Health Life Expectancy Research Articles

The Role of Government Health Expenditure in Driving Economic Growth: Evidence from OECD Countries

This study examines the influence of government health expenditure and life expectancy on economic growth. The study makes use of panel data analysis and utilizes data from the OECD nations between 2000 and 2021. The study applies panel data analysis using POLS, FEM and REM models and dynamic GMM models. The study also gauges the moderating role of life expectancy on the relationship between government health expenditure and economic growth. The results indicate that government expenditure on health hurts economic growth. A detrimental relationship between life expectancy and economic growth indicates that higher life expectancy could result in elevated healthcare and financial expenses. Nevertheless, the interactive regression model suggests that there is no significant moderation of the association between government expenditure on health and economic growth by life expectancy, implying that the influence of government health expenditure on economic growth is generally unaffected by demographic changes. These findings emphasize the significance of differentiating between the short-term and long-term economic consequences of healthcare expenditure. This study offers insights into the optimization of public spending in OECD nations to promote sustainable economic growth and enhance public health outcomes.

Early Health Impacts of a Primary Care Consultation Model for People Served by Assertive Community Treatment teams.

The cardiometabolic health outcomes and life expectancy of people living with serious mental illness (SMI) continue to significantly flag behind that of the general population. This study explores the possibility of using the evidence-based Assertive Community Treatment (ACT) model and infrastructure to increase access to primary care and improve cardiometabolic outcomes of people with SMI. Four ACT teams in a large urban area received the services of a primary care consultant who was co-located at a Federally Qualified Health Center (FQHC), met regularly with ACT team clinicians to review a cardiometabolic registry of participants, and engaged participants in primary care services. Health screening rates, primary care utilization, and cardiometabolic outcomes-body mass index, blood pressure, hemoglobin A1c, cholesterol, and tobacco smoking status-were monitored over the course of a year. The efficacy of this integrated care model was also explored through focus groups with ACT team staff and participants. Significant improvements in screening rates were found for the ACT teams that received this integrated care intervention; however, only modest improvements in cardiometabolic outcomes were found. Future longitudinal, multi-site studies are needed to fully determine the impact of integrated care models on the physical health outcomes of this vulnerable population.

Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review.

Although a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human somatic cells both in health and disease conditions. The activity and expression of SIRTs affect important metabolic pathways, such as cell survival, senescence, proliferation, energy production, stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity. Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic inflammatory responses that are too early to be detected by disease-specific biomarkers. In this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.

Impact Of State Expenditures On The Increase In Life Expectancy In Brazil

This study analyses the impact of state public health expenditure on life expectancy in Brazil between 1990 and 2021, focusing on how investments in the health sector influence the population's longevity. The research uses a panel data model to explore the correlation between health spending and life expectancy, considering per capita income as a secondary variable. The results show a significant positive relationship between increased health spending and improvements in life expectancy across Brazilian states. However, another relevant finding indicates that health spending has become insufficient to significantly boost life expectancy, possibly due to rising healthcare costs driven by an ageing population. This ageing has generated increasing pressure for more health resources, requiring expanded expenditure in this sector. This study aims to contribute to the debate on the effectiveness of state health policies and encourages future investigations into optimising public health investments to maximise benefits for the population

Systematic review on the efficacy and safety of cytisine against nicotine dependence

Tobacco is one of the main causes of preventable mortality in our environment, in addition to having been correlated with numerous diseases. Smoking cessation improves health status and life expectancy. Pharmacological treatment of smoking cessation increases the likelihood that patient will successfully quit smoking. A search was carried out in the PubMed and UpToDate databases, obtaining a total of 11 systematic reviews or meta-analyses published in the last five years. After applying inclusion criteria and reading summaries, 5 total articles were obtained for the final review. Cytisine is a safe and effective treatment for smoking cessation. The most effective treatment in the clinical trials reviewed is varenicline associated with nicotine replacement therapy.There is less evidence collected on cytisine treatment, but it shows that it is also an effective therapy in smoking cessation, also demonstrating its usefulness in the long term. In addition, therapy with cytisine seems to entail fewer adverse effects than treatment with varenicline.

Multi-Dimensional Healthy Aging Interventions: Evidence from an Age-Friendly Community Program in Italy

In this paper, we evaluate a pre-pandemic multi-dimensional healthy aging program promoted by an Italian private Foundation to provide new insights on interventions that address both health and social needs within an age-friendly community framework. Using propensity score matching and linear regression models, with specific controls for individuals’ self-selection into the program, we compare lifestyles, physical health, mental conditions, and healthy life expectancy of subjects enrolled into the program with those of similar, but non-enrolled, subjects. Our main finding is that, to be more effective, healthy aging interventions should target the key dimensions of aging - physical, mental, and social - in a holistic approach. Indeed, we show that the multi-dimensionality of the healthy aging intervention under study - the contemporaneous target of older adults’ physical, mental, and social health - is crucial in improving both quantity and quality of life.

Screening for Breast Cancer: A Comparative Review of Guidelines.

Breast cancer is the most common malignancy diagnosed in the female population worldwide and the leading cause of death among perimenopausal women. Screening is essential, since earlier detection in combination with improvements in breast cancer treatment can reduce the associated mortality. The aim of this study was to review and compare the recommendations from published guidelines on breast cancer screening. A total of 14 guidelines on breast cancer screening issued between 2014 and 2022 were identified. A descriptive review of relevant guidelines by the World Health Organization (WHO), the U.S. Preventive Services Task Force (USPSTF), the American Cancer Society (ACS), the National Comprehensive Cancer Network (NCCN), the American College of Obstetricians and Gynecologists (ACOG), the American Society of Breast Surgeons (ASBrS), the American College of Radiology (ACR), the Task Force on Preventive Health Care (CTFPHC), the European Commission Initiative on Breast Cancer (ECIBC), the European Society for Medical Oncology (ESMO), the Royal Australian College of General Practitioners (RACGP) and the Japanese Journal of Clinical Oncology (JJCO) for women both at average and high-risk was carried out. There is a consensus among all the reviewed guidelines that mammography is the gold standard screening modality for average-risk women. For this risk group, most of the guidelines suggest annual or biennial mammographic screening at 40-74 years, while screening should particularly focus at 50-69 years. Most of the guidelines suggest that the age limit to stop screening should be determined based on the women's health status and life expectancy. For women at high-risk, most guidelines recommend the use of annual mammography or magnetic resonance imaging, while the starting age should be earlier than the average-risk group, depending on the risk factor. There is discrepancy among the recommendations regarding the age at onset of screening in the various high-risk categories. The development of consistent international practice protocols for the most appropriate breast cancer screening programs seems of major importance to reduce mortality rates and safely guide everyday clinical practice.

Hypothyroidism in Older Adults: A Narrative Review

The prevalence of hypothyroidism increases along with aging, resulting in one of the most common comorbidities among patients over 75 years. The leading causes of hypothyroidism in older adults are iatrogenic, Hashimoto's thyroiditis, and medications. The narrative review aimed to discuss the clinical characteristics of hypothyroidism in older adults and the impact of hormonal replacement therapy on survival rates. Thyroid function declines over time due to physiological changes in the thyroid stimulating hormone signaling, iodine absorption and metabolism, thyroid hormone metabolism, and activity at peripheral sites. A serum TSH value over the upper limit of the normal reference range is not necessarily attributable to hypothyroidism. However, an appropriate diagnostic work-up is required to rule out true hypothyroidism and discriminate the etiology (i.e., thyroid autoimmune diseases, iodine deficiency, drug-induced hypothyroidism). Levothyroxine treatment should be considered in cases of overt hypothyroidism. A complete risk-to-benefit assessment, particularly considering the overall health status, life expectancy, cognitive function, mood, and cardiovascular and neurological background, should be considered before treating subclinical hypothyroidism with more potential benefits in patients under 75 years old. Levothyroxine formulations facilitating hormone absorption and increasing compliance to long-term treatment should be preferred. TSH target should usually be set over 3 mIU/ml. Defining optimal diagnostic approaches and targeted therapeutic strategies should be considered in the personalized management of aged patients with hypothyroidism.

INTER-REGIONAL POVERTY DISPARITIES IN JAVA, INDONESIA: AN ANALYSIS OF KEY INFLUENCING FACTORS (2010-2020)

This study seeks to investigate the evolution of poverty in Java from 2010 to 2020, as well as the regional factors that contributing to disparities in poverty between regions. The results of the analysis indicate a downward trend in the number and proportion of poor people on the island of Java but a rise during the COVID-19 pandemic. There are regional distribution groups with high and low poverty rates. The results of the ANOVA reveal significant differences in the occurrence of urban poverty on the island of Java based on province and regional status but not by zone. Positively and negatively, the majority of the predictors have a very significant relationship with poverty. Six regional variables (level of consumption (expenditure), level of health (life expectancy), income per capita, level of education (number of years of schooling), population density (people/km2), and economic potential (GRDP at current prices)) account for 68.10% of the variation in the number of poor people in Java, while the remaining 31.9% is determined by other variables. The model of variation in Java's poverty is determined by three variables: per capita income, GRDP, and public consumption level.

Japanese value set for the EORTC QLU-C10D: A multi-attribute utility instrument based on the EORTC QLQ-C30 cancer-specific quality-of-life questionnaire

PurposeThis study aimed to develop a Japanese value set for the EORTC QLU-C10D, a multi-attribute utility measure derived from the cancer-specific health-related quality-of-life (HRQL) questionnaire, the EORTC QLQ-C30. The QLU-C10D contains ten HRQL dimensions: physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, and bowel problems.MethodsQuota sampling of a Japanese online panel was used to achieve representativeness of the Japanese general population by sex and age (≥ 18 years). The valuation method was an online discrete choice experiment. Each participant considered 16 choice pairs, randomly assigned from 960 choice pairs. Each pair included two QLU-C10D health states and life expectancy. Data were analyzed using conditional logistic regression, parameterized to fit the quality-adjusted life-year framework. Preference weights were calculated as the ratio of each dimension-level coefficient to the coefficient for life expectancy.ResultsA total of 2809 eligible panel members consented, 2662/2809 (95%) completed at least one choice pair, and 2435/2662 (91%) completed all choice pairs. Within dimensions, preference weights were generally monotonic. Physical functioning, role functioning, and pain were associated with the largest utility weights. Intermediate utility weights were associated with social functioning and nausea; the remaining symptoms and emotional functioning were associated with smaller utility decrements. The value of the worst health state was − 0.221, lower than that seen in most other existing QLU-C10D country-specific value sets.ConclusionsThe Japan-specific QLU-C10D value set is suitable for evaluating the cost and utility of oncology treatments for Japanese health technology assessment and decision-making.

ANALYZING THE RELATIONSHIP BETWEEN HEALTH EXPENDITURE, RENEWABLE ENERGY AND LIFE EXPECTANCY: EVIDENCE FROM ASIAN COUNTRIES

This study investigates the relationship between health expenditures, renewable energy and life expectancy in Asian countries within a model covering the period 2000-2020. GDP data are also included in the model. In the study, after applying cross-sectional dependence test and Cross-sectional Augmented Dickey-Fuller unit root tests, panel cointegration test is employed to show whether there is a long-run mutual relationship between health expenditures and other variables, and then Dumitrescu-Hurlin (2012) panel causality analysis method is used to test the causality between the relevant variables in Asian countries. According to the empirical findings, while causality is found between health expenditures and renewable energy in most of the Asian countries, there is also a high level of causality between life expectancy and health expenditures. Moreover, the cointegration test between health expenditures and other variables confirms that there is a long-run relationship between the variables. It is concluded that policy makers in Asian economies should develop policy frameworks that provide opportunities for renewable energy consumption and support investment in renewable energy projects to promote the use of clean technologies. Thus, an increase in renewable energy consumption can lead to economic prosperity by not only improving quality of life but also increasing productivity.

Breast cancer screening motivation and behaviours of women aged over 75 years: a scoping review

BackgroundThis scoping review aimed to identify and present the evidence describing key motivations for breast cancer screening among women aged ≥ 75 years. Few of the internationally available guidelines recommend continued biennial screening for this age group. Some suggest ongoing screening is unnecessary or should be determined on individual health status and life expectancy. Recent research has shown that despite recommendations regarding screening, older women continue to hold positive attitudes to breast screening and participate when the opportunity is available.MethodsAll original research articles that address motivation, intention and/or participation in screening for breast cancer among women aged ≥ 75 years were considered for inclusion. These included articles reporting on women who use public and private breast cancer screening services and those who do not use screening services (i.e., non-screeners).The Joanna Briggs Institute (JBI) methodology for scoping reviews was used to guide this review. A comprehensive search strategy was developed with the assistance of a specialist librarian to access selected databases including: the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Web of Science and PsychInfo. The review was restricted to original research studies published since 2009, available in English and focusing on high-income countries (as defined by the World Bank). Title and abstract screening, followed by an assessment of full-text studies against the inclusion criteria was completed by at least two reviewers. Data relating to key motivations, screening intention and behaviour were extracted, and a thematic analysis of study findings undertaken.ResultsA total of fourteen (14) studies were included in the review. Thematic analysis resulted in identification of three themes from included studies highlighting that decisions about screening were influenced by: knowledge of the benefits and harms of screening and their relationship to age; underlying attitudes to the importance of cancer screening in women's lives; and use of decision aids to improve knowledge and guide decision-making.ConclusionThe results of this review provide a comprehensive overview of current knowledge regarding the motivations and screening behaviour of older women about breast cancer screening which may inform policy development.

Multicenter Study on Breast Cancer in the Geriatric Population: Insights for Effective Treatment Strategies.

Breast cancer is common among women aged 65 and over. There is a significant lack of evidence regarding the treatment of breast cancer in patients in this age group due to the rare inclusion of these patients in clinical studies. However, it is known that survival in elderly patients with breast cancer is significantly reduced in those not receiving standard therapy. Several factors, including patients' comorbidities, performance status, life expectancy, and tumor pathological and molecular characteristics, can affect the outcomes of treatment. In this study, we aimed to update the knowledge in this field by assessing these factors among the geriatric population in our multicenter dataset. This retrospective study analyzed data from 335 breast cancer patients aged 65 and over who received adjuvant radiotherapy at five oncology centers (Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul,Meram Medical Faculty - Necmettin Erbakan University, Konya,Prof. Dr. Cemil Tascioglu City Hospital, Istanbul,Umraniye Training and Research Hospital, Istanbul, andIstanbul Oncology Hospital, Istanbul) between May 2010 and September 2022. Demographic, clinical, and pathological data were collected, including age, gender, clinical symptoms, tumor characteristics, treatment approaches, and outcomes. Statistical analyses, including descriptive statistics, Kaplan-Meier analysis, log-rank test, and Cox regression analysis, were performed using IBMSPSSStatistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States), with a significance level of p < 0.05. The tumor characteristics and survival time of 335 breast cancer patients were examined. In the results, performance status, T stage, and perineural invasion were found to be factors affecting the survival of elderly breast cancer patients. In multivariate analysis, it was seen that performance status played an important role as an independent prognostic factor. The treatment of breast cancer in the geriatric age group necessitates a personalized approach, taking into account the patient's overall health status, life expectancy, and comorbidities.

Microsurgical Resection of Brainstem Cavernous Malformations in Older Adults: A Multicenter, 30-Year Experience.

Microsurgical resection is the only curative intervention for symptomatic brainstem cavernous malformations (BSCMs), but the management of these lesions in older adults (≥65 years) is not well described. This study sought to address this gap by examining the safety and efficacy of BSCM resection in a cohort of older adults. Records of patients who underwent BSCM resection over a 30-year period were reviewed retrospectively. Baseline characteristics and outcomes were compared between older (≥65 years) and younger (<65 years) patients. Of 550 patients with BSCM who met inclusion criteria, 41 (7.5%) were older than 65 years. Midbrain (43.9% vs 26.1%) and medullary lesions (19.5% vs 13.6%) were more common in the older cohort than in the younger cohort ( P = .01). Components of the Lawton BSCM grading system (ie, lesion size, crossing axial midpoint, developmental venous anomaly, and timing of hemorrhage) were not significantly different between cohorts ( P ≥ .11). Mean (SD) Elixhauser comorbidity score was significantly higher in older patients (1.86 [1.06]) than in younger patients (0.66 [0.95]; P < .001). Older patients were significantly more likely than younger patients to have poor outcomes at final follow-up (28.9% vs 13.8%, P = .01; mean follow-up duration, 28.7 [39.1] months). However, regarding relative neurological outcome (preoperative modified Rankin Scale to final modified Rankin Scale), rate of worsening was not significantly different between older and younger patients (23.7% vs 14.9%, P = .15). BSCMs can be safely resected in older patients, and when each patient's unique health status and life expectancy are taken into account, these patients can have outcomes similar to younger patients.

Health status, life expectancy and early claiming of pension

Prior to 2011, individual life expectancy played no role in the Norwegian old-age pension system. However, after the 2011 reform, life expectancy became a central factor for early pension take-up. Asymmetric information is crucial in most insurance markets, including the new pension system, where employees can flexible claim a public pension from the age of 62. Individuals who expect to live longer than the average for their birth cohort can maximize their pension wealth by deferring pension claiming, while those with a shorter life expectancy should draw their pension as early as possible. This raises concerns that adverse selection may pose a risk to the sustainability of the new pension system. To investigate this issue, we use chronic disease as a proxy for life expectancy and examine its relationship with employment and pension decisions. Our findings show that individuals with a chronic health condition are more likely to draw a pension and continue working when they reach 62 years of age compared to those without a chronic health condition. This suggests potential adverse selection issues in the pension system, although our results suggest small effects after adjusting for unobservables.

The Impact of Health Expenses on Economic Growth: Empirical Evidence from SAARC Countries

This study seeks to empirically explore the influence of health expenditure on economic growth in SAARC countries. Gross domestic product (GDP) the proxy variable of economic growth has been used as a dependent variable and current health expenses (CHE) as the independent variable. The panel dynamic OLS (DOLS), panel fully modified OLS (FMOLS), panel OLS, panel co inte gration test, along with Granger causality test have been used to determine the link between health expenses and economic growth. The result presented that health expenses and economic growth have a bidirectional causa l relationship in the short run. The f indings of the panel fully modified OLS (FMOLS) also showed that long run economic growth is increasingly and significantly affected by health expenses, HDI, infant mortality, and life expectancy. Therefore, this st udy presents empirical evidence to the po licymakers of SAARC nations that increasing health expenditures contribute to a country's economic growth.

"It Can't Hurt!": Why Many Patients With Limited Life Expectancy Decide to Accept Lung Cancer Screening.

Lung cancer screening (LCS) has less benefit and greater potential for iatrogenic harm among people with multiple comorbidities and limited life expectancy. Yet, such individuals are more likely to undergo screening than healthier LCS-eligible people. We sought to understand how patients with marginal LCS benefit conceptualize their health and make decisions regarding LCS. We interviewed 40 people with multimorbidity and limited life expectancy, as determined by high Care Assessment Need scores, which predict 1-year risk of hospitalization or death. Patients were recruited from 6 Veterans Health Administration facilities after discussing LCS with their clinician. We conducted a thematic analysis using constant comparison to explore factors that influence LCS decision making. Patients commonly held positive beliefs about screening and perceived LCS to be noninvasive. When posed with hypothetical scenarios of limited benefit, patients emphasized the nonlongevity benefits of LCS (eg, peace of mind, planning for the future) and generally did not consider their health status or life expectancy when making decisions regarding LCS. Most patients were unaware of possible additional evaluations or treatment of screen-detected findings, but when probed further, many expressed concerns about the potential need for multiple evaluations, referrals, or invasive procedures. Patients in this study with multimorbidity and limited life expectancy were unaware of their greater risk of potential harm when accepting LCS. Given patient trust in clinician recommendations, it is important that clinicians engage patients with marginal LCS benefit in shared decision making, ensuring that their values of desiring more information about their health are weighed against potential harms from further evaluations.

Impacts of Poverty and Lifestyles on Mortality: A Cohort Study in Predominantly Low-Income Americans

Low socioeconomic status has been linked to increased mortality. However, the impacts of poverty, alone or combined with health behaviors, on mortality and life expectancy have not been adequately investigated. Data from the Southern Community Cohort Study was used, including nearly 86,000 participants recruited during 2002-2009 across 12 US southeastern states. Analysis was conducted from February 2022 to January 2023. During a median follow-up of 12.1 years, 19,749 deaths were identified. A strong dose-response relationship was found between household incomes and mortality, with a 3.3-fold (95%CI=3.1-3.6) increased all-cause mortality observed for individuals in the lowest income group (<$15,000/year) compared with those in the highest group (≥$50,000/year). Within each income group, mortality monotonically increased with declining healthy lifestyle score. Risk was significantly lower among those in the lowest income but healthiest lifestyle group, compared to those with the highest income but unhealthiest lifestyle (HR=0.82, 95%CI=0.69-0.97). Poor White participants appeared to experience higher all-cause mortality than poor Black participants. Life expectancy was more than 10.0 years shorter for those in the lowest income group compared with those in the highest income group. Poverty is strongly associated with increased risk of death, but the risks could be modestly abated by a healthier lifestyle. These findings call for a comprehensive strategy for enhancing a healthy lifestyle and improving income equality to reduce death risks, particularly among those experiencing health disparities due to poverty.

Global health inequality: analyses of life disparity and healthy life disparity.

Alongside average health measures, namely, life expectancy (LE) and healthy life expectancy (HLE), we sought to investigate the inequality in lifespan and healthy lifespan at the worldwide level with an alternative indicator. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, we evaluated the global distribution of life disparity (LD) and healthy life disparity (HLD) for 204 countries and territories in 2019 by sex and socio-demographic index (SDI), and also explored the relationships between average and variation health indicators. Substantial gaps in all observed health indicators were found across SDI quintiles. For instance, in 2019, for low SDI, female LE and HLE were 67.3 years (95% confidence interval 66.8, 67.6) and 57.4 years (56.6, 57.9), and their LD and HLD were 16.7 years (16.5, 17.0) and 14.4 years (14.1, 14.7). For high SDI, female LE and HLE were greater [83.7 years (83.6, 83.7) and 70.2 years (69.3, 70.7)], but their LD and HLD were smaller [10.4 years (10.3, 10.4) and 7.9 years (7.7, 8.0)]. Besides, all estimates varied across populations within each SDI quintile. There were also gaps in LD and HLD between males and females, as those found in LE and HLE. In addition to the disadvantaged LE and HLE, greater LD and HLD were also found in low SDI countries and territories. This reveals the serious challenge in achieving global health equality. Targeted policies are thus necessary for improving health performance among these populations.

A metagenomics study reveals the gut microbiome as a sex-specific modulator of healthy aging in Hainan centenarians

BackgroundSex differences in health status and life expectancy are widely accepted to exist. The mechanisms underlying it are still poorly understood. In this study, we aimed to clarify the influences and contributions of sex on the gut microbiome in healthy centenarians and to explore the different roles played by the gut microbiome in healthy aging between the sexes. ResultsTaking covariates of different dimensions into account (social demographics, anthropometry, the activities of daily living, dietary structure, mental state, blood tests, lifestyle and disease history), our data showed that sex was one of the most significant covariates affecting the gut microbiome of healthy centenarians at both the species and Kyoto Encyclopedia of Genes and Genomes Orthology (KO) levels. The beta diversity between the sexes were significantly different (Adonis test: p = 0.011, R2 = 0.031), and the male centenarians had a greater alpha diversity than the females (Simpson and Shannon test: P<0.05). At the species level, we identified 31 species enriched in males and 7 species enriched in females. The composition and function patterns of the microbiome varied between the sexes. Further functional analysis showed that males' gut microbiome exhibited greater resistance to oxidative stress compared to females. In contrast to men, the species associated with healthy aging dominated among healthy female centenarians, while the species associated with unhealthy aging were relatively rare. ConclusionsThe present study reveals that the gut microbiome structure and resistance to oxidative stress in healthy centenarians differ between the sexes and provides new insights into the possible sex-specific role of the gut microbiome in healthy aging.