnetic resonance imaging and vector flow Doppler ultrasound served as imaging methods. Hemodynamic parameters such as wall shear stress, flow velocities and pressure gradients were analyzed. The flow analysis revealed characteristic flow-patterns in the 3D-printed aortic arch. The blood-flow in the arch presented complex patterns, including the formation of helixes and vortices. Higher proximal peak velocities and lower flow volumes were found for biological valves. The mock circulatory loop in combination with modern radiological imaging provides a sufficient basis for the hemodynamic comparison of aortic valves.

Infectious endocarditis complicated with intracranial infected aneurysm rupture and sinus of valsalva aneurysm rupture

BackgroundInfectious endocarditis (IE) is an infectious disease caused by direct invasion of the heart valve, endocardium, or adjacent large artery endocardium by pathogenic microorganisms. Despite its relatively low incidence, it has a poor prognosis and a high mortality. Intracranial infectious aneurysms (IIA) and ruptured sinus of Valsalva aneurysm (RSVA) are rare complications of IE.Case presentationWe report a young male patient with symptoms of respiratory tract infection, heart murmurs and other symptoms and signs. The patient also had kidney function impairment and poor response to symptomatic therapy. Blood culture was negative, but echocardiography was positive, which met the diagnostic criteria for infective endocarditis. Moreover, an echocardiography showed a ruptured sinus of Valsalva aneurysm with a ventricular septal defect. Finally, secondary rupture of an IIA with multiple organ damage led to a poor clinical outcome.ConclusionTherefore, in the clinical setting, for young patients with unexplained fever, chest pain, or palpitations, we need to be highly vigilant, considering the possibility of infective endocarditis and promptly performing blood culture, echocardiography, cerebrovascular imaging and so on, in order to facilitate early proper diagnosis and treatment.

Numerical model of the aortic valve prosthetic frame

Aim: To perform a quantitative analysis of the effectiveness of three concepts of heart valve prosthesis support frames from the perspective of their safety under the most critical loads, conducted through numerical modeling.Materials and Methods. The study utilized three computer-generated concepts of stent-like support frames, created based on the analysis of similar balloon-expandable prostheses. The modeling was conducted using Abaqus/CAE software and included the analysis of two key loads characteristic for this element: compression and implantation phases. A linear description of cobalt-chromium was used as the material model. The feasibility of the concepts was quantitatively assessed using von Mises stress and its qualitative distribution on the surface of the models as stress contours.Results. The analysis revealed that two of the three proposed models experienced stresses exceeding the strength limit (933 MPa) – 999.6 and 954.0 MPa during the compression phase and reaching 1022.4 and 1044.7 MPa, respectively, during the implantation phase. Concept 3 had significantly lower stresses during loading; however, in the working state, the indicators approached the threshold, reaching 924.2 MPa.Conclusion. Numerical modeling identified the inefficacy of concepts 1 and 2 and directions for optimizing concept 3 – reducing amplitudes to form a “strength reserve” for stress. The analysis emphasized the importance of numerical modeling in the early assessment and optimization of medical devices.

Causal relationship between immunophenotypes and mitral valve prolapse: a bidirectional Mendelian randomization study.

Emerging evidence indicates a significant link between various immune cell types and the development of heart valve disorders. Mitral valve prolapse (MVP) is a common condition that can lead to heart failure, arrhythmias, and even sudden death. Currently, the role of immune cells in MVP is not well understood. Thus, this study aimed to explore the causal relationship between immunophenotypes and the risk of MVP. This study conducted a two-sample Mendelian randomization (MR) analysis to examine the link between 731 immunophenotypes and MVP. Publicly available data from genome-wide association studies were used for both the exposures and outcomes. The primary method for assessing the causal relationship between mitral valve prolapse and the 731 immunophenotypes was the inverse variance weighted method. Additionally, to ensure the MR results were reliable and valid, sensitivity analyses, including leave-one-out analysis, the Cochran Q-test, and the Egger intercept test, were conducted. The findings indicated that multiple immune cell phenotypes potentially cause changes in the risk of developing MVP. After adjusting for the false discovery rate, nine immune phenotypes were found to increase the risk of MVP, while nine others appeared to decrease it. In addition, reverse MR analysis found no causal relationship between MVP and these eighteen immunophenotypes. Through genetic analyses, this research demonstrated a significant causal relationship between certain immune cells and MVP, providing new insights for future basic and clinical research.