To investigate the relationship between the decreased immunity associated with infirmity and low body weight at birth as a consequence of intrauterine growth retardation in Japanese Black calves with stillbirth/perinatal weak calf syndrome, the thymuses and spleens of 13 calves with this syndrome, weighing less than 20 kg at birth, were examined histopathologically. Cytokeratin staining of the thymus was also carried out to examine its composition. The thymus and spleen were classified as grades 0-4 and I-III according to their hypoplasia, respectively. All calves showed a decreased number of thymocytes. One calf was classified as grade 1, which was characterized by a starry sky appearance. Five calves were classified as grade 2, demonstrating a reversion of the cortex-to-medulla ratio, and the rest were classified as grades 3 and 4 showing an indistinguishable boundary between the cortex and medulla. The thymuses of grade 3 and 4 were occupied by stroma cells, and their Hassall bodies and other structures were rarely observed. Six of 13 calves showed a decreased number of splenocytes, grade II or III, and their red and white pulp regions were unclear. The intrauterine growth retardation caused by lack of growth factors during the fetal period might have induced thymic hypoplasia associated with decreased immunity in the calves with stillbirth/perinatal weak calf syndrome. Therefore, intrauterine growth retardation might be associated with one of the causes of decreased immunity involved in infirmity in this syndrome.