The crude ethanolic extract of the fruits of Ficus hispida Linn. (Family: Moraceae) growing in southeast part of Bangladesh has been evaluated for its possible antinociceptive and neuropharmacological properties. The ethanolic extract of the fruits of F. hispida exhibited statistically significant (p < 0.001) writhing inhibition in acetic acid-induced writhing model in white albino mice (Swiss-webstar strain). The crude extract produced 30.41% inhibition of writhing at the dose of 250 mg/kg body weight and 62.84% inhibition of writhing at the dose of 500 mg/kg body weight, while the standard drug diclofenac inhibition was found to produce 75.68% at a dose of 25 mg/kg body weight. The extract of F. hispida fruits also potentiated the pentobarbital induced sleeping time in mice, decreased the open field score in open field test, decreased the number of hole crossed from one chamber in the hole cross test and decreased the head dip responses in hole board test. Acute toxicity test showed that the plant might be safe for pharmacological uses. Therefore, the obtained results tend to suggest the antinociceptive and neuropharmacological activities of the ethanolic extract of the fruits of F. hispida and thus, provide the scientific basis for the traditional uses of this plant part as a remedy for pain and depression. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation. Key words: Ficus hispida, antinociceptive, acetic acid-induced writhing model, neuropharmacological.