Heart Pump Research Articles

"Form follows function": the developmental morphology of the cardiac atria.

Although the heart atria have a lesser functional importance than the ventricles, atria play an important role in the pathophysiology of heart failure and supraventricular arrhythmias, particularly atrial fibrillation. In addition, knowledge of atrial morphology recently became more relevant as cardiac electrophysiology and interventional procedures in the atria gained an increasingly significant role in the clinical management of patients with heart disease. The atrial chambers are thin-walled, and several vessels enter at the level of the atria. The left and right atrium have different structures and shape. In general, both atrial chambers have the venous part, the appendage, and the vestibule; different aspects of each part allow us to distinguish morphologically between the left and right atrium. The human atrial conduction system consists of the sinus node and the atrioventricular node with no histologically specialized conduction pathways in the atrial chamber and an interatrial connection. The data show that the propagation of the impulse depends mainly on the myocardial architecture in the atria and the orientation of the myocytes plays a significant role in conduction. To complete the picture, it is also important to know how the atria develop and what is the embryonic origin of its different structures, as this may play a role in the development of some pathological conditions such as atrial fibrillation or certain types of congenital heart defects. Functional impairment of the atria can in some situations severely compromise heart pumping function, and conversely, can support it if other areas are damaged, balancing the blood flow to the body for some time. Key words Morphology of atrial chambers, Pectinate muscles, Atrial function.

Advancing 3D Engineered In Vitro Models for Heart Failure Research: Key Features and Considerations.

Heart failure is characterized by intricate myocardial remodeling that impairs the heart's pumping and/or relaxation capacity, ultimately reducing cardiac output. It represents a major public health burden, given its high prevalence and associated morbidity and mortality rates, which continue to challenge healthcare systems worldwide. Despite advancements in medical science, there are no treatments that address the disease at its core. The development of three-dimensional engineered in vitro models that closely mimic the (patho)physiology and drug responses of the myocardium has the potential to revolutionize our insights and uncover new therapeutic avenues. Key aspects of these models include the precise replication of the extracellular matrix structure, cell composition, micro-architecture, mechanical and electrical properties, and relevant physiological and pathological stimuli, such as fluid flow, mechanical load, electrical signal propagation, and biochemical cues. Additionally, to fully capture heart failure and its diversity in vivo, it is crucial to consider factors such as age, gender, interactions with other organ systems and external influences-thereby recapitulating unique patient and disease phenotypes. This review details these model features and their significance in heart failure research, with the aim of enhancing future platforms that will deepen our understanding of the disease and facilitate the development of novel, effective therapies.

Entropy Analysis in Magnetized Blood-Based Hybrid Nanofluid Flow via Parallel Disks

Magnetized hybrid nanofluid combined with ferrite and silver in a blood-based liquid presents their vital role in several aspects such as artificial heart pumping system, drug delivery process, the flow of blood in the artery, etc. This is because the high heat transportation rate of the nanofluid is caused by the inclusion of nanoparticles. The current investigation is based on the characteristic of particle concentration comprised of Fe3O4 and Ag in the base liquid blood that passed in between two infinite parallel disks filled with porous matrix. The electrically conducting fluid associated to maximum of 1.5% of volume concentration from each of the solid particles affects the flow phenomena. However, the impact of thermal radiation vis-à-vis the heat dissipation provides efficient heat transport properties with the inclusion of the effective thermal conductivity assumed from the Hamilton-Crosser model. The proposed conductivity model describes the role of particle shapes on the enhanced thermal properties. Further, numerical treatment is obtained for the transformed designed problem following similarity rules that are used for the conversion of the governing equations into their non-dimensional form. The computation of various flow profiles leads to get the entropy generation due to the irreversibility processes. Along with the fluid velocity and temperature distributions, the study is carried out for the entropy as well as the computation of Bejan number and afterwards the simulation of the shear and heat transportation rate are also depicted graphically. The main finding of the proposed study is that solid particle concentrations have a substantial impact to increasing fluid velocity in magnitude, resulting in a narrower wall thickness at both channel walls. Thermal radiation was shown to be more effective at increasing entropy generation and Bejan value.

Hemolysis analysis of centrifugal blood pump based on numerical simulation

Abstract The operation of blood pump will cause mechanical damage to red blood cells and lead to hemolysis. Based on this, CFD technology is used to simulate the three-dimensional flow field of centrifugal blood pump. According to the analysis of velocity field, pressure field and stress field; Based on the hemolysis power function model, the hemolysis performance of blood pump is predicted by Lagrange particle tracking method, and the impeller structure is adjusted to improve its flow performance and reduce the hemolysis index. The research results can provide a basis for the structural improvement and performance improvement of centrifugal heart pump.

Development Of Smart Band For Vital Signs Monitoring System Based On Internet Of Things

Abstract Vital signs are important health parameters because they indicate the physiological functions of the human body. Heart rate (HR), blood pressure, body temperature, oxygen saturation (SpO2), and respiration rate are vital signs used to determine whether a person is healthy or not. HR is the rate at which the heart pumps blood and is measured by the number of heart beat per minute (beats per minute / BPM). Oxygen saturation (SpO2) indicates the level of hemoglobin in the blood that can bind to oxygen. This study aims to develop a smart band prototype for monitoring heart rate (HR) and oxygen saturation using optical spectroscopy methods and the implementation of the Internet of Things (IoT). This smart band prototype uses the MAX30102 sensor, ESP32, push button, Blynk, and Arduino IDE AVR software. The research results show that the prototype’s accuracy for HR measurement is ±98.5%, and the accuracy for SpO2 is ±99.3%. The measurement results can be sent and displayed in the Blynk application as well as to email. It can be concluded that this smart band can detect HR and SpO2 in real-time and has the potential to improve the quality of healthcare services.

Hybrid LSTM models-based detection of left ventricular hypertrophy in electrocardiogram signals

This research investigates various deep learning techniques to automatically classify Left Ventricular Hypertrophy (LVH) from electrocardiogram (ECG) signals. LVH frequently results from persistently high blood pressure, causing the heart pump harder and thicken the ventricular walls. It is associated with an increased risk of heart attacks, heart failure, stroke, and sudden cardiac death. The significance of this research lies in the early and precise detection of LVH, facilitating timely interventions and ultimately improving patient health. The non-invasive nature of ECG monitoring, integrated with the efficiency of deep learning models, contributes to faster and more accessible to enhance diagnostic accuracy and efficiency in identifying LVH. The objective of this research is to assess and compare the performance of GRU3Net, Double-Bilayer LSTM, and Conv2LSTM, Dual-LSTM models in the classification of Left Ventricular Hypertrophy (LVH) based on electrocardiogram (ECG) signals, utilizing a dataset sourced from the PTB Diagnostic ECG Database. The implemented deep learning models yielded noteworthy results. Specifically, the GRU3Net model achieved a high accuracy of 96.1%, showcasing an optimal configuration for overall accuracy. The Double-Bilayer LSTM model followed with an accuracy of 91.7%. However, a decline in accuracy was observed in both the Dual-LSTM and Conv2LSTM models, with the former registering an accuracy of 90.8% and the latter decreasing further to 87.3%.

State of the art treatment with Impella® in cardiac surgery inAustria.

Since 2022, the mechanical left ventricular support system Impella5.5® has been used in Austria for patients with cardiogenic shock, advanced heart failure, post-cardiotomy and low output syndrome. The surgical insertion of the Impella5.5 via the subclavian artery or alternatively via the ascending aorta has become an established procedure for medium-term treatment in patients with cardiogenic shock and bridging scenarios, such as bridge to recovery, bridge to left ventricular assist device (LVAD), bridge to decision, and bridge to heart transplant (HTx) in Austria. All Impella left ventricular heart pumps share the common feature of unloading the left ventricle, with the Impella5.5 achieving afull cardiac output of 5.5l/min. The stable positioning via transaxillary or transaortic insertion enables rapid extubation and mobilization of patients in the intensive care unit (ICU), leading to asignificantly shorter ICU stay. The combined support of Impella5.5 with venoarterial extracorporeal membrane oxygenation (VA-ECMO) has also proven effective in certain scenarios. Several nonrandomized studies demonstrated the effectiveness and safety of the Impella5.5 in practice, which have been included in multiple international guidelines. The advantages of the Impella5.5 in practice include the easy handling with high positional stability, and low complications rates. This article describes the significance of surgical Impella treatment in Austria from the perspective of Austrian clinical experts.

State of the art treatment with Impella® in cardiac surgery in Austria

Since 2022, the mechanical left ventricular support system Impella 5.5® has been used in Austria for patients with cardiogenic shock, advanced heart failure, post-cardiotomy and low output syndrome. The surgical insertion of the Impella 5.5 via the subclavian artery or alternatively via the ascending aorta has become an established procedure for medium-term treatment in patients with cardiogenic shock and bridging scenarios, such as bridge to recovery, bridge to left ventricular assist device (LVAD), bridge to decision, and bridge to heart transplant (HTx) in Austria. All Impella left ventricular heart pumps share the common feature of unloading the left ventricle, with the Impella 5.5 achieving a full cardiac output of 5.5l/min. The stable positioning via transaxillary or transaortic insertion enables rapid extubation and mobilization of patients in the intensive care unit (ICU), leading to a significantly shorter ICU stay. The combined support of Impella 5.5 with venoarterial extracorporeal membrane oxygenation (VA-ECMO) has also proven effective in certain scenarios. Several nonrandomized studies demonstrated the effectiveness and safety of the Impella 5.5 in practice, which have been included in multiple international guidelines. The advantages of the Impella 5.5 in practice include the easy handling with high positional stability, and low complications rates. This article describes the significance of surgical Impella treatment in Austria from the perspective of Austrian clinical experts.

Associated between hypertension and body mass index, cholesterol, and blood sugar levels in elderly women

Hypertension remains a significant public health problem, including in Indonesia. The highest number of sufferers is known to be the group of elderly women. Hypertension can occur because the heart pumps blood throughout the body strongly due to thickening and stiffness of the artery walls. The thickening increases with age.This study assesses the relationship between BMI, cholesterol, and blood glucose levels and women's systolic and diastolic blood pressure. This observational study was conducted using a cross-sectional design, where 330 women aged 60 years or older in West Aceh Regency were involved as samples.The correlations were conducted by simple linear regression (bivariate) and multiple linear regression tests to determine the relationship between independent variables (systolic and diastolic blood pressure) and dependent variables (BMI, cholesterol, and blood sugar level). The results of bivariate test show the correlation of BMI, cholesterol, and blood sugar levels, with systolic blood pressure are weak, as indicated by the r values below 0.25. Meanwhile, BMI with diastolic blood pressure is moderate (r=0.272). In contrast, the correlation cholesterol and blood sugar levels with diastolic blood pressure are weak, with r values below 0.25. Multivariate analysis through linear regression showed that BMI (p<0.001), cholesterol (p<0.001), and blood glucose levels (p=<0.013) were significantly associated with systolic blood pressure. Furthermore, diastolic blood pressure was only significantly associated with BMI (p<0.001). BMI plays an essential role in both systolic and diastolic blood pressure, while cholesterol and blood glucose levels only contribute to systolic blood pressure, not to diastolic blood pressure.

MYH11 rare variant augments aortic growth and induces cardiac hypertrophy and heart failure with pressure overload.

Smooth muscle cell-specific myosin heavy chain, encoded by MYH11, is selectively expressed in smooth muscle cells (SMCs). Pathogenic variants in MYH11 predispose to a number of disorders, including heritable thoracic aortic disease associated with patent ductus arteriosus, visceral myopathy, and megacystis-microcolon-intestinal hypoperistalsis syndrome. Rare variants of uncertain significance occur throughout the gene, including MYH11 p.Glu1892Asp, and we sought to determine if this variant causes thoracic aortic disease in mice. Genomic editing was used to generate Myh11 E1892D/E1892D mice. Wild-type (WT) and mutant mice underwent cardiovascular phenotyping and with transverse aortic constriction (TAC). Myh11 E1892D/E1892D and WT mice displayed similar growth, blood pressure, root and ascending aortic diameters, and cardiac function up to 13 months of age, along with similar contraction and relaxation on myographic testing. TAC induced hypertension similarly in Myh11 E1892D/E1892D and WT mice, but mutant mice showed augmented ascending aortic enlargement and increased elastic fragmentation on histology. Unexpectedly, male Myh11 E1892D/E1892D mice two weeks post-TAC had decreased ejection fraction, stroke volume, fractional shortening, and cardiac output compared to similarly treated male WT mice. Importantly, left ventricular mass increased significantly due to primarily posterior wall thickening, and cardiac histology confirmed cardiomyocyte hypertrophy and increased collagen deposition in the myocardium and surrounding arteries. These results further highlight the clinical heterogeneity associated with MYH11 rare variants. Given that MYH11 is selectively expressed in SMCs, these results implicate a role of vascular SMCs in the heart contributing to cardiac hypertrophy and failure with pressure overload.

Abstract We021: Connexin 43 mediates macrophage induced cardiomyocyte proliferation and heart regeneration

Background: Heart regeneration is a potential strategy to recover pumping function after cardiac injury and protect against heart failure. Macrophages have been demonstrated to promote heart regeneration, while its mechanism has not been addressed. Modulating the interaction between macrophages and cardiomyocytes through connexin 43 (CX43) may provide a clinical therapy for preventing further deterioration of patients with heart injury and restoring the lost myocardium. Hypothesis: We hypothesize that macrophages can interact with cardiomyocytes via CX43, leading to promotion of cardiac proliferation and heart regeneration. Aims: Our study aims to provide the evidence of macrophages contacting cardiomyocytes through CX43 and promoting heart regeneration. Methods and Results: Through cell co-culture experiments, we found that macrophages attache to cardiomyocytes via CX43, subsequently promoting myocyte proliferation as evidenced by proliferative markers. Blocking the CX43 connection by SiRNA between two cells suspended cardiomyocyte proliferation in vitro. We generated macrophage-specific CX43 deficient mice (CX43 Mφ/- ) by crosing CD11b-Cre mice and CX43-flox mice. We performed apical resection operation on 1 day-old CX43 Mφ/- mice and harvested the hearts at 21 day-post-resection. CX43 Mφ/- mice demonstrated either the heart regeneration ability nor pumping function. Applying single-cell RNA sequencing in CX43 Mφ/- hearts, we illustrated the unique transcriptional signature of macrophage and cardiomyocyte in macrophage-specific CX43 deficient mice. Conclusion: Our study provides the evidence that macrophages attache to cardiomyocyte via CX43 after cardiac injury, promote cardiomyocyte proliferation and heart regeneration. This discovery may offer a new target for clinical treatment of myocardial infarction.

The impact of comorbidities on the physical and psychological dimension in heart failure patients

Assessing patients' quality of life is frequently used in medical research. Patients di-agnosed with heart failure (HF) have reduced exercise tolerance and reduced quality of life due to reduced heart pump function. The objectives of the study are (i) to assess quality of life and comorbidities in HF patients; (ii) to compare quality of life in the physical and psychological do-mains according to drug treatment followed and (iii) to identify predictors of the two domains as-sessed. Methods. A cross-sectional study was conducted between February 2023 and May 2024. A total of 169 patients with HF were included and were distributed into two groups: the HF -S/V group (N=64) who received treatment with sacubitril/valsartan and the HF -CT group (N=105) received treatment with conventional therapy. Two questionnaires were used to assess patients: the World Health Organization's Quality of Life Questionnaire (WHOQOL-BREF) questionnaire and the Charlson Comorbidity Index (CCI). Results: The values determined for physical and psy-chological health were significantly lower for Group HF - S/V (51.391 ± 22.232 vs. 61.79 ± 20.04, p=0.002, respectively 59.203 ± 16.871 vs. 64.933 ± 17.448, p=0.038). Approximately 25% of all re-cruited patients distributed in the 2nd CCI category (CCI score 3-4) have an overall poor and moderately poor perception of quality of life vs. 35.5% of patients distributed in the 3rd CCI cate-gory (CCI ≤ 5); 55% of them belong to the HF - S/V group. A good perception of health status is held by 29 (17.16% of the HF group) of the patients distributed in the 2nd CCI category and 28 (16.56%) have a low and moderate perception. Conclusions: The values for the Physical health domain are moderately low, while the values obtained for the psychological domain show that this domain is less affected. Predictors identified for physical health and psychological well-being are patient age, weight, CCI. Keywords: heart failure; comorbidities; quality of life; physical dimension; psychological dimension

Clinical outcomes among cardiogenic shock patients supported with high-capacity Impella axial flow pumps: A report from the Cardiogenic Shock Working Group

BackgroundThe Impella 5.0 and 5.5 pumps (Abiomed, Danvers, MA) are large-bore transvalvular micro-axial assist devices used in cardiogenic shock (CS) for patients requiring high-capacity flow. Despite their increasing use, real-world data regarding indications, rates of utilization and clinical outcomes with this therapy are limited. ObjectivesTo examine clinical profiles and outcomes of patients in a contemporary, real-world CS registry of patients who received an Impella 5.0/5.5 alone or in combination with other temporary mechanical circulatory support (tMCS) devices. MethodsThe CS Working Group (CSWG) Registry includes patients from 34 US hospitals. For this analysis, data from patients who received an Impella 5.0/5.5 between 2020-2023 were analyzed. Use of Impella 5.0/5.5 with or without additional tMCS therapies, duration of support, adverse events and outcomes at hospital discharge were studied. Adverse events including stroke, limb ischemia, bleeding and hemolysis were not standardized by the registry but reported per individual CSWG Primary Investigator discretion. For those who survived, rates of native heart recovery (NHR) or heart replacement therapy (HRT) including heart transplant (HT), or durable ventricular assist device (VAD) were recorded. We also assessed outcomes based on based on shock etiology (acute myocardial infarction or MI-CS vs. heart failure-related CS or HF-CS). ResultsAmong 6,205 patients, 754 received an Impella 5.0/5.5 (12.1%), including 210 MI-CS (27.8%) and 484 HF-CS (64.1%) patients. Impella 5.0/5.5 was used as the sole tMCS device in 32% of patients, while 68% of pts received a combination of tMCS devices. Impella cannulation sites were available for 524/754 (69.4%) of patients, with 93.5% axillary configuration. Survival to hospital discharge for those supported with an Impella 5.0/5.5 was 67%, with 20.4% NHR and 45.5% HRT. Compared to HF-CS, patients with MI-CS supported on Impella 5.0/5.5 had higher in-hospital mortality (45.2% vs 26.2%, p<0.001) and were less likely to receive HRT (22.4% vs 56.6%, p<0.001. For patients receiving a combination of tMCS during hospitalization, this was associated with higher rates of limb ischemia (9% vs. 3%, p<0.01), bleeding (52% vs. 33%, p<0.01), and mortality (38% vs 25%; p<0.001) compared to Impella 5.0/5.5 alone. Among Impella 5.5 recipients, the median duration of pump support was 12.9 days (IQR: 6.8-22.9) and longer in patients bridged to HRT (14 days; IQR: 7.7-28.4). ConclusionsIn this multi-center cohort of patients with CS, use of Impella 5.0/5.5 was associated with an overall survival of 67.1% and high rates of HRT. Lower adverse event rates were observed when Impella 5.0/5.5 was the sole support device used. Further study is required to determine whether a strategy of early Impella 5.0/5.5 use for CS improves survival. Condensed abstractHigh capacity Impella heart pumps provide up to 5.5 L/min of flow, while axillary surgical cannulation allows for ambulation. Patients with advanced cardiogenic shock from acute myocardial infarction or heart failure requiring temporary mechanical circulatory support may benefit from upfront use of Impella 5.5 to improve overall survival, including native heart recovery or successful bridge to durable left ventricular assist device surgery or heart transplantation, and to reduce adverse event rates.

Thrombus Detection in the Artificial Heart Pump Based on Electrical Impedance Spectroscopy

Thrombus Detection in the Artificial Heart Pump Based on Electrical Impedance Spectroscopy

Soluble guanylate cyclase stimulator as an emerging therapeutic option in the management of arrhythmias in heart failure rat model

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): This research was supported by VEGA grant no. 2/0002/20 and 2/0006/23, the Slovak Research and Development Agency under contract no. 21-0410, European Regional Development Fund: ITMS2014+: 313011AVG3. This research was also partially supported by the Ministry of Health of the Czech Republic within the project for the development of the research organization [grant number 00023001 (IKEM)—institutional support] and also supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Program EXCELES, Project No. LX22NPO5104)—Funded by the European Union—Next Generation EU Heart failure (HF) is a complex clinical syndrome characterized by a decrease in the efficiency of the heart pump, leading to a decline in hemodynamic status and cardiac remodelling, that can contribute to the formation of a substrate for arrhythmias. Antiarrhythmic drug therapy is still suboptimal and current therapies are not efficacious enough. The purpose of the current study was therefore to examine the efficiency of nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) stimulator. We used as an experimental model male hypertensive Ren-2 transgenic rats (TGR, n = 16), normotensive Hannover Sprague–Dawley rats (HSD, n = 17), and a rat model of HF surgically induced by aortocaval fistula (ACF) in rats of both strains (n = 27). After ACF induction were rats treated by sGC stimulator BAY41-8543 (3 mg/kg/day for 30 weeks) alone or combined with angiotensin-converting enzyme inhibitor (ACEi) Trandolapril (0.25 mg/kg/day for 30 weeks). Age of the animals at the end of the experiment was 40 weeks. Left ventricle tissue and plasma samples were used for further analyses. Treatment by sGC stimulator significantly decreased rats' mortality, and systolic blood pressure, and significantly increased levels of antioxidant enzyme superoxide dismutase 1, matrix metalloproteinase 2, total and phosphorylated connexin 43 as well as protein kinase C epsilon, implicated in remodelling of extracellular matrix and intercellular communication, in the left ventricle of TGR rats. Application of sGC stimulator slightly normalized elevated collagen deposition and hydroxyproline content in the left ventricular tissue of TGR rats. Unfortunately, we did not observe any effect of the sGC stimulator in the TGR ACF group. These results support the hypothesis that sGC stimulators might represent a class of drugs suitable for combating heart failure with partially anti-arrhythmic potential, but further studies are needed.

SURVEY ON WBC CLASSIFICATION AND DETECTION USING YOLO

Our heart pumps red blood constantly, carrying waste products, hormones, nutrition, oxygen, and other essential health markers. Blood cells in this fluid are made up of many components, including platelets, RBCs, and WBCs. Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils are further subdivided into WBCs. To precisely identify and treat numerous kinds of blood-related illnesses, the detection and analysis of these blood cells is necessary for advanced diagnostics in medicine. Convolutional neural networks (CNNs), for example, are highly relied upon in modern medical diagnostics for the examination of blood cells. The precision and potency of blood cell identification procedures have been greatly improved by CNNs and Additional approaches to deep learning like RNNs and YOLO. The persistence of this research is to list challenges in White Blood cell detection and classification problem. Deep learning-based blood cell identification and classification approaches based on Single Stage approaches. Single Stage Approach involve You only look Once (YOLO). It explores the various architectures for feature selection and classification starting from YoloV1 toV5 and it’s various modifications. In this paper would be looking at things like network parameters, training procedure, and transfer learning application for each variation. It also assesses model complexity, accuracy, performance, generalization, computational efficiency, and transfer learning capabilities, in addition to variables like data amount and source.

Climate change consequences on the systemic heart of female Octopus maya: oxidative phosphorylation assessment and the antioxidant system.

There is evidence that indicates that temperature modulates the reproduction of the tropical species Octopus maya, through the over- or under-expression of many genes in the brain. If the oxygen supply to the brain depends on the circulatory system, how temperature affects different tissues will begin in the heart, responsible for pumping the oxygen to tissues. The present study examines the impact of heat stress on the mitochondrial function of the systemic heart of adult O. maya. The mitochondrial metabolism and antioxidant defense system were measured in the systemic heart tissue of female organisms acclimated to different temperatures (24, 26, and 30°C). The results show that acclimation temperature affects respiratory State 3 and State 4o (oligomycin-induced) with higher values observed in females acclimated at 26°C. The antioxidant defense system is also affected by acclimation temperature with significant differences observed in superoxide dismutase, glutathione S-transferase activities, and glutathione levels. The results suggest that high temperatures (30°C) could exert physical limitations on the circulatory system through the heart pumping, affecting nutrient and oxygen transport to other tissues, including the brain, which exerts control over the reproductive system. The role of the cardiovascular system in supporting aerobic metabolism in octopus females is discussed.

Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart.

Penn State University is developing a pediatric total artificial heart (TAH) as a bridge-to-transplant device that supports infants and small children with single ventricle anomalies or biventricular heart failure to address high waitlist mortality rates for pediatric patients with severe congenital heart disease (CHD). Two issues with mechanical circulatory support devices are thrombus formation and thromboembolic events. This in vitro study characterizes flow within Penn State's pediatric total artificial heart under physiological operating conditions. Particle image velocimetry (PIV) is used to quantify flow within the pump and to calculate wall shear rates (WSRs) along the internal pump surface to identify potential thrombogenic regions. Results show that the diastolic inflow jets produce sufficient wall shear rates to reduce thrombus deposition potential along the inlet side of the left and right pumps. The inlet jet transitions to rotational flow, which promotes wall washing along the apex of the pumps, prevents flow stasis, and aligns flow with the outlet valve prior to systolic ejection. However, inconsistent high wall shear rates near the pump apex cause increased thrombogenic potential. Strong systolic outflow jets produce high wall shear rates near the outlet valve to reduce thrombus deposition risk. The right pump, which has a modified outlet port angle to improve anatomical fit, produces lower wall shear rates and higher thrombus susceptibility potential (TSP) compared to the left pump. In summary, this study provides a fluid dynamic understanding of a new pediatric total artificial heart and indicates thrombus susceptibility is primarily confined to the apex, consistent with similar pulsatile heart pumps.

Heart pump increases survival in STEMI-related cardiogenic shock.

Heart pump increases survival in STEMI-related cardiogenic shock.

(579) - The Effects on Renal Function with Impella 5.5 Heart Pump Supports on Patients with Cardiorenalsyndrome Who Underwent Heart Transplantation

(579) - The Effects on Renal Function with Impella 5.5 Heart Pump Supports on Patients with Cardiorenalsyndrome Who Underwent Heart Transplantation