Heart Blood Vessels Research Articles

A study of nutritional assessment in paediatric patients with congenital heart disease in a tertiary care centre

: Congenital heart disease refers to any anatomical defect in the heart or major blood vessels present in children at birth. CHD (congenital heart disease) occurs in round about 1% of live births in developed countries. In developing countries due to poor resources, delayed diagnosis and surgery for CHD leads to a vicious cycle of congestive heart failure and respiratory infections, resulting in a high prevalence of preoperative malnutrition in patients with CHD. The incidence of congenital heart disease at birth is variable, incidence figures use to range between 5-8/1000 live births before the introduction of echocardiography but due to better diagnosis in today’s era many more milder forms are being detected, so the current estimates range from 8-12/1000 live births.: To assess the nutritional status in patients with CHD using clinical evaluation, anthropometry.: It is a cross-sectional observational stud. In our study a total of 75 cases of congenital heart disease were examined in a period of 18 months: Out of 75 patients 56 (74.66%) were <=5years and male predominance were seen. Most of the patient were having Acyanotic CHD: That there are multiple factors that are responsible for malnutrition in children with CHD including, poor socioeconomic strata, already poor health conditions in the general population, recurrent hospitalizations and recurrent lower respiratory tract infections.

Design of a Heart Rate Monitoring Application Based on Internet of Things (IoT) Technology with WhatsApp Blast

The highest death rate based on data from WHO (World Health Organization) is due to heart-related diseases. In 2015, more than 17 million people in the world died from heart disease and blood vessel disorders. About 75% of deaths from heart disease occur in developing countries with low to moderate income. Based on SRS (sample registration system) data in 2014, heart disease was the highest cause in Indonesia, namely 12.9%. With IoT (Internet of Things) technology, it can make it easier to provide information to survivors, namely carrying out early heart detection if there are several anomalies that occur in the human body, especially heartbeats that do not comply with the provisions. Utilizing the Max30102 sensor in collaboration with several other IoT devices can be integrated with a web-based system which is used for monitoring based on incoming data from IoT devices. This system is capable of recording heart data in humans in real time by providing notifications to heart survivors via WhatsApp blasting technology.

Relationship Between Anxiety Level and Sleep Quality in Patients Pre-Cardiac Surgery at Dr. Kariadi Hospital, Semarang, Indonesia

Introduction: Cardiac surgery is a medical procedure that aims to improve the heart's structure and blood vessels. The procedure is performed within 4 to 6 hours. This can cause anxiety in patients and family members. Excessive anxiety can lead to increased blood pressure, tachycardia, depression, and even sleep disturbances before and after cardiac surgery. Poor sleep quality affects quality of life, health status, and activities of daily living. The aim of this study was to determine the relationship between anxiety levels and sleep quality in patients with pre-cardiac surgery. Methods: This research was a descriptive correlation with a cross-sectional approach. The convenience sampling technique was used to select 65 respondents for the sample. The Hamilton Anxiety Rating Scale (HARS) questionnaire was used to gather information on anxiety levels. The Pittsburgh Sleep Quality Index (PSQI) questionnaire assessed the respondents' sleep quality before heart surgery. The obtained data was subjected to analysis using the Spearman-Rho test.Results: There were 36 respondents (55.38%) who had moderate sleep quality and experienced mild anxiety 28 respondents (43.08%). The Spearman rho correlation test of r value was 0.106 in the results. There is no relationship between anxiety level and sleep quality in cardiac pre-surgery patients.Conclusion: The majority of patients with pre-cardiac surgery at Dr. Kariadi Hospital Semarang experience anxiety and sleep disorders. Nurses can consider to manage the anxiety and sleep disorders experienced by patients.

INTRODUCING THE EFFECTS OF SMOKING ON THE HEART AND BLOOD VESSELS TO REDUCE SMOKING BEHAVIOR AMONG STUDENTS

Smoking causes various diseases in our bodies, such as heart disease and blood vessel disorders, lung cancer, oral cavity cancer, laryngeal cancer, high blood pressure, impotence as well as pregnancy disorders and fetal defects. The dangers of smoking are not only aimed at smokers (active smokers) but also for non-smokers who inhale cigarette smoke around smokers (passive smokers) and in fact the effects received from passive smokers will be much more dangerous than active smokers. Because of the many negative impacts that arise for teenage smokers, it is necessary to provide knowledge and understanding to teenagers, especially Islamic boarding school children, regarding the dangers posed by smoking. The goal is to increase understanding by providing education to Students regarding the effects of smoking on the heart and blood vessels as an effort to reduce smoking behavior among students in PP. Al Hikam Bangkalan. The methods used in counseling are lectures and questions answer. Before counseling, participants were given a pre-test, then after counseling, participants were given a post-test. The results of the pre-test and post-test are assessed and then data processing and evaluation are carried out. Pre-test results and post-test regarding knowledge of the effects of smoking on the heart and blood vessels through a questionnaire, there was a direct increase in scores by students who took part in this activity. The percentage increase in average value was 9.7%. This significant increase in the average value indicates a change in the level of knowledge of the participants after attending the counseling session. Introducing the effects of smoking on the heart and blood vessels as an effort to reduce smoking behavior among students in PP. Al Hikam Bangkalan has increased knowledge and understanding of the dangers of smoking.

Identifying educational needs and knowledge gaps in healthcare professionals for effective management of acute myocardial infarction

This study aims to examine the educational needs and knowledge gaps of healthcare professionals in treating Acute Myocardial Infarction (AMI), a leading cause of death worldwide due to its impact on the heart muscles and blood vessels. Although healthcare workers generally understand how to manage AMI, there are crucial areas where their knowledge could be improved. The research involved 65 healthcare professionals from Jordan University Hospital, collecting data through surveys with structured questions and analyzing it with descriptive statistics. The findings indicate that while nurses are proficient in recognizing symptoms and managing care for AMI patients, including medication administration and patient education, they require more resources and training. Specifically, they need better training in oxygen therapy, emergency procedures, and advising patients on lifestyle changes. The study highlights the need for targeted, patient-focused education to address these gaps and improve AMI management in hospitals.

Comparison of Logistic Regression, Random Forest and Adaboost Algorithms for Diabetes Mellitus Classification

Diabetes mellitus is a chronic disease that affects the way the body regulates sugar (glucose). High blood sugar levels can lead to health complications including heart problems, eye disorders, nerve damage, kidney and blood vessel disorders. It is important for early detection of diabetes by utilizing data mining technology. Data mining has various classification models that can be used to detect diabetes, including logistic regression, random forest and adaboost. The comparison of the three algorithms aims to find out which algorithm is most appropriate in the classification of diabetes. From the results obtained, the random forest algorithm has the best performance in the classification of diabetes mellitus compared to other algorithms.

Segmentation and Volumetric Analysis of Heart from Cardiac CT Images.

Cardiac CT is a valuable diagnostic tool in evaluating cardiovascular diseases. Accurate segmentation of the heart and its structures from cardiac CT and MRI images is essential for diagnosing functional abnormalities, treatment plans and cardiovascular diseases management. Accurate segmentation and quantitative assessments are still a challenge. Manual delineation of the heart from the scan images is labour-intensive, time-consuming, and error prone as it depends on the radiologist's experience. Thus, automated techniques are highly desirable as they can significantly improve the efficiency and accuracy of image analysis. This work addresses the above problems. A new, image-driven, fast, and fully automatic segmentation method was developed to segment the heart from CT images using a processing pipeline of adaptive median filter, multi-level thresholding, active contours, mathematical morphology, and the knowledge of human anatomy to delineate the regions of interest. The algorithm proposed is simple to implement and validate and requires no human intervention. The method is tested on the 'Image CHD' DICOM images (multi-centre, clinically approved single-phase de-identified images), and the results obtained were validated against the ground truths provided with the dataset. The results show an average Dice score, Jaccard score, and Hausdorff distance of 0.866, 0.776, and 33.29mm, respectively, for the segmentation of the heart's chambers, aorta, and blood vessels. The results and the ground truths were compared using Bland-Altmon plots. The heart was correctly segmented from the CT images using the proposed method. Further this segmentation technique can be used to develop AI based solutions for segmentation.

The Relationship between Hypertension and the Risk of Falls in the Elderly

Increasing age will result in changes that occur, one of which is a decline in the cardiovascular system, especially hypertension. Hypertension that lasts a long time and if not treated properly will cause damage to the blood vessels in the heart. Damage to the heart's blood vessels will cause blood flow to the heart muscles to be obstructed. This can cause a heart attack which will increase the risk of falls. The aim of this study was to determine whether there is a relationship between hypertension and the risk of falls in the elderly. The design used is descriptive correlation and a cross sectional approach. The research sample was 82 respondents in the work area of the Rejosari Health Center, Pekanbaru City. using purposive sampling technique. The analysis used is the chi-square test. Based on the results of statistical tests, it shows that there is a relationship between hypertension and the risk of falls in the elderly, with P Value (0.001) alpha (0.05). Based on the results obtained, it was concluded that high blood pressure could result in a risk of falls in the elderly.

Сердечно-сосудистые осложнения иммунотерапии гематологических злокачественных опухолей (обзор литературы)

In clinical oncology in general, tumor treatment is closely related to a highly relevant issue of chemotherapy-induced adverse events. Among side effects, cardiovascular toxicity occupies the foremost place. The strategy of controlling the cardiovascular complications associated with antitumor drug and cell therapies presupposes an early diagnosis of changes in the heart muscle and blood vessels at the stage of subclinical manifestations of adverse events. The present literature review provides the analysis of data on immunotherapy side effects in hematological malignancies with a focus on cardiovascular complications. The review comprehensively discusses the characteristics of cardiovascular complications associated with immune checkpoint inhibitors, CAR-T cell products, bispecific antibodies as well as immunomodulatory and antiangiogenic drugs.

Penyuluhan Pengetahuan Bahaya merokok pada Remaja di Desa Doda Kecamatan Kinovari Kabupaten Sigi Sulawesi Tengah

Adolescence according to WHO is the phase between childhood and adulthood in the age range between 10 to 19 years. The world's youth age group is 1.2 billion or 18% of the world's population. Cigarettes and tobacco products consumed by humans are generally are plant leaves (Nicotina, tabacum, nicotina rustica, and other species) that are burned, smoked, inhaled or chewed. There is 2550, a chemical in processed tobacco leaves. Some chemicals quickly cause health problems, lung damage, and weakening of stamina, if burnt cigarette smoke contains about 4000 chemicals, 43 of which are toxic such as nicotine such as nicotine (pesticide), CO (toxic gas), tar. The high prevalence of smokers in Indonesia will increase the risk of these diseases which threaten not only active smokers but also smokers. In active smokers, the danger threatens all organs of the body with impaired function to cancer such as those of the heart and blood vessels (coronary heart disease and blood vessels), respiratory tract (COPD, asthma and nasopharyngeal cancer), and disorders of the reproductive system and pregnancy (disability fetuses, miscarriages, pelvic infections and cancer in the organs of passive smoking adults and children). Users of tobacco products are decreasing, the number of teenagers aged 13-15 who smoke cigarettes has increased in 2014 (18.3%), 2019 (18.8% ). The method used is face-to-face through counseling and using questionnaires, the application of education in the health sector. The results of health education activities through this training are that there is an increase in knowledge about the dangers of smoking by 70% and 70% of adolescents wish to stop smoking

Disease Prognosis of Fetal Heart’s Four-Chamber and Blood Vessels in Ultrasound Images Using CNN Incorporated VGG 16 and Enhanced DRNN

Fetal Heart Disease (FHD) based Structural Heart Disorders (SHD) occur when certain features of the heart develop abnormally. These flaws may cause blood flow to circulate in the erroneous spot, slow down, or be utterly blocked. Heart Defects (HD) caused via FHD or disorders that primarily impact embryonic heart conditions are alternatively referred to as Congenital Heart Defects (CHD). Multiple prior investigation algorithms such as Multi-Resolution Convolutional Neural Network (MRCNN), Deep Convolutional Neural Network (DCNN), Faster-RCNN (FRCNN) and DANomaly Wgan-GP and Convolutional Neural Network (DGACNN) rendered in the detection of FHD. Yet, the models have endured several challenges due to fuzzy constraints and irrelevant adherence. The intended aim is to detect the dilemma of the fetal heart in UltraSound (US) images using two distinct tier methods. The initial tier detects the fetal heart chamber's walls and valves using the Convolutional Neural Network (CNN)-incorporated Visual Geometry Group 16 (VGG 16) technique for processing fetal ultrasound images, allowing it to detect and dissolve anomalies in heart walls. This initial investigation concerns improving the image's quality in each subsequent sequence, from lowest to most improved using the conventional Augmented Wiener Filtering (AWF) approach. Succeeding, an instance-level Region of Interest (ROI) segmentation for exploiting the feature mining approach will be carried out via spatial features masking and ground-truth labeling framework for septal defect diagnosis. The second tier determines the flaws in fetal heart blood flow size, structure and vessels utilizing Deep Recurrent Neural Network (DRNN) integrated with region-based texture characteristics Local-Binary-Pattern (LBP), Histogram-of-Oriented-Gradient (HOG) and the Bags Of Features (BOF) segmentation framework via image acquiring. In eventual, the histogram equalization enhancement algorithm with Median Modified Wiener Filter (MMWF) is enumerated to enhance the visual quality, tests for signal-to-noise ratio, rate of variations, and noise proportion for sorting the blood vessels of the input fetal image. The analyzed CNN’s VGG 16 and DRNN model’s efficiency via Matrix Laboratory (MATLAB) has detected the cardiac features both in normal and abnormal ranges with an overall accuracy of 99.89% and 98.7%.

The Relationship between HbA1c and Glucosuria in Diabetes Mellitus (DM) Patients

Diabetes mellitus is a condition of abnormalities in blood glucose metabolism that can cause various macroangiopathy complications such as disorders of the peripheral blood vessels, heart blood vessels, cerebral blood vessels as well as microangipathic complications such as diabetic retinopathy disorders, nephropathy and neuropathy. HbA1c describes the level of sugar in the blood for the last 3 months. Glucose is not found in normal urine because it is reabsorbed back into the blood vessels by renal filtration. The aim of this study was to determine the relationship between HbA1c levels and glucosuria in people with diabetes mellitus. The design of this study is a cross-sectional approach to DM patients. The sampling technique used was purposive sampling. Data analysis was carried out by means of Spearman's rank correlation test. Results Correlation analysis showed that there was a significant relationship between HbA1c levels and glucosuria in DM patients p-value 0.005 with a coefficient value of 0.597. The conclusion from this study is that there is a significant relationship with a strong correlation strength and a positive correlation direction for DM sufferers.

Foetal Echocardiography vs. Neonatal Echocardiography for Diagnosis of Congenital Heart Diseases

Congenital heart disease (CHD) is a structural abnormality in the heart or major intrathoracic blood vessels that has been present since birth. The antenatal detection of congenital cardiac disease has been greatly enhanced by the advent of fetal echocardiography as a crucial component of prenatal ultrasound evaluation. Nevertheless, antenatal CHD diagnosis rates are still lower than those for the majority of other significant structural defects. Aim : Assess the effectiveness of fetal in comparison to neonatal echocardiography. This study is conductedin accordance to the PRISMA statement. Studies were identified from several open-access electronic databases (PubMed Central, ScienceDirect, Google Scholar). Risk of bias of each study was evaluated using Cochrane Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. Data were descriptively examined and narratively reported. Twelve studies were included in the review. All included studies were considered low-risk. From 12 studies that were included in our study, all recommend fetal echocardiography for prenatal assessment. Lowest reported sensitivity was 64.5%, highest value was 100%. Lowest repoted specificity was 88.9%, highest value was 99.96%. Diagnostic accuracy was reported in 4 studies, with a value of 93 – 99.82% Factors that might be associated with the accuracy of fetal echocardiography are high anatomic complexity, maternal comorbidities, and fellow as initial imager. Fetal echocardiography was found to have a high specificity but limited sensitivity. Low sensitivity suggests that fetal echocardiography results could be inaccurate whereas high specificity means that a negative echocardiography result is often sufficient to predict the absence of CHD. There are some factors that may affect the accuracy of fetal echocardiography, mostly resulting from fetal or maternal factors, such as high complexity of the anomaly, fetal position, late gestation, maternal obesity, and less-esperienced sonographer.

The Role of Al-Hijamah in Efforts to Prevent Heart Disease and Blood Vessels: A Systematic Review and Meta-analysis

The Role of Al-Hijamah in Efforts to Prevent Heart Disease and Blood Vessels: A Systematic Review and Meta-analysis

Role of Cardiac Rehabilitation in Improving Outcomes After Myocardial Infarction.

Myocardial infarction, an integral part of acute coronary syndrome (ACS), occurs due to atherosclerotic narrowing of the coronary (heart) blood vessels. Acute coronary syndrome, being one of the major cardiovascular diseases (CVDs), has led to a significant amount of mortality and morbidity, the majority of it due to MI. Over a long period following an MI, the physical, psychological, social, emotional, and occupational well-being are greatly impacted. Cardiac rehabilitation (CR) can address the above and help improve long-term well-being and overall quality of life. The benefits of CR include enhanced exercise capacity, risk factor reduction, improved quality of life (QOL), reduced mortality, and hospital readmissions. We used a systematic literature review (SLR) approach in this article to provide a global overview of cutting-edge CR in the post-MI phase. We reviewed 45 articles from journals of good repute published between 2013 and December 1st, 2023, focusing on seven selected papers for in-depth analysis. The analysis was focused on factors such as the positive outcomes of CR and the effects of CR post-MI. There are only a few statistically significant studies in a few domains of CR benefits, namely decreased mortality, cardiac events, depression, depression-associated mortality, hospital readmissions, increased left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic volume (LVESV), metabolic equivalent of task (MET), maximal oxygen consumption (VO2max), and the six-minute walk test (6MWT), and as a result, increased physical performance. Further research is needed to enhance the understanding of its mechanisms and statistically prove its effectiveness in all other domains. As CR continues to evolve, referral and participation in CR should be increased as it improves overall health and well-being.

Thoracic cavity of the Shirazi cats: New insights using computed tomography and magnetic resonance imaging.

Our study provided a comprehensive characterization of the thorax of Shirazi cats by comparing the relevant soft and bone windows of computed tomography (CT) and magnetic resonance imaging (MRI) with cross, sagittal and coronal sectional anatomy. We outlined the mediastinum and its anatomic relationships with the trachea, oesophagus, lungs, heart, cranial and caudal vena cavae, and other thoracic structures using the data series gathered from adult normal Shirazi cats. The cranial mediastinum extended from the thoracic inlet to the 4th intercostal space, the middle mediastinum extended from the 5th and 7th intercostal spaces and was occupied by the heart and large blood vessels and the caudal mediastinum extended as a short and narrow portion from the 8th intercostal space to the diaphragm. The contents of the mediastinum and its relationship with the lungs and diaphragm were clearly presented in coronal-sectional anatomy and CT slices. The diaphragm was clearly observed in the lung windows of the ventral thorax. Sagittal-sectional anatomy and CT clarified the thorax's architecture and its contents, with higher density in the soft windows. The distribution of thoracic vessels on cross- and coronal-contrast CT scans was clearly visible. In addition, MRI scans provided an excellent anatomic reference of the thorax with the help of cross, coronal and sagittal scans, especially in the heart and blood vessels. Our study provides a valuable atlas for the diagnosis of malformations of the thoracic structures and offers better assessments for helping veterinary radiologists and clinicians in diagnostic processes.

Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in women in developed societies. Unfavorable structural and functional adaptations within the heart and central blood vessels with sedentary aging in women can act as the substrate for the development of debilitating CVD conditions such as heart failure with preserved ejection fraction (HFpEF). The large decline in cardiorespiratory fitness, as indicated by maximal or peak oxygen uptake (V̇o2max and V̇o2peak, respectively), that occurs in women as they age significantly affects their health and chronic disease status, as well as the risk of cardiovascular and all-cause mortality. Midlife and older women who have performed structured endurance exercise training for several years or decades of their adult lives exhibit a V̇o2max and cardiac and vascular structure and function that are on par or even superior to much younger sedentary women. Therefore, regular endurance exercise training appears to be an effective preventative strategy for mitigating the adverse physiological cardiovascular adaptations associated with sedentary aging in women. Herein, we narratively describe the aging and short- and long-term endurance exercise training adaptations in V̇o2max, cardiac structure, and left ventricular systolic and diastolic function at rest and exercise in midlife and older women. The role of circulating estrogens on cardiac structure and function is described for consideration in the timing of exercise interventions to maximize beneficial adaptations. Current research gaps and potential areas for future investigation to advance our understanding in this critical knowledge area are highlighted.

The problem of inpatient thrombosis of coronary arteries in patients with COVID-19 on the background of intensive antithrombotic therapy

Myocardial infarction claims million lives on the planet each year. Pharmacotherapy in combination with percutaneous coronary interventions have significantly reduced morbidity and mortality in this cohort. Despite optimal therapy and prophylaxis, there is a group of patients with recurrent, often fatal, coronary thromboses. During the COVID-19 pandemic, some patients developed episodes of thrombosis in blood vessels of various organs, including brain, heart or lungs, even on therapeutic anticoagulation. The patient was admitted to the department of cardiology and reperfusion therapy, with a confirmed diagnosis of COVID-19 resulted in acute ST-segment elevation myocardial infarction. Patient underwent urgent coronary angiography with thromboaspiration and stenting of the infarct-dependent right coronary artery followed by optimal medical treatment with the use of triple antithrombotic therapy. His condition became stable with the resolution of ST-segment elevation on electrocardiogram. A few days later, the condition of the patient deteriorated again with recurrent of chest pain and a new ST segment elevation. Repeated coronary angiography revealed recurrent thrombosis in the right coronary artery. The mechanisms of thrombosis in COVID-19 are not fully understood. Among possible, the direct effect of the virus on tissues, activation of pro-inflammatory system and coagulation system, impaired vasodilation, and decreased fibrinolytic activity are discussed. These mechanisms may lead to vascular thrombosis in different organs, particularly heart, lungs, and brain.

The Relationship Between Physical Activity And Diet With Nutritional Status In Students At The Iik Strada Indonesia Campus In Kediri City

In Indonesia, the nutritional problem that is being faced is the problem of undernutrition but more nutritional problems are starting to emerge simultaneously (double burden). Generally, adolescent age groups need enough energy to do diverse physical activities, light physical activity such as sitting or lying down, talking, reading, playing games and watching TV is more at risk of causing heart disease and blood vessels. The purpose of this study was to determine the relationship between physical activity and diet with nutritional status in students at the IIK Strada Indonesia campus in Kediri City. The method used is a quantitative method with a cross sectional type of research. The population in this study was all 7th semester fakar faculty students majoring in public health, pharmacy and hospital administration. The sample size was 42 respondents. The results of the study found a relationship between diet and nutritional status in students at the IIK STRADA Indonesia campus in Kediri City where the results of the chi-square test analysis obtained a p-value of 0.002. There is no relationship between physical activity and nutrition ststus in students at the IIK STRADA Indonesia campus in Kediri City where the results of the chi-square test analysis obtained a p-value of 0.757. ). For respondents whose nutritional status is lacking, it is recommended to increase nutritional intake according to needs and do physical activity according to their abilities. Physical activity that is done regularly such as brisk walking or jogging can reduce fat accumulation so as to reduce a person's risk of overweight conditions. Studentswhose diet is lacking and have thin nutritional status, according to the results of the existing questionnaire that this is because respondents in a day their food intake is less because their eating habits are less varied types. In addition, students in terms of eating they are too picky so that they are not controlled what they eat.

Abstract P3154: Characterized Expression Of MicroRNAs In Plasma Exosome In Patients With Coronary Chronic Total Occlusion

Backgrounds: Even with similar coronary artery occlusion, chronic total occlusion (CTO) has different clinical features from acute myocardial infarction (AMI). MicroRNAs (miRNA; miR) have been regarded as biomarker to identify heterogenous patients, as well as new therapeutic targets in cardiovascular disease. We aimed to identify exosomal miRNA important for CTO. Methods: Patients with percutaneous coronary intervention (PCI) of CTO (n=30) and AMI (n=30) were performed miRNA expression profiling via exosomal small RNA sequencing in the plasma for these groups. Receiver operating characteristic (ROC) analysis, gene ontology, and functional pathway were analyzed in the miRNA exhibiting >4 absolute fold changes with FDR < 0.05. Results: We detected 10 miRNAs -including miR-21-5p, miR-206, miR-215-5p, and miR-1-3p upregulated in CTO and 3 miRNAs -including miR-9-5p, miR-3529-3p, and miR-127-3p downregulated in CTO as compared to AMI (FDR q < 0.05). Gene enrichment and pathway analysis showed that the target genes of the 10 upregulated miRNAs were involved in regulation of osteoblast proliferation and interleukin-4 and interleukin-13 signaling. In contrast, the target genes of the 3 down-regulated miRNAs were enriched in heart valve development and blood vessel development. We selected 7 miRNAs -including miR-21-5p, miR-206, miR-215-5p, miR-1-3p, miR-9-5p, miR-3529-3p, and miR-127-3p which were related to major pathway term in gene ontology and validated by quantitative real-time polymerase chain reaction (qRT-PCR). In qRT-PCR analysis, the expression levels of miR-9-5p and miR-127-3p of plasma exosome were both lower in CTO than those of AMI, similar to the results of exosomal small RNA sequencing. The ROC curve were analyzed in the 2 miRNAs and for the integrative miRNA expression score showed high accuracy in distinguishing between the CTO and AMI (AUC = 0.948) with 79% specificity and 97% sensitivity. Conclusions: We identified significantly different miRNA expression patterns between the CTO and AMI. The levels of these miRNAs in plasma exosomes may be promising markers that distinguish CTO from AMI.