The tribological characteristics of the head–disk interface are investigated during load–unload for air and helium-filled drives as a function of the pitch static angle and the roll static angle between slider and disk. A custom-made experimental tester inside a sealed environmental chamber was used to determine the regions of “safe” pitch static angle and “safe” roll static angle in air and helium environment during the load–unload process. The presence of head–disk contacts during load–unload were evaluated by measuring the acoustic emission signal and the decrease in rotational speed of the spindle. Scanning electron microscopy and optical surface analysis were used to investigate wear of the slider and the redistribution of lubricant on the disk surface after 10,000 load–unload cycles. The results indicate that the tribological performance of the head–disk interface is improved in helium environment compared to air environment.