This article looks at the possible implications of English regional government for the promotion and provision of healthcare. Elected assemblies may allow more locally tailored policies aimed at reducing health inequalities, which vary substantially between regions. They may also increase the democratic accountability of health services and help to 'join-up' health and other policy domains. The obstacles to devolved control over health care include the inherently centralized nature of health care provision in Britain and strong public support for a National Health Service. Given these potentials and constraints, this article attempts to identify those areas of health policy that feasibly could be devolved to English regional assemblies.