Health Care Financing Research Articles

Socioeconomic status and depression in later life: longitudinal mediation effects of activities of daily living

BackgroundSocioeconomic status (SES) is associated with both depression and activities of daily living (ADL and IADL). However, the role of ADL as a biological mechanism in the relationship between SES and late-life depression, examined through longitudinal data, remains understudied. This study explored the longitudinal mediation effects of basic ADL or IADL on the SES-depression link in older adults.MethodsData from the China Health and Retirement Longitudinal Study (N = 4104) were utilized. Mediation analysis was performed using parallel process latent growth curve modeling.ResultsThe average age of participants was 57.76 years, and 55.7% being females. Significant linear growth over time was observed in ADL, IADL, and depression. Adjusting for covariates, SES was positively linked to the initial levels (intercepts) of ADL (βiADL=-0.100[-0.143, -0.057]), IADL (βiIADL=-0.140[-0.185, -0.095]), and depression (βiDEP=-0.103[-0.158, -0.048]). However, SES showed no significant correlation with the rate of change (slopes) in ADL, IADL, or depression (P > 0.05). The intercepts of ADL (βiDEP = 0.566[0.503, 0.629]) and IADL (βiDEP = 0.607[0.544, 0.670]) were positively correlated with the depression intercept but negatively with the depression slope. Conversely, the slopes of ADL and IADL were positively associated with the depression slope. These results suggest a negative indirect relationship between SES and the initial level of depression, but a positive indirect relationship with the rate of increase in depression through ADL (or IADL) intercept.ConclusionsHigher SES is associated with a lower initial risk of depression and ADL difficulties. However, this same higher SES may relate to a faster increase in ADL difficulties and depression among middle-aged and older adults. The findings underscore the need for increased governmental healthcare funding and improved healthcare accessibility. Additionally, maintaining adequate sleep and physical activity can help prevent disability and reduce depression risk later in life, particularly among older adults with lower SES.

Evaluating Health Policy Effectiveness in Reducing the Economic Burden of Non-Communicable Diseases in Bangladesh

Non-communicable diseases (NCDs) represent a significant and growing public health challenge in Bangladesh, contributing to a substantial economic burden. Non-communicable diseases (NCDs), including cardiovascular diseases, diabetes, chronic kidney disease, cancers, and chronic respiratory conditions, represent a major health challenge in Bangladesh, contributing to substantial morbidity, mortality, and economic burden. The economic impact is profound, affecting both individuals and the broader economy through healthcare costs, loss of productivity, and long-term financial strain. This review aims to evaluate the effectiveness of health policies in mitigating the economic burden of NCDs in Bangladesh. The article begins with an overview of the prevalence and risk factors associated with NCDs, followed by an examination of the national health policies aimed at prevention, treatment, and management. The evaluation considers both successes and challenges, with a focus on policy implementation, healthcare financing, and access to care. Case studies highlight specific policy interventions that have demonstrated measurable success in reducing NCD prevalence and associated costs. The findings suggest that while significant progress has been made in policy formulation, challenges remain in ensuring comprehensive implementation and equitable access to healthcare services. Cost-effective strategies, such as scaling up preventive measures and improving healthcare infrastructure, are essential for reducing the economic burden of NCDs. The review concludes with recommendations for strengthening existing policies and exploring innovative approaches to sustain and enhance the impact of health policies on NCD management in Bangladesh.

Enrollment and Uptake of Health Care Financing Schemes among Adult Inpatients in Baringo County, Kenya

A high burden of healthcare expenditure precludes the poor from access to quality healthcare services. Due to the dearth of studies detailing healthcare financing in rural-based counties in Kenya, the study examined enrolment and uptake of healthcare financing schemes among adult inpatients in Baringo County, Kenya. The study employed a descriptive cross-sectional research design and was situated in Baringo County Referral Hospital with a target population of about 8,400 monthly or more than 100,000 patients annually. A sample size of 398 patients/and or caregivers was selected based on the stratified simple random sampling method. The results indicated age > 35 years (OR = 0.76120, p = 0.004), Occupation (OR = 0.65730, p = 0.000), income levels (OR = 1.67921, p = 0.000), marital status (OR = 0.38342, p = 0.000) and household size > 4 but less than 9 (OR = 3.66847, p = 0.000) and explain about 21.58 per cent in the enrolment in a healthcare insurance scheme. The conclusions are that demographic factors (age, marital status, occupation, income levels and household size) influence enrolment This implies that young unmarried individuals < 35 years, employed with income > Ksh 20,000 and with household size < 5 persons were more likely to enrol for a healthcare financial scheme. The study recommends that a universal healthcare financing scheme should be implemented to make healthcare financing more affordable and accessible through policy interventions

Healthcare sectors in EU countries: Their impact on employment and infrastructure development

This scientific study aims to thoroughly assess the current status and evaluate key indicators influencing healthcare and the workforce in selected European Union (EU) member states. Building upon this ambitious research agenda, we focused on a comprehensive descriptive analysis of selected indicators within the healthcare sector, including healthcare financing schemes, overall employment in healthcare and social care, the number of graduates in healthcare (including physicians and general practitioners), as well as migration patterns within the healthcare sector. The data forming the basis of this analysis were systematically gathered from Organization for Economic Co-operation and Development (OECD) and Eurostat databases. Subsequently, we conducted a robust correlation analysis to explore the intricate relationships among these indicators. Our research endeavour aimed to identify and quantify the impact of these indicators on each other, with a focus on their implications for overall healthcare and the workforce in the respective countries. Based on the findings obtained, we derived several significant conclusions and recommendations. For instance, we identified that increasing employment in the healthcare sector may be associated with the overall quality of healthcare provision in a given country. These findings have important implications for policymaking and decision-making at the EU level. Therefore, we recommend that policymakers in these countries consider implementing measures to further develop the healthcare sector while also helping to retain and attract qualified professionals in the healthcare industry. Such recommendations could include improving healthcare infrastructure, incentivizing professional education and further training in the healthcare sector, and implementing policies to support healthcare provision more broadly.

Machine Learning in Medicare Fraud Detection: Safeguarding Public Resources

Fraud in receipt and provision of Medicare is one of the most dangerous threats to public healthcare delivery systems, wasting billions of dollars annually and distorting the foundations upon which healthcare solutions are based. Conventional approaches to identifying fraud have become ineffective owing to the new and complex techniques undertaken by fraudsters. Through this paper, an effort is made to discuss the role of ML in identifying and combating Medicare fraud, specifically to preserve public assets. Using supervised learning, unsupervised learning, and deep learning are promising methods to detect patterns that are possibly related to fraud activities. Applying these techniques can help analyze a huge amount of data, learn from precedents, and identify elaborate and sophisticated trends that are hardly discernable using traditional approaches. This paper will provide an extensive investigation of various ML approaches to Medicare fraud detection. At this step, we experimentally analyze the most popular and effective ones, like decision trees, random forests, SVM, creative neural networks, and clusters. From the results obtained, it is clear that these advanced ML techniques can enhance the performance of fraud detection methods by dramatically minimizing false positives and enhancing the early detection of fraudsters in claims processing. In addition, the ethical concerns, future prospects, and difficulties of employing ML in this particular field. The use of machine learning in Medicare fraud prevention and identification mechanisms to prevent fraud greatly has the potential to transform the protection of public resources, which is crucial to ensuring that healthcare funds are used optimally.

Cardiovascular equity and health center funding: Associations of unmet hypertension and diabetes need by race/ethnicity and federal grants at federally qualified health centers, 2014-2019.

Racial and ethnic disparities in chronic disease are a major public health priority. To determine if the amount of federal grant funding to federally-qualified health centers (FQHCs) was associated with baseline overall prevalence of uncontrolled hypertension and uncontrolled diabetes, as well as prevalence by racial and ethnic subgroup. Cross-sectional multivariate regression analysis of Uniform Data System 2014-2019, which includes clinic-level data from each FQHC regarding demographics, chronic disease control by race and ethnicity, and grant funding. Our main exposure were the average values of the prevalence of uncontrolled hypertension and uncontrolled diabetes among the overall population and by racial and ethnic group from 2014-2016. Average federal grant funding per patient from 2017-2019, as measured by annual health center funding from the Bureau of Primary Health Care (BPHC) and overall federal grant funding. We analyzed 1,205 FQHCs from 2014-2019; the average BPHC grant per patient across all FQHCs in 2019 was $168 while the average total federal grant was $184 per patient. Increasing shares of total patients with uncontrolled hypertension or uncontrolled diabetes were not associated with increased total federal grant funding in either unadjusted or adjusted analysis. Increased shares of patients who are American Indian or Alaskan Native (AI-AN) with uncontrolled hypertension and diabetes were associated with increasing total federal grant funding in both unadjusted and adjusted analysis (adjusted beta hypertension $168.3, p <0.001; adjusted beta diabetes 59.44, p = 0.02). However, cardiovascular clinical need among other racial and ethnic groups was not significantly associated with grant funding. FQHCs with higher overall rates of uncontrolled hypertension or diabetes do not receive more federal funds, and there is no significant association between federal funding levels and rates of uncontrolled blood pressure or diabetes within most racial and ethnic groups, with the exception of AI-AN populations. To narrow inequities in cardiovascular disease, HRSA should consider more explicitly targeting federal grants to clinics with higher levels of clinical need.

Qualitative assessment of the enablers and barriers of COVID-19 vaccination integration, into routine immunization Programme at primary health care facilities in Ekiti state, Nigeria

BackgroundThe introduction of the COVID-19 vaccine influenced discussions to explore integrating COVID-19 vaccination into routine immunization (RI) programs. Subsequently, the WHO Strategic Advisory Group Experts (SAGE) on immunization plausibly advised countries to leverage the COVID-19 vaccination rollout as a transformative opportunity to establish a resilient immunization system, through an integrated immunization system, resulting in strengthened primary healthcare services.ObjectiveThis study assessed the enablers and barriers to integrating COVID-19 vaccination into the routine immunization programme in Ekiti state, Nigeria.MethodsThis study utilized a qualitative research approach to obtain information from 40 participants selected purposively across the primary healthcare facilities, LGA, and state levels. A three-tier approach was employed to select the LGAs. At the same time, In-depth interviews were conducted to elicit relevant information on the assessment of enablers and barriers to integrating COVID-19 vaccination into routine immunization through an interview guide. All the audio interview files were transcribed into English Language, coded, and presented using a thematic approach.ResultsA total of 40 healthcare workers across Ekiti state were selected to participate in this study. Our study found the enablers of integrating COVID-19 into routine immunization to include demand generation and social mobilization, health education, health workers training, data validation, financing, and supervision. However, rumors, demand for incentives, Adverse Events Following Immunization (AEFI), manpower shortage, poor internet network services, and bad road networks were reported as barriers to integrating COVID-19 vaccination into routine immunization in Ekiti state.ConclusionWhile the enablers of integrating COVID-19 vaccination into routine immunization may outweigh its barriers, it is pertinent to know that the efforts towards integrating COVID–19 vaccination in the RI Program is a call to all stakeholders to ensure sustainability. The identified barriers in the study must be addressed to ensure a strengthened health system. Therefore, achieving a successful integration and uptake of vaccination/immunization is anchored on driving demand generation, social mobilization, health education, availability of healthcare workers, integrated supervision, and financing.

General practitioner and nurse experiences of type 2 diabetes management and prescribing in primary care: a qualitative review following the introduction of funded SGLT2i/GLP1RA medications in Aotearoa New Zealand.

To explore the views of general practitioners (GPs) and nurses on type 2 diabetes (T2D) management, including the use of recently funded T2D medications in New Zealand (NZ) and their perceived barriers to providing optimal care. T2D is a significant health concern in NZ, particularly among Māori and Pacific adults. Characterised by prolonged hyperglycaemia, T2D is generally a progressive condition requiring long-term care. Semi-structured interviews were conducted between July and December 2022 with 21 primary care clinicians (10 GPs and 11 nurses/nurse prescribers) from nine different general practice clinics across the Auckland and Waikato regions of NZ. Framework analysis was conducted to identify common themes in clinicians' perceptions and experiences with T2D management. Three themes were identified: health-system factors, new medications, and solution-based approaches. Lack of clinician time, healthcare funding, staff shortages, and burn-out were identified as barriers to T2D management under health-system factors. The two newly funded medications, empagliflozin and dulaglutide, were deemed to be a positive change for T2D care in that they improved patient satisfaction and clinical outcomes, but several clinicians were hesitant to prescribe these medications. Participants suggested that additional education and specialist diabetes support would be helpful to inform optimal medication prescribing and that better use of a multi-disciplinary team (clinical and support staff) could support T2D care by reducing workload, addressing cultural gaps in healthcare delivery, and reducing burnout. An improved primary care work environment, including appropriate professional development to support prescribing of new medications and the value of collaboration with a non-regulated workforce, may be required to facilitate optimal T2D management in primary care. Future research should focus on interventions to increase support for both clinical teams and patients while adopting a culturally appropriate approach to increase patient satisfaction and improve health outcomes.

Healthcare Expenditure, Health Outcomes and Economic Growth: A Study of BRICS Countries

This study examines the relation of health spending, health indicators and macroeconomic variables of the BRICS economies with economic growth by using panel data that span the years 2000–2019. According to the panel data analysis, the amount of government spending on healthcare has a positive effect on the gross domestic product (GDP) and gross national income per capita of the BRICS countries. Indicators of healthcare are positively related to GDP and GDP/capita. The exceptions are neonatal mortality and life expectancy at birth, both of which do not exhibit a statistically significant positive relation. The two dependent variables, GDP and GDP/capita, have a positive relation with the rate of population growth; however, GDP has a negative relation with inflation. When GDP and GDP/capita are used as dependent variables, the Hausman test indicates that the cross-section random-effect model is more significant than other models. Due to the positive relationship between GHE, GDP and GDP/capita, the government should play a major role in ensuring high-quality healthcare. Out-of-pocket expense increases in BRICS indicate a reduction in healthcare funds, limiting medical services for all citizens. There is a need to focus on healthcare infrastructure.

Is tranexamic acid appropriate for all patients undergoing high-risk surgery?

Tranexamic acid (TXA), an antifibrinolytic agent, reduces surgical bleeding in a variety of procedures, such as cardiac, orthopedic, abdominal, and urologic surgery, cesarean section, and neurosurgery. However, there are surgical interventions for which its use is not yet widespread, and some caution persists because of concerns regarding thrombotic risk. The purpose of this review is to analyze the most recent evidence in various subgroups of surgical specialties and the association of TXA with thrombotic events and other side effects (e.g. seizures). Recent clinical trials and meta-analyses have shown that the efficacy and safety vary according to the clinical context, timing of administration, and dose. Some reports found that TXA reduces major bleeding by 25% without a significant increase in thrombotic events. Wider use of TXA has the potential to improve surgical safety, avoid unnecessary blood use, and save healthcare funds.

Security design: A review

Security design, which broadly speaking deals with the issue of designing optimal contractual mechanisms for overcoming various frictions between agents, is the subject of an extensive literature. This paper presents a review of recent work on security design and is organized around the applications of security design in various fields of finance starting with classic corporate finance applications such as capital structure and corporate governance, financial intermediation applications such as securitization and contingent capital, the interaction of market and security design, as well as emerging applications such as fintech, sustainable finance and healthcare finance. Future research is also discussed.

Healthcare Access and Financing: A Legal and Public Health Perspective

The welfare provisions of the current Constitution centre on healthcare. The Indian Constitution's Article 42 declares that the state has an obligation to take all reasonable steps to promote public health. Additionally, Article 47 of the Indian Constitution, another article containing Directive Principles of State Policy, mandates that the state carry out its primary duties to improve public health by raising the standard of living, improving nutrition, and improving public health. In particular, the state must work to outlaw the use of drugs and alcohol, unless prescribed, as these substances are harmful to health. It follows that welfare regulations clearly place an obligation on the state to increase its assistance in promoting the health of those individuals who are unable to pay for the expensive medical care needed to treat their illnesses. In light of the urgency and importance of the issue, the World Health Organisation designated Universal Health Coverage (UHC) as its top goal. Ensuring that everyone has access to necessary health services of adequate quality and is shielded from the financial burden of medical expenses is the goal of universal health coverage. In underdeveloped nations, financial security against medical expenses is just as important as access to healthcare.

Horizontal Inequality in Healthcare Utilisation in Rural Sabah, Malaysia

Ensuring universal access to healthcare is essential for societal equity. However, significant inequalities exist within global healthcare systems, resulting in unequal access to services and divergent health outcomes. Socioeconomic inequity, poor living conditions, and inadequate healthcare infrastructure perpetuate poor health among poor communities. Despite greater healthcare needs, economically disadvantaged populations face substantial barriers to obtaining necessary services. This research evaluates the equitable aspect of healthcare utilisation in Sabah’s rural areas to guide policy formulation. Nabawan, a rural area in Sabah with high poverty rates, was selected to assess income-related inequality and inequity in healthcare utilisation. Using the horizontal equity index and decomposition analysis, it was found that economic status significantly influences healthcare distribution, typically favouring the affluent. Central to this analysis is the concept of “equal treatment for equal need,” ensuring individuals with similar healthcare needs receive similar care regardless of economic status. Results indicate that wealthier individuals are slightly more likely to utilise healthcare services, although the difference is minimal. To address disparities, enhancing targeted financial assistance programs like PeKa B40 could reduce out-of-pocket expenses for low-income households. Additionally, increasing healthcare funding for rural infrastructure and training local healthcare workers can ensure equitable access for all households.

Improving the equity of U.S. health care financing: A commentary on Jacobs and Hill

Improving the equity of U.S. health care financing: A commentary on Jacobs and Hill

Relationship Between Radiation Oncology Department National Institutes of Health Funding and Institutional Community Inclusion/Investment

PURPOSE Disparities in health care access and funding allocation persist among racial minorities and low-income populations. Radiation oncology departments play a crucial role in cancer treatment, yet the extent to which these departments serve historically underrepresented communities following receipt of National Institutes of Health (NIH) funding remains unclear. METHODS Radiation oncology departments awarded NIH funding from 2019 to 2021 were studied using the 2023 Lown Institute Hospital Index rankings for community benefit and inclusivity to assess the relationship between measures of community benefit and inclusivity and NIH radiation oncology department research funding. RESULTS Twenty-two radiation oncology departments were analyzed in this study. A significant positive correlation was identified between the NIH research funding these departments received and their institutional rankings for overall community benefit (tau = 0.38; P &lt; .034). Additionally, there was a trend toward significance for the relationship between NIH funding and institutional rankings for community investment spending (tau = 0.497; P &lt; .053). No significant correlation was observed for other variables, including institutional rankings for charity care spending, Medicaid as a portion of patient revenue or services provided to patients from minoritized groups, low-income backgrounds, or those with lower levels of education. CONCLUSION Our findings indicate a significantly positive correlation between NIH funding received by radiation oncology departments and overall community benefit (measured by spending on financial assistance, community investment, and Medicaid). This suggests that departments receiving NIH funding may be incentivized to allocate resources toward initiatives aimed at improving community health outcomes extending beyond direct patient care.

Hysterectomy Rate Following Endometrial Ablation in Ontario: A Cohort Analysis of 76,446 Patients

Background: Endometrial Ablation (EA) is an alternative to hysterectomy for the management of abnormal uterine bleeding (AUB); however, it does not eliminate the need for future surgical re-intervention. Objectives: The primary objective of this study was to establish long-term clinical outcomes including the risk of hysterectomy in women who had undergone a primary EA. Materials and Methods: This is a retrospective population-based cohort study utilising administrative data from the Canadian province of Ontario. This study assesses patients undergoing surgery in a publicly funded health care system. Main Outcome Measures: We assessed women in Ontario undergoing a primary EA over a 15-year period. The primary outcome was hysterectomy within 5 years of primary EA. Secondary outcomes included myomectomy and repeat EA. All outcomes were also reported for 1, 3, 5, 10 and 15 years of follow-up. Logistic regression was used to establish predictors of hysterectomy within 5 years of primary EA. Results: A total of 76,446 primary EAs were evaluated from 2002-2017, with 16,480 (21.56%) undergoing a subsequent surgical intervention. The average age of primary EA was 43.8 (+/- 6.3) years. Within 5 years, the evaluable cohort was 52,464, with 8,635 (16.46%) of women having proceeded to hysterectomy, 664 (1.27%) to myomectomy, and 2,468 (2.8%) to repeat ablation. By 15-years follow-up, the evaluable cohort was 1,788, with 28.75% had undergone a hysterectomy, 2.01% a myomectomy, and 5.20% a repeat EA. On logistic regression analysis, advancing age at time of EA was associated with significantly decreased odds of hysterectomy (OR=0.94, 95% CI 0.935-0.944, p&lt;.0001) as was increasing surgical experience (OR=0.997, 95% CI 0.994-1.000, p=.022). Conversely, complex diagnosis (OR=1.102, 95% CI 1.042-1.164, p&lt;.0001) and previous abdominal surgery (OR=1.288, 95% CI 1.222-1.357, p&lt;0.0001) were associated with increased risk of subsequent hysterectomy. Conclusion: Primary EA is associated with a high risk of progression to subsequent hysterectomy or other surgical intervention, without evidence of plateau of risk with long term follow-up. What is new? This study has the longest follow-up assessing hysterectomy outcomes in women undergoing a primary EA, with 28.75% of women having undergone a hysterectomy within 15 years of their EA.

Hysterectomy Rate Following Endometrial Ablation in Ontario: A Cohort Analysis of 76,446 Patients

Background: Endometrial Ablation (EA) is an alternative to hysterectomy for the management of abnormal uterine bleeding (AUB); however, it does not eliminate the need for future surgical re-intervention. Objectives: The primary objective of this study was to establish long-term clinical outcomes including the risk of hysterectomy in women who had undergone a primary EA. Materials and Methods: This is a retrospective population-based cohort study utilising administrative data from the Canadian province of Ontario. This study assesses patients undergoing surgery in a publicly funded health care system. Main Outcome Measures: We assessed women in Ontario undergoing a primary EA over a 15-year period. The primary outcome was hysterectomy within 5 years of primary EA. Secondary outcomes included myomectomy and repeat EA. All outcomes were also reported for 1, 3, 5, 10 and 15 years of follow-up. Logistic regression was used to establish predictors of hysterectomy within 5 years of primary EA. Results: A total of 76,446 primary EAs were evaluated from 2002-2017, with 16,480 (21.56%) undergoing a subsequent surgical intervention. The average age of primary EA was 43.8 (+/- 6.3) years. Within 5 years, the evaluable cohort was 52,464, with 8,635 (16.46%) of women having proceeded to hysterectomy, 664 (1.27%) to myomectomy, and 2,468 (2.8%) to repeat ablation. By 15-years follow-up, the evaluable cohort was 1,788, with 28.75% had undergone a hysterectomy, 2.01% a myomectomy, and 5.20% a repeat EA. On logistic regression analysis, advancing age at time of EA was associated with significantly decreased odds of hysterectomy (OR=0.94, 95% CI 0.935-0.944, p&lt;.0001) as was increasing surgical experience (OR=0.997, 95% CI 0.994-1.000, p=.022). Conversely, complex diagnosis (OR=1.102, 95% CI 1.042-1.164, p&lt;.0001) and previous abdominal surgery (OR=1.288, 95% CI 1.222-1.357, p&lt;0.0001) were associated with increased risk of subsequent hysterectomy. Conclusion: Primary EA is associated with a high risk of progression to subsequent hysterectomy or other surgical intervention, without evidence of plateau of risk with long term follow-up. What is new? This study has the longest follow-up assessing hysterectomy outcomes in women undergoing a primary EA, with 28.75% of women having undergone a hysterectomy within 15 years of their EA.

Incidentalomas in Chest Radiograph of Apparently Healthy Individuals Presenting for Pre-Employment Medical Examination in Enugu State, Nigeria.

A chest radiograph is the most commonly requested and performed imaging for diagnosis and screening including medical examination. The study aimed to determine the prevalence and pattern of incidentalomas in radiographs of cases presenting for pre-employment medical examination. This was a retrospective review of chest radiographs conducted for patients presenting for pre-employment medical examination from January to December 2022. Relevant data including sociodemographic characteristics, clinical details and chest radiograph reports were retrieved using study proforma from all patients with complete medical data were analyzed using statistical package for social sciences (SPSS) version 23 with the level of statistical significance set as P <0.05 taken as statistically significant. Three hundred and eleven chest radiographs of subjects aged 20-49 years were evaluated, of which 22 (7.1%) incidentalomas were found. Most were females (55%). Of these incidentalomas, 12 (54.6%) were in the cardiovascular system, while the skeletal and pulmonary systems accounted for eight (36.4%) and two (9.1%), respectively. In all participants, clinically significant findings were eight (2, 6%), comprising of cardiomegaly five (1.6%), leash of vessels in the upper zone one (0.3%), blunt costophrenic angle one (0.3%), and right-sided aortic arch one (0.3%). Age and gender have no statistical significance in the incidental findings. Although the incidence of clinically significant incidentalomas appears low in our environment where beliefs and lack of adequate healthcare financing prevent the majority from seeking timely medical attention, chest radiograph remains an invaluable tool for pre-employment medical examination. Some underlying medical conditions could be picked up, further investigation sought to save life, and it serves as a baseline with which future findings may be compared.

The refined Pathways to Cures Research Roadmap for multiple sclerosis cures

Background: Multiple sclerosis is a chronic immune-mediated disease of the central nervous system affecting nearly 3 million people worldwide. Although much progress has been made in the understanding and treatment of MS, cures remain elusive. Objectives: To accelerate the development of cures for MS by updating the Pathways to Cures Research Roadmap based on a contemporary understanding of disease. The refined Roadmap will help to promote research in scientific areas with great potential to reveal insights leading to cures and inspire greater coordination of global resources. Methods: Refinements to the Roadmap were achieved during a Global Summit that included close to 200 academic and industry scientists, health care providers, policy makers, funders, and people with MS from 15 countries. Results: The refined Roadmap describes three pathways that target opportunities for generating scientific insights leading to cures. Recommendations for accelerating research progress include, lowering barriers for global data sharing, enhancing collaboration and coordination among research supporters, committing to sustained funding, considering implications for implementation, engaging PwMS and committing to diversity, equity, and inclusion in the global MS movement. Conclusion: The refined roadmap provides a strategic framework for tackling the complexities of MS and advancing prevention strategies, effective treatments, and cures.

Referring wisely: knowing when and how to make subspecialty consultations in hospital medicine.

Subspecialty consultations are becoming highly prevalent in hospital medicine, due to an ageing population with multimorbid conditions and increasingly complex care needs, as well as medicolegal fears that lead to widespread defensive medical practices. Although timely subspecialty consultations in the appropriate clinical context have been found to improve clinical outcomes, there remains a significant proportion of specialty referrals in hospital medicine which are inappropriate, excessive, or do not add value to patient care. In this article, we sought to provide an overview of the common problems pertaining to excessive quantity and suboptimal quality of inpatient subspecialty consultations made in real-world practice and highlight their implications for healthcare financing and patient care. In addition, we discuss the underlying contributing factors that predispose to inappropriate use of the specialist referral system. Finally, we offer a practical, multitiered approach to help rationalize subspecialty consultations, through (i) a systematic model ('WISE' template) for individual referral-making, (ii) development of standardized healthcare institutional referral guidelines with routine clinical audits for quality control, (iii) adopting an integrated generalist care model, and (iv) incorporating training on effective referral-making in medical education.