The following problem is solved by the present research: the probable sources of Paleozoic hydrocarbon deposits are determined on the basis of modeling the hydrocarbon foci of generation Paleozoic-Mesozoic oil source formations (for example, the southeast of Western Siberia, Tomsk Region). The research area is the lands Ostanino field group: the Selveikin area of deep drilling, the Ostaninskoye and Gerasimovskoye oil and gas condensate fields. Pre-Jurassic strata with oil source potential, including the Paleozoic Larinskaya (S1lr), Mirnaya (D13mr), Chuzikskaya (D2cz), Chaginskaya (D3cg) and Kehoregskaya (C1kh) formations, as well as Jurassic Bazhenovskaya (J3bg) and Tyumenskaya (J1-2tm ) formations, and, accordingly, the reservoirs of the weathering crust and bed-rock Paleozoic reservoirs are the objects of study. The subject of analysis was selected in accordance with the concept of the geothermal regime of the subsoil, as a leading factor in the implementation of the generation potential of the parent sediments. The research methods are digital paleotemperature modeling and historical-geological analysis. The results and conclusions concerning the fundamental problems of “Paleozoic oil” are obtained. 1. Source of the Paleozoic oil deposits can be both the Domanic type rocks of the Paleozoic formations and the Jurassic oil source formations. Thus, both upward vertical interstratal HC migration and downward HC migration can take place. Therefore, the two concepts of “main source” are compatible and should not be considered, as often, orthodoxly alternative. 2. The domanicoid rocks of the Paleozoic formations are most likely the source for Paleozoic gas and gas condensate deposits. 3. Paleozoic formations the roof of the bed-rock Paleozoic (on the Ostankinskaya group of fields – C1kh and D3cg) can be only the source of the «Paleozoic oil» and gas deposits in the Pre-Jurassic oil and gas complex. 4. Bazhenov formation – J3bg may be the “Jurassic” source of oil deposits in the Pre-Jurassic oil and gas complex. The results were obtained and conclusions were drawn concerning the applied (search) aspects of the problem: 1. Results additionally substantiate the author’s search criterion for the oil and gas content of the Paleozoic – these are anomalous geophysical and petrophysical characteristics of the Jurassic section. 2. The absence of hydrocarbon deposits in the Jurassic section is most likely a negative sign of the Paleozoic oil and gas content. 4. The low density of the modern heat flow (less than 40 mW/m2) is most likely a negative sign of oil deposits in the Paleozoic. 3. High paleotemperatures in terms of VR (more than 175oC) are most likely a negative sign of oil and gas deposits in the Paleozoic. 4. Reasons have been obtained to state that oil deposits in the Paleozoic cannot be richer than oil deposits in the Jurassic.