Letters1 February 2011Preventing Alzheimer Disease and Cognitive DeclineFrederick Naftolin, MD, PhD and S. Mitchell Harman, MD, PhDFrederick Naftolin, MD, PhDFrom New York University School of Medicine, New York, NY 10016, and Kronos Longevity Research Institute, Phoenix, AZ 85016.Search for more papers by this author and S. Mitchell Harman, MD, PhDFrom New York University School of Medicine, New York, NY 10016, and Kronos Longevity Research Institute, Phoenix, AZ 85016.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-3-201102010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The National Institutes of Health (NIH) State-of-the-Science Conference Panel statement (1) suggesting that estrogen and progesterone may contribute to causation of Alzheimer disease has raised concern and elicited alarmed calls from patients regarding their future. We believe that the panel's conclusion is erroneous because it is based solely on the outcome of the Women's Health Initiative (WHI) trial's substudy WHIMS (Women's Health Initiative Memory Study), which had the same risk value as that shown in the NIH statement (2).WHIMS had an inappropriate experimental construction using age-driven postrandomization apportionment of participants. Because of this, WHIMS was limited ...