In today's dynamic and uncertain business environment, the ability of public institutions and healthcare systems to respond swiftly to changes while maintaining high-performance standards is of paramount importance. This study delves into the intricate relationship between supply chain agility and healthcare performance within the context of (Public Hospitals) Nimba County, Liberia. The aim of this study is to identify and analyze the key factors that influence supply chain agility and subsequently impact healthcare service delivery and overall performance in public hospitals in Nimba County, Liberia. Drawing on a comprehensive review of existing literature, this research synthesizes the multifaceted determinants that shape supply chain agility in the unique setting of public institutions (Hospitals) and healthcare preference in Nimba County, Liberia. The regression model with the independent variables (Inventory control, Procurement, Information Technology and Warehouse management) showed a strong positive correlation with the dependent variable. These predictors explained about 60.41% of the variance in the dependent variables, with addition of these predictors have significantly improved the model's performance, as indicated by the low p-value (0.000) for the F Change statistic. The research recommends the management of the public hospitals in Nimba County and Liberia at large, to enhance its implementation to realize its impact at higher levels. Among these practices to put more emphasis on skills development, supportive supervision and performance review. In conclusion, this study offers a comprehensive analysis of the factors influencing supply chain agility in public institutions and their subsequent impact on healthcare performance in Nimba County, Liberia.