This review paper explores the theoretical insights and practical lessons learned from the implementation of telemedicine and healthcare Information and Communication Technology (ICT) in Africa and the United States. By comparing the challenges, strategies, and outcomes of telemedicine initiatives in these diverse healthcare settings, the paper highlights the importance of context-specific solutions, supportive policy frameworks, and the role of technology in overcoming barriers to healthcare access. The analysis reveals key theoretical frameworks such as the adaptive model of telemedicine implementation and the ecosystem approach, emphasizing the necessity for flexibility, interoperability, and equity in telemedicine services. The paper concludes with implications for healthcare providers, policymakers, ICT developers, and recommendations for future research, aiming to enhance the global understanding and deployment of telemedicine.