Health Effects Research Articles

The perceptions of harmfulness. Addictiveness and social acceptance of hookah smoking among adolescents in Turkey

ABSTRACT Background Hookah smoking among adolescents is a growing public health concern, potentially fueled by a lack of awareness regarding its health risks. This study aimed to determine the risk factors associated with hookah smoking and explore adolescents’ perceptions of its harmfulness, addictiveness and social acceptability. Methods Between October 2019 and April 2020, 400 adolescents aged 12 to 18 years participated in an interviewer-administered survey including socio-demographic characteristics, past medical history, lifestyle behaviors, tobacco use of adolescents and their immediate circle, knowledge on hookah’s health risks, perceptions of hookah’s addictiveness and social acceptability. Results Among adolescents 6.8% were regular hookah smokers, while 14.5% had tried hookah at least once. Adolescents who believed hookah was not addictive were more likely to perceive it as socially acceptable (p < 0.001). The perception of social acceptance increased by 1.68 times with each year of age, 2.05 times in the presence of a smoking teacher, and 10.14 times with having tried hookah once. Conclusions This study highlights that adolescents’ limited knowledge of hookah’s negative health effects and addictive nature contributes to its social acceptance. Moreover, in addition to family members and friends, teachers significantly impact adolescents’ hookah use and their perceptions of its harmfulness, social acceptability and addictiveness.

Synergistic susceptibility to environmental lead toxicity in chronic kidney disease.

While high levels of lead exposure, as occurs accidentally or occupationally, can cause toxicity across multiple organ systems, the hazard of commonly encountered levels of lead in the environment remains unresolved. Challenges to researching the health effects of lead include its complex interplay with renal function, rendering analyses at risk of unaccounted confounding, and the likely small effect size of environmental levels of exposure. While children are known to be disproportionately susceptible to lead toxicity, resulting in appropriately more stringent regulatory surveillance for those under 5 years old, emerging evidence suggests that those with chronic kidney disease (CKD) similarly are at a greater risk. This review summarizes the role of environmental lead toxicity as a potential cause and consequence of CKD. Whether environmental lead exposure causes CKD remains debatable, with little recent research advancing the conflicting, mostly cross-sectional, analyses from years ago. However, an emerging body of evidence suggests that CKD increases the susceptibility to lead toxicity. Higher circulating lead levels and lower urinary excretion result in greater lead accumulation in CKD, with simultaneous greater risk of clinically meaningful disease. Recent studies suggest that levels of lead found commonly in the United States drinking water supply, and currently permissible by the Environmental Protection Agency, associate with hematologic toxicity in those with advanced CKD. Whether environmental lead contamination may have additional negative health impact among this at-risk population, including cardiovascular and neurocognitive disease, warrants further study. The underlying pathophysiology of kidney disease synergizes the susceptibility to environmental lead toxicity for those with CKD. Low levels of exposure, as found commonly in the United States water supply, may have adverse health impact in CKD. Further research will be needed to determine if more stringent environmental regulations are warranted to protect the health of all.

Genome-Wide DNA methylation profile analysis identifies differentially methylated loci associated with personal PM2.5 exposure in adults with asthma

Particulate matter with aerodynamic diameters ≤2.5 µm (PM2.5) is a major environmental risk factor for acute asthma exacerbation, and the underlying mechanism is not completely understood. Studies have indicated that DNA methylation is a potential mechanism linking PM2.5 to its health effects. We conducted a panel study involving 24 adult patients with asthma in Beijing,China between 2017 and 2019. PM2.5 and other atmospheric pollutant exposure data were repeatedly measured. Blood samples were collected for genome-wide DNA methylation analysis. A linear mixed-effects (LME) model was conducted to identify differentially methylated probes (DMPs) associated with PM2.5 exposure. After filtering out probes that did not meet the criteria through quality control, 811,001 CpG sites were included in the LME model, and 36 DMPs were strongly associated with personal PM2.5 exposure at false discovery rate (FDR) < 0.05, of which 22 and 14 DMPs negatively and positively correlated with personal PM2.5 exposure, respectively. Functional analysis revealed that DMPs affected smooth muscle cell contraction and development, extracellular matrix synthesis and secretion, T cell activation and differentiation, and inflammatory factor production. This study provides evidence linking personal PM2.5 exposure to genome-wide DNA methylation in adult patients with asthma. Identifying enrichment pathways can provide biological insights into the acute health effects of PM2.5.

‘Life became harder with COVID-19’: exploring the experiences of the COVID-19 pandemic among youth living in eThekwini district, South Africa

BackgroundIn South Africa, pervasive age and gender inequities have been exacerbated by the COVID-19 pandemic and public health response. We aimed to explore experiences of the COVID-19 pandemic among youth in eThekwini district, South Africa.MethodsBetween December 2021-May 2022 we explored experiences of the COVID-19 pandemic on youth aged 16–24 residing in eThekwini, South Africa. We collated responses to the open-ended question “Has the COVID-19 pandemic affected you in any other way you want to tell us about?” in an online survey focused on understanding the pandemic’s multi-levelled health and social effects. We used a thematic analysis to summarise the responses.ResultsOf 2,068 respondents, 256 (12.4%, median age = 22, 60.9% women) completed the open-ended survey question (11% in isiZulu). Results were organized into three main themes encompassing (1) COVID-19-related loss, fear, grief, and exacerbated mental and physical health concerns; (2) COVID-19-related intensified hardships, which contributed to financial, employment, food, education, and relationship insecurities for individuals and households; and (3) positive effects of the pandemic response, including the benefits of government policies and silver linings to government restrictions.ConclusionsWe found that South African youth experienced significant grief and multiple losses (e.g., death, income, job, and educational) during the COVID-19 pandemic. Trauma-aware interventions that provide economic and educational opportunities must be included in post-COVID recovery efforts.

Early-Life Disease Exposure and Its Heterogeneous Effects on Mortality Throughout Life: Sweden, 1905-2016.

Exposure to infectious diseases in early life has been linked to increased mortality risk in later life in high-disease settings, such as eighteenth- and nineteenth-century Europe. Less is known about the long-term effects of early-life disease exposure in milder disease environments. This study estimates heterogeneous effects from disease exposure in infancy on later-life mortality in twentieth-century Sweden, by socioeconomic status at birth and sex. Using historical population data for southern Sweden, we study 11,515 individuals who were born in 1905-1929 from age 1 until age 85. We measure exposure to disease using the local post-early neonatal mortality rate in the first 12 months after birth and apply flexible parametric survival models. For females, we find a negative effect on life expectancy (scarring) at ages 1-85 following high disease exposure in infancy, particularly for those born to unskilled workers. For males, we find no negative effect on later-life survival, likely because stronger mortality selection in infancy outweighs scarring. Thus, even as the incidence of infectious diseases declined at the start of the twentieth century, early-life disease exposure generated long-lasting negative but heterogeneous population health effects.

Studies on uranium concentration in groundwater samples and its associated health hazards to the residents of surrounding regions of Manchanabele reservoir, Bengaluru, Karnataka, India.

Uranium occurs naturally in groundwater and surface water. Being a radioactive element, high uranium concentration can cause impact on human health. The health effects associated with consumption of uranium through water includes increased cancer risk and kidney toxicity. In view of this, an attempt was made in the present study to establish the level of radiological and chemical toxicity of uranium. Radiological toxicity was evaluated in terms of lifetime cancer risk and chemical toxicity through hazard quotient. For the said purpose, groundwater samples from the selected villages of the surrounding region of the Manchanabele reservoir, southwest of Bengaluru, were collected. The collected groundwater samples were analysed for Uranium mass concentration using Light emitting diode (LED) fluorimeter and is found to range from 0.88 to 581.47ppb with a GM of 20.82ppb. The result reveals that ~ 66% of the samples show concentration of uranium within the safe limit of 30ppb as set by the World Health Organisation. The radiological risk estimated in terms of lifetime cancer risk is in the range of 0.0028 × 10-3 to 1.85 × 10-3 with a GM of 0.066 × 10-3. The chemical toxicity risk measured as lifetime annual daily dose is found to range from 0.03 to 21.65μg per kg per d with a GM of 0.77μg per kg per d.

Metal distribution in three organs and edibility assessment on Coptodon rendalli from the Umgeni River impacted by metallurgic industrial activities

Fish is among the most affordable and readily available protein sources for communities residing near water bodies. However, the recent pollution status of aquatic ecosystems has rendered fish consumption risky for human health. The study evaluated metal levels in the liver, gill, and muscle tissues of Redbreast tilapia (Coptodon rendalli) from Inanda and Nagle dams in the uMgeni River system. Metals, Al, Sb, Cd, Cr, Fe, Mn, Mo, Pb, and Zn were analysed using ICP-OES. Fish size showed no significant difference between the two dams (p > 0.05) whereas a descending trend liver > gill > muscle was observed for most metal levels at both dams. Moreover, there was a clear separation for metal levels in the liver, gill, and muscle between the two dams (p < 0.001) and a similar trend was observed for organs in each dam (p < 0.001). No relationship was observed between fish length and metal levels and no definite trend was observed for inter-metal relationships. Antimony, Cr, and Pb showed THQs greater than 1 at both dams which suggests health risks for consumers. Molybdenum has also shown a concerning THQs with some individuals exhibiting values ranging from 0.5 – 0.9. These findings suggest that consuming C. rendalli from the Inanda and Nagle dams could result in adverse health effects from Sb, Cr and Pb.

Quantitative stakeholder-driven assessment of radiation protection issues via a PIANOFORTE online survey.

To enhance stakeholder engagement and foster the inclusion of interests of citizens in radiation protection research, a comprehensive online survey was developed within the framework of the European Partnership PIANOFORTE. This survey was performed in 2022 and presented an opportunity for a wide range of stakeholders to voice their opinions on research priorities in radiation protection for the foreseeable future. Simultaneously, it delved into pertinent issues surrounding general radiation protection. The PIANOFORTE e-survey was conducted in the English language, accommodating a diverse range of participants. Overall, 440 respondents provided their insights and feedback, representing a broad geographical reach encompassing 29 European countries, as well as Canada, China, Colombia, India, and the United States. To assess the outcomes, the Positive Matrix Factorization numerical model was applied, in addition to qualitative and quantitative assessment of individual responses, enabling the discernment of four distinct stakeholder groups with varying attitudes. While the questionnaire may not fully represent all stakeholders due to the limited respondent pool, it is noteworthy that approximately 70% of the participants were newcomers to comparable surveys, demonstrating a proactive attitude, a strong willingness to collaborate and the necessity to continuously engage with stakeholder groups. Among the individual respondents, distinct opinions emerged particularly regarding health effects of radiation exposure, medical use of radiation, radiation protection of workers and the public, as well as emergency and recovery preparedness and response. In cluster analysis, none of the identified groups had clear preferences concerning the prioritization of future radiation protection research topics.

The Effect of Wood Species on Fine Particle and Gaseous Emissions from a Modern Wood Stove

Residential wood combustion (RWC) is a significant source of gaseous and particulate emissions causing adverse health and environmental effects. Several factors affect emissions, but the effects of the fuel wood species on emissions are currently not well understood. In this study, the Nordic wood species (named BirchA, BirchB, Spruce, SpruceDry, Pine and Alder) were combusted in a modern stove, and the emissions were studied. The lowest emissions were obtained from the combustion of BirchA and the highest from Spruce and Alder. The fine particle mass (PM2.5) was mainly composed of elemental carbon (50–70% of PM2.5), which is typical in modern appliances. The lowest PAH concentrations were measured from BirchA (total PAH 107 µg/m3) and Pine (250 µg/m3). In the ignition batch, the PAH concentration was about 4-fold (416 µg/m3). The PAHs did not correlate with other organic compounds, and thus, volatile organic compounds (VOCs) or organic carbon (OC) concentrations cannot be used as an indicator of PAH emissions. Two birch species from different origins with a similar chemical composition but different density produced partially different emission profiles. This study indicates that emission differences may be due more to the physical properties of the wood and the combustion conditions than to the wood species themselves.

The impact of Intermittent Fasting on Weight Loss and Metabolic Health - a review of the latest research

Introduction and purpose Intermittent fasting (IF) is a dietary pattern that alternates between periods of fasting or reduced caloric intake and periods of unrestricted eating. There are three primary types of IF: Alternate Day Fasting (ADF), Time-Restricted Eating (TRE), and Periodic Fasting (PF). This review article summarizes the impact of IF on weight loss. Additionally, it examines the broader health effects of IF, including its influence on cardiovascular risk, diabetes management, and neurodegenerative diseases. Description of the state of knowledge Fasting, the practice of abstaining from or limiting food intake for a specified period, has been a cultural and religious tradition worldwide for centurie. Common IF methods alternating 24-hour periods of fasting with days of eating, TRE restricts eating to specific windows of time each day, and PF includes patterns such as the 5:2 diet, where fasting occurs on two days each week. Conclusions The analysis of the review article demonstrates that intermittent fasting (IF) leads to weight loss, aiding in the treatment of obesity. Moreover, IF reduces glycated hemoglobin levels and increases periods of normoglycemia, potentially benefiting diabetes patients. Nonetheless, there is a lack of sufficient research to confirm the safety of IF for diabetics, given the risk of hypoglycemia. Research also indicates that IF positively impacts cardiovascular risk factors by lowering total cholesterol, LDL-C, and triglyceride levels. Additionally, while IF might reduce the risk of certain cancers by addressing obesity, it is not advised for cancer patients due to inadequate scientific evidence. Furthermore, some studies indicate that IF could be advantageous in managing certain neurological diseases.

Estimating spatially varying health effects of wildland fire smoke using mobile health data

Abstract Wildland fire smoke exposures are an increasing threat to public health, highlighting the need for studying the effects of protective behaviours on reducing health outcomes. Emerging smartphone applications provide unprecedented opportunities to deliver health risk communication messages to a large number of individuals in real-time and subsequently study the effectiveness, but also pose methodological challenges. Smoke Sense, a citizen science project, provides an interactive smartphone app platform for participants to engage with information about air quality, and ways to record their own health symptoms and actions taken to reduce smoke exposure. We propose a doubly robust estimator of the structural nested mean model that accounts for spatially and time-varying effects via a local estimating equation approach with geographical kernel weighting. Moreover, our analytical framework also handles informative missingness by inverse probability weighting of estimating functions. We evaluate the method using extensive simulation studies and apply it to Smoke Sense data to increase the knowledge base about the relationship between health preventive measures and health-related outcomes. Our results show that the protective behaviours’ effects vary over space and time and find that protective behaviours have more significant effects on reducing health symptoms in the Southwest than the Northwest region of the U.S.

Assessing the hazard of diesel particulate matter (DPM) in the mining industry: A review of the current state of knowledge

In the confined spaces of underground mines, the exposure of over 10,000 miners in the U.S. to diesel exhaust and diesel particulate matter (DPM) is an occupational inevitability, particularly in metal and nonmetal mineral extraction. These workers routinely operate amidst diesel-powered equipment, often outdated and highly polluting, extracting resources such as limestone, gold, and salt. The acute health effects of such exposure are significant, leading to symptoms like headaches and flu-like conditions, with the impact being more pronounced in these closed work environments. This review scrutinizes DPM’s hazard in the mining sector, consolidating the extant knowledge and exploring ongoing research. It encapsulates our understanding of DPM’s physicochemical properties, existing sampling methods, health ramifications, and mitigation technologies. Moreover, it underscores the necessity for further study in areas such as the evolution of DPM’s physicochemical attributes, from its genesis at high-pressure, high-temperature conditions within diesel engines to its emission into the mine atmosphere. A key research gap is the intricate interaction of DPM with specific characteristics of the mine environment—such as relative humidity, ambient temperature, the presence of other mineral dust, and the dynamics of ventilation air. These factors can significantly alter the physicochemical profile of DPM, influencing both its in-mine transport and its deposition behavior. Consequently, this can affect the respiratory health of miners, modifying the toxicity and the respiratory deposition of DPM particles. Identified research imperatives include (1) the advancement of instrumentation for accurate number measurement of DPM to replace or supplement traditional gravimetric methods; (2) the development of long-lasting, cost-effective control technologies tailored for the mining industry; (3) an in-depth investigation of DPM interactions within the unique mine microclimate, considering the critical components like humidity and other aerosols; and (4) understanding the differential impact of DPM in mining compared to other industries, informing the creation of mining-specific health and safety protocols. This review’s findings underscore the urgency to enhance emission control and exposure prevention strategies, paving the way for a healthier underground mining work environment.

A comprehensive perspective on potentially hazardous elements (PHEs) bound with particulate matters in ambient air of landfill sites: a systematic review and probabilistic risk assessment.

Air pollution from Potentially Hazardous Elements bound with particulate matter (PHEs bound PM) in landfill air is a significant concern for human health. To date, no comprehensive research has focused on the health risks of PHEs bound to PM in landfill air. This systematic review aimed to examine PHEs, including Lead (Pb), Cadmium (Cd), Chromium (Cr), Arsenic (As), Nickel (Ni), and Zinc (Zn) bound with PM in landfill air and assess the health risk for workers and waste management personnel. The systematically search was made in different electronic databases. After the screening, 18 most relevant studied focused on PHEs bound PM in landfill air were selected. The data extraction analysis indicated that mean concentrations of Pb, Cd, Cr, As, Ni, and Zn in landfill air were 0.3037, 0.0941, 0.4093, 0.0221, 0.2768, and 0.7622μg/m3, respectively. Except for Pb, the concentrations of other PHEs bound to PM exceeded USEPA air quality standards. In addition, Non-carcinogenic risks from Cd, Cr, and Ni exposure exceeded permissible limits (HQ > 1), while As had an HQ value of 0.401. Carcinogenic risks from As, Cd, Ni, and Pb exposure were 1.31 × 10-5, 5.10 × 10-4, 3.51 × 10-5, and 2.03 × 10-6, respectively. Notably, the lifetime carcinogenic risk for workers exposed to Cr in polluted air (6.17 × 10-3) exceeded permissible limits (10-4 to 10-6). In conclusion, given the high carcinogenic and non-carcinogenic risks of some PHEs bound PM in landfills, it is necessary to conduct more research on the health effects of interaction with these PHEs bound PM on communities and the environment in different countries. Also, it is necessary to evaluate the role of different landfill operational activities on atmospheric dispersion of PHEs bound PM) in landfill air.

Harm Reduction in Tobaccoism : What Does the Scientific Evidence Say?

Smoking is considered a chronic disease caused by chemical dependence of nicotine. This is highly addicting, it in the brain system it influences our emotions, increases the feeling of pleasure/humor and reduces the anxiety. In a planet with about 8 billion people, around 1,36 billion are smokers. Cigarette smoking is the leading cause of preventable death in the world, around 8 million people die every year. A global public health problem, and those who smoke are vulnerable to 50 tobacco-related diseases, several kinds of cancer, lung diseases, cardiovascular disease, erectile dysfunction, female infertility and pregnancy complications. In 2020, according to data from the World Health Organization, 22,3% of the world population consumed tobacco, 36,7% of men and 7,8%of women. In Brazil, due to policies implemented to smoking control, we had a significant drop in the of period (1989 to 2019) from 34,8% of smokers to 12,6% and in 2021, the total percentage of smokers age 18 or over was 9.1%. All forms of tobacco consumption are harmful to health and there is no safe level. Cigarette smoke 4.720 different toxic substances such as nicotine, irritants, tar and carbon monoxide. In the last 15 years, new heated tobacco devices have arrived on the market with promises of less harm to health. In 78 countries this products are available, including Japan, The United States, Canada, Portugal, Australia, Italy and The United Kingdom. As they do not cause tobacco combustion, they created significantly lower levels of toxic substances, which is the strongest arguments made by defenders of those products. A systematic review of the literature in 2018 on heated tobacco products identified 31 studies randomly and blind over those devices, 11 independent and 20 funded by the products manufacturers, needing further long-term research. Another systematic review (relevant studies from 2015 to February 2021), both “in vitro” as alive has shown that the benefits of heated tobacco are controversial and more research is needed to the short-and-long term health effects. Another large concern is that availability of these smokeless products may encourage cigarette consumption, especially among young people and often with the combined use of traditional cigarettes and heated tobacco products.

Assessment of groundwater fluoride and human health effects in a hard rock province of south India: Implications from Pollution Index Model (PIM) and GeographicalInformationSystem (GIS) techniques.

This research examines whetherthe groundwater in the Sivakasi Region of South India is suitable for consumption, and assesses the possible health hazards for various age demographics including infants, children, teenagers, and adults. A totalof 77 groundwater samples were gathered, covering a total area of 580km2 and analyzed for major and minor ions. The hydrogen ion concentration (pH) of the samples indicates neutral to marginally alkaline. The total dissolved solids (TDS) fluctuate from 255 to 2701mg/l and electrical conductivity varies from 364 to 3540µS/cm. A wide range of fluoride concentration was detected (0.1 to 3.2mg/l) with nearly 38% groundwater samples surpassing the proposed limit (1.5 mg/l) suggestedby the World Health Organization in 2017. Gibbs plot analysis suggested that most of thesamples were influenced by geogenic factors, primarily rock weathering in this region. Correlation analysis showed that most of the samples were impacted by both natural and human sources. The pollution index of groundwater (PIG) fluctuated from 0.67 to 2.60 with approximately 30% and 53% of samples falling into insignificant and low pollution categories, respectively. Furthermore, 10% and 5% of total samples were characterized as moderate and high pollution levels, and 2% asvery high pollution category. Spatial analysis using GIS revealed that 440.63km2 were within safe fluoride levels according to theWHO standards, while 139.32km2 were identified as risk zone. The principal component analysis (PCA1) showedstrong positive loadings on EC (0.994), TDS (0.905), Mg2+ (0.910), Cl- (0.903) and HCO3- (0.923) indicating rock water interaction. PCA2 accounts the high positive factor loading on HCO3- (0.864) indicating ion exchange and mineral leaching. The PCA1 and PCA2 indicated that variables such as mineral leaching and rock water interaction are themajor mechanisms contributing to the chemical signatures in groundwater, which may support for theelevated fluoride levels in certain areas. Risk assessments, including Hazard Quotient results showed that 71%, 61% 38%, and 34% of groundwater samples exceededthe permissible THI limit (THI > 1) for infants, children, teenagers, and adults, respectively. The study recommends implementing measures such as denitrification, defluorination, rainwater harvesting, and improved sanitation infrastructure to enhance the health conditions in the study region. Additionally, it suggests introducing educational programs in rural areas to create awarenessabout the health dangers due to consumptionof water with high fluoride levels.

Social and environmental outcomes of urban street tree bed stewardship

Abstract As projections of exponential urbanization persist, promoting the health of urban populations is one of the most urgent and challenging issues of the 21st century. By taking a planetary health approach and considering the reciprocal relationship between human health and the health of ecosystems, the integration of nature-based solutions into cities can address multiple urban challenges at once. Citizen stewardship of street trees and street tree beds is one such nature-based solution that challenges rapid urbanization while offering a healthier and greener future. Not only does citizen stewardship of street trees play a significant role in tree longevity, but our research suggests that the process of stewardship itself also positively impacts the health and wellbeing of stewards themselves. In this study, we sought to assess the motivations of street tree citizen stewards and the perceived social, environmental, and health effects of stewarding street tree beds in Freiburg, Germany. Based on a questionnaire-based survey and semi-structured interviews with tree stewards, we found that the most common motivations of citizen stewards were modeling positive environmental behavior as well as a desire to help the environment and one’s community. The perceived outcomes included a strong sense of place, a meaningful connection to nature, and the belief that stewarding a street tree bed is good for one’s mental health as well as the environment. Participants also considered street tree beds to be their personal gardens, suggesting that street tree beds may serve as restorative spaces that strengthen public health and social capital while sustaining urban greening. This case study expands the scientific discourse of urban gardening while suggesting that citizen stewardship of street trees and tree beds offers myriad co-benefits for urban ecosystems and public health.

Computational analysis of electromagnetic field exposure in passengers near high- current contact wire environments.

The electromagnetic environment of a railway station is composed of electrical, magnetic, and electromagnetic fields, which are generated by various sources such as traction current, voltage, pantograph-catenary arc, locomotive braking, wheel-rail rolling arc, and communication systems. However, there is public growing concern among the public about the potential negative human health effects of this electromagnetic environment. To analyze the distribution of electromagnetic fields in human tissues, electromagnetic simulation software is used to create a model that includes six track contact wires and four waiting passengers on three platforms. This model is used to analyze the magnetic field environment created by high currents in the contact wires of a multi-track high-speed railway station. By varying the loads on different contact wires, the distribution of electric field and magnetic flux density within human tissues of waiting passengers on different platforms is studied using this model. When the track is unoccupied, the calculation results show that the maximum values of the electric field and magnetic flux density of the passenger's human body tissue at the blind way on the platform and 1m of the blind way are 17.6mVm-1 and 52.7 μT, respectively. These values increase by 9.28mVm-1 and 16.4 μT compared to when the track is occupied. When more contact wires are loaded with currents, the electric field mode and magnetic flux density mode of human tissues increase at the same position on the platform. Specifically, when the contact wires of six tracks are loaded with current at the same time, the maximum values of the electric field mode and magnetic flux density mode of the waiting passengers' human tissues at the blind way on different platforms are 29.6mVm-1 and 88.1 μT, respectively. These maximum values are lower than the public electromagnetic exposure limits that are designated by the International Commission on Non-Ionizing Radiation Protection guidelines. The research results demonstrate that the magnetic field environment generated by the current in the contact wires of a railway station with six tracks does not pose a health risk to human tissues of passengers waiting at the blind way and 1m of the blind way on the platform. These findings can provide valuable data reference for the formulation of relevant standards for the design of electrified rail transit, as well as the suppression of electromagnetic interference and protection of human bioelectromagnetism.

Case Report: Difficulties faced by a home oxygen therapy patient who died after the Fukushima Daiichi nuclear power plant accident

Following the Great East Japan Earthquake (GEJE) and the Fukushima Daiichi nuclear power plant accident in 2011, mandatory evacuation orders were issued to residents living near the nuclear power plant in Fukushima prefecture, including some patients receiving home oxygen therapy. Although the vulnerability of patients with home oxygen therapy (one of the population groups most vulnerable to disasters) has been noted, there is little information on the health effects of evacuation in the event of a radiation disaster. A 90-year-old man diagnosed with chronic obstructive pulmonary disease since the age of 70, and lived in a town located approximately 20 km south of the nuclear power plant, died 8 months after the disaster due to worsening health conditions. This case reveals the potential for both physical and psychological burdens experienced by vulnerable groups like patients undergoing home oxygen therapy during evacuations in times of disaster. Although it is only a case report and the information is limited, severe respiratory distress requiring home oxygen therapy may present a significant risk factor for disaster-related deaths, especially in cases where evacuations are prolonged, such as in nuclear disasters. Due to the challenge of obtaining prompt public support immediately after a disaster, home oxygen therapy patients may need to prioritize self-help and mutual assistance in their disaster preparedness efforts.

Better Together: Tandem Mass Spectrometry Achieves up to 50 Times Lower Quantification of 62 Disinfection Byproducts in Drinking Water.

Disinfection byproducts (DBPs) are ubiquitous contaminants present in nearly all drinking water and are associated with adverse health effects in human epidemiologic studies. The most toxic DBPs are unregulated and often occur at concentrations well below regulated DBPs; thus, quantification at low parts-per-trillion (ng/L) levels is critical in assessing exposure. We developed a new liquid-liquid extraction-gas chromatography-tandem mass spectrometry (LLE-GC-MS/MS) method with the first analysis by tandem gas chromatography-mass spectrometry of 23 priority unregulated DBPs including 13 haloacetamides, 3 haloacetic acids, 2 haloacetonitriles, 1 haloacetaldehyde, 2 haloketones, and 2 halonitromethanes. When combined with our previous GC-MS/MS method for haloacetic acids and previously reported MS/MS transitions that we optimized for this method, the analysis of 62 regulated and priority unregulated DBPs at lower quantification limits is achieved. Limits of quantification for most DBPs were between 5 and 30 ng/L with r2 > 0.99 and an average of 9 times lower limits of quantification (LOQs) compared to LLE-GC-MS using selected ion monitoring (SIM). Relative standard deviations ranged from 0.7 to 30% for 61 DBPs in spiked samples. This new method was validated using tap waters from four US cities, where individual DBP concentrations ranged from 5 to 126,882 ng/L. This project provides the most comprehensive GC-MS/MS method for DBP analysis to date and is capable of analyzing volatile and semivolatile DBPs across nine different compound classes, including a class not previously analyzed by GC-MS/MS.

Messages About Tobacco and Alcohol Co-users.

People who use both alcohol and combustible tobacco have an increased risk of developing cancer. Few interventions have been developed to inform people about the risks of co-use. This study developed and tested messages about the risks of alcohol and combustible tobacco co-use among adults. In June-July 2021, we surveyed 1,300 U.S. adults who used both alcohol and combustible tobacco products within the past 30 days. After reporting their awareness of diseases caused by tobacco and alcohol co-use, participants were randomly assigned to four between-subjects experiments that manipulated specific cancer health effects vs. the word "cancer"; cancer health effects vs. noncancer health effects; different descriptions of co-use (e.g., Using alcohol and tobacco…, Drinking alcohol and smoking tobacco…); and co-use vs. single-use messages. Participants saw one message for each experiment and rated each message using a validated perceived message effectiveness (PME) scale. Awareness of health effects caused by alcohol and tobacco co-use ranged from moderately high for throat cancer (65.4%) to moderately low for colorectal cancer (23.1%). Messages about cancer health effects increased PME more than messages about non-cancer health effects (B=0.18, p=0.01). Messages about some specific cancers-including oral cancer (B=-0.20, p=0.04) and colorectal cancer (B=-0.22, p=0.02) decreased PME more than messages with only the word "cancer." No significant differences were identified for descriptions of co-use or co-use vs. single-use messages. Messages about some cancer health effects of co-using alcohol and tobacco may be effective when communicating the harms of both drinking alcohol and using tobacco.