Background (Introduction): Infertility is a global health issue affecting millions of people of reproductive age worldwide. According to WHO, available data suggests that between 48 million couples and 186 million individuals have infertility globally. According to ayurveda, womb preparation is the most important factor to attain fertility. Herbo-metallic formulations prepared using SOPs can play a significant role in eliminating doshas in a short duration of time. They are known for their minimum dose, maximum efficacy, and least side effects. They help to keep all the hormones and the reproductive system in an equilibrium state. They remove all the toxins from the body and regularize menstrual cycles. They possess Rasayan (Immuno-modulatory) and Yogavahi (Nano-carriers; Act accordingly) properties. Aims/objective: To evaluate the role of Herbo-metallic formulations in infertility. Methodology: All the material and data are collected from ancient treatises, Research papers under google scholar, pubmed, Elsevier, etc. search engines. Results: Various research have been reviewed for the impact of Rasaushadhi (Herbo-mineral/metallic formulations) on fertility and the result found to be quiet satisfying as they are Ushana in virya (Potency) and act directly on target organ (Reproductive tract) in shorter duration is prepared as per the classical procedure. Discussion: For healthy progeny, ritu (Menstrual cycle), kshetra (Reproductive tract), beeja (Ovum/sperm), and ambu (Nutrition) factors must be in homeostasis. Metallic preparations can be harmful and toxic if they are not prepared properly. The indications, dose, vehicle(Anupan), period of drug administration, interval or duration of treatment, disease diagnosed, nature or Prakruti of the patient, Pathya-apathya, etc. are major factors that should always be considered by the physician before prescribing Rasaushadhi to the patients. Conclusion: As herbo-mineral formulations play a very significant role in ayurveda and they are capable to cure severe disorders in a minimum dose and time. Therefore, this article reviews several Rasaushadhis along with their pharmacokinetics concerning infertility.