Healthy Israeli Research Articles

Oocyte freezing intention for non-medical reasons: the interplay with childbearing intention, age and self efficacy

ABSTRACT In recent years, the possibility for healthy women to consider or undertake oocyte freezing for non-medical reasons (OFNMR) allows women who want to have biological children, to enable motherhood at a later time, while protecting against age-related fertility decline. The present study explored the intended OFNMR among healthy Israeli women by looking at the interplay of age, childbearing intention and general self-efficacy – a personal resource. Two hundred fifty-one Israeli women were recruited through social networks and online forums related to women’s issues in general. Participants completed self-report questionnaires addressing socio-demographic data, childbearing intention, general self-efficacy, and OFNMR intention. The results revealed that the association between women’s age and OFNMR intention was insignificant. However, childbearing intention moderated the association between women’s age and OFNMR intention. Specifically, the association between age and OFNMR intention was positive and significant for women with childbearing intention while for women without childbearing intention, it was negative and significant. General self-efficacy was not found to be associated with OFNMR intention. The current study shed light on the role of childbearing intention in the context of fertility decisions, especially among women who verbalize their intention for OFNMR. Routine discussion between health-care professionals and women regarding childbearing intentions is recommended, especially with women nearing age-related decline in fertility

Impact of dietary fats on mental health: Omega-3, saturated, and trans fats in a healthy Israeli population

This study investigates the relationship between dietary fat consumption and mental health in a healthy Israeli population, addressing a gap in research regarding the effects of specific fats—Omega-3, saturated fats, and trans fats—on mental well-being. Despite existing studies on general eating patterns and mental health, limited research focuses on these specific dietary fats within this population. A sample of 98 participants was analysed using a correlational design and measures, including nutrition and psychological self-reported questionnaires. Results revealed that higher consumption of trans fats was significantly associated with increased depressive symptoms, with depressive scores significantly higher in those with a high trans-fat intake (M = 16.67, SD = 5.81) compared to those with lower intake (M = 10.25, SD = 4.95). Additionally, the interaction between trans-fat consumption and PUFA/SFA ratio significantly predicted depressive scores (β = 10.86, p < .001 for high PUFA/SFA ratio; β = 3.77, p < .001 for low PUFA/SFA ratio). Similarly, higher trans-fat consumption was linked to increased anxiety symptoms, as indicated by anxiety scores (β = 12.08, p < .001 for high PUFA/SFA ratio; β = 5.22, p < .05 for low PUFA/SFA ratio). Conversely, consumption of saturated fats did not significantly affect mental health, though interactions with PUFA/SFA ratios were noted (β = .14, p < .05 for high PUFA/SFA ratio). The study highlights the complex relationships between different types of fatty acids and mental health, contributing to a deeper understanding of how specific dietary fats impact mental well-being. These findings suggest potential avenues for nutritional interventions to improve mental health, mainly by reducing trans-fat intake.

Blending Towards Healthier Lifestyles: The Impact of Regular Fruit and Vegetable Smoothie Consumption on Dietary Patterns and Sustainable Health Behaviors.

This research aimed to characterize the nutritional, health and basic sustainability practices among regular smoothies' consumers (RSC; ≥ 1-2 servings/week for ≥ 2 months). Cross-sectional survey. Self-report online multiple-choice questionnaire survey of random sample of adults from online retailer database and community. 193 healthy Israeli adults (75.6% females, mean age 40.65 ± 14.36) completed an online multiple-choice validated survey from May 2022 to August 2023. Demographic, anthropometric, and lifestyle habits, including physical activity, FV consumption, and sustainability practices. Data were analyzed using chi-square tests for categorical variables and Mann-Whitney tests for non-normally distributed continuous variables. The level of statistical significance was set at .05. RSC were significantly older (P < .001) and more physically active (P = .025) than occasional smoothie consumers (OSC). They consumed more FV, reaching nutritional recommendations, and exhibited significant lifestyle changes, including reduced meat (P = .013) and processed food consumption (P = .013), and regular meal consumption (P = .045). RSC used fewer disposables (P = .002) compared to OSC and non-smoothie consumers (P = .001). RSC demonstrated a higher incidence of weight reduction compared to weight gain. RSC is significantly associated with health and nutritional sustainability.

Sex modifies the associations of regional fat with cognitive functioning and AD‐related brain volumes, in Israeli middle‐aged adults at high AD risk

AbstractBackgroundHigh body mass index (BMI) has been consistently linked to poorer cognition and higher dementia risk, with different associations in males and females. However, BMI does not represent well specific fat depots. We examined in middle‐aged adults at high Alzheimer’s dementia (AD) risk, whether regional abdominal adiposity is associated with cognitive functioning and brain indices and whether sex modifies these associations.Methods204 healthy Israeli middle‐aged AD offspring (59.44 [SD = 7.60] years old, 60% females) underwent abdominal Magnetic Resonance Imaging (MRI) to quantify hepatic, pancreatic, and peripheral fat %‐visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A broad cognitive battery defined global cognition and specific cognitive domains (episodic memory, working memory, executive functions, and language). A subsample of 142 participants had brain MRI to assess regional brain volumes (total gray matter [GM], hippocampus, and inferior, middle, and superior frontal gyrus [IFG, MFG, and SFG, respectively]). Partial correlations examined associations of regional abdominal adiposity with cognitive functioning, and brain indices, adjusting for age, sex, education, BMI, and time interval between abdominal MRI and the dependent variable. Fisher‐z transformation compared partial correlations between males and females.ResultsIn the whole sample, the only significant association was of higher hepatic fat % with lower GM volume (r = ‐264, p = 0.003), with similar associations in males and females. Only in males, higher pancreatic fat % was associated with lower global cognitive functioning (Males: r = ‐.276, p = .028; Females: r = 0.009, p = 0.93), executive functioning (Males: r = ‐0.267, p = 0.034; Females: r = 0.015, p = 0.87) and episodic memory (Males: r = ‐0.278, p = 0.027; Females: r = 0.068, p = 0.484) as well as with lower IFG volume (Males: r = ‐0.343, p = .017; Females: r = 0.117; p = 0.326). Also only in males, higher VAT% was associated with SFG volume (Males: r = .261, p = .045; Females: r = ‐0.198; p = 0.091).ConclusionIn middle‐aged males, but not in females, at high AD risk, regional abdominal adiposity, primarily pancreatic fat, was associated with lower cognitive functioning and lower AD‐related brain volumes. Results suggest sex differences in the contributions of fat to brain and cognitive aging. Since fat % is modifiable, these results may suggest that interventions to decrease distinct fats for the advancement of brain health must be sex‐specific.

Relationships of the gut microbiome with cognitive development among healthy school-age children.

The gut microbiome might play a role in neurodevelopment, however, evidence remains elusive. We aimed to examine the relationship between the intestinal microbiome and cognitive development of school-age children. This cross-sectional study included healthy Israeli Arab children from different socioeconomic status (SES). The microbiome was characterized in fecal samples by implementing 16S rRNA gene sequencing. Cognitive function was measured using Stanford-Binet test, yielding full-scale Intelligence Quotient (FSIQ) score. Sociodemographics and anthropometric and hemoglobin measurements were obtained. Multivariate models were implemented to assess adjusted associations between the gut microbiome and FSIQ score, while controlling for age, sex, SES, physical growth, and hemoglobin levels. Overall, 165 children (41.2% females) aged 6-9 years were enrolled. SES score was strongly related to both FSIQ score and the gut microbiome. Measures of α-diversity were significantly associated with FSIQ score, demonstrating a more diverse, even, and rich microbiome with increased FSIQ score. Significant differences in fecal bacterial composition were found; FSIQ score explained the highest variance in bacterial β-diversity, followed by SES score. Several taxonomic differences were significantly associated with FSIQ score, including Prevotella, Dialister, Sutterella, Ruminococcus callidus, and Bacteroides uniformis. We demonstrated significant independent associations between the gut microbiome and cognitive development in school-age children.

Characterization of Pterygomaxillary Suture Morphology: A CBCT Study

One of the most challenging procedures during maxillary osteotomy is pterygomaxillary suture (PMS) separation, due to the difficulty of directly inspecting this suture and the anatomical complexity of the adjacent structures. Knowing the precise anatomical dimensions and the position of the PMS, namely, the angle at which to approach this structure, may help in determining the proper osteotome. It will also help the oral and maxillofacial surgeon to perform this sensitive procedure more precisely and to minimize surgical complications (e.g., internal maxillary artery injury and unfavorable fracture during separation). The current study aimed to evaluate the morphology of PMS in an adult Israeli population using CBCT scans of the maxilla. Fifty CBCTs of healthy males (n = 27) and females (n = 23) were collected and analyzed. The vertical height, maximal thickness, and angulation of the PMS relative to the midsagittal plane of the skull were evaluated on both the right and left sides of the patient. An independent samples t-test was carried out to determine PMS morphological differences between males and females. A related samples t-test was conducted to determine the PMS morphological differences between the right and left sides. No significant differences in PMS parameters were found between sides in males and females (p &gt; 0.225). Both males and females exhibited similar height and angulation of the PMS (p &gt; 0.486). Interestingly, the PMS thickness was statistically greater in males (p = 0.029); however, this difference was clinically insignificant. The mean dimensions of the PMS in a healthy Israeli adult population are presented and discussed, as well as the clinical and methodological implications.

Grip strength in healthy Israeli adults: Comparison to internationally reported normative data.

Grip strength is frequently used in research and clinical work and is commonly compared to normative data in clinical settings. To enable accurate interpretation of grip strength values, normative reference values should be close to the demographic, occupational, cultural and geographic characteristics of the individual tested. Investigate the effects of gender, age, work-group and hand dominance on grip strength for the Israeli population, and to compare the grip strength to two normative studies from the United States. A cross sectional study. The grip strength of 637 healthy adults was measured using a Jamar dynamometer. The effects for age, gender, hand dominance, and work strain were investigated. Israeli sample results were compared to US norms. Within the Israeli sample, a significant age effect was found for both men and women. This effect was most apparent among the 70+ age groups, in which grip strength was weaker than all the other groups. Males were significantly stronger than females, in both hands, and the dominant hand was significantly stronger, regardless of gender. Results also demonstrated a medium to large effect for type of work on grip strength portraying high manual strain workers to have stronger grip strength. Overall, the grip strength in the Israeli sample was weaker than both US samples. Clinicians should be cautious when comparing grip strength to published norms from a different culture/geographical region. The amount of manual strain invested in various occupational roles should be considered in the assessment and intervention process.

Yield of targeted genotyping for the recurring pathogenic variants in cancer susceptibility genes in a healthy, multiethnic Israeli population.

Several recurring pathogenic variants in BRCA1/BRCA2 and other cancer susceptibility genes are encountered in ethnically diverse Jewish populations. The yield of genotyping for these recurring pathogenic variants in healthy Israeli individuals unselected for ethnicity, sex, or a family history of cancer has not been previously reported. Individuals voluntarily participating in annual medical surveillance at the Institute of Medical Screening of Sheba Medical Center were offered genotyping for predominant pathogenic variants in BRCA1/BRCA2 and recurring variants in CHEK2, MUTYH, APC, and the Lynch syndrome genes via a chip-based assay at the oncogenetic service of Sheba Medical Center from May 15, 2018, to December 15, 2020. All study participants were unrelated to one another. The study was approved by the Sheba ethics committee. Overall, 1764 individuals, including 1008 females (57%), with a mean age of 54.2 years (range, 25-86 years) were genotyped. The yield of the testing was 4% (71 of 1764), and it was higher in Ashkenazi Jews (AJs) and mixed AJ-non-AJ participants (4.75% [58 of 1222]; 1.8% for BRCA1/BRCA2 pathogenic variants) than non-AJ patients (2.2% [9 of 401]; 1% for BRCA1 pathogenic variants). When BRCA1/BRCA2 pathogenic variants were excluded, 2.44% carried low-penetrance variants, including CHEK2 c.1283C>T (n = 3), APC c.3920T>A (n = 36), and heterozygous MUTYH c.1187G>A (n = 4). A family history of cancer was not associated with a higher yield of pathogenic variant detection. The observed rates of positive genotyping in a healthy, unselected, multiethnic Israeli population warrant consideration of the inclusion of targeted genotyping of selected pathogenic variants in high-penetrance and perhaps lower penetrance cancer susceptibility genes for all Jewish individuals in Israel, regardless of their ethnicity or family history of cancer.

Risk-reducing salpingo-oophorectomy and breast cancer incidence among BRCA-mutation carriers.

10548 Background: Uncertainty exists with regard to the role of bilateral salpingo-oophorectomy in altering the risk of breast cancer in BRCA-mutation carriers. Methods: Included were 1645 healthy Jewish Israeli BRCA1/2 -mutation carriers from a single center without prophylactic mastectomy. Carriers with and without risk-reducing bilateral salpingo-oophorectomy (RRBSO) were matched according to BRCA-mutation type (BRCA1 vs. BRCA2) and year of birth (±1 year). Hormonal and reproductive variables were compared and incidence of breast cancer recorded. Association between RRBSO and breast cancer was studied. Results: Seventy-seven and 50 matched-pairs had BRCA1 and BRCA2 mutation respectively. Fifty-two carriers had breast cancer, 21 in RRBSO-group and 31 in no- RRBSO group, with no statistically significant difference. When analysing each mutation group separately, stratified by age at surgery, no association between RRBSO and breast cancer incidence was found among BRCA1-mutation carriers. However, in BRCA2 mutation carriers, RRBSO was associated with a statistically significant decreased overall incidence of breast cancer, HR = 0.2 (confidence interval 0.44-0.913, p = 0.038). Breast cancer incidence was lower after 5, 10,15 and 20 years in BRCA2-mutation carriers with RRBSO compared to no-RRBSO. Age at menarche, age at surgery, parity and oral contraceptive use were not significant risk factors for breast cancer. Hormone replacement therapy was used by 62 mutation carriers, 52 in the RRBSO group and 10 in the no-RRBSO group, and its use did not alter breast cancer risk (p = 0.463). Conclusions: According to our findings, RRBSO is associated with a reduced risk of breast cancer only in BRCA2 mutation carriers, regardless of HRT use.

Health-Related Quality of Life in Children and Adolescents with Nonclassic Congenital Adrenal Hyperplasia

Objective: Nonclassic congenital adrenal hyperplasia (NCCAH) is a late-onset milder form of congenital adrenal hyperplasia that differs dramatically from the classic form. Health-related quality of life (HRQOL) in pediatric patients with the sole diagnosis of NCCAH has not been determined; therefore, in this study, we aimed to determine whether HRQOL is compromised in comparison to the general population. Methods: Single-center, cross-sectional, case-control study. Twenty-three hydrocortisone-treated children and adolescents (7 males) diagnosed with NCCAH by cosyntropin stimulation test and CYP21A2 gene mutation analysis were recruited to this study; 6 healthy siblings were also recruited. HRQOL was assessed by the child and parent-proxy PedsQL Inventory and compared between NCCAH subjects and healthy siblings. HRQOL scores of NCCAH subjects were compared with known standards from the U.S. and Israeli general healthy populations. Anthropometric measurements of children and parents were performed and compared between NCCAH subjects and healthy siblings. Pearson correlation coefficients were calculated. Results: HRQOL scores of the participants and parents did not differ between NCCAH subjects and healthy siblings. The HRQOL emotional domain scores of the NCCAH patients and parent were significantly lower than the healthy U.S. pediatric population (P = .046) but not different from established standards of the healthy Israeli population (P = .583). Anthropometric measurements were within the normal range and did not differ between NCCAH subjects and their siblings. Total, school functioning, and psychosocial HRQOL domain scores were positively correlated with body mass index-standard deviation score in NCCAH subjects. Conclusion: HRQOL was not adversely affected by NCCAH among adequately treated children and adolescents. Abbreviations: BMI = body mass index; CAH = congenital adrenal hyperplasia; HRQOL = health-related quality of life; NCCAH = nonclassic congenital adrenal hyperplasia; PedsQL = Pediatric Quality of Life Inventory; SDS = standard deviation score.

Environment dominates over host genetics in shaping human gut microbiota

Up to now, it was thought that genetics would play a major role in shaping the gut flora. However, this study, in a cohort of 1,046 healthy Israeli individuals with a well-defined clinical phenotype, suggests that only 2-8% of human microbiome variability is explained by genetics, as compared to 92-98% explained by environmental influences. This study shows that the microbiome is not significantly associated with genetic ancestry or with individual SNPs. There was significant similarity among the microbiomes of genetically unrelated individuals who share a household, but no such similarity among relatives without a history of household sharing. The gut’s microbiome is mostly influenced by lifestyles; our diets, physical activity and mediation history. It was recently reported that the microbiome has an important impact on immune responses, and it seems that this may be a new route whereby lifestyles may influence immune and other health outcomes. An obvious yet unknown question arising from such observations is whether manipulating the microbiome could influence later health and disease.

Correction: The effect of CAG repeats length on differences in hirsutism among healthy Israeli women of different ethnicities.

[This corrects the article DOI: 10.1371/journal.pone.0195046.].

Respiratory carriage of the novel Kingella negevensis species by young children.

Kingella negevensis, a novel Kingella species implicated in a pediatric joint infection, has been recently characterized but its epidemiology remains largely unknown. The pharyngeal carriage of K. negevensis was studied by re-examining the results of a previous longitudinal study conducted in a cohort of healthy Israeli children from whom upper respiratory tract specimens were sequentially cultured between the ages of 2 and 36 months. Isolates were identified as K. negevensis by a species-specific nucleic amplification assay and genotyped by pulsed-field gel electrophoresis. β-lactamase production was determined by the nitrocephin test. Kingella negevensis was detected in 26 of 4,472 (0.58%) oropharyngeal cultures obtained from 24 of 716 children (3.35%) and was not isolated from any of 4,472 nasopharyngeal specimens. Following the first 6 months of life during which none of the children was colonized, the prevalence of carriage gradually increased reaching a peak of 1.09% at 24 months of age and decreased thereafter. Kingella negevensis strains showed genomic heterogeneity, and two clones represented 22 of 26 (84.62%) isolates. Twelve of the 26 (46.15%) isolates, belonging to two distinct clones, produced β-lactamase. Kingella negevensis shows remarkable similarities with K. kingae in terms of colonization site, age-related patterns of acquisition and carriage, and clonal distribution of β-lactamase production. Additional research is needed to investigate potential colonization sites of K. negevensis outside the respiratory tract, explore the mechanisms of pharyngeal colonization by the organism, and determine its role as an invasive human pathogen.

A neural correlate for common trait dissociation: Decreased EEG connectivity is related to dissociative absorption.

Dissociation refers to a disintegration between psychological elements; common manifestations are embodied in "absorption and imaginative involvement," a propensity for being immersed in a stimulus while oblivious to the environment, and acting without awareness. Trait dissociation was hypothesized to relate to lower EEG signal connectivity, but studies on healthy populations are scarce. The present study set out to examine whether dissociative absorption in a nonclinical sample would be associated with decreased intrahemispheric coherence. In 84 healthy Israeli soldiers (49% females; Mage = 22.24, SD = 2.64), resting-state electroencephalography (rsEEG) was recorded for a period of 3 min with eyes closed and 3 min with eyes open. Decreased coherence was related to high dissociative absorption in the long (frontal-occipital) range, and in one of the pairs of the short range (central-parietal). The effects emerged mostly in the left hemisphere, in both eyes-open and eyes-closed conditions, and for a range of spectral bands, although long-range effects were more pronounced in slow-wave bands (theta and delta). Dissociative absorption is manifested in segregated cortical activity, supporting the notion that it may represent less integrated mental functioning. The findings contribute to our understanding of the neural correlates of consciousness and personality.

Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet’s Uveitis and Vary Between Populations

ABSTRACTPurpose: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet’s uveitis.Methods: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted from peripheral blood leukocytes and genotyped.Results: The risk allele, A, in rs1800871, of IL-10 gene was highly prevalent in Behcet’s uveitis and healthy control samples alike; highest among the Turkish groups. Prevalence of G allele, in rs1495965, in the IL23R-IL12RB2 gene was high in Behcet’s uveitis patients, and among healthy Turkish and Israelis of Middle Eastern origin, while lower among the other Israeli control group (77.9%, 78.9%, 27.8%, respectively, P < 0.001).Conclusion: Our findings highlight the differences between populations and may account for the increased prevalence of the disease among Turkish and Israelis of Middle Eastern origin. Further studies are required to map other healthy and affected populations.

The effect of CAG repeats length on differences in hirsutism among healthy Israeli women of different ethnicities.

PurposeVariations in the degree of hirsutism among women of different ethnic backgrounds may stem from multiple etiologies. Shorter length of the polymorphic CAG repeats of the androgen receptor (AR) gene may be associated with increased activity of the receptor leading to hirsutism. We hypothesized that there are ethnic differences in the degree of hirsutism that is unrelated to androgen levels among Israeli women, and that the CAG repeats length may contribute to these differences. Anti-androgenic therapies, such as spironolactone, could be suggested if a shorter CAG repeats length is found to affect the difference in the degree of hirsutism between the ethnic groups.MethodsHealthy Israeli Jewish women aged 18–45 years of Ashkenazi and non-Ashkenazi origin were invited to participate. Hirsutism was assessed using the simplified Ferriman–Gallwey (sFG) score, and serum total testosterone levels were measured as well. The CAG repeats length was determined by PCR. Methylation-sensitive methods were used to detect the fractional activity of each allele, and the weighted mean was calculated for the CAG repeats length.ResultsOne-hundred and eight women were recruited (49 Ashkenazi and 59 non-Ashkenazi). The Ashkenazi women had a significantly lower degree of hirsutism (P<0.01), lower mean BMI (P = 0.003), total testosterone levels (P = 0.017), and longer weighted bi-allelic CAG repeats mean (P = 0.015) compared to non-Ashkenazi women. For the group as a whole, there was a significant negative correlation between the number of CAG repeats in the AR gene and the sFG score, while the number of repeats was not related to testosterone levels. Stepwise logistic regression revealed that ethnic origin and the CAG repeats length were the strongest factors affecting hirsutism (P<0.001, P = 0.03, respectively).ConclusionsThere is a significant difference in the degree of hirsutism between Ashkenazi and non-Ashkenazi women in Israel that is partially explained by CAG repeats length.

Grip Strength in Healthy Israeli Adults

Objectives: This study had 2 primary objectives. The first was to establish normative data for grip strength for the adult population in Israel. The second objective was to compare the results of this derived Israeli normative data to internationally reported measures. Two published studies were used for comparison. One study consolidated data from 12 different studies that originated from 8 different countries. The other study was limited to data from Australia. Methodology: A total of 574 healthy adult volunteers had their grip strength tested. This study was conducted over a 3-year period (2013-2015). Testing with regard to position and technique was performed in accordance with recommendations of the American Society of Hand Therapists. Grip strength was determined using the Jamar dynamometer from the average of 3 trials for each hand. Normative data were established based on age, handedness, and sex. More specifically, to allow comparison to international data, the age was subdivided in both 5- and 10-year intervals. The results from this study were then compared with international standards using a 1-sample t test. Results: Looking first at Israeli normative data, across ages and handedness, males were 45% stronger than females. Right-handed people were on average 9% stronger on their right compared with their left side. Left-handed people had the similar average strength on both side. Compared with the Australian data, Israeli men were 3% weaker and Israeli women were 15% weaker. When the data were subdivided based on age, the Israeli population was weaker but statistical significance was reached only for men below the age of 30 years and for women below the age of 60 years. When the Israeli data were compared with the consolidated norms, Israeli men were 10% weaker and women were 23% weaker. Conclusion: Normative data for grip strength were established for the Israeli population and compared with internationally published data. The lower grip strength of the Israeli population we speculate may be related to the lower demands placed on the hands for “white-collar” occupations relative to manual labor. It may also be related to lower average population size, weight, or hand girth when comparing the populations.

The death and owning of the companion dog: Association between resource loss and stress in healthy Israeli women

Abstract Dog owners often regard their dogs as family members that provide companionship and feelings of security and of being loved. The loss of a dog may be experienced as a stressful life event and lead to bereavement. The aim of this study was to explore the contribution of a Conservation of Resources (COR) theory to the understanding of the effects pet dogs might have on their healthy adult owners' stress. We performed a cross-sectional study of 110 current dog owners and 103 bereaved owners, all females. Veterinarians from 48 private clinics from central Israel referred the researchers to owners who euthanized their pet dogs in 1-month period. The control group included owners who had lived with the dogs for more than 2 years. Based on the COR theory, 2 new instruments to measure resource losses and gains of owners were assembled. The level of stress was assessed by the Perceived Stress and the Somatic Complaints scales. Stress was stronger for bereaved owners (statistically significant). In multivariate regression, for current owners, the factors correlated with stress were: number of cigarettes, performing or not performing sports activity in previous 2 weeks, and dog-related losses. For bereaved owners, the factors that correlated with stress were number of cigarettes and losses owing to a dog's death. The findings of the study supported the hypothesis that stress among bereaved owners is higher than that among the current owners. It seems that the death of a dog is a stressful life event.

Prevalence of overweight, obesity and metabolic syndrome components in children, adolescents and young adults with type 1 diabetes mellitus.

We aimed to determine the prevalence of overweight and obesity among children, adolescents and young adults with type 1 diabetes mellitus (T1DM), and to assess the prevalence of the metabolic syndrome and its components. The study cohort comprised 326 (168 women) consecutive patients aged 5 to 30 years diagnosed with T1DM and followed up in the Juvenile Diabetes Clinic, Maccabi Health Care Services. Anthropometric measurements, blood pressure, presence of additional diseases, other medications, HbA1c , triglycerides and high density lipoprotein cholesterol levels were obtained. The mean age in the study group was 18.5 ± 6.0 years, and the mean diabetes duration was 8.7 ± 5.0 years. Mean HbA1c level was 8.1 ± 1.3%. Nineteen per cent of the study population was overweight (85th > body mass index < 95th percentile) and 5.2% was obese (body mass index ≥ 95th percentile). Female patients aged 15 ≤ 18 and 18 ≤ 25 years were significantly overweight compared with healthy Israeli women in the same age groups, 33.3% versus 12.7% and 26.3% versus 7.8%, respectively, p < 0001. There were no obese female patients in the 15 ≤ 18 age group. Among the men in all age groups, there was no difference in the prevalence of overweight and obesity compared with healthy men in the general population. There was no difference in the age of onset, disease duration, HbA1c levels, treatment with anti-depressants and associated morbidities between the normal weight, overweight and obese groups. Obese patients had lower levels of HDL and increased prevalence of hypertension and metabolic syndrome. Overweight but not obesity was more prevalent in women with T1DM. Metabolic syndrome and its components were more prevalent among overweight and obese individuals with T1DM than among normal weight individuals.

Dopamine system genes are associated with orienting bias among healthy individuals

Healthy individuals display subtle orienting bias, manifested as a tendency to direct greater attention toward one hemispace, and evidence suggests that this bias reflects an individual trait, which may be modulated by asymmetric dopamine signaling in striatal and frontal regions. The current study examined the hypothesis that functional genetic variants within dopaminergic genes (DAT1 3′ VNTR, dopamine D2 receptor Taq1A (rs1800497) and COMT Val158Met (rs4680)) contribute to individual differences in orienting bias, as measured by the greyscales paradigm, in a sample of 197 young healthy Israeli Jewish participants. For the Taq1A variant, homozygous carriers of the A2 allele displayed significantly increased leftward orienting bias compared to the carriers of the A1 allele. Additionally, and as previously reported by others, we found that bias towards leftward orienting of attention was significantly greater among carriers of the 9-repeat allele of the DAT1 3′ VNTR as compared to the individuals who were homozygous for the 10-repeat allele. No significant effect of the COMT Val158Met on orienting bias was found. Taken together, our findings support the potential influence of genetic variants on inter-individual differences in orienting bias, a phenotype relevant to both normal and impaired cognitive processes.