Introduction and Background: Healthcare-acquired infections [HCAI] account for 10-30% of all hospitaladmissions, according to the World Health Organization [WHO]. An estimated 1.4 million people are infected withHCAI at any given time.1 As the burden of health-care-associated infections grows, so does the seriousness of diseaseand treatment difficulty, which is exacerbated by multi-drug-resistant pathogen infections.2 Health care providersare reverting to the fundamentals of infection control by employing common steps such as hand hygiene.3 TheWHO’s global initiative on patient safety programmers has made “Clean Care is Safer Care” a top priority.it is timefor developing countries to formulate the much-needed policies for implementation of basic infection preventionpractices in health care set-up.4Nurses, the “nucleus of the health-care system,” spend more time with patients than any other health-care worker, andtheir adherence to hand-washing protocols appears to be more important in preventing disease transmission amongpatients. Hand hygiene is thought to be the most important factor in preventing healthcare-associated infections(HAI). Hand hygiene programmes with a variety of components have been shown to increase compliance amonghealthcare workers and, as a result, minimise infections. One such initiative is the World Health Organization’simplementation of an evidence-based definition called “My five moments for hand hygiene.”5The investigator seeks to study the compliance to hand hygiene practices among staff nurses, working in the obstetricaland gynaecological wards. The research is an endeavour to increase the awareness and educate nurses about the needfor compliance to hand hygiene practices.Aim: A.The aim of this study was to see how well health care workers in the intensive care unit kept their handsclean (ICU)B. To determine the causes of noncompliance, andC. To investigate the effectiveness of a multimodal intervention approach in enhancing compliance.Methodology: This Quasi experimental one group pre-intervention and post intervention study compares thecompliance to hand hygiene practices before and after a multimodal interventional strategySetting: The study was conducted in ICU ward in hospitalResult: The study needed a sample size of 64 nurses to achieve an 80 percent power and a 5% error rate. A t testwas used to compare the mean pre- and post-test scores. ANOVA was used to examine the relationships betweenthe baseline variables. Hand hygiene enforcement among staff nurses increased dramatically from 45.31 percentto 65.78 percent following multimodal intervention strategies. (P0.0001) Hand hygiene techniques have improvedsignificantly (hand wash technique mean score increased from 5.97 + 1.284 to 8.16 + 1.158 (p 0.05) and hand rubtechnique score increased from 4.52 + 0.992 to 6.69 + 1.489 (p 0.05)).The private wards had considerably better handhygiene than the general wards.XI. Conclusion: The results of this study show that when multimodal interventional interventions were used, handhygiene compliance improved.