Trauma Healing Research Articles

Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing.

Wound healing is a complicated biological process that leads to the regeneration of damaged skin tissue. Determining the methods to promote wound healing has become a hot topic in medical cosmetology and tissue repair research. Mesenchymal stem cells (MSCs) are a group of stem cells with the potential of self-renewal and multi-differentiation. MSCs transplantation has a broad application prospect in wound healing therapy. Many studies have demonstrated that the therapeutic capacity of MSCs is mainly mediated by paracrine actions. Exosomes (EXOs), which are nanosized vesicles carrying a variety of nucleic acids, proteins and lipids, are an important component of paracrine secretion. It has been demonstrated that exosomal microRNAs (EXO-miRNAs) play a key role in the function of exosomes. In this review, we focus on current research on miRNAs from MSC-derived exosomes (MSC-EXO miRNAs) in terms of sorting, releasing and function and their effects on inflammation regulation, epidermal cell function, fibroblast function, and extracellular matrix formation. At last, we discuss the current attempts to improve the treatment of MSC-EXO-miRNAs. Many studies have demonstrated that MSC-EXO miRNAs play a key role in promoting wound healing. They have been shown to regulate inflammation response, enhance epidermal cell proliferation and migration, stimulate fibroblast proliferation and collagen synthesis, and regulate extracellular matrix formation. Besides, there have been a number of strategies developed to promote MSC-EXO and MSC-EXO miRNAs for wound healing treatment. Utilizing the association of exosomes from MSCs with miRNAs may be a promising strategy to promote trauma healing. MSC-EXO miRNAs may provide a new approach to promote wound healing and improve the quality of life for patients with skin injuries.

PERAN PERAWAT PADA BENCANA GEMPA BUMI DI CIANJUR

A disaster becomes an extraordinary event that disrupts and threatens life and livelihoods caused by nature and humans, or both. The existence of natural disasters can have both small and large impacts on the environment. The thing that can be done to reduce the consequences of disasters is that synergy from various parties is needed, one of which is the involvement of nurses. Nurses have a huge role to play in preparing and handling communities in the face of disasters. As health workers, nurses are at the forefront of disaster management so that they can anticipate the prevention of disasters and their impacts (Doondori, A. K., & Paschalia, Y. P. 2021). Cianjur Regency is one of the areas that experienced the impact of natural disasters, namely earthquakes. The earthquake occurred on November 21, 2022 at 13:21:10 WIB with a magnitude of 5.6 in the Cianjur area, West Java. The earthquake caused a lot of infrastructure damage and casualties. This has a great influence on the condition of the community, one of which is in terms of health biopsychosocially and spiritually. Based on the phenomenon that occurs along with the existence of the role of the nurse as a healthcare provider. Universitas Esa Unggul sent a team of health volunteers to carry out several activities for the community such as, providing comprehensive nursing services, becoming collaborators, conducting education and trauma healing. This action is considered sufficient to help patients who have health problems both who come to the post and who are in refugee tents. They feel happy because of the existence of health service facilities so that the public can consult, get education and also trauma healing.

Idioms of distress: Feasibility trial findings on reducing somatic symptoms through a community-based, culturally integrated intervention in Somaliland

Background Somatic complaints play a central role in the posttraumatic psychological symptom presentation among people within many cultural contexts. One theory about the function of somatic symptoms suggests that diffuse bodily complaints serve as idioms of distress. However, few studies have examined the effect of culturally adapted trauma interventions on reducing somatic symptoms specifically implemented in a low-income country. Methods We examined the effects of Islamic Trauma Healing – a brief, group- and mosque-based, lay-led intervention – on somatic symptom reduction in a pre-post feasibility study conducted in Somaliland. Inclusion criteria were DSM-5 trauma exposure and DSM-5 re-experiencing or avoidance. Participants (N = 26; 12 men, 14 women) reported large intervention effects for somatic symptoms ( g = 2.74, SSS-8). Higher pre-intervention somatic symptoms showed moderate to large associations with higher overall PTSD symptoms ( r = .43, P = .03). At post-intervention, somatic symptoms were only significantly associated with higher PTSD avoidance symptoms ( r = .41, P = .04) and lower well-being ( r = -.49, P = .01). No gender effects on total somatic symptom scores were observed. Discussion Results of this feasibility trial bring into focus overlap between mental health symptom reporting and somatic concerns as conceptualized within the context of cultural idioms of distress. Moreover, these findings suggest that diffuse transdiagnostic somatic symptoms could offer opportunity to learn about the intersections among culture, posttraumatic stress, and idioms of distress as mechanisms in global mental health intervention development.

Effects of Stromal Vascular Fraction and Platelet-Rich Plasma Treatment on Capillary Histopathology During Anal Trauma Healing in Rats: An in Vivo Study

INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt the anal sphincter and cause considerable morbidity. Non-invasive anal trauma therapies have been widely developed, including growth factors administered as platelet-rich plasma (PRP) and stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) and limited growth factor. This study aimed to assess PRP and SVF effects on capillary histopathology in the anal trauma Wistar rat model. MATERIALS AND METHODS: This experimental study used a rat model. Rats were divided into three groups: Group A (n=12) was treated with PRP and SVFs; Group B (n=12) was treated with normal saline (placebo); Group C (n=4) was sacrificed on day 0 to obtain baseline capillary counts. Groups A and B were further divided into three subgroups, sacrificed on days 1, 7, and 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between Groups A and B (p=0.037, analysis of variance). On day 7, there was a significant difference between Groups A and B (p=0.001). CONCLUSION: Mean capillary density significantly improved in anal trauma treated with a combination of PRP and SVFs compared to control. Our findings support the use of PRP and SVFs to aid recovery of patients with anal trauma.

Group Coloring Therapy As Trauma Healing For Child Community Affected By Mount Semeru Eruption: A Case Study

Children are one of the populations most affected by the eruption of Mount Semeru. Post-disaster trauma can have a higher risk of producing post-traumatic stress disorder compared to other traumatic events. Group coloring play therapy can be an intervention that can reduce traumatic feelings by helping children express traumatic feelings, feel relaxed, and restore children's ability to interact with children around them. This research uses a case study method with the target of children who experience anxiety due to traumatic experiences of the eruption of Mount Semeru, The ages of the children in this study were categorized into two groups, namely children aged 1-5 years (45.9%) and children aged 6-11 years (54.1%), Evaluation in the intervention program is divided into 3 parts (the structure, process evaluation, and results during activities where children affected by the eruption of Mount Semeru are happy with the activities carried out and are able to interact with group mates. Group play therapy is able to have a positive impact on children affected by the Semeru eruption. after the intervention. children are able to express their traumatic feelings, are able to interact between team members, and show a happy and enthusiastic attitude during therapy.

Truth and Reconciliation: A Necessity for Trauma Healing in Post Conflict Restructuring

Truth and Reconciliation: A Necessity for Trauma Healing in Post Conflict Restructuring

Spiritually Oriented Trauma Healing in Nigeria: A Program Evaluation to Assess Trauma-Symptom Reduction and Spiritual Growth

There is a significant gap in the need for and provision of treatment of post-traumatic stress disorder (PTSD), especially in low- to middle-income countries such as Nigeria. This study sought to evaluate the effectiveness of a faith-based program in the reduction of PTSD symptoms and the improvement of relationship with God. Participants were all Nigerians living in the middle and northern parts of Nigeria, selected by a local church and a local Christian non-profit organization. Three 5-day workshops were completed in two locations with a total of 41 participants. The Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ( DSM-5) and the Spiritual Assessment Inventory were used as measures implemented pre and post intervention for program evaluation. Paired-sample t-tests showed significant reductions of PTSD symptoms, with a moderate effect on the whole group and a large effect on those who reached the cut-off for PTSD prior to the workshop. Improvement in relationship with God was also evident. Overall, the program appeared beneficial to participants, suggesting that culturally sensitive, faith-based workshops may be a strategic way to address high rates of PTSD in high-conflict areas.

Manual development and efficacy of Mindful Living Group activities to promote trauma healing during the COVID-19 pandemic in China.

Disasters can be traumatic with a profound and lasting impact on individuals. During the COVID-19 pandemic, our team developed the Mindful Living Group (MLG) activities manual based on Eastern body-mind wisdom and Western trauma healing theory to provide psychological assistance for trauma healing. In this study, we introduce a framework developed for the 10-session MLG activities manual, which consists of three core modules. Thirty-one participants living all over the country who had experienced traumatic stress resulting from the COVID-19 pandemic received the MLG intervention. This single-arm intervention study offered psychological assistance during the pandemic. The MLG intervention included 10 weekly 2-h sessions held online. Participants completed the initial interview, pre-test, post-test, and 1-month follow-up interviews. The effectiveness of the MLG activities manual was evaluated using psychological measures, including Self-Rating Depression Scale, Self-Rating Anxiety Scale, Mindful Attention Awareness Scale, Post-traumatic Growth Inventory, General Self-Efficacy Scale, and the Perceived Social Support Scale. Compared with the pretest level, the post-test levels of depression (F = 42.78, p < 0.001, η 2 = 0.59) and anxiety (F = 23.40, p < 0.001, η 2 = 0.44) were significantly lower; and mindfulness (F = 12.98, p =0.001, η 2 =0.30), posttraumatic growth (F = 27.06, p < 0.001, η 2 = 0.48), general self-efficacy (F = 13.20, p = 0.001, η 2 = 0.31), and perceived social support (F = 16.27, p < 0.001, η 2 = 0.35) were significantly higher (ANOVA). Further correlation analysis revealed a significant negative relationship of mindfulness with both depression (r = -0.43, p = 0.015) and anxiety (r = -0.35, p = 0.053), and significant positive relationships of mindfulness with posttraumatic growth (r = 0.40, p = 0.025), general self-efficacy (r = 0.52, p = 0.003), and perceived social support (r = 0.40, p = 0.024). These preliminary findings showed the effectiveness of MLG activities for trauma healing. The mechanisms underlying mindfulness promoting trauma healing are discussed based on both Eastern body-mind wisdom and Western theories of trauma healing. Identifier, ChiCTR2000034164.

Long-Term Impact of Domestic Violence on Individuals—An Empirical Study Based on Education, Health and Life Satisfaction

This paper takes the China Health and Retirement Longitudinal Survey (CHARLS) as a sample to assess the long-term impacts of domestic violence experienced in childhood on individuals. First, from the four dimensions of injury from violence, negligent care, emotional abuse and witness to domestic violence, an indicator system for quantifying domestic violence is constructed. Second, the simultaneous equation of self-evaluation health and life satisfaction is estimated by the seemingly unrelated regression model. Starting with education, health and life satisfaction, the long-term impact of domestic violence experiences on individuals is quantitatively assessed, providing empirical evidence for preventing and curing domestic violence and healing trauma. The empirical research shows the following: (1) An experience of domestic violence significantly reduces educational achievements. Compared with the three dimensions of injury from violence, negligent care and witnessing domestic violence, emotional abuse has the greatest negative impact on educational achievements. (2) Domestic violence significantly reduces the self-assessed health level and life satisfaction and increases the subjective mental health risk. Based on the complexity and concealment of domestic violence, combined with empirical research conclusions, this paper proposes countermeasures to prevent and control domestic violence.

Community Service for Cianjur Earthquake Victims Through Education and Empowerment

The research aims to discuss community service and concern for earthquake victims that occurred in Cianjur. Want to analyze the process of community service for victims of the Cianjur earthquake and want to know the level of concern from volunteers for the victims of the Cianjur earthquake. The research method uses a qualitative approach that describes the phenomena observed at the research location. The technique of collecting data is through direct field surveys for victims of the Cianjur disaster. Interviews by asking questions of volunteers and disaster victims, who were visited at the service location. Documentation studies of television media and internet media, information from volunteers, officials and other communities. Results and conclusions: (1). In the implementation of community service and concern from community volunteers from West Java, Banten and Jakarta to help and lighten their burden, from various institutions and communities. With various vehicles carrying aid in the form of food supplies, clothes, medicines and in the form of funds for the Cianjur earthquake victims. (2). Implementation of community service through education for school-age children in the form of education on traumatic healing, reading and writing the Koran, giving light questions about learning, singing, giving gifts of toys and food in the form of textbooks, dolls and other toys. Community service in the form of road repairs and lighting for power outages. Distribution of groceries, women's clothing, men's clothing and children's clothing, free medical and health care.

Genome-wide analysis of dysregulated RNA-binding proteins and alternative splicing genes in keloid.

Introduction: The pathogenesis of keloids remains unclear. Methods: In this study, we analyzed RNA-Seq data (GSE113619) of the local skin tissue of 8 keloid-prone individuals (KPI) and 6 healthy controls (HC) before and 42days after trauma from the gene expression omnibus (GEO) database. The differential alternative splicing (AS) events associated with trauma healing between KPIs and HCs were identifified, and their functional differences were analyzed by gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathways. The co-expression relationship of differentially alternative splicing genes and differentially expressed RNA binding proteins (RBPs) was established subsequently. Results: A total of 674 differential AS events between the KD42 and the KD0 and 378 differential AS events between the HD42 and the HD0 were discovered. Notably, most of the differential genes related to keloids are enriched in actin, microtubule cells, and cortical actin cytoskeletal tissue pathway. We observed a signifificant association between AS genes (EPB41, TPM1, NF2, PARD3) and trauma healing in KPIs and HCs. We also found that the differential expression of healthy controls-specifific trauma healing-related RBPs (TKT, FDPS, SAMHD1) may affect the response of HCs to trauma healing by regulating the AS of downstream trauma healing-related genes such as DCN and DST. In contrast, KPIs also has specifific differential expression of trauma healing related RBPs (S100A9, HspB1, LIMA1, FBL), which may affect the healing response of KPIs to trauma by regulating the AS of downstream trauma healing-related genes such as FN1 and TPM1. Discussion: Our results were innovative in revealing early wound healing-related genes (EPB41, TPM1, NF2, PARD3) in KPI from the perspective of AS regulated by RBPs.

PENERAPAN HUKUM TERHADAP ANAK YANG MELAKUKAN ABORTUS DIKAITKAN DENGAN PASAL 49 AYAT 2 KUHP.

Today there is a lot of sexual violence against minors. A religious teacher as well as a scout and paskibraka trainer at SMPN Tangerang molested his students and the victim received trauma healing services for his psychic healing. If a child commits a crime, it is regulated under Law Number 11 of 2012 concerning the Juvenile Justice System. Imprisonment for children is only used as a last resort (ultimum remedium). The issue of abortion is regulated in Article 346 of the Criminal Code, namely that a woman intentionally causes the abortion or death of her womb or orders someone else to cause the perpetrator to be sentenced to a maximum imprisonment of four years divided by two. The author considers it important to examine this issue because children are the younger generation who must receive special protection. Problem Formulation How is the application of the law to children who have abortions? Can the crime of abortion committed by children be categorized into Article 49 paragraph 2 of the Criminal Code. Objectives and Uses of Theoretical Research is expected to provide benefits and expand thinking on the development of legal science in the field of Criminal Law, especially in the crime of abortion due to rape. The method that the author uses in this research is normative juridical. In conclusion, children who have an abortion due to rape can be categorized into article 49 paragraph 2 of the Criminal Code. (noodweer exces) into forgiving reasons (fait d'axcuse) because it eliminates the element of guilt of the criminal offender.&#x0D; Keywords: Rape; child; abortion

Yoga and the Healing of Interpersonal Trauma: A Qualitative Meta-Analysis.

Although emerging research indicates that yoga facilitates healing from interpersonal trauma, consensus is lacking as to yoga's main facilitative factors. To address this limitation, we employed qualitative meta-analysis to analyze data from six qualitative studies (n = 105) that examined the healing agents of yoga that facilitated recovery from interpersonal trauma. The analysis process included coding data from each study and analyzing codes across all of the studies to derive meta-categories. Three researchers engaged in dual-level analyses (i.e., both inductive and deductive) to support consistency, address any inconsistencies, and develop a consensus. We identified and categorized six meta-categories based on the original 45 themes from the six studies and found differing levels of convergence across the studies. Meta-categories with high levels of convergence included (1) stabilization: coping strategies to reduce trauma-related symptoms; (2) authenticity, inner attunement, and self-acceptance; (3) equanimity: calming the mind and mindfulness; and (4) community: reduced isolation through safe connection with others. Our findings offer a more integrated, comprehensive, and consolidated understanding of the specific ways yoga can facilitate recovery from interpersonal trauma and demonstrate how qualitative meta-analysis methodology can tie together the richness of similar, stand-alone qualitative studies.

Unveiling The Dream: The New Frontiers of Dream Technology and Radical Rest

This article situates the meeting points of dream tech and the radical rest movement, centering on Black creative and community practices to contextualize the emergence of dream tech in academic research labs, tech startups, consumer markets, and artistic incubations. The article describes the rise of the Radical Rest movement, led by Black activists and artists, in response to the need to reclaim sleep and dreams from colonial agendas and capitalist systems of oppression. This movement has developed parallel to the rapid growth of sleep technology, offering new products for sleep-deprived consumers of the global North. The next frontier of this new multibillion-dollar industry is dream neurotech—technology that directly interfaces with the dreaming mind. The article introduces dream tech by unearthing a largely forgotten dream that shaped the trajectory of modern Western science, a trajectory that is contrasted with views about consciousness in sleep espoused by classical Indian philosophers. With this historical and global context for understanding how sleep and dreams are measured and quantified, the article then historicizes racial sleep inequities in the U.S. to frame how systematic oppression continues to have adverse effects on the sleep health of Black Americans. The article examines the aims of commercial dream tech, discerning agendas and assumptions that reverberate with the Cartesian dualism underlying Western scientific views of dreams, selfhood, and consciousness. These views will be complicated by the practices and values of Black activists and artists in the contemporary Radical Rest movement. Their work uplifts physical and emotional rest as a powerful site for healing trauma and resisting the oppressive vectors of white supremacy and capitalism.

Strategi Trauma Healing Shalom Dalam Mengatasi Ketakutan Anak Pada Masa Gempa berdasarkan Lukas 24: 44-47 dan Yohannes 20: 19-23

Trauma healing shalom (THS) is an reflection of healing the impact of an earthquake that occurred based on Luke 24:44-47 and John 20:19-23. Trauma Healing shalom includes actions to provide relaxation, strength of faith and calm in a child's life. THS activities include singing, healing, action, learning, optimization and meetings. Trauma healing shalom aims to provide peace for children, eliminate fear and replace it with faith with the hope that God is a helper and savior. The research method is a mixture of qualitative and quantitative by using purpose sampling with community service actions. THS action was carried out on 1500 children, with a total sampling population of 125 people in the Purbatua area, Hutatinggi, Parmonangna District. This Community Service is carried out by the IAKN Tarutung academic community team in the Purbatua forest, Hutatinggi, Parmonangan District, North Tapanuli. With the trauma of shalom therapy, the child is happy, peaceful and strong, not tense and can eliminate the anxiety and fear that is in his life because of the earthquake. The method used is qualitative purpose sampling through community service actions.

The Journey of the Wounding Heart：Trauma Healing Therapy in the Novel &lt;i&gt;Malika’s Sofa&lt;/i&gt; by Yoshimoto Banana

Yoshimoto Banana’s novels are referred to as ‘self-help’ literature. As a result of Yoshimoto’s impactful role in literature, it has the power to be of use in self-healing. One of them is Yoshimoto Banana’s novel which describes the search for meaning within oneself by reconnecting with nature called &lt;i&gt;Marika no Sofa&lt;/i&gt; (Malika’s Sofa). This novel tells the story of a female doctor named Junko sensei and Malika, her patient who has many personalities. The symptoms of DID (Dissociative Identity Disorder) are shown by Yoshimoto in this novel, and it shows an interesting part that is highlighted how Yoshimoto offers a method of trauma healing by traveling and dialogue. In addition, in this study, the friendship connection and empathy emotion between the therapist and her patient are seen from the &lt;i&gt;imago dialogue&lt;/i&gt; approach in Alfred Adler’s therapy. And then, followed by the natural therapy method using green trees approach. The researcher chose to use the concept of &lt;i&gt;shinrin yoku&lt;/i&gt; (forest bathing), which is an immersion in the natural surroundings to have a good physiological effect and provide relaxation on the mind and body. Junko sensei and Malika’s trip to Bali can also be interpreted as a desire (motivation) to leave old wounds in the healing stage. Both of them rediscovered something that had been missing in their lives for a long time, it is to feel and live a full life like humans.

Implementation of Human Concern in Education and Empowerment of Earthquake Victims in Cianjur Regency

The purpose of this study was to determine the level of public awareness of the earthquake victims that occurred in the Cianjur Regency. Want to analyze the educational process of the Cianjur earthquake victims and want to know the empowerment of each volunteer for the earthquake victims. The research method used is qualitative which describes the phenomena that occur in the research location. Data collection techniques in the form of direct observation of the community and environment around the disaster. Interviews with the victim community, officials, and other volunteers who were met at the research location. Documentation studies from various sources, such as the internet, information from fellow volunteers, and various Watch-Ap groups. Conclusion: (1). The implementation of the level of concern from all the people of West Java, Jakarta, and Banten are very enthusiastic to help and assist, as evidenced by the various institutions, communities, and vehicles carrying supplies in the form of funds as well as food and clothing, thronging the earthquake victim area. (2). Implementation of education directed at school-age children in the form of volunteers in the form of Trauma Healing in the form of reading the Koran using the Iqro model, quizzing learning questions, singing, and giving gifts in the form of snacks and textbooks. Community empowerment in the form of Strengthening faith and destiny as to why earthquakes occur, and information about knowledge of how earthquakes occur. Distribution of groceries, women's clothing, men's clothing, and children's clothing, and free medical and health care

Religious Psychosocial Healing for the Trauma of the Children of the Terrorists

&lt;p&gt;This study aims to reveal the trauma-healing process with a religious psychosocial approach to the children of the terrorists. Qualitative method is used to describe the trauma healing process analytically. The subjects in this study were 10 children of perpetrators of acts of terrorism in Surabaya, Magetan, Banten, and Bogor, who were cared for at the Islamic Boarding School, the Central Java Fostering House, Indonesia. Data collection techniques include in-depth interviews, observation, and documentation. This study found that the children of the terrorists have traumas in the form of feelings of excessive threat, remembering repeated and continuous events, and feeling helpless. To get rid of this trauma, the Central Java Islamic Boarding School conducted trauma healing with a religious psychosocial approach through three phases. First, creating a sense of security and stabilizing emotions. Second, training the children to make peace with the trigger of the trauma. Third, training the children to naturally socialize with the pesantren, school, and community environment. The novelty of this research lies in the integration of psychological, social, and religious approaches in trauma healing. The implication of this research is to enrich the trauma-healing model of the children of the terrorists.&lt;/p&gt;

Trauma Healing on Domestic Violence: The Effectiveness of Islamic Feminist Counseling

This research is motivated by the rise of violence cases experienced by women. Domestic violence against women is very vulnerable due to the urge present in the perpetrators to behave aggressively because of the stressors they are facing and the widespread belief in a patriarchal culture, which is the root cause of violence between husband and wife. In this case, Islamic feminist counseling seeks to recover and reduce depression in women victims of violence by building awareness of their gender roles based on an Islamic perspective. Therefore, this research aims to discover how Islamic feminist counseling can heal the trauma of women victims of domestic violence. This research was conducted through a qualitative approach. The data collection techniques used were document study, observation, and in-depth interviews, with two counselees (using pseudonyms in this article) in domestic violence cases. The data validity technique employed in this study was a triangulation of data collection techniques and data sources, while data analysis was performed deductively and inductively. The results revealed that the counselor carried out three stages of Islamic feminist counseling: conceptualization, intervention, and termination. At all stages, the counselor has achieved each stage’s goals, although with different techniques for the two counselees at each counseling stage.

Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair.

Acute myocardial infarction (AMI) is accompanied by a systemic trauma response that impacts the whole body, including blood. This study addresses whether macrophages, key players in trauma repair, sense and respond to these changes. For this, healthy human monocyte-derived macrophages are exposed to 20% human AMI (n = 50) or control (n = 20) serum and analyzed by transcriptional and multiparameter functional screening followed by network-guided data interpretation and drug repurposing. Results are validated in an independent cohort at functional level (n = 47 AMI, n = 25 control) and in a public dataset. AMI serum exposure results in an overt AMI signature, enriched in debris cleaning, mitosis, and immune pathways. Moreover, gene networks associated with AMI and with poor clinical prognosis in AMI are identified. Network-guided drug screening on the latter unveils prostaglandin E2 (PGE2) signaling as target for clinical intervention in detrimental macrophage imprinting during AMI trauma healing. The results demonstrate pronounced context-induced macrophage reprogramming by the AMI systemic environment, to a degree decisive for patient prognosis. This offers new opportunities for targeted intervention and optimized cardiovascular disease risk management.