Abstract Background/Objectives Blockchain technology is revolutionizing various industries by enhancing security, transparency, and efficiency. In healthcare, its small-scale application demonstrates the potential to transform healthcare. This study explores how cryptocurrency and blockchain technology enhance healthcare financial stability, secure medical information exchange, increase payment recovery and interoperability. Methods Guided by the Diffusion of Innovations (DOI) Theory, this study reviews 34 articles on blockchain and cryptocurrency adoption in healthcare. We performed a thematic analysis focusing on empirical data, theoretical analyses, and existing implementations. Data were categorized by DOI elements: relative advantage, compatibility, complexity, trialability, observability, and social system. The findings were synthesized into a detailed framework for adopting these technologies in healthcare. Results Our analysis shows that cryptocurrency offers a secure, decentralized payment platform, eliminating the need for third-party intermediaries. Blockchain adoption enhances payment and patient record protection. Cryptographic methods ensure data integrity, transparency, and security, preventing modifications once recorded. Altering data requires consensus from the network majority, protecting healthcare providers from ransomware attacks. Conclusions Evidence suggests that cryptocurrency and blockchain will disrupt healthcare payments, data management, and accommodate interoperability within the next decade. These technologies promise improved security, improved public health research, and increased trust in the healthcare system. Key messages • Our research will be assessing the challenges of integrating digital coins and blockchain technology into the healthcare system. • Examine the potential benefits and risks of implementing blockchain technology in healthcare settings.
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