Harmful Food Research Articles

Olfactory Disorders and Quality of Life--An Updated Review

Olfactory disorders are common and affect about one-fifth of the general population. The main causes of olfactory loss are post viral upper respiratory infection, nasal/sinus disease, and head trauma and are therefore very frequent among patients in ear, nose, and throat clinics. We have systematically reviewed the impact of quantitative, qualitative, and congenital olfactory disorders on daily life domains as well as on general quality of life and depression. From the extensive body of literature, it can be concluded that loss of the sense of smell leads to disturbances in important areas, mainly in food enjoyment, detecting harmful food and smoke, and to some extent in social situations and working life. Most patients seem to deal well and manage those restrictions. However, a smaller proportion has considerable problems and expresses a noticeable reduction in general quality of life and enhanced depression. The impact of coping strategies is discussed.

A review of the systemic adverse effects of areca nut or betel nut.

Areca nut is widely consumed by all ages groups in many parts of the world, especially south-east Asia. The objective of this review is to systematically review and collate all the published data that are related to the systemic effects of areca nut. The literature search was performed by an electronic search of the Pubmed and Cochrane databases using keywords and included articles published till October 2012. We selected studies that covered the effect of areca nut on metabolism, and a total of 62 studies met the criteria. There is substantial evidence for carcinogenicity of areca nut in cancers of the mouth and esophagus. Areca nut affects almost all organs of the human body, including the brain, heart, lungs, gastrointestinal tract and reproductive organs. It causes or aggravates pre-existing conditions such as neuronal injury, myocardial infarction, cardiac arrhythmias, hepatotoxicity, asthma, central obesity, type II diabetes, hyperlipidemia, metabolic syndrome, etc. Areca nut affects the endocrine system, leading to hypothyroidism, prostate hyperplasia and infertility. It affects the immune system leading to suppression of T-cell activity and decreased release of cytokines. It has harmful effects on the fetus when used during pregnancy. Thus, areca nut is not a harmless substance as often perceived and proclaimed by the manufacturers of areca nut products such as Pan Masala, Supari Mix, Betel quid, etc. There is an urgent need to recognize areca nut as a harmful food substance by the policy makers and prohibit its glamorization as a mouth freshener. Strict laws are necessary to regulate the production of commercial preparations of areca nut.

The olfactory neuron AWC promotes avoidance to normally palatable food following chronic dietary restriction

Changes in metabolic state alter foraging behavior and food preference in animals. Here, I show that normally attractive food becomes repulsive to Caenorhabditis elegans if animals are chronically undernourished as a result of alimentary tract defects. This behavioral plasticity is achieved in two ways: increased food leaving and induction of aversive behavior towards food. A particularly strong food avoider is defective in the chitin synthase that makes the pharyngeal lining. Food avoidance induced by underfeeding is mediated by cGMP signaling in the olfactory neurons AWC and AWB, and the gustatory neurons ASJ and ASK. Food avoidance is enhanced by increased population density and is reduced if the animals are unable to correctly interpret their nutritional state as a result of defects in the AMP kinase or TOR/S6kinase pathways. The TGF-β/DBL-1 pathway suppresses food avoidance and the cellular basis for this is distinct from its role in aversive olfactory learning of harmful food. This study suggests that nutritional state feedback via nutrient sensors, population size and olfactory neurons guides food preference in C. elegans.

고등학생들의 구강건강행위에 영향을 미치는 요인

Objectives : This study was to infectify variable the factors influencing oral health behaviors in high school students. Methods : Data were collected from 241 high school students Busan and Kyungnam Province for four weeks in July 2012. The SPSS 18.0 program was used for data analysis, which included t-test, correlation analysis, multiple logistic regression analysis. Results : Positive correlation in the order of social support(r=.381), self-efficiency(r=.309) with perceived benefit of oral health behavior and social support with total heal index(r=.298) are shown. In the contrary, the relation between social support(r=-.400), subjective oral health status(r=-.222) with impairments of oral health behavior have negative one. Experience in three or more tooth brushing has an effect on social support and subjective oral health status(p<.05). Perceived benefit(p<.001) of oral health life and subjective oral health status(p<.05) are affected by recognition of correct tooth brushing. Intake of harmful food on tooth has an effects on perceived benefit, self-efficiency, total health index and subjective oral health status(p<.05). Conclusions : In conclusion, systematic activation of oral health education in school and correct self-activity of oral health will promote oral health of youth.

Food taboos in medicine: a hypothesis for pathophysiology regarding harmful food

Food taboos in medicine: a hypothesis for pathophysiology regarding harmful food

ZEN and the art of breast health maintenance

Zearalenone (ZEN) is a non-steroidal mycoestrogen that widely contaminates agricultural products. ZEN and its derivatives share similar molecular mechanisms and activity with estrogens and interact with ERα and ERβ leading to changes in the reproductive system in both animals and humans. The reduced form of ZEN, α-ZEA ralenol, has been used as an anabolic agent for animals and also proposed as hormonal replacement therapy in postmenopausal women. Furthermore, both zearelanol ZEN and derivatives have been patented as oral contraceptives. ZEN has been widely used in the United States since 1969 to improve fattening rates in cattle by increasing growth rate and feed conversion efficiency. Evidence of human harm from this practice is provided by observations of central precocious puberty. As a result, this practice has been banned by the European Union. As ZEN has been associated with breast enlargement in humans, it has been included in many bust-enhancing dietary supplements but epidemiological evidence is lacking with regard to breast cancer risk. Extensive work with human breast cancer cell lines has shown estrogenic stimulation in those possessing ER but a reduction in DMBA-induced breast cancers in rodents given ZEN. Protein disulfide isomerase provides a molecular biomarker of dietary exposure to ZEN and its derivatives allowing the detection and control of harmful food intake. The interaction of ZEN with anti-estrogens, anticancer agents and antioxidants requires further investigation.

Consequences of acclimation to Microcystis on the selective feeding behavior of the calanoid copepod Eudiaptomus gracilis

We tested the hypothesis that calanoid copepods would adapt to extended periods of Microcystis exposure by increasing selective feeding on alternative food. Copepod (Eudiaptomus gracilis) clearance rates were compared before and after a 5‐d acclimation to Microcystis aeruginosa using paired food mixtures containing a microcystin‐producing (MC+) or ‐lacking (MC‐) strain and the green alga Chlamydomonas reinhardtii. Acclimation reduced the ingestion of Microcystis, increased ingestion of Chlamydomonas, and subsequently increased feeding selectivity. The effect of acclimation was more pronounced for food mixtures with MC+ Microcystis, suggesting that E. gracilis uses a strain‐specific cue related to microcystin or microcystin itself to avoid harmful food. The results indicate that exposure to sublethal abundances of Microcystis may increase copepod tolerance to blooms, given sufficient alternative food. Zooplankton grazing behavior should, therefore, be viewed as flexible and adaptive to extended periods of cyanobacteria blooms.

Bioreduction-Mediated Food-Drug Interactions: Opportunities for Oncology Nutrition

Chemical and biochemical processes underlying food-drug interactions in cancer therapy have not been well addressed with a systematic focus, even though they offer significant potential for enhancing the efficacy of cancer chemotherapy. Bioreductive anticancer drugs are metabolically activated by reductase enzymes. The levels and activities of relevant metabolic enzymes are regulated by transcription factors, which are under the control of chemical interactions with small molecules, including bioactive food components (BFCs) such as minerals, vitamins, and a variety of phytochemicals. One important and well-established process is the upregulation of enzymes involved in xenobiotic metabolism and redox regulation. Thus, BFCs might help to overcome resistances of some cancer cells towards anticancer agents or to increase efficacy by sensitizing cancer cells towards synergistic drugs. By understanding chemical and biochemical processes involved in food-drug interactions, not only can the risk of harmful food-drug interactions be diminished, but appropriate nutritional recommendations for cancer patients can be made and new functional foods with specific benefits in anticancer therapy may be developed.

Natural history of IgE-dependent food allergy diagnosed in children during the first three years of life

The aim of the study was to analyze: the course of allergy diagnosed during first three years of life, frequency of food tolerance development and impact of factors which have potential meaning in that process. The study was performed in 115 children with IgE-dependent allergy, diagnosed during first three years of life, treated in 2nd Department of Pediatrics and Allergology of Polish Mothers Health Center in Lodz. All children were invited to our clinic in order to analyze course of the allergy after period of minimum 5 years since diagnosis. The results of the study revealed that food tolerance was acquired by high percentage of examined children (87.9%) among 83 children with food allergy. However among 32 children with initial inhalant allergy there were still no food sensitizations. The frequency of this process increased with age of examined children. The study revealed that such factors as lack of family history of atopy, clinical manifestation limited to one system, lack of inhalant allergy, type of allergen, good social conditions, have positive impact on tolerance development. High percentage of children with food allergy is able to develop the status of food immunotolerance. Factors which predispose to development of food allergy have also negative impact on ability to acquiring tolerance to harmful food. The study indicates the need of constant and wide education about decreasing exposure to allergy predisposing factors which could increase chance of food tolerance development.

Стохастическая модель динамики биологического сообщества в условиях потребления особями вредных пищевых ресурсов

Стохастическая модель динамики биологического сообщества в условиях потребления особями вредных пищевых ресурсов

A Study on How Sasang Constitutional Diet Influenced the Formation of Eight Constitutional Diet

Abstract A Study on How Sasang Constitutional Diet Influenced the Formation of Eight Constitutional Diet Yong-Jae Jeung, Seong-Sik Park Dept. of Constitutional Medicine, College of Oriental Medicine, Dongguk Univ 1. Objectives This study intends to identify the contents of Sasang Constitutional Diet through a book by Lee Je-Ma, to review the implied contents, and to analyze the influence of this information and principles on the formation of Eight Constitutional Diet. 2. Results and Conclusions 1) The Sasang Constitutional Diet was systematically established by Lee Je-Ma, and is composed by the principles of ‛food is on different from medicine(食藥同源)’, principles of ‘reinforcement of one organ(一臟補强)’, principles of ‘should not be mixed(混用不可)’ and principles of ‘food abstinence’(飮食節制)’. 2) The Eight Constitutional Diet has already been studied before 1962, and “Classification Of Constitutional Regimen and Diet”, which recorded harmful and good food, has been used in clinical practices since 1962. The basis that can transform Eight Constitutional Diet into Sasang Constitutional Diet can be found in the fact that the Eight Constitution is based on the Sasang constitution. However, because clinical research on the relationship between 8 constitution and Sasang constitution is still sketchy, directly transforming the current Eight Constitutional Diet into Sasang Constitutional Diet seems unreasonable.

Гейміфікація як модель маркетингового механізму управління безпекою харчування дітей

Гейміфікація як модель маркетингового механізму управління безпекою харчування дітей

Food safety knowledge and practice by the stages of change model in school children.

In this study, 342 grade 4-6 elementary school students in Gyeonggi-do were recruited to determine their readiness to change food safety behavior and to compare their food safety knowledge and practices by the stages of change. The subjects were divided into three stages of change; the percentage of stage 1 (precontemplation) was 10.1%, the percentage of stage 2 (contemplation and preparation) was 62.4%, and that of stage 3 (action and maintenance) was 27.5%. Food safety knowledge scores in stage 3 (4.55) or stage 2 (4.50) children were significantly higher than those in stage 1 children (4.17) (P < 0.05). The two food safety behavior items "hand washing practice" and "avoidance of harmful food" were significantly different among the three groups (P < 0.05). Stages of change were significantly and positively correlated with food safety knowledge and practice. Age was significantly and negatively correlated with the total food safety behavior score (r = -0.142, P < 0.05). The most influential factor on the stage of change was a mother's instruction about food safety (P < 0.01).

The Food Marketing Defense Model: Integrating Psychological Research to Protect Youth and Inform Public Policy

Marketing practices that promote calorie-dense, nutrient-poor foods directly to children and adolescents present significant public health risk. Worldwide, calls for government action and industry change to protect young people from the negative effects of food marketing have increased. Current proposals focus on restricting television advertising to children under 12 years old, but current psychological models suggest that much more is required. All forms of marketing pose considerable risk; adolescents are also highly vulnerable; and food marketing may produce far-reaching negative health outcomes. We propose a food marketing defense model that posits four necessary conditions to effectively counter harmful food marketing practices: awareness, understanding, ability and motivation to resist. A new generation of psychological research is needed to examine each of these processes, including the psychological mechanisms through which food marketing affects young people, to identify public policy that will effectively protect them from harmful influence.

Geophysics and nutritional science: toward a novel, unified paradigm

This article discusses a few basic geophysical processes, which collectively indicate that several nutritionally adverse elements of current Western diets also yield environmentally harmful food consumption patterns. We address oceanic dead zones, which are at the confluence of oceanography, aquatic chemistry, and agronomy and which are a clear environmental problem, and agriculture’s effects on the surface heat budget. These exemplify the unknown, complex, and sometimes unexpected large-scale environmental effects of agriculture. We delineate the significant alignment in purpose between nutritional and environmental sciences. We identify red meat, and to a lesser extent the broader animal-based portion of the diet, as having the greatest environmental effect, with clear nutritional parallels.

Natural variation in Drosophila larval reward learning and memory due to a cGMP-dependent protein kinase

Animals must be able to find and evaluate food to ensure survival. The ability to associate a cue with the presence of food is advantageous because it allows an animal to quickly identify a situation associated with a good, bad, or even harmful food. Identifying genes underlying these natural learned responses is essential to understanding this ability. Here, we investigate whether natural variation in the foraging (for) gene in Drosophila melanogaster larvae is important in mediating associations between either an odor or a light stimulus and food reward. We found that for influences olfactory conditioning and that the mushroom bodies play a role in this for-mediated olfactory learning. Genotypes associated with high activity of the product of for, cGMP-dependent protein kinase (PKG), showed greater memory acquisition and retention compared with genotypes associated with low activity of PKG when trained with three conditioning trials. Interestingly, increasing the number of training trials resulted in decreased memory retention only in genotypes associated with high PKG activity. The difference in the dynamics of memory acquisition and retention between variants of for suggests that the ability to learn and retain an association may be linked to the foraging strategies of the two variants.

The essential balance: Risks and benefits in food safety and quality

Food composition analysis is concerned with both beneficial and harmful food components in the human diet: nutrients, bioactive non-nutrients, anti-nutrients, toxicants, contaminants and other potentially useful and dangerous elements. The concept of food safety in the past excluded elements of nutrition such as known risk factors for certain chronic diseases and nutrients in the form of fortificants and supplements. Concerns about genetically modified foods, functional foods, high levels of nutrient additives and nutritional supplements are now being taken into consideration in the risk and safety activities of both the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO). “Food safety” generally refers to the content of various chemical and microbiological elements in food. More consumer awareness of food safety and quality issues, along with government and industry action, is bringing about a more preventive, food chain approach—sometimes called “from farm to table”—in many countries, so as to improve traditional food safety systems. FAO has adopted this food-chain approach and defines it as recognition that the responsibility for the supply of safe, healthy and nutritious food is shared by all involved, from primary production to final preparation and consumption. Compositional changes (representing either risks or benefits) in food can be introduced at every link. Although developments may be largely beneficial, food composition needs to be monitored to ensure that no harm results to consumers. Finally, collaborative international efforts are needed in order to resolve issues of food-quality and safety across boundaries in a global world trade context. A “holistic food chain approach” would recognize that responsibility for supplying safe and nutritious food lies with all those involved in food production.

Dietary behaviour of pregnant versus non-pregnant women

This study investigates dietary behaviour and the perceived role of food for health of pregnant versus non-pregnant women. Data were collected between 15 January 2003 and 15 March 2003 in Belgium. One hundred and forty-eight pregnant and 130 non-pregnant women aged between 20 and 40 years completed a self-administered questionnaire about their dietary behaviour and nutritional attitudes. Both sub-samples match with respect to individual factors such as relevant socio-demographics and general food perceptions. Pregnant women report higher consumption of fruits, which results in a better score for fibre intake. They also report higher consumption of beef and dairy products, as well as a higher fat intake. No difference in fish consumption between pregnant and non-pregnant women is observed. In line with recommendations, pregnant women report reduced consumption of food products with heightened safety-related risks, lower use of alcohol and tobacco, and safer food handling practices. Reduced intake of raw vegetables for food safety reasons is not compensated by higher intake of cooked vegetables. Pregnant women also report a lower frequency of moderate physical activity. Most differences in food choice by pregnant versus non-pregnant women pertain to the avoidance of specific, potentially harmful food groups. A substantial share of pregnant women does not follow upon recommendations with respect to alcohol use and exposure to tobacco. Personal medical sources for pregnant women and personal social sources for non-pregnant women are reported as the most attended sources of diet-related information. The perceived role of food for health is not different between pregnant and non-pregnant women, and there were no significant interaction effects between pregnancy and presence of children, which indicates that the observed differences in dietary behaviour can be attributed to the state of being pregnant.

Nutrition in pregnancy

Nutrition in pregnancy

LAY BELIEFS ABOUT HEPATITIS AMONG NORTH AMERICAN CHINESE: IMPLICATIONS FOR HEPATITIS PREVENTION

The objective was to learn about the hepatitis prevention behavior of relatively unacculturated North American Chinese adults, along with their knowledge, beliefs, and perceptions with regard to hepatitis, screening, and vaccination. Forty Chinese men and women, aged 18-64, were recruited from immigrant communities in Seattle, Washington, and Vancouver, British Columbia. Semi-structured interviews (Cantonese or Mandarin) were audiotaped, translated, transcribed verbatim, and coded. Open coding, axial coding, constant comparison methods, and QSR NUD*IST 5 software was used for analysis. Findings were validated using eight focus groups. Findings indicated that many interviewees lack accurate knowledge with regard to hepatitis, often confusing the different types. Perceived causes of hepatitis included potentially harmful food (e.g., fried foods or potentially contaminated foods), alcohol, contact with infected individuals, stress, and inadequate rest. Preventive strategies associated with Chinese health beliefs included the use of Chinese herbal medicine, maintaining a stress-free mind, strengthening the body's natural defenses, and getting enough sleep. Other preventive strategies were the practice of good hygiene, vaccination, and the avoidance of contact with infected persons. Vaccination was not seen as primary, as 65% of those who had heard of hepatitis vaccination did not cite it as a means for hepatitis prevention until asked. Also, participants lacked information about the types and purposes of hepatitis vaccination and were worried about side effects. In conclusion, any attempt to promote hepatitis testing and vaccination among the North American Chinese should take traditional beliefs and practices into consideration.