The aim of this study was to determine the predict factors of the therapeutic response in left ventricular ejection fraction (LVEF) and remodeling in patients with non-ischemic cardiomyopathy who were receiving treatment with b blockers. We hypothesized LGE by CMR imaging predicted therapeutic response in LVEF and remodeling in patients with non-ischemic cardiomyopathy who were receiving treatment with b blockers. Methods This study included 19 heart failure patients (mean age 52 years, 15 men) who had non-ischemic origin confirmed by coronary angiography and underwent LGE by CMR imaging at 1 month after the initiation of b blocker therapy. Of these, 16 patients received Carvedilol 10 mg/day and 3 patients received Metoprolol 4 mg/day at 1 month of the beta blocker therapy. All patients were treated with a standard heart failure regimen of angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). LVEF was measured according to the Simpson’s modified method using echocardiography at 1 and 6 months. Results Of the 19 patients, 11 (58 %) patients had positive LGE images. Overall, LVEF significantly increased (27 ± 8 to 47 ± 11 %, p<0.0001) and BNP significantly decreased (275 ± 281 to 70 ± 92 pg/ml, p<0.0001). The improvement of LVEF significantly differed between the LGE positive (13 ± 8 %) and negative (31 ± 15 %) patients (p=0.004). Conclusions LGE by CMR imaging predicted therapeutic response in LVEF and remodeling in patients with non-ischemic cardiomyopathy treated with b blockers.