AbstractThis article elaborates on the struggle to decolonize knowledge and introduces a decolonial‐inspired framework for conducting research. This is then demonstrated through the example of a project examining Latinx immigrant and Indigenous Health on California's Central Coast. In this case, a mixed‐methods ethnographic approach was used to capture the complexity of migrant experiences. Utilizing participant observation, interviews, focus groups, news data analysis, and a comprehensive survey, the study integrated community input and reflexivity. The article emphasizes linguistic and cultural factors, showcasing how structural factors of race and Indigeneity impact the dynamics of evaluation methods. The decolonial‐inspired approach also emphasizes making research useful by guiding the dissemination of findings in a way that fosters transparency and accountability. In this case, the study engages with policymakers and community leaders advocating for health equity and justice.