Healthy Life Research Articles

Stacking classifier method for prediction of human body performance

<p>A healthy body is the capital of success and supports human activities. To maintain health, humans need to avoid disease. A healthy life is everyone’s dream and should start early. Busy activities often hinder a healthy lifestyle. Nonetheless, it is important for every individual to lead a healthy lifestyle. Human activities determine health and the implementation of a healthy life. One method that can perform classification with machine learning is extreme gradient boosting (XGBoost). XGBoost is one of the techniques in machine learning for regression analysis and classification based on gradient boosting decision tree (GBDT). By using gradient descent to minimize the error when creating a new model, the algorithm is called gradient boosting. In determining a classification starting from determining the model to the results, usually only using one algorithm method, and combining other methods together with the method is an algorithm called random forest classifier. Among these merging methods are, stacking classifier, voting classifier, and bagging classifier. The conclusion obtained from the results of this research is that the test results show that the stacking classifier achieves the highest accuracy of 76.07%, making it the best method in this research. And the stacking classifier has a precision of 76.96%, recall of 75.83%, and F1-score of 75.81%. This shows that the model has a good balance between the ability to provide true positive results and the ability to recover positive data.</p>

Oculomics: A Crusade Against the Four Horsemen of Chronic Disease.

Chronic, non-communicable diseases present a major barrier to living a long and healthy life. In many cases, early diagnosis can facilitate prevention, monitoring, and treatment efforts, improving patient outcomes. There is therefore a critical need to make screening techniques as accessible, unintimidating, and cost-effective as possible. The association between ocular biomarkers and systemic health and disease (oculomics) presents an attractive opportunity for detection of systemic diseases, as ophthalmic techniques are often relatively low-cost, fast, and non-invasive. In this review, we highlight the key associations between structural biomarkers in the eye and the four globally leading causes of morbidity and mortality: cardiovascular disease, cancer, neurodegenerative disease, and metabolic disease. We observe that neurodegenerative disease is a particularly promising target for oculomics, with biomarkers detected in multiple ocular structures. Cardiovascular disease biomarkers are present in the choroid, retinal vasculature, and retinal nerve fiber layer, and metabolic disease biomarkers are present in the eyelid, tear fluid, lens, and retinal vasculature. In contrast, only the tear fluid emerged as a promising ocular target for the detection of cancer. The retina is a rich source of oculomics data, the analysis of which has been enhanced by artificial intelligence-based tools. Although not all biomarkers are disease-specific, limiting their current diagnostic utility, future oculomics research will likely benefit from combining data from various structures to improve specificity, as well as active design, development, and optimization of instruments that target specific disease signatures, thus facilitating differential diagnoses.

<황제내경 소문 상고천진론>의 양생법과 공동체 기반 건강 노화 요인의 비교고찰

We reexamined the meaning of <Hwangjenaegyeong Somun Sanggocheonjinron> by drawing on findings from studies on Blue Zones and healthy communities. The first chapter of Sanggocheonjinron highlighted the concept of living in harmony with the principles and essence of the universe. It emphasized the importance of a balanced diet, coupled with a regular lifestyle, as fundamental factors for achieving health and longevity. Chapter 2 highlighted the significance of harmonious community living as a key element for overall well-being. Chapter 4 further emphasized the importance of living one’s life in accordance with the principles of nature and community living. Numerous investigations into longevity and well-being have been conducted. Notably, an examination of the lifestyle of elderly people living in Blue Zones—regions densely populated with people living beyond 100 years without significant health issues—demonstrated that these people thrive by embracing a sense of purpose, leading simple lives, engaging in natural daily activities, and effectively managing stress. According to the findings, eating a vegetarian diet, avoiding excessive eating and drinking, and cultivating connections within a healthy community and family all helped to maintain health. While genetic factors were acknowledged to contribute to human longevity, constituting approximately 25%, the remaining portion was recognized as being influenced by lifestyle choices. Consequently, the pursuit of a healthy and long life, as advocated in the Hwangjenaegyeong and Blue Zones, emphasized the importance of belonging to a healthy community and cultivating healthy lifestyle habits.

A healthy habitual score for dietary intake is associated with primary dysmenorrhea among adolescent school girls

Background: Primary dysmenorrhea is one of the most common gynecological complaints among adolescent and young females in their reproductive age that affects their daily activities and social life. Nutritional habits are considered as risk factor for primary dysmenorrhea. ‘Thus the aim of our study was to assess the relation between healthy habits score for dietary intake and prevalence of primary dysmenorrhea. Methods: The present study was conducted on 432 adolescent school girls (218 girls with nil to mild dysmenorrhea and 214 girls with moderate to severe dysmenorrhea). Healthy habitual scores (HHS) was calculated from 5 modifiable dietary intake habits considering high risk habit as ‘0’ and low risk habit as ‘1’ giving a composite score ranging from 0 to 5. We classified the healthy life style score into three category: 0-2 as low; 3 as medium and 4-5 as high. Correlation between HHS and its components with incident of primary dysmenorrhea were evaluated. HHS and risk of primary dysmenorrhea were evaluated using logistic regression analysis. The significance level of the all the tests were considered at a level of 0.05. Results: Significant correlation was obtained between incident of primary dysmenorrhea and all tested habits. Magnitude of correlation was higher for HHS than individual habit. Among tested habitual factors sugar intake, skipping breakfast and frequency of junk food intake was positively correlated where as negative correlation was obtained between primary dysmenorrhea and dietary intake of vit-E and calcium. Considering low HHS as reference group odd ratio significantly low in medium and high HHS groups. Thus risk of primary dysmenorrhea was more among adolescent girls those led unhealthy dietary habits like take more sugar, frequently take junk foods and skipping breakfast and take vit-E and calcium below recommended amount. Conclusion: Avoiding of Junk food, skipping breakfast and intaking of vit-E and calcium as per recommended amount and restricting sugar intake is recommended as a healthy dietary habit to minimize the risk of primary dysmenorrhea.

The Zhongyong Dialectic: A Bridge into the Relational World

Abstract Three tensions are said to exist in my relational theory, i.e. between ontology and behavior, between structure and process, and between substance and procedure. Underlying these tensions is a crucial question: How to identify the subject and object and understand the domination–subordination power relationship therein? These seeming inconsistencies appear if observed through a dualistic lens but may well disappear when viewed from the zhongyong dialectic, which, as an epistemological and methodological device, assumes no binary dichotomy in the first place. It believes in immanent relationality and dynamic transformability, holding that interaction based on difference rather than homogeneity generates healthy life and arguing that subject and object, structure and process, substance and procedure—all these categories constructed as dichotomous opposites are in fact mutually transformable as related parts of a whole. The evolution of global society, from international society of nation-states, to global society of humans, and to planetary society of all on earth (or beyond), clearly indicates the relational transformability across the ostensible subject–object divide. Power relations exist, but any unilateral exercise of power is ephemeral, for power over will not last, while power to will.

Can Income Inequality Reduce the Happiness of a Healthy Population?

The relationship between health and happiness is well established. However, disability and the burden of disease can also affect the happiness of the local population. We argue that income inequality can worsen the positive effect of health on happiness levels. Using data from 136 economies from 2005 to 2019, we estimate a dynamic panel model that controls the endogeneity and simultaneity issues, and measure the effect of healthy life expectancy on happiness at varying levels of income inequality. We find evidence that healthy life expectancy is significantly and positively associated with happiness, however, at high levels of income inequality, this effect reduces. We shed new perspectives on the costs of income inequality.

Analysis of School Health Unit Program Practices with Clean and Healthy Living Behavior

Analysis of School Health Unit Program Practices with Clean and Healthy Living Behavior

Investigating various factors that influence perceived mental health in physical activity participation in West Sumatera, Indonesia: An approach using SEM-PLS

Problem Statement. Individual involvement in physical activity or sports is very important for the survival of a healthy and quality life, so the supporting and influencing factors need to be investigated. Purpose. This study aims to test a model related to factors that influence perceptions of mental health, including cognitive awareness, emotions, spirituality, and social environment for sports participants. Methods. A total of 1,351 volunteers from 18 regions in West Sumatra participated in this study. The data collection technique used a survey via Google Forms, distributed via WhatsApp social media. Data were analyzed using the Partial Least Square (PLS) method by assessing content validity, Average Variance Extracted (AVE), Inner Model, and hypothesis testing. Result. The results showed that cognitive awareness significantly affects awareness of the social environment (t = 13.142; P<0.05) and perceptions of mental health (t = 4.458; P<0.05). Emotional awareness significantly affects the relationship of awareness of the social environment (t = 5.572; P<0.05) and perceptions of mental health (t = 4.870; P<0.05). Environmental and social awareness significantly affects mental health perceptions (t = 7.397; P<0.05). Spiritual awareness significantly affects awareness of the social environment (t = 4.014; P<0.05) and perceptions of mental health (t = 5.851; P<0.05). Conclusions. It can be concluded that aspects of cognitive, emotional, and spiritual awareness and social environment are essential in influencing perceptions of mental health in individuals participating in sports. The findings highlight the importance of paying attention to cognitive, emotional, spiritual, and social environmental aspects of mindfulness for the sports community or other stakeholders to help create an environment that supports the quality of life of participants involved in sports

Medical expenses and its determinants in female patients with urological disorder

BackgroundThe rising older adult population has led to an increase in the prevalence of chronic diseases and medical expenses. Women tend to have a longer healthy life expectancy than men and are more likely to be exposed to urological disorders around the age of 50, resulting in substantial healthcare expenses throughout their lifetime. Urological disorders often require continuous treatment owing to their high risk of recurrence, contributing to an increased financial burden from medical costs. This study aimed to identify factors influencing medical expense in female patients with urological disorders and propose strategies to alleviate the associated financial burden.MethodsWe used data from the Korea Health Panel Survey conducted from 2011 to 2016. The final sample comprised 2,932 patients who visited hospitals for urological disorders. To identify the factors influencing medical expense among female patients with urological disorders, we employed a generalized estimating equation model.ResultsThe results indicated that younger people and patients with middle-income levels tended to incur higher medical expenses. Furthermore, patients receiving treatment at tertiary hospitals and those enrolled in National Health Insurance also incurred higher health expenses.ConclusionsThis study suggests that effective management of medical expenses related to urological disorders in women requires improvements in healthcare accessibility to facilitate early detection and continuous disease management. In addition, the findings highlight the potential benefits of digital health and non-face-to-face treatments in addressing these needs.

Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.

The study evaluated how ingestion of nicotinamide mononucleotide (NMN) for 12weeks by older adults affected blood nicotinamide adenine dinucleotide (NAD +) levels and physical function, particularly walking function. Information concerning sleep, and stress was also collected as secondary endpoints. In this randomized, placebo-controlled, double-blind, parallel-group comparison study, 60 participants were randomly allocated into a placebo group or NMN group. Members of the NMN group consumed 250mg/day NMN for 12weeks. Motor function tests, blood NAD metabolite analysis, and questionnaires were conducted at the start of the study and 4 and 12weeks after intake. This trial was registered at umin.ac.jp/ctr as UMIN000047871 on June 22nd, 2022.At primary outcome, at both 4weeks and 12weeks, the NMN and placebo groups had no significant differences in a stepping test. At secondary outcomes, after 12weeks of NMN intake, the NMN group had a significantly shorter 4-m walking time than the placebo group as well as significantly higher blood levels of NAD + and its metabolites. A significant negative correlation was observed between the change in the 4-m walking time and the change in blood NAD + , N1-methyl-2-pridone-5-carboxamide (2-PY), and N1-methyl-4-pridone-3-carboxamide (4-PY) at 12weeks. The NMN group had improved sleep quality at 12weeks relative to the placebo group as evidenced by lower scores for "Daytime dysfunction" and "Global PSQI" on the Pittsburgh Sleep Questionnaire. No adverse effects related to test substance consumption were observed. Together, these results indicate that NMN intake could increase blood NAD + levels, maintain walking speed, and improve sleep quality in older adults. Interventions involving NMN aimed at maintaining walking speed could contribute to extended healthy life expectancy.

Healthy Neighbourhoods Hub (HNH) Framework: A Practical Guide for Fostering Healthy and Inclusive Living in Florence’s Urban Environment

By 2050, an estimated 69% of the global population will reside in urban areas, underscoring the pivotal role of city neighbourhoods in enhancing quality of life by respecting and accommodating diverse identities and needs. The physical environment of neighbourhoods significantly influences community health and well-being, alongside social factors and access to health services. In Italy, prioritising health-promoting and accessible designs in neighbourhoods can form a solid foundation for urban health strategies. This study introduces a theoretical framework developed for the Healthy Neighbourhoods Hub (HNH) project in Florence, Italy, aiming to enhance health and accessibility across different scales. The HNH framework categorises healthy and inclusive neighbourhoods into 7 themes, 25 general characteristics, and 67 specific attributes, supported by verifiable variables derived from comprehensive research and design tools. This innovative framework addresses the need for multilevel, multidisciplinary approaches, and spatialization efforts to ensure equitable benefits for all community members.

An Analysis of Land Rights for Slum Dwellers

Human rights, under article 21 of the Indian constitution protects the Slum dwellers and forced Eviction violates the fundamental right of millions of people living in slums. The Constitution of India and the universal declaration of human rights give slum dwellers the right to choose their place of residence, and the right to a healthy life. However, the absence of a comprehensive development plan for slums is accelerating a spatial divide. The right not to be forcibly evicted is an element of the human right to adequate housing.

Development Indexes, Environmental Cost Impact, and Well-Being: Trends and Comparisons in Italy

In 1990, the United Nations (UN) presented the Human Development Index (HDI) as a measure of human development that considers three fundamental dimensions: a long and healthy life, being knowledgeable, and having a decent standard of living. This paper proposes some considerations about human well-being factors based on HDI analysis, also introducing some considerations on environmental pollution. As regards environmental issues, two different pollutants are considered together with their environmental costs: (i) greenhouse gas (GHG) emissions, which have an impact on a global scale, and (ii) emissions from fine particulate matter, primarily having an impact on a local scale. Thus, a new index based on the external environmental costs is proposed, and two scenarios are discussed. On the other hand, as it concerns human well-being, the results of surveys among the population are used. Furthermore, other features regarding health services and demographic aspects are taken into account, too. Italy is analysed as a case study over the last three decades. Easterlin’s considerations are verified based on the variation of perceived well-being related to the changes in GDP. The Italian case study shows that despite having achieved a satisfactory HDI level, there is a wide margin for improvement from both the environmental and the well-being standpoints.

The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019

BackgroundThe European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with those in 2010.MethodsWe used the Global Burden of Disease 2019 study estimates and 95% uncertainty intervals for the whole EU and each country to evaluate age-standardised death, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) rates for Level 2 causes, as well as life expectancy and healthy life expectancy (HALE).ResultsIn 2019, the age-standardised death and DALY rates in the EU were 465.8 deaths and 20,251.0 DALYs per 100,000 inhabitants, respectively. Between 2010 and 2019, there were significant decreases in age-standardised death and YLL rates across EU countries. However, YLD rates remained mainly unchanged. The largest decreases in age-standardised DALY rates were observed for “HIV/AIDS and sexually transmitted diseases” and “transport injuries” (each -19%). “Diabetes and kidney diseases” showed a significant increase for age-standardised DALY rates across the EU (3.5%). In addition, “mental disorders” showed an increasing age-standardised YLL rate (14.5%).ConclusionsThere was a clear trend towards improvement in the overall health status of the EU but with differences between countries. EU health policymakers need to address the burden of diseases, paying specific attention to causes such as mental disorders. There are many opportunities for mutual learning among otherwise similar countries with different patterns of disease.

Measuring population health using health expectancy estimates from morbidity and mortality databases.

The progressive incorporation of quality of life indicators in health planning meets a critical need: The evaluation of the performance of health services, which are under stress by multiple causes, but in particular by an ageing population. In general, national health plans rely on health expectancies obtained using the Sullivan method. The Sullivan health expectancy index combines age-specific mortality rates and age-specific prevalence of healthy life, obtained from health surveys. The objective of this work is to investigate an equivalent estimation, using available information from morbidity and mortality datasets. Mortality and morbidity information, corresponding to years 2016 and 2017, was obtained for the population of the county of Baix Empordà (Catalonia), N = 91,130. Anonymized individual information on diagnoses, procedures and pharmacy consumption contained in the individual clinical record (ICD and ATC codes), were classified into health states. Based on the observed health transitions and mortality, life expectancies by health state were obtained from a multistate microsimulation model. Healthy life expectancies at birth and 65 years for females and males were respectively HLE0female = 39.94, HLE0male = 42.87, HLE65female = 2.43, HLE65male = 2.17. These results differed considerably from the Sullivan equivalents, e.g., 8.25 years less for HLE65female, 9.26 less for HLE65male. Point estimates for global life expectancies at birth and 65 years of age: LE0female = 85.82, LE0male = 80.58, LE65female = 22.31, LE65male = 18.86. Health indicators can be efficiently obtained from multistate models based on mortality and morbidity information, without the use of health surveys. This alternative method could be used for monitoring populations in the context of health planning. Life Expectancy results were consistent with the standard government reports. Due to the different approximation to the concept of health (data-based versus self-perception), healthy life expectancies obtained from multistate micro simulation are consistently lower than those calculated with the standard Sullivan method.

Analysis of disease burden of welder's pneumoconiosis in Jiangsu Province

Objective: To investigate the current status of disease burden and its influencing factors among welder's pneumoconiosis patients, and provide scientific basis for taking targeted intervention measures. Methods: From June 2022 to June 2023, the patients with welder's pneumoconiosis in Jiangsu Province were selected from 1956 to 2020 as the research objects, and disability adjusted life years (DALY) were used as the comprehensive index to study the disease burden. The direct and indirect economic losses caused by the diseases were calculated, and the factors affecting the disease burden were discussed by multiple linear regression method. Results: A total of 974 cases of welder's pneumoconiosis were reported in Jiangsu Province, the cumulative loss of DALY was 6300.73 person-years, and the per capita loss was 6.47 person-years. Among them, the healthy life years lost due to disability (YLD) was 6156.50 person-years (97.71%) , and the healthy life years lost due to premature death (YLL) was 144.23 person-years (2.29%) . Multiple linear regression analysis showed that the main factors affecting DALY were disability grade, diagnostic age, pneumoconiosis grade and length of dust exposure (P<0.05) . The total economic loss caused by 974 welder's pneumoconiosis patients was 1831838160.18 yuan, and the per capita loss was 1880737.33 yuan. Among them, the direct economic loss was 970917563.75 yuan (53.00%) , and the indirect economic loss was 860920596.43 yuan (47.00%) . Conclusion: Welder's pneumoconiosis causes serious disease burden to patients, and at the same time causes huge economic losses to individuals and society, which seriously hinders the development of society. Taking effective control measures to prevent the incidence of welder's pneumoconiosis is the key to reduce the disease burden.

ANALYSIS OF REGULATORY AND LEGAL SUPPORT FOR THE PREVENTION OF DIABETES MELLITUS IN CHILDREN

Diabetes mellitus has become one of the most prevalent chronic diseases in childhood today. International forecasts suggest that the incidence of diabetes will continue to rise in the coming decades, leading to a lifelong burden for millions of children worldwide. Therefore, prediction, prevention, and optimal treatment of diabetes, as well as early prevention of serious long-term complications, remain essential. Providing highly qualified medical care to diabetic patients is a crucial step in preventing the development of complications. The purpose of this article is to review existing research on diabetes prevention strategies for children, considering the different levels of medical care support available. Materials and Methods. This study investigates the organization of preventive care for children with diabetes in Ukraine. Researchers employed three key methods: bibliosemantic analysis, content analysis focused on analyzing Ukraine relevant regulations and legal frameworks, and the method of systemic approach and analysis to gain a comprehensive understanding of how preventive care is currently organized for children with diabetes in Ukraine. Results. In Ukraine, preventive measures and the provision of medical care to pediatric patients with diabetes in the past years and today are regulated by a number of documents and orders of the Ministry of Health. As part of the Comprehensive Program “Diabetes Mellitus” (1999) and in accordance with the Order of the Ministry of Health of Ukraine “On Improving the Organization of Providing Endocrinological Care to the Population of Ukraine” (2006), the State Register of Patients with Diabetes Mellitus (SYNADIAB) was created. The next step was the approval of the State Target Program “Diabetes Mellitus”. Subsequently, the Project of the national program “Health 2020: Ukrainian Dimension” became an effective tool, which outlined the main principles of the program implementation in the “Endocrinology” section for 2013-2020. It defined measures at all stages of diabetes prevention, such as primary prevention, which consists of maintaining and strengthening the general state of health and preventing or delaying the development of diabetes; secondary prevention should improve early detection of diabetes mellitus; tertiary prevention, which ensures the effectiveness and safety of treatment of children with diabetes to prevent the development of long-term complications. Today, the guidelines for the management of children with diabetes mellitus have been continued in such documents as “Diabetes Mellitus in Children”, Evidence-Based Clinical Guidelines (2023) and Standards of Care (2023). Conclusion. Diabetes mellitus is a chronic disease that ranks third in prevalence after cardiovascular and cancerous diseases and second in the structure of endocrine diseases after thyroid gland pathology. Today, the prevalence of diabetes mellitus among children is constantly increasing and, therefore, solving the issues associated with this disease is one of the priority tasks for the national health care system. This is because diabetes mellitus is associated with a high risk of complications leading to loss of work capacity, disability, and mortality across various population groups. Organizing high-quality medical care and establishing an effective prevention system based on the latest medical technologies is crucial. Diabetes demands attention. Understanding the risks and prevention of the disease can significantly increase the chances of protection and a long, healthy life through timely treatment.

Poor healthy lifestyle and life's essential 8 are associated with higher risk of new-onset migraine: a prospective cohort study.

Lifestyle are closely related to migraine. However, there is a lack of studies investigating the association between Healthy lifestyle or Life's Essential 8 (LE8) and the risk of migraine. The objective of this research was to investigate the relationship between Healthy lifestyle scores and Life's essential 8 scores, and migraine. 332,895 UK Biobank participants without migraine were included. Healthy lifestyle were assessed using seven lifestyle factors, and categorized as poor, intermediate, or ideal. LE8, based on the American Heart Association (AHA) Guidelines for Cardiovascular Health (CVH), consist of eight indicators classified as low, moderate, or high CVH. The Cox proportional hazard model was employed to examine the association between Healthy lifestyle scores, LE8 scores, and migraine, with calculations for population-attributable fraction (PAF) and cumulative incidence. During a median follow-up of 13.58 years, participants in intermediate (HR: 0.91; 95% CI: 0.85, 0.99) or ideal category of Healthy lifestyle (HR: 0.81; 95% CI: 0.73, 0.91) significantly reduced migraine risk compared to the poor category. Similarly, high CVH (HR: 0.73; 95% CI: 0.58, 0.92) also lowered migraine risk, while moderate CVH (HR: 0.93; 95% CI: 0.85, 1.02) did not show a difference compared to low CVH. If all individuals adhered to higher categories of Healthy lifestyle and LE8, approximately 11.38% and 22.05% of migraine cases could be prevented. Among individual lifestyle factors, maintaining an ideal body mass index (BMI), physical activity, sleep duration, sleep pattern, and sedentary time were associated with substantial reductions in migraine risk, by 5.65%, 0.81%, 10.16%, 16.39%, and 6.57%, respectively. Our study provides evidence that poor Healthy lifestyle and Life's Essential 8 are associated with higher risk of new-onset migraine.

Review of the Development of Meniscus Centralization.

With an aging population, extending healthy life expectancy is a global challenge. Maintaining healthy knee joint function is one of the essential factors to preserve the ability to walk and extend healthy life expectancy. Meniscus centralization was introduced in 2012 as a procedure for meniscus extrusion, one of the causes of knee osteoarthritis (OA). Initially, it was performed only for lateral meniscus (LM) extrusion, and favorable 2-year results were reported in 2016. Gradually, basic studies supporting the effectiveness of meniscus centralization have been reported, and it has also been performed for medial meniscus (MM) extrusion, with some positive results reported. Although the surgical procedures vary among the institutions, the basic concept is to reattach the loosened meniscotibial ligament to the edge of the tibial plateau to re-tension it. This review will discuss the history of development and the current status of meniscus centralization. Current research shows that meniscus centralization is not performed in isolation but is often used as an augmentation along with the conventional repair of meniscus injuries, particularly posterior root tears. Biomechanical studies demonstrated that MM centralization with a posteromedial anchor can better restore meniscus function. Despite its relatively short publication history of just over ten years, meniscus centralization has shown potential as a treatment to curb the progression of knee OA and extend a healthy life. While more evidence is needed, this conclusion underscores the promising role for meniscus centralization, making it a topic of significant interest for knee surgeons and researchers.

Cardio-oncology rehabilitation: are we ready?

Cardio-oncology rehabilitation (CORE) is not only an essential component of cancer rehabilitation but also a pillar of preventive cardio-oncology. Cardio-oncology rehabilitation is a comprehensive model based on a multitargeted approach and its efficacy has been widely documented; when compared with an 'exercise only' programme, comprehensive CORE demonstrates a better outcome. It involves nutritional counselling, psychological support, and cardiovascular (CV) risk assessment, and it is directed to a very demanding population with a heavy burden of CV diseases driven by physical inactivity, cancer therapy-induced metabolic derangements, and cancer therapy-related CV toxicities. Despite its usefulness, CORE is still underused in cancer patients and we are still at the dawning of remote models of rehabilitation (tele-rehabilitation). Not all CORE is created equally: a careful screening procedure to identify patients who will benefit the most from CORE and a multidisciplinary customized approach are mandatory to achieve a better outcome for cancer survivors throughout their cancer journey. The aim of this paper is to provide an updated review of CORE not only for cardiologists dealing with this peculiar population of patients but also for oncologists, primary care providers, patients, and caregivers. This multidisciplinary team should help cancer patients to maintain a healthy and active life before, during, and after cancer treatment, in order to improve quality of life and to fight health inequities.