We determined the profile of participants in the multi-level annual marathons held in Alabama Black Belt counties in terms of lifestyle characteristics and considered how these characteristics relate to a family history of cancer. Data on socioeconomic, health, and lifestyle characteristics of respondents were collected during the Annual Healthy Lifestyle Marathons of 2013-2019. These events were five miles in length and allowed participants to walk, bike, or run. Characteristics of respondents were compared using frequencies, percentages, and cross-tabulations. Most of the respondents with a family history of cancer were within the 18 to 24-year age category; had an annual income in the range of under U.S. $10,000; had received some college training; reported their overall health as good; and were African American. Although low consumption of fruits and vegetables has a demonstrated association with being diagnosed with cancer, in 2019 only 43% of respondents reported frequent intake of fruits and vegetables. Community-based health programs are critically needed to improve health in rural Black Belt communities.