A female patient born in 1931 suffered mental decline for about 1 year. She could no longer conduct her usual activities and home chores and could not hear without a hearing aid. Brain magnetic resonance imaging (MRI) performed in February, 2008, revealed degenerative changes. Treatment consisted of repeated sessions of intermittent hypoxic training (IHT), and individualized vitamins, amino acids, microelements, supplementation, and nutritional adjustment. Until April, 2009, the patient had completed four cycles of IHT and 8 months of the supplementation program. The patient gradually recovered her healthy mental state; she resumed shopping and cooking and began playing piano again, which she was not capable of doing last year. An MRI of her brain performed during April, 2009, showed no degenerative changes.