Non-medical prescribing chemotherapy clinics are a vital resource that are cost effective and reduce waiting times for patients to receive treatment. Nurses in advanced roles need to undertake regular continuous professional development (CPD) and education to ensure the successful running of such clinics. Training in health assessment will ensure a structured approach that includes comprehensive history taking and meticulous physical examination. Carrying out these two parts consecutively enables the examiner to assess the presenting complaint, establish an accurate differential diagnosis and provide any necessary interventions. Such an approach ensures the safe delivery of chemotherapy with early identification and management of potential side effects of treatment.